Association between HIV infection and the risk of heart failure with reduced ejection fraction and preserved ejection fraction in the antiretroviral therapy era: Results from the veterans aging cohort study

JAMA Cardiology

Volumn 2, Issue 5, 2017, Pages 536-546

  Freiberg, Matthew S ^a,b   Chang, Chung Chou H ^c   Skanderson, Melissa ^d   Patterson, Olga V ^b,e   DuVall, Scott L ^b,e   Brandt, Cynthia A ^d,f   So Armah, Kaku A ^g   Vasan, Ramachandran S ^g   Oursler, Kris Ann ^b,h   Gottdiener, John ^h   Gottlieb, Stephen ^h   Leaf, David ⁱ   Rodriguez Barradas, Maria ^j,k   Tracy, Russell P ^l   Gibert, Cynthia L ^m,n   Rimland, David ^o,p   Bedimo, Roger J ^q   Brown, Sheldon T ^b,r   Goetz, Matthew Bidwell ^i,s   Warner, Alberta ^i,s   Crothers, Kristina ^t   Tindle, Hilary A ^a   Alcorn, Charles ^u   Bachmann, Justin M ^a   Justice, Amy C ^d,f   Butt, Adeel A ^v   more..

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^e UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^f YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j BAYLOR COLLEGE OF MEDICINE   (United States)

^k MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^l UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^m GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

ⁿ VETERANS AFFAIRS MEDICAL CENTER   (United States)

^o EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^p ATLANTA VA MEDICAL CENTER   (United States)

^q VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

^r MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^s VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^t UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^u UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^v WEILL CORNELL MEDICAL COLLEGE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; VIRUS RNA; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ADULT; AGE; AGING; ANTIRETROVIRAL THERAPY; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; COHORT ANALYSIS; CONTROLLED STUDY; DEMOGRAPHY; DISEASE ASSOCIATION; ETHNICITY; FEMALE; FOLLOW UP; GENDER; HEART FAILURE WITH PRESERVED EJECTION FRACTION; HEART FAILURE WITH REDUCED EJECTION FRACTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; NONHUMAN; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RACE; RISK ASSESSMENT; SOCIAL ASPECT; VETERAN; VIRUS LOAD; CASE CONTROL STUDY; CD4 LYMPHOCYTE COUNT; GOVERNMENT; HEART FAILURE; HEART STROKE VOLUME; MIDDLE AGED; PATHOPHYSIOLOGY; PROPORTIONAL HAZARDS MODEL; RISK FACTOR; RISK REDUCTION; UNITED STATES;

ADULT; ANTI-HIV AGENTS; CASE-CONTROL STUDIES; CD4 LYMPHOCYTE COUNT; COHORT STUDIES; FEMALE; HEART FAILURE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; RISK ASSESSMENT; RISK FACTORS; RISK REDUCTION BEHAVIOR; STROKE VOLUME; UNITED STATES; UNITED STATES DEPARTMENT OF VETERANS AFFAIRS; VETERANS; VIRAL LOAD;

EID: 85020463714     PISSN: 23806583     EISSN: 23806591     Source Type: Journal    
DOI: 10.1001/jamacardio.2017.0264     Document Type: Article

References (46)

1. AIDS.gov. Global HIV/AIDS overview. https://www.aids.gov/federal-resources/around-the-world/global-aids-overview/. Updated November 29, 2016. Accessed March 7, 2017.
2. Palella FJ Jr, Delaney KM, Moorman AC, et al; HIV Outpatient Study Investigators. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med. 1998;338(13):853-860.
3. Greene M, Justice AC, Lampiris HW, Valcour V. Management of human immunodeficiency virus infection in advanced age. JAMA. 2013;309(13): 1397-1405.
4. Freiberg MS, Chang CC, Kuller LH, et al. HIV infection and the risk of acutemyocardial infarction. JAMA Intern Med. 2013;173(8):614-622.
5. Triant VA, Lee H, Hadigan C, Grinspoon SK. Increased acutemyocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease. J Clin Endocrinol Metab. 2007;92(7):2506-2512.
6. Currier JS, Taylor A, Boyd F, et al. Coronary heart disease in HIV-infected individuals. J Acquir Immune Defic Syndr. 2003;33(4):506-512.
7. Silverberg MJ, Leyden WA, Xu L, et al. Immunodeficiency and risk ofmyocardial infarction among HIV-positive individuals with access to care. J Acquir Immune Defic Syndr. 2014;65(2):160-166.
8. Butt AA, Chang CC, Kuller L, et al. Risk of heart failure with human immunodeficiency virus in the absence of prior diagnosis of coronary heart disease. Arch Intern Med. 2011;171(8):737-743.
9. Remick J, Georgiopoulou V, Marti C, et al. Heart failure in patients with human immunodeficiency virus infection: epidemiology, pathophysiology, treatment, and future research. Circulation. 2014; 129(17):1781-1789.
10. Al-Kindi SG, ElAmm C, Ginwalla M, et al. Heart failure in patients with human immunodeficiency virus infection: epidemiology and management disparities. Int J Cardiol. 2016;218:43-46.
11. Velagaleti RS, Pencina MJ, Murabito JM, et al. Long-term trends in the incidence of heart failure aftermyocardial infarction. Circulation. 2008;118 (20):2057-2062.
12. Borlaug BA, Redfield MM. Diastolic and systolic heart failure are distinct phenotypes within the heart failure spectrum. Circulation. 2011;123(18): 2006-2013.
13. Fontes-Carvalho R, Mancio J, Marcos A, et al. HIV patients have impaired diastolic function that is not aggravated by anti-retroviral treatment. Cardiovasc Drugs Ther. 2015;29(1):31-39.
14. Luo L, Zeng Y, Li T, et al; China AIDS Clinical Trial 0810 Group. Prospective echocardiographic assessment of cardiac structure and function in Chinese persons living with HIV. Clin Infect Dis. 2014;58(10):1459-1466.
15. Cerrato E, D'Ascenzo F, Biondi-Zoccai G, et al. Cardiac dysfunction in pauci symptomatic human immunodeficiency virus patients: ameta-analysis in the highly active antiretroviral therapy era. Eur Heart J. 2013;34(19):1432-1436.
16. Reinsch N, Neuhaus K, Esser S, et al; German Competence Network for Heart Failure; German Competence Network for HIV AIDS. Prevalence of cardiac diastolic dysfunction in HIV-infected patients: results of the HIV-HEART study. HIV Clin Trials. 2010;11(3):156-162.
17. Malebranche R, Tabou Moyo C, Morisset PH, Raphael NA, Wilentz JR. Clinical and echocardiographic characteristics and outcomes in congestive heart failure at the Hospital of the State University of Haiti. Am Heart J. 2016;178:151-160.
18. Hsue PY, Hunt PW, Ho JE, et al. Impact of HIV infection on diastolic function and left ventricular mass. Circ Heart Fail. 2010;3(1):132-139.
19. Reinsch N, Kahlert P, Esser S, et al. Echocardiographic findings and abnormalities in HIV-infected patients: results from a large, prospective, multicenter HIV-heart study. Am J Cardiovasc Dis. 2011;1(2):176-184.
20. Mondy KE, Gottdiener J, Overton ET, et al; SUN Study Investigators. High prevalence of echocardiographic abnormalities among HIV-infected persons in the era of highly active antiretroviral therapy. Clin Infect Dis. 2011;52(3):378-386.
21. Centers for Disease Control and Prevention. HIV/AIDS: risk by age group. http://www.cdc.gov/hiv/group/age/index.html. Published 2016. Accessed June 14, 2016.
22. Centers for Disease Control and Prevention. HIV/AIDS: risk by racial/ethnic groups. http://www.cdc.gov/hiv/group/racialethnic/index.html. Published 2016. Accessed June 14, 2016.
23. Fultz SL, Skanderson M, Mole LA, et al. Development and verification of a "virtual" cohort using the National VA Health Information System. Med Care. 2006;44(8)(suppl 2):S25-S30.
24. Saczynski JS, Andrade SE, Harrold LR, et al. A systematic review of validated methods for identifying heart failure using administrative data. Pharmacoepidemiol Drug Saf. 2012;21(suppl 1):129-140.
25. Yancy CW, Jessup M, Bozkurt B, et al;Writing Committee Members; American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2013;128(16): e240-e327.
26. Garvin JH, DuVall SL, South BR, et al. Automated extraction of ejection fraction for quality measurement using regular expressions in Unstructured Information Management Architecture (UIMA) for heart failure. J AmMed Inform Assoc. 2012;19(5):859-866.
27. McGinnis KA, Brandt CA, Skanderson M, et al. Validating smoking data from the Veteran's Affairs Health Factors dataset, an electronic data source. Nicotine Tob Res. 2011;13(12):1233-1239.
28. Lenfant C, Chobanian AV, Jones DW, Roccella EJ; Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Seventh report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7): resetting the hypertension sails. Hypertension. 2003;41(6):1178-1179.
29. Butt AA, McGinnis K, Rodriguez-Barradas MC, et al; Veterans Aging Cohort Study. HIV infection and the risk of diabetes mellitus. AIDS. 2009;23 (10):1227-1234.
30. Goulet JL, Fultz SL, McGinnis KA, Justice AC. Relative prevalence of comorbidities and treatment contraindications in HIV-mono-infected and HIV/HCV-co-infected veterans. AIDS. 2005;19(suppl 3):S99-S105.
31. Kraemer KL, McGinnis KA, Skanderson M, et al. Alcohol problems and health care services use in human immunodeficiency virus (HIV)-infected and HIV-uninfected veterans. Med Care. 2006;44(8) (suppl 2):S44-S51.
32. Klein J, Moeschberger M. Survival Analysis: Techniques for Censored and Truncated Data. 2nd ed. New York, NY: Springer; 2003.
33. Levy D, Kenchaiah S, Larson MG, et al. Long-term trends in the incidence of and survival with heart failure. N Engl J Med. 2002;347(18): 1397-1402.
34. Deeks SG, Tracy R, Douek DC. Systemic effects of inflammation on health during chronic HIV infection. Immunity. 2013;39(4):633-645.
35. Lee DS, Vasan RS. Novel markers for heart failure diagnosis and prognosis. Curr Opin Cardiol. 2005;20(3):201-210.
36. Meng X, Yang J, Dong M, et al. Regulatory T cells in cardiovascular diseases. Nat Rev Cardiol. 2016;13(3):167-179.
37. Freiberg MS, Bebu I, Tracy R, et al; Infectious Disease Clinical Research Program HIV Working Group. D-dimer levels before HIV seroconversion remain elevated even after viral suppression and are associated with an increased risk of non-AIDS events. PLoS One. 2016;11(4):e0152588.
38. Fiala M, Popik W, Qiao JH, et al. HIV-1 induces cardiomyopathyby cardiomyocyte invasion and gp120, Tat, and cytokine apoptotic signaling. Cardiovasc Toxicol. 2004;4(2):97-107.
39. Lopes de Campos WR, Chirwa N, London G, et al. HIV-1 subtype C unproductively infects human cardiomyocytes in vitro and induces apoptosis mitigated by an anti-Gp120 aptamer. PLoS One. 2014;9(10):e110930.
40. Currie PF, Goldman JH, Caforio AL, et al. Cardiac autoimmunity in HIV related heart muscle disease. Heart. 1998;79(6):599-604.
41. Barbaro G. Pathogenesis of HIV-associated heart disease. AIDS. 2003;17(suppl 1):S12-S20.
42. Barbaro G. Metabolic and cardiovascular complications of highly active antiretroviral therapy for HIV infection. Curr HIV Res. 2006;4(1):79-85.
43. El-Sadr WM, Lundgren J, Neaton JD, et al; Strategies for Management of Antiretroviral Therapy (SMART) Study Group. CD4+ count-guided interruption of antiretroviral treatment. N Engl J Med. 2006;355(22):2283-2296.
44. Friis-Møller N, Sabin CA, Weber R, et al; Data Collection on Adverse Events of Anti-HIV Drugs (DAD) Study Group. Combination antiretroviral therapy and the risk ofmyocardial infarction. N Engl J Med. 2003;349(21):1993-2003.
45. Bibbins-Domingo K, Pletcher MJ, Lin F, et al. Racial differences in incident heart failure among young adults. N Engl J Med. 2009;360(12):1179-1190.
46. Bloomfield GS, Alenezi F, Barasa FA, Lumsden R, Mayosi BM, Velazquez EJ. Human immunodeficiency virus and heart failure in lowand middle-income countries. JACC Heart Fail. 2015;3(8):579-590.