-
1
-
-
0142209158
-
Drug induced QT prolongation and torsades de pointes
-
Y. G. Yap, A. J. Camm, Drug induced QT prolongation and torsades de pointes. Heart 89, 1363-1372 (2003).
-
(2003)
Heart
, vol.89
, pp. 1363-1372
-
-
Yap, Y.G.1
Camm, A.J.2
-
2
-
-
26944438354
-
Drugs, QTc interval prolongation and final ICH E14 guideline: An important milestone with challenges ahead
-
R. R. Shah, Drugs, QTc interval prolongation and final ICH E14 guideline: An important milestone with challenges ahead. Drug Saf. 28, 1009-1028 (2005).
-
(2005)
Drug Saf.
, vol.28
, pp. 1009-1028
-
-
Shah, R.R.1
-
3
-
-
79952055751
-
Advancing regulatory science
-
M. A. Hamburg, Advancing regulatory science. Science 331, 987 (2011).
-
(2011)
Science
, vol.331
, pp. 987
-
-
Hamburg, M.A.1
-
4
-
-
84881283663
-
Revolution dawning in cardiotoxicity testing
-
K. R. Chi, Revolution dawning in cardiotoxicity testing. Nat. Rev. Drug Discov. 12, 565-567 (2013).
-
(2013)
Nat. Rev. Drug Discov.
, vol.12
, pp. 565-567
-
-
Chi, K.R.1
-
5
-
-
84896692500
-
Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium
-
P. T. Sager, G. Gintant, J. R. Turner, S. Pettit, N. Stockbridge, Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium. Am. Heart J. 167, 292-300 (2014).
-
(2014)
Am. Heart J.
, vol.167
, pp. 292-300
-
-
Sager, P.T.1
Gintant, G.2
Turner, J.R.3
Pettit, S.4
Stockbridge, N.5
-
6
-
-
50049127535
-
In silico risk assessment for drug-induction of cardiac arrhythmia
-
S. Suzuki, S. Murakami, K. Tsujimae, I. Findlay, Y. Kurachi, In silico risk assessment for drug-induction of cardiac arrhythmia. Prog. Biophys. Mol. Biol. 98,52-60 (2008).
-
(2008)
Prog. Biophys. Mol. Biol.
, vol.98
, pp. 52-60
-
-
Suzuki, S.1
Murakami, S.2
Tsujimae, K.3
Findlay, I.4
Kurachi, Y.5
-
7
-
-
79955419099
-
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk
-
G.R. Mirams, Y. Cui, A. Sher, M. Fink, J. Cooper, B.M. Heath, N.C. McMahon, D.J. Gavaghan, D. Noble, Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovasc. Res. 91,53-61 (2011).
-
(2011)
Cardiovasc. Res.
, vol.91
, pp. 53-61
-
-
Mirams, G.R.1
Cui, Y.2
Sher, A.3
Fink, M.4
Cooper, J.5
Heath, B.M.6
McMahon, N.C.7
Gavaghan, D.J.8
Noble, D.9
-
8
-
-
84880045844
-
Evaluation of an in silicocardiacsafetyassay:Using ion channel screening data topredictQT interval changes in the rabbit ventricular wedge
-
K.A. Beattie, C. Luscombe, G. Williams, J. Munoz-Muriedas, D.J. Gavaghan, Y. Cui, G.R. Mirams, Evaluation of an in silicocardiacsafetyassay:Using ion channel screening data topredictQT interval changes in the rabbit ventricular wedge. J. Pharmacol. Toxicol. Methods 68,88-96 (2013).
-
(2013)
J. Pharmacol. Toxicol. Methods
, vol.68
, pp. 88-96
-
-
Beattie, K.A.1
Luscombe, C.2
Williams, G.3
Munoz-Muriedas, J.4
Gavaghan, D.J.5
Cui, Y.6
Mirams, G.R.7
-
9
-
-
4444381436
-
Multiphysics simulation of left ventricular filling dynamics using fluid-structure interaction finite element method
-
H. Watanabe, S. Sugiura, H. Kafuku, T. Hisada, Multiphysics simulation of left ventricular filling dynamics using fluid-structure interaction finite element method. Biophys. J. 87, 2074-2085 (2004).
-
(2004)
Biophys. J.
, vol.87
, pp. 2074-2085
-
-
Watanabe, H.1
Sugiura, S.2
Kafuku, H.3
Hisada, T.4
-
10
-
-
79959867969
-
Transmural and ap-icobasal gradients in repolarization contribute to T-wave genesis in human surface ECG
-
J. Okada, T. Washio, A. Maehara, S. Momomura, S. Sugiura, T. Hisada, Transmural and ap-icobasal gradients in repolarization contribute to T-wave genesis in human surface ECG. Am. J. Physiol. Heart Circ. Physiol. 301, H200-H208 (2011).
-
(2011)
Am. J. Physiol. Heart Circ. Physiol.
, vol.301
, pp. H200-H208
-
-
Okada, J.1
Washio, T.2
Maehara, A.3
Momomura, S.4
Sugiura, S.5
Hisada, T.6
-
11
-
-
84857900336
-
Approximation for cooperative interactions of a spatially-detailed cardiac sarcomere model
-
T. Washio, J. Okada, S. Sugiura, T. Hisada, Approximation for cooperative interactions of a spatially-detailed cardiac sarcomere model. Cell. Mol. Bioeng. 5, 113-126 (2011).
-
(2011)
Cell. Mol. Bioeng.
, vol.5
, pp. 113-126
-
-
Washio, T.1
Okada, J.2
Sugiura, S.3
Hisada, T.4
-
12
-
-
84868089279
-
Multi-scale simulations of cardiac electrophysiology and mechanics using the University of Tokyo heart simulator
-
S. Sugiura, T. Washio, A. Hatano, J. Okada, H. Watanabe, T. Hisada, Multi-scale simulations of cardiac electrophysiology and mechanics using the University of Tokyo heart simulator. Prog. Biophys. Mol. Biol. 110, 380-389 (2012).
-
(2012)
Prog. Biophys. Mol. Biol.
, vol.110
, pp. 380-389
-
-
Sugiura, S.1
Washio, T.2
Hatano, A.3
Okada, J.4
Watanabe, H.5
Hisada, T.6
-
13
-
-
84890939632
-
Multiscale heart simulation with cooperative stochastic cross-bridge dynamics and cellular structures
-
T. Washio, J. Okada, A. Takahashi, K. Yoneda, Y. Kadooka, S. Sugiura, T. Hisada, Multiscale heart simulation with cooperative stochastic cross-bridge dynamics and cellular structures. SIAM J. Multiscale Model Simul. 11, 965-999 (2013).
-
(2013)
SIAM J. Multiscale Model Simul.
, vol.11
, pp. 965-999
-
-
Washio, T.1
Okada, J.2
Takahashi, A.3
Yoneda, K.4
Kadooka, Y.5
Sugiura, S.6
Hisada, T.7
-
14
-
-
79952954616
-
A parallel multilevel technique for solving the bidomain equation on a human heart with Purkinje fibers and a torso model
-
T. Washio, J. Okada, T. Hisada, A parallel multilevel technique for solving the bidomain equation on a human heart with Purkinje fibers and a torso model. SIAM Rev. 52,717-743 (2010).
-
(2010)
SIAM Rev.
, vol.52
, pp. 717-743
-
-
Washio, T.1
Okada, J.2
Hisada, T.3
-
15
-
-
84874776151
-
Patientspecificsimulation of bodysurface ECG using the finite element method
-
J. Okada, T. Sasaki, T. Washio, H. Yamashita, T. Kariya, Y. Imai, M. Nakagawa, Y. Kadooka, R. Nagai, T. Hisada, S. Sugiura, Patientspecificsimulation of bodysurface ECG using the finite element method. PACE 36,309-321 (2013).
-
(2013)
PACE
, vol.36
, pp. 309-321
-
-
Okada, J.1
Sasaki, T.2
Washio, T.3
Yamashita, H.4
Kariya, T.5
Imai, Y.6
Nakagawa, M.7
Kadooka, Y.8
Nagai, R.9
Hisada, T.10
Sugiura, S.11
-
16
-
-
0344492207
-
Relationships between preclinical cardiac electrophysiology clinical QT interval prolongation and torsade de pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development
-
W. S. Redfern, L. Carlsson, A. S. Davis, W. G. Lynch, I. MacKenzie, S. Palethorpe, P. K. Siegl, I. Strang, A. T. Sullivan, R. Wallis, A. J. Camm, T. G. Hammond, Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development. Cardiovasc. Res. 58,32-45 (2003).
-
(2003)
Cardiovasc. Res.
, vol.58
, pp. 32-45
-
-
Redfern, W.S.1
Carlsson, L.2
Davis, A.S.3
Lynch, W.G.4
MacKenzie, I.5
Palethorpe, S.6
Siegl, P.K.7
Strang, I.8
Sullivan, A.T.9
Wallis, R.10
Camm, A.J.11
Hammond, T.G.12
-
17
-
-
33845194767
-
A rabbit Langendorffheartproarrhythmia model:Predictivevalueforclinical identification ofTorsades de Pointes
-
C. L. Lawrence, M. H. Bridgland-Taylor, C. E. Pollard, T. G. Hammond, J.-P. Valentin, A rabbit Langendorffheartproarrhythmia model:Predictivevalueforclinical identification ofTorsades de Pointes. Br. J. Pharmacol. 149, 845-860 (2006).
-
(2006)
Br. J. Pharmacol.
, vol.149
, pp. 845-860
-
-
Lawrence, C.L.1
Bridgland-Taylor, M.H.2
Pollard, C.E.3
Hammond, T.G.4
Valentin, J.-P.5
-
18
-
-
0027517892
-
Comparative assessment ofibutilide, D-sotalol, clofilium, E-4031, and UK-68,798 in a rabbit model of proarrhythmia
-
L. Buchanan, G. Kabell, M. N. Brunden, J. K. Gibson, Comparative assessment ofibutilide, D-sotalol, clofilium, E-4031, and UK-68,798 in a rabbit model of proarrhythmia. J. Cardiovasc. Pharmacol. 220,540-549 (1993).
-
(1993)
J. Cardiovasc. Pharmacol.
, vol.220
, pp. 540-549
-
-
Buchanan, L.1
Kabell, G.2
Brunden, M.N.3
Gibson, J.K.4
-
19
-
-
48149095643
-
Keyclinical considerations for demonstrating the utilityofpreclinical modelsto predict clinical drug-induced torsades de pointes
-
P.T. Sager, Keyclinical considerations for demonstrating the utilityofpreclinical modelsto predict clinical drug-induced torsades de pointes. Br. J. Pharmacol. 154, 1544-1549 (2008).
-
(2008)
Br. J. Pharmacol.
, vol.154
, pp. 1544-1549
-
-
Sager, P.T.1
-
20
-
-
0034805825
-
Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes
-
B. Darpo, Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes. Eur. Heart J. Suppl. 3, K70-K80 (2001).
-
(2001)
Eur. Heart J. Suppl.
, vol.3
, pp. K70-K80
-
-
Darpo, B.1
-
21
-
-
0031583760
-
Effect of prophylactic amiodarone on mortality after acute myo-cardial infarction and in congestive heart failure: Meta-analysis of individual data from 6500 patients in randomised trials
-
A. T. M.-A. Investigators
-
A. T. M.-A. Investigators, Effect of prophylactic amiodarone on mortality after acute myo-cardial infarction and in congestive heart failure: Meta-analysis of individual data from 6500 patients in randomised trials. Lancet 350, 1417-1424 (1997).
-
(1997)
Lancet
, vol.350
, pp. 1417-1424
-
-
-
22
-
-
84880116735
-
MICE models: Superior totheHERG model in predicting TorsadedePointes
-
J. Kramer, C. A. Obejero-Paz, G. Myatt, Y. A. Kuryshev, A. Bruening-Wright, J. S. Verducci, A.M. Brown, MICE models: Superior totheHERG model in predicting TorsadedePointes. Sci. Rep. 3, 2100 (2013).
-
(2013)
Sci. Rep.
, vol.3
, pp. 2100
-
-
Kramer, J.1
Obejero-Paz, C.A.2
Myatt, G.3
Kuryshev, Y.A.4
Bruening-Wright, A.5
Verducci, J.S.6
Brown, A.M.7
-
23
-
-
33845612264
-
Cellular basis for the repolarization waves of the ECG
-
C. Antzelevitch, Cellular basis for the repolarization waves of the ECG. Ann. N. Y. Acad. Sci. 1080, 268-281 (2006).
-
(2006)
Ann. N. Y. Acad. Sci.
, vol.1080
, pp. 268-281
-
-
Antzelevitch, C.1
-
24
-
-
28344433057
-
Preclinical cardiac safety assessment of pharmacological compounds using an integrated system-based computer model of the heart
-
D. Bottino, R. C. Penland, A. Stamps, M. Traebert, B. Dumotier, A. Georgiva, G. Helmlinger, G. S. Lett, Preclinical cardiac safety assessment of pharmacological compounds using an integrated system-based computer model of the heart. Prog. Biophys. Mol. Biol. 90, 413-443 (2006).
-
(2006)
Prog. Biophys. Mol. Biol.
, vol.90
, pp. 413-443
-
-
Bottino, D.1
Penland, R.C.2
Stamps, A.3
Traebert, M.4
Dumotier, B.5
Georgiva, A.6
Helmlinger, G.7
Lett, G.S.8
-
25
-
-
84867283408
-
Application of cardiac electro-physiology simulations to pro-arrhythmic safety testing
-
G. R. Mirams, M. R. Davies, Y. Cui, P. Kohl, D. Noble, Application of cardiac electro-physiology simulations to pro-arrhythmic safety testing. Br. J. Pharmacol. 167, 932-945 (2012).
-
(2012)
Br. J. Pharmacol.
, vol.167
, pp. 932-945
-
-
Mirams, G.R.1
Davies, M.R.2
Cui, Y.3
Kohl, P.4
Noble, D.5
-
26
-
-
84872373202
-
Computational assessment of drug-induced effects on the electrocardiogram: From ion channel to body surface potentials
-
N. Zemzemi, M. O. Bernabeu, J. Saiz, J. Cooper, P. Pathmanathan, G. R. Mirams, J. Pitt-Francis, B. Rodriguez, Computational assessment of drug-induced effects on the electrocardiogram: From ion channel to body surface potentials. Br. J. Pharmacol. 168, 718-733 (2013).
-
(2013)
Br. J. Pharmacol.
, vol.168
, pp. 718-733
-
-
Zemzemi, N.1
Bernabeu, M.O.2
Saiz, J.3
Cooper, J.4
Pathmanathan, P.5
Mirams, G.R.6
Pitt-Francis, J.7
Rodriguez, B.8
-
27
-
-
84875871606
-
Current pharmacogenomic studies on hERG potassium channels
-
F. Z. He, H. L. McLeod, W. Zhang, Current pharmacogenomic studies on hERG potassium channels. Trends Mol. Med. 19, 227-238 (2013).
-
(2013)
Trends Mol. Med.
, vol.19
, pp. 227-238
-
-
He, F.Z.1
McLeod, H.L.2
Zhang, W.3
-
28
-
-
2542441586
-
Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels
-
B. D. Anson, M. J. Ackerman, D. J. Tester, M. L. Will, B. P. Delisle, C. L. Anderson, C. T. January, Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels. Am. J. Physiol. 286, H2434-H2441 (2004).
-
(2004)
Am. J. Physiol.
, vol.286
, pp. H2434-H2441
-
-
Anson, B.D.1
Ackerman, M.J.2
Tester, D.J.3
Will, M.L.4
Delisle, B.P.5
Anderson, C.L.6
January, C.T.7
-
29
-
-
33744529577
-
Torsades de pointes induced by antibiotics
-
D. Justo, D. Zeltser, Torsades de pointes induced by antibiotics. Eur. J. Intern. Med. 17,254-259 (2006).
-
(2006)
Eur. J. Intern. Med.
, vol.17
, pp. 254-259
-
-
Justo, D.1
Zeltser, D.2
-
30
-
-
4344577023
-
Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties
-
C. Antzelevitch, L. Belardinelli, A. C. Zygmunt, A. Burashnikov, J. M. Di Diego, J. M. Fish, J. M. Cordeiro, G. Thomas, Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation 110, 904-910 (2004).
-
(2004)
Circulation
, vol.110
, pp. 904-910
-
-
Antzelevitch, C.1
Belardinelli, L.2
Zygmunt, A.C.3
Burashnikov, A.4
Di Diego, J.M.5
Fish, J.M.6
Cordeiro, J.M.7
Thomas, G.8
-
31
-
-
85042082152
-
Late cardiac sodium current can be assessed using automated patch-clamp
-
M. Chevalier, B. Amuzescu, V. Gawali, H. Todt, T. Knott, O. Scheel, H. Abriel, Late cardiac sodium current can be assessed using automated patch-clamp. FWOORes. 3, 245 (2014).
-
(2014)
FWOORes.
, vol.3
, pp. 245
-
-
Chevalier, M.1
Amuzescu, B.2
Gawali, V.3
Todt, H.4
Knott, T.5
Scheel, O.6
Abriel, H.7
-
32
-
-
79958158591
-
Simulation of the undiseased human cardiac ventricular action potential: Model formulation and experimental validation
-
T. O'Hara, L. Virag, A. Varro, Y. Rudy, Simulation of the undiseased human cardiac ventricular action potential: Model formulation and experimental validation. PLOS Comput. Biol. 7, e1002061 (2011).
-
(2011)
PLOS Comput. Biol.
, vol.7
, pp. e1002061
-
-
O'Hara, T.1
Virag, L.2
Varro, A.3
Rudy, Y.4
-
33
-
-
67650891603
-
Mathematical models of the electrical action potential of Purkinje fibre cells
-
P. Stewart, O. V. Aslanidi, D. Noble, P. J. Noble, M. R. Boyett, H. Zhang, Mathematical models of the electrical action potential of Purkinje fibre cells. Philos. Trans. A Math. Phys. Eng. Sci. 367, 2225-2255 (2009).
-
(2009)
Philos. Trans. A Math. Phys. Eng. Sci.
, vol.367
, pp. 2225-2255
-
-
Stewart, P.1
Aslanidi, O.V.2
Noble, D.3
Noble, P.J.4
Boyett, M.R.5
Zhang, H.6
-
34
-
-
0027447573
-
Simulating the electrical behavior of cardiac tissue using the bidomain model
-
C. S. Henriquez, Simulating the electrical behavior of cardiac tissue using the bidomain model. Crit. Rev. Biomed. Eng. 21, 1-77 (1993).
-
(1993)
Crit. Rev. Biomed. Eng.
, vol.21
, pp. 1-77
-
-
Henriquez, C.S.1
-
35
-
-
85047690449
-
How the anisotropy of the intracellular and extracellular conductivities influences stimulation of cardiac muscle
-
B. Roth, How the anisotropy of the intracellular and extracellular conductivities influences stimulation of cardiac muscle. J. Math. Biol. 30, 633-646 (1992).
-
(1992)
J. Math. Biol.
, vol.30
, pp. 633-646
-
-
Roth, B.1
-
36
-
-
0344513990
-
Clarithromycin reduces /sus and /to currents in human atrial myocytes with minor repercussions on action potential duration
-
P. Gluais, M. Bastide, D. Grandmougin, G. Fayad, M. Adamantidis, Clarithromycin reduces /sus and /to currents in human atrial myocytes with minor repercussions on action potential duration. Fundam. Clin. Pharmacol. 17, 691-701 (2003).
-
(2003)
Fundam. Clin. Pharmacol.
, vol.17
, pp. 691-701
-
-
Gluais, P.1
Bastide, M.2
Grandmougin, D.3
Fayad, G.4
Adamantidis, M.5
|