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Volumn 10, Issue , 2017, Pages 133-139

Emerging targeted therapies for plaque psoriasis – Impact of ixekizumab

Author keywords

Biologic medication; IL 12; IL 17; IL 23; Ixekizumab; Psoriasis

Indexed keywords

BRODALUMAB; ETANERCEPT; GUSELKUMAB; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 23; IXEKIZUMAB; SECUKINUMAB; TILDRAKIZUMAB; USTEKINUMAB;

EID: 85020541224     PISSN: None     EISSN: 11787015     Source Type: Journal    
DOI: 10.2147/CCID.S111007     Document Type: Review
Times cited : (7)

References (37)
  • 1
    • 84894080694 scopus 로고    scopus 로고
    • Psoriasis prevalence among adults in the United States
    • Rachakonda TD, Schupp CW, Armstrong AW. Psoriasis prevalence among adults in the United States. J Am Acad Dermatol. 2014;70(3):512–516.
    • (2014) J am Acad Dermatol , vol.70 , Issue.3 , pp. 512-516
    • Rachakonda, T.D.1    Schupp, C.W.2    Armstrong, A.W.3
  • 2
    • 36048964489 scopus 로고    scopus 로고
    • The histopathologic spectrum of psoriasis
    • Murphy M, Kerr P, Grant-Kels JM. The histopathologic spectrum of psoriasis. Clin Dermatol. 2007;25(6):524–528.
    • (2007) Clin Dermatol , vol.25 , Issue.6 , pp. 524-528
    • Murphy, M.1    Kerr, P.2    Grant-Kels, J.M.3
  • 3
    • 84859073115 scopus 로고    scopus 로고
    • Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis
    • Leonardi C, Matheson R, Zachariae C, et al. Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N Engl J Med. 2012;366(13):1190–1199.
    • (2012) N Engl J Med , vol.366 , Issue.13 , pp. 1190-1199
    • Leonardi, C.1    Matheson, R.2    Zachariae, C.3
  • 4
    • 37349131221 scopus 로고    scopus 로고
    • Pathophysiology of psoriasis: Recent advances on IL-23 and Th17 cytokines
    • Fitch E, Harper E, Skorcheva I, Kurtz SE, Blauvelt A. Pathophysiology of psoriasis: recent advances on IL-23 and Th17 cytokines. Curr Rheumatol Rep. 2007;9(6):461–467.
    • (2007) Curr Rheumatol Rep , vol.9 , Issue.6 , pp. 461-467
    • Fitch, E.1    Harper, E.2    Skorcheva, I.3    Kurtz, S.E.4    Blauvelt, A.5
  • 5
    • 84956500741 scopus 로고    scopus 로고
    • Anti-IL-17 medications used in the treatment of plaque psoriasis and psoriatic arthritis: A comprehensive review
    • Canavan TN, Elmets CA, Cantrell WL, Evans JM, Elewski BE. Anti-IL-17 medications used in the treatment of plaque psoriasis and psoriatic arthritis: a comprehensive review. Am J Clin Dermatol. 2016;17(1):33–47.
    • (2016) Am J Clin Dermatol , vol.17 , Issue.1 , pp. 33-47
    • Canavan, T.N.1    Elmets, C.A.2    Cantrell, W.L.3    Evans, J.M.4    Elewski, B.E.5
  • 7
    • 84872275425 scopus 로고    scopus 로고
    • The emerging role of IL-17 in the pathogenesis of psoriasis: Preclinical and clinical findings
    • Martin DA, Towne JE, Kricorian G, et al. The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings. J Invest Dermatol. 2013;133(1):17–26.
    • (2013) J Invest Dermatol , vol.133 , Issue.1 , pp. 17-26
    • Martin, D.A.1    Towne, J.E.2    Kricorian, G.3
  • 8
    • 84872348231 scopus 로고    scopus 로고
    • Targeting IL-17 in psoriasis: From cutaneous immunobiology to clinical application
    • Ariza ME, Williams MV, Wong HK. Targeting IL-17 in psoriasis: from cutaneous immunobiology to clinical application. Clin Immunol. 2013;146(2):131–139.
    • (2013) Clin Immunol , vol.146 , Issue.2 , pp. 131-139
    • Ariza, M.E.1    Williams, M.V.2    Wong, H.K.3
  • 9
    • 77951091571 scopus 로고    scopus 로고
    • Circulating Th17, Th22, and Th1 cells are increased in psoriasis
    • Kagami S, Rizzo HL, Lee JJ, Koguchi Y, Blauvelt A. Circulating Th17, Th22, and Th1 cells are increased in psoriasis. J Invest Dermatol. 2010;130(5):1373–1383.
    • (2010) J Invest Dermatol , vol.130 , Issue.5 , pp. 1373-1383
    • Kagami, S.1    Rizzo, H.L.2    Lee, J.J.3    Koguchi, Y.4    Blauvelt, A.5
  • 10
    • 34249079176 scopus 로고    scopus 로고
    • Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
    • Acosta-Rodriguez EV, Rivino L, Geginat J, et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol. 2007;8(6):639–646.
    • (2007) Nat Immunol , vol.8 , Issue.6 , pp. 639-646
    • Acosta-Rodriguez, E.V.1    Rivino, L.2    Geginat, J.3
  • 11
    • 34547734621 scopus 로고    scopus 로고
    • Phenotypic and functional features of human Th17 cells
    • Annunziato F, Cosmi L, Santarlasci V, et al. Phenotypic and functional features of human Th17 cells. J Exp Med. 2007;204(8):1849–1861.
    • (2007) J Exp Med , vol.204 , Issue.8 , pp. 1849-1861
    • Annunziato, F.1    Cosmi, L.2    Santarlasci, V.3
  • 12
    • 42149087160 scopus 로고    scopus 로고
    • Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells
    • Lowes MA, Kikuchi T, Fuentes-Duculan J, et al. Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. J Invest Dermatol. 2008;128(5):1207–1211.
    • (2008) J Invest Dermatol , vol.128 , Issue.5 , pp. 1207-1211
    • Lowes, M.A.1    Kikuchi, T.2    Fuentes-Duculan, J.3
  • 13
    • 84862860846 scopus 로고    scopus 로고
    • IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis
    • Krueger JG, Fretzin S, Suarez-Farinas M, et al. IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis. J Allergy Clin Immunol. 2012;130(1):145–154. e9.
    • (2012) J Allergy Clin Immunol , vol.130 , Issue.1 , pp. 145-154
    • Krueger, J.G.1    Fretzin, S.2    Suarez-Farinas, M.3
  • 14
    • 0141955042 scopus 로고    scopus 로고
    • Psoriasis disease severity measures: Comparing efficacy of treatments for severe psoriasis
    • Weisman S, Pollack CR, Gottschalk RW. Psoriasis disease severity measures: comparing efficacy of treatments for severe psoriasis. J Dermatolog Treat. 2003;14(3):158–165.
    • (2003) J Dermatolog Treat , vol.14 , Issue.3 , pp. 158-165
    • Weisman, S.1    Pollack, C.R.2    Gottschalk, R.W.3
  • 15
    • 27744503544 scopus 로고    scopus 로고
    • Translating the science of quality of life into practice: What do dermatology life quality index scores mean?
    • Hongbo Y, Thomas CL, Harrison MA, Salek MS, Finlay AY. Translating the science of quality of life into practice: what do dermatology life quality index scores mean? J Invest Dermatol. 2005;125(4):659–664.
    • (2005) J Invest Dermatol , vol.125 , Issue.4 , pp. 659-664
    • Hongbo, Y.1    Thomas, C.L.2    Harrison, M.A.3    Salek, M.S.4    Finlay, A.Y.5
  • 16
    • 84945443119 scopus 로고    scopus 로고
    • Tildrakizumab (MK-3222), an antiinterleukin-23p19 monoclonal antibody, improves psoriasis in a phase IIb randomized placebo-controlled trial
    • Papp K, Thaci D, Reich K, et al. Tildrakizumab (MK-3222), an antiinterleukin-23p19 monoclonal antibody, improves psoriasis in a phase IIb randomized placebo-controlled trial. Br J Dermatol. 2015;173(4): 930–939.
    • (2015) Br J Dermatol , vol.173 , Issue.4 , pp. 930-939
    • Papp, K.1    Thaci, D.2    Reich, K.3
  • 17
    • 84936763292 scopus 로고    scopus 로고
    • A phase 2 trial of guselkumab versus adalimumab for plaque psoriasis
    • Gordon KB, Duffin KC, Bissonnette R, et al. A phase 2 trial of guselkumab versus adalimumab for plaque psoriasis. N Engl J Med. 2015;373(2): 136–144.
    • (2015) N Engl J Med , vol.373 , Issue.2 , pp. 136-144
    • Gordon, K.B.1    Duffin, K.C.2    Bissonnette, R.3
  • 18
    • 43449139402 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, doubleblind, placebo-controlled trial (PHOENIX 2)
    • Papp KA, Langley RG, Lebwohl M, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, doubleblind, placebo-controlled trial (PHOENIX 2). Lancet. 2008;371(9625): 1675–1684.
    • (2008) Lancet , vol.371 , Issue.9625 , pp. 1675-1684
    • Papp, K.A.1    Langley, R.G.2    Lebwohl, M.3
  • 19
    • 84859775345 scopus 로고    scopus 로고
    • US Food and Drug Administration. 25 September, Accessed 25 July 2016
    • Karen Riley. FDA approves new drug to treat psoriasis. US Food and Drug Administration. 25 September 2009. Available from: https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2009/ ucm183851.htm. Accessed 25 July 2016.
    • (2009) FDA Approves New Drug to Treat Psoriasis
    • Riley, K.1
  • 20
    • 84975815496 scopus 로고    scopus 로고
    • Brodalumab for the treatment of psoriasis: A review of phase III trials
    • Farahnik B, Beroukhim K, Abrouk M, et al. Brodalumab for the treatment of psoriasis: a review of phase III trials. Dermatol Ther (Heidelb). 2016;6(2):111–124.
    • (2016) Dermatol Ther (Heidelb) , vol.6 , Issue.2 , pp. 111-124
    • Farahnik, B.1    Beroukhim, K.2    Abrouk, M.3
  • 21
    • 84975882393 scopus 로고    scopus 로고
    • Anti-IL-17 agents for psoriasis: A review of phase III data
    • Farahnik B, Beroukhim K, Nakamura M, et al. Anti-IL-17 agents for psoriasis: a review of phase III data. J Drugs Dermatol. 2016;15(3): 311–316.
    • (2016) J Drugs Dermatol , vol.15 , Issue.3 , pp. 311-316
    • Farahnik, B.1    Beroukhim, K.2    Nakamura, M.3
  • 22
    • 84942876148 scopus 로고    scopus 로고
    • Phase 3 studies comparing brodalumab with ustekinumab in psoriasis
    • Lebwohl M, Strober B, Menter A, et al. Phase 3 studies comparing brodalumab with ustekinumab in psoriasis. N Engl J Med. 2015;373(14): 1318–1328.
    • (2015) N Engl J Med , vol.373 , Issue.14 , pp. 1318-1328
    • Lebwohl, M.1    Strober, B.2    Menter, A.3
  • 23
    • 84954258528 scopus 로고    scopus 로고
    • Amgen Press Release. Amgen, 22 May, Accessed 25 July 2016
    • Trish Hawkins. Amgen to Terminate Participation in Co-development and Commercialization of Brodalumab. Amgen Press Release. Amgen, 22 May 2015. Available from: http://www.prnewswire.com/news-releases/amgen-to-terminate-participation-in-co-development-and-commercial ization-of-brodalumab-300088098.html. Accessed 25 July 2016.
    • (2015) Amgen to Terminate Participation in Co-Development and Commercialization of Brodalumab
    • Hawkins, T.1
  • 24
    • 84984695181 scopus 로고    scopus 로고
    • Efficacy and safety of brodalumab in patients with moderate to severe plaque psoriasis: Results of AMAGINE-1, a phase 3, randomized, double-blind, placebo-controlled study through week
    • Papp K, Reich K, Leonardi C, et al. Efficacy and safety of brodalumab in patients with moderate to severe plaque psoriasis: results of AMAGINE-1, a phase 3, randomized, double-blind, placebo-controlled study through week JAAD. 2015;72(5):AB233.
    • (2015) JAAD , vol.72 , Issue.5
    • Papp, K.1    Reich, K.2    Leonardi, C.3
  • 25
    • 84904545875 scopus 로고    scopus 로고
    • ERASURE Study Group; FIXTURE Study Group. Secukinumab in plaque psoriasis–results of two phase 3 trials
    • Langley RG, Elewski BE, Lebwohl M, et al; ERASURE Study Group; FIXTURE Study Group. Secukinumab in plaque psoriasis–results of two phase 3 trials. N Engl J Med. 2014;371(4):326–338.
    • (2014) N Engl J Med , vol.371 , Issue.4 , pp. 326-338
    • Langley, R.G.1    Elewski, B.E.2    Lebwohl, M.3
  • 26
    • 84922933349 scopus 로고    scopus 로고
    • FEATURE Study Group. Secukinumab administration by pre-filled syringe: Efficacy, safety and usability results from a randomized controlled trial in psoriasis (FEATURE)
    • Blauvelt A, Prinz JC, Gottlieb AB, et al; FEATURE Study Group. Secukinumab administration by pre-filled syringe: efficacy, safety and usability results from a randomized controlled trial in psoriasis (FEATURE). Br J Dermatol. 2015;172(2):484–493.
    • (2015) Br J Dermatol , vol.172 , Issue.2 , pp. 484-493
    • Blauvelt, A.1    Prinz, J.C.2    Gottlieb, A.B.3
  • 27
    • 84929629144 scopus 로고    scopus 로고
    • JUNCTURE study group. Efficacy, safety and usability of secukinumab administration by autoinjector/pen in psoriasis: A randomized, controlled trial (JUNCTURE)
    • Paul C, Lacour JP, Tedremets L, et al; JUNCTURE study group. Efficacy, safety and usability of secukinumab administration by autoinjector/pen in psoriasis: a randomized, controlled trial (JUNCTURE). J Eur Acad Dermatol Venereol. 2015;29(6):1082–1090.
    • (2015) J Eur Acad Dermatol Venereol , vol.29 , Issue.6 , pp. 1082-1090
    • Paul, C.1    Lacour, J.P.2    Tedremets, L.3
  • 29
    • 84959135632 scopus 로고    scopus 로고
    • 22 March, Accessed 25 July 2016
    • FDA approves new psoriasis drug Taltz. US Food and Drug Administration. 22 March 2016.Available from: https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm491872.htm. Accessed 25 July 2016.
    • (2016) US Food and Drug Administration
  • 31
    • 85001976260 scopus 로고    scopus 로고
    • Phase 3 trials of ixekizumab in moderate-to-severe plaque psoriasis
    • Gordon KB, Colombel JF, Hardin DS. Phase 3 trials of ixekizumab in moderate-to-severe plaque psoriasis. N Engl J Med. 2016;375(21):2102.
    • (2016) N Engl J Med , vol.375 , Issue.21 , pp. 2102
    • Gordon, K.B.1    Colombel, J.F.2    Hardin, D.S.3
  • 32
    • 84938992082 scopus 로고    scopus 로고
    • UNCOVER-2 and UNCOVER-3 investigators. Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): Results from two phase 3 randomised trials
    • Griff iths CE, Reich K, Lebwohl M, et al; UNCOVER-2 and UNCOVER-3 investigators. Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials. Lancet. 2015; 386(9993):541–551.
    • (2015) Lancet , vol.386 , Issue.9993 , pp. 541-551
    • Griff Iths, C.E.1    Reich, K.2    Lebwohl, M.3
  • 33
    • 84975132508 scopus 로고    scopus 로고
    • Effect of ixekizumab treatment on work productivity for patients with moderate-to-severe plaque psoriasis: Analysis of results from 3 randomized phase 3 clinical trials
    • Armstrong AW, Lynde CW, McBride SR, et al. Effect of ixekizumab treatment on work productivity for patients with moderate-to-severe plaque psoriasis: analysis of results from 3 randomized phase 3 clinical trials. JAMA Dermatol. 2016;152(6):661–669.
    • (2016) JAMA Dermatol , vol.152 , Issue.6 , pp. 661-669
    • Armstrong, A.W.1    Lynde, C.W.2    McBride, S.R.3
  • 34
    • 84880329838 scopus 로고    scopus 로고
    • A prospective, interventional assessment of psoriasis quality of life using a nonskinspecific validated instrument that allows comparison with other major medical conditions
    • Bhutani T, Patel T, Koo B, Nguyen T, Hong J, Koo J. A prospective, interventional assessment of psoriasis quality of life using a nonskinspecific validated instrument that allows comparison with other major medical conditions. J Am Acad Dermatol. 2013;69(2):e79–e88.
    • (2013) J am Acad Dermatol , vol.69 , Issue.2 , pp. e79-e88
    • Bhutani, T.1    Patel, T.2    Koo, B.3    Nguyen, T.4    Hong, J.5    Koo, J.6
  • 35
    • 84906278947 scopus 로고    scopus 로고
    • Social impact of the burden of psoriasis: Effects on patients and practice
    • Feldman SR, Malakouti M, Koo JY. Social impact of the burden of psoriasis: effects on patients and practice. Dermatol Online J. 2014; 20(8).
    • (2014) Dermatol Online J , vol.20 , Issue.8
    • Feldman, S.R.1    Malakouti, M.2    Koo, J.Y.3
  • 36
    • 84869831363 scopus 로고    scopus 로고
    • Association between tumor necrosis factor inhibitor therapy and myocardial infarction risk in patients with psoriasis
    • Wu JJ, Poon K-YTY, Channual JC, Shen AY. Association between tumor necrosis factor inhibitor therapy and myocardial infarction risk in patients with psoriasis. Arch. Dermatol. 2012;148(11): 1244–1250.
    • (2012) Arch. Dermatol. , vol.148 , Issue.11 , pp. 1244-1250
    • Wu, J.J.1    Poon, K.-Y.2    Channual, J.C.3    Shen, A.Y.4
  • 37
    • 84939463415 scopus 로고    scopus 로고
    • Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate to severe plaque psoriasis: CLEAR, a randomized controlled trial
    • Thaçi D, Blauvelt A, Reich K, et al. Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate to severe plaque psoriasis: CLEAR, a randomized controlled trial. J Am Acad Dermatol. 2015;73(3):400–409.
    • (2015) J am Acad Dermatol , vol.73 , Issue.3 , pp. 400-409
    • Thaçi, D.1    Blauvelt, A.2    Reich, K.3


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