Tailoring treatment of haemophilia B: Accounting for the distribution and clearance of standard and extended half-life FIX concentrates

Thrombosis and Haemostasis

Volumn 117, Issue 6, 2017, Pages 1023-1030

  Iorio, Alfonso ^a   Fischer, Kathelijn ^b   Blanchette, Victor ^c   Rangarajan, Savita ^d   Young, Guy ^e   Morfini, Massimo ^f  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d BASINGSTOKE AND NORTH HAMPSHIRE HOSPITAL   (United Kingdom)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f Italian Association of Haemophilia Centres (AICE)   (Italy)

Author keywords

Extended half life; Factor IX; Haemophilia B; Personalised; Pharmacokinetics; Tailored

Indexed keywords

BLOOD CLOTTING FACTOR 9 CONCENTRATE; COLLAGEN TYPE 4; RECOMBINANT BLOOD CLOTTING FACTOR 9; BLOOD CLOTTING FACTOR; BLOOD CLOTTING FACTOR 9; HEMOSTATIC AGENT; PROTHROMBIN COMPLEX CONCENTRATES;

AREA UNDER THE CURVE; AUTORADIOGRAPHY; BLEEDING; COMPARTMENT MODEL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; EXTRAVASCULAR SPACE; HEMOPHILIA B; HUMAN; LIMIT OF QUANTITATION; PARTIAL THROMBOPLASTIN TIME; PERSONALIZED MEDICINE; PHARMACODYNAMICS; PHARMACOKINETICS; POPULATION RESEARCH; PRIORITY JOURNAL; PROPHYLAXIS; REVIEW; VOLUME OF DISTRIBUTION; WATER CONTENT; CLINICAL PROTOCOL; COMPLICATION; COST BENEFIT ANALYSIS; HALF LIFE TIME;

BLOOD COAGULATION FACTORS; CLINICAL PROTOCOLS; COST-BENEFIT ANALYSIS; FACTOR IX; HALF-LIFE; HEMOPHILIA B; HEMORRHAGE; HEMOSTATICS; HUMANS; PRECISION MEDICINE;

EID: 85020247012     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH16-12-0942     Document Type: Review

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