Pharmacokinetic properties of recombinant FVIIa in inherited FVII deficiency account for a large volume of distribution at steady state and a prolonged pharmacodynamic effect

Thrombosis and Haemostasis

Volumn 112, Issue 2, 2014, Pages 424-425

  Morfini, Massimo ^a   Batorova, Angelika ^b   Mariani, Guglielmo ^c   Auerswald, Günter ^d   Bernardi, Francesco ^c   Di Minno, Giovanni ^e   Dolce, Alberto ^f   Fede, Calogero ^f   Giansily Blaizot, Muriel ^g   Ingerslev, Jörgen ^h   Martinowitz, Uri ⁱ   Napolitano, Mariasanta ^j   Pinotti, Mirko ^c   Schved, Jean Francois ^g  

^a Agency for Hemophilia and Regional Reference Center for Inherited Bleeding Disorders   (Italy)

^b UNIVERSITY HOSPITAL BRATISLAVA   (Slovakia)

^c UNIVERSITY OF FERRARA   (Italy)

^d KLINIKUM BREMEN MITTE   (Germany)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^f ITALIAN NATIONAL INSTITUTE OF STATISTICS   (Italy)

^g MONTPELLIER UNIVERSITY HOSPITAL   (France)

^h AARHUS UNIVERSITY HOSPITAL   (Denmark)

ⁱ TEL AVIV UNIVERSITY   (Israel)

^j UNIVERSITY OF PALERMO   (Italy)

more..

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 7A; COAGULATING AGENT; RECOMBINANT FVIIA; RECOMBINANT PROTEIN;

AREA UNDER THE CURVE; BLOOD CLOTTING FACTOR DEFICIENCY; DRUG HALF LIFE; HUMAN; LETTER; PHARMACODYNAMICS; PLASMA VOLUME; PRIORITY JOURNAL; BLOOD; BLOOD CLOTTING; BLOOD CLOTTING TEST; DRUG EFFECTS; DRUG MONITORING; FACTOR VII DEFICIENCY; GENETIC PREDISPOSITION; GENETICS; HEREDITY; PHENOTYPE; PREDICTIVE VALUE; PROCEDURES; REGISTER; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

BLOOD COAGULATION; BLOOD COAGULATION TESTS; COAGULANTS; DRUG MONITORING; FACTOR VII; FACTOR VII DEFICIENCY; FACTOR VIIA; GENETIC PREDISPOSITION TO DISEASE; HEREDITY; HUMANS; PHENOTYPE; PREDICTIVE VALUE OF TESTS; RECOMBINANT PROTEINS; REGISTRIES; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84905181404     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH13-12-1045     Document Type: Letter

References (4)

1. Berrettini M, Mariani G, Schiavoni M, et al. Pharmacokinetic evaluation of recombinant, activated factor VII in patients with inherited factor VII deficiency. Haematologica 2001; 86: 640-645.
2. Mathijssen NCJ, Masereeuw R, Holme PA, et al. Increased volume of distribution for recombinant activated factor VII and longer plasma-derived factor VII half-life may explain their long lasting prophylactic effect. Thromb Res 2013; 132: 256-262.
3. Mathijssen NC, Masereeuw R, Verbeek K, et al. Prophylactic effect of recombinant factor VIIa in factor VII deficient patients. Br J Haematol 2004; 125: 494-499.
4. Napolitano M, Giansily-Blaizot M, Dolce A, et al. Prophylaxis in congenital factor VII deficiency: indications, efficacy and safety. Results from the Seven Treatment Evaluation Registry (STER). Haematologica 2013; 98: 538-544.