Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women

Science

Volumn 356, Issue 6341, 2017, Pages 938-945

  Klatt, Nichole R ^a   Cheu, Ryan ^a   Birse, Kenzie ^b,c   Zevin, Alexander S ^a   Perner, Michelle ^b,c   Noël Romas, Laura ^b,c   Grobler, Anneke ^d   Westmacott, Garrett ^e   Xie, Irene Y ^b,c   Butler, Jennifer ^b,c   Mansoor, Leila ^d   McKinnon, Lyle R ^c,d   Passmore, Jo Ann S ^d,f   Karim, Quarraisha Abdool ^d,g   Karim, Salim S Abdool ^d,g   Burgener, Adam D ^b,c,h  

^a UNIVERSITY OF WASHINGTON   (United States)

^b PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^c UNIVERSITY OF MANITOBA   (Canada)

^d UNIVERSITY OF KWAZULU NATAL   (South Africa)

^e PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^f UNIVERSITY OF CAPE TOWN   (South Africa)

^g Karolinska University Hospital ^*  (United States)

^h KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; RIBOSOME RNA; TENOFOVIR; ANTIVIRUS AGENT; PROTEOME; RNA 16S;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIMICROBIAL ACTIVITY; BACTERIUM; EFFICIENCY MEASUREMENT; HUMAN IMMUNODEFICIENCY VIRUS; IDENTIFICATION METHOD; MICROBIAL COMMUNITY; REPRODUCTIVE BIOLOGY; WOMENS HEALTH;

AFRICAN; ANAEROBIC BACTERIUM; ARTICLE; BACTERIAL METABOLISM; COMPARATIVE STUDY; DRUG EFFICACY; DRUG METABOLISM; FEMALE; GARDNERELLA VAGINALIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INCIDENCE; LACTOBACILLUS; MICROBIAL COMMUNITY; MICROBIAL DIVERSITY; MOBILUNCUS; NONHUMAN; PREVOTELLA; PRIORITY JOURNAL; PROTEIN ANALYSIS; TARGET CELL; VAGINA FLORA; ADULT; BACTERIUM; BIODIVERSITY; GARDNERELLA; GENETICS; ISOLATION AND PURIFICATION; MASS SPECTROMETRY; METABOLISM; MICROBIOLOGY; MICROFLORA; PHYSIOLOGY; SOUTH AFRICA; VAGINA;

BACTERIA (MICROORGANISMS); GARDNERELLA VAGINALIS; LACTOBACILLUS;

ADULT; ANTIVIRAL AGENTS; BACTERIA; BIODIVERSITY; FEMALE; GARDNERELLA; HIV INFECTIONS; HUMANS; LACTOBACILLUS; MASS SPECTROMETRY; MICROBIOTA; PROTEOME; RNA, RIBOSOMAL, 16S; SOUTH AFRICA; TENOFOVIR; VAGINA;

EID: 85020240798     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aai9383     Document Type: Article

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