Perforin and CD107a testing is superior to NK cell function testing for screening patients for genetic HLH

Blood

Volumn 129, Issue 22, 2017, Pages 2993-2999

  Rubin, Tamar S ^a   Zhang, Kejian ^a   Gifford, Carrie ^a   Lane, Adam ^a   Choo, Sharon ^b   Bleesing, Jack J ^a   Marsh, Rebecca A ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; PERFORIN; PRF1 PROTEIN, HUMAN;

AGED; ARTICLE; BLOOD; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; FLUORESCENCE; GENE MUTATION; GENE SEQUENCE; HEMOPHAGOCYTIC SYNDROME; HUMAN; MAJOR CLINICAL STUDY; NATURAL KILLER CELL; NEXT GENERATION SEQUENCING; PREDICTIVE VALUE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SANGER SEQUENCING; SENSITIVITY AND SPECIFICITY; ADOLESCENT; ADULT; CHILD; CYTOTOXICITY TEST; DEGRANULATION; DNA MUTATIONAL ANALYSIS; FLOW CYTOMETRY; GENETIC SCREENING; GENETICS; IMMUNOLOGY; INFANT; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MALE; METABOLISM; MIDDLE AGED; MUTATION; NEWBORN; PRESCHOOL CHILD; STATISTICAL MODEL; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; CELL DEGRANULATION; CHILD; CHILD, PRESCHOOL; CYTOTOXICITY TESTS, IMMUNOLOGIC; DNA MUTATIONAL ANALYSIS; FEMALE; FLOW CYTOMETRY; GENETIC TESTING; HUMANS; INFANT; INFANT, NEWBORN; KILLER CELLS, NATURAL; LOGISTIC MODELS; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 1; MALE; MIDDLE AGED; MUTATION; PERFORIN; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 85020244425     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2016-12-753830     Document Type: Article

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