-
1
-
-
0032511583
-
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
-
UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352 (1998), 837–853.
-
(1998)
Lancet
, vol.352
, pp. 837-853
-
-
-
2
-
-
58149389215
-
Glucose control and vascular complications in veterans with type 2 diabetes
-
Duckworth, W., Abraira, C., Moritz, T., et al. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 360 (2009), 129–139.
-
(2009)
N Engl J Med
, vol.360
, pp. 129-139
-
-
Duckworth, W.1
Abraira, C.2
Moritz, T.3
-
3
-
-
45149131667
-
Effects of intensive glucose lowering in type 2 diabetes
-
Gerstein, H.C., Miller, M.E., Byington, R.P., et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 358 (2008), 2545–2559.
-
(2008)
N Engl J Med
, vol.358
, pp. 2545-2559
-
-
Gerstein, H.C.1
Miller, M.E.2
Byington, R.P.3
-
4
-
-
45149133036
-
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
-
Patel, A., MacMahon, S., Chalmers, J., et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 358 (2008), 2560–2572.
-
(2008)
N Engl J Med
, vol.358
, pp. 2560-2572
-
-
Patel, A.1
MacMahon, S.2
Chalmers, J.3
-
5
-
-
34250212715
-
Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
-
Nissen, S.E., Wolski, K., Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 356 (2007), 2457–2471.
-
(2007)
N Engl J Med
, vol.356
, pp. 2457-2471
-
-
Nissen, S.E.1
Wolski, K.2
-
6
-
-
85033206184
-
Guidance for industry: diabetes mellitus — evaluating cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes
-
Available at: Accessed November 28, 2016
-
Food and Drug Administration Center for Drug Evaluation and Research. Guidance for industry: diabetes mellitus — evaluating cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes. Available at: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm071627.pdf Accessed November 28, 2016.
-
-
-
-
7
-
-
84937053742
-
Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes
-
Green, J.B., Bethel, M.A., Armstrong, P.W., et al. Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes. N Engl J Med 373 (2015), 232–242.
-
(2015)
N Engl J Med
, vol.373
, pp. 232-242
-
-
Green, J.B.1
Bethel, M.A.2
Armstrong, P.W.3
-
8
-
-
84978839381
-
Liraglutide and cardiovascular outcomes in type 2 diabetes
-
Marso, S.P., Daniels, G.H., Brown-Frandsen, K., et al. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med 375 (2016), 311–322.
-
(2016)
N Engl J Med
, vol.375
, pp. 311-322
-
-
Marso, S.P.1
Daniels, G.H.2
Brown-Frandsen, K.3
-
9
-
-
84948740668
-
Lixisenatide in patients with type 2 diabetes and acute coronary syndrome
-
Pfeffer, M.A., Claggett, B., Diaz, R., et al. Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. N Engl J Med 373 (2015), 2247–2257.
-
(2015)
N Engl J Med
, vol.373
, pp. 2247-2257
-
-
Pfeffer, M.A.1
Claggett, B.2
Diaz, R.3
-
10
-
-
84883765959
-
Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
-
Scirica, B.M., Bhatt, D.L., Braunwald, E., et al. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med 369 (2013), 1317–1326.
-
(2013)
N Engl J Med
, vol.369
, pp. 1317-1326
-
-
Scirica, B.M.1
Bhatt, D.L.2
Braunwald, E.3
-
11
-
-
84883745765
-
Alogliptin after acute coronary syndrome in patients with type 2 diabetes
-
White, W.B., Cannon, C.P., Heller, S.R., et al. Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med 369 (2013), 1327–1335.
-
(2013)
N Engl J Med
, vol.369
, pp. 1327-1335
-
-
White, W.B.1
Cannon, C.P.2
Heller, S.R.3
-
12
-
-
84930085787
-
Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial
-
Zannad, F., Cannon, C.P., Cushman, W.C., et al. Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial. Lancet 385 (2015), 2067–2076.
-
(2015)
Lancet
, vol.385
, pp. 2067-2076
-
-
Zannad, F.1
Cannon, C.P.2
Cushman, W.C.3
-
13
-
-
84944800184
-
Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
-
Zinman, B., Wanner, C., Lachin, J.M., et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 373 (2015), 2117–2128.
-
(2015)
N Engl J Med
, vol.373
, pp. 2117-2128
-
-
Zinman, B.1
Wanner, C.2
Lachin, J.M.3
-
14
-
-
85019983309
-
Management of type 2 diabetes mellitus: available therapies
-
Thrasher, J., Management of type 2 diabetes mellitus: available therapies. Am J Cardiol 130 (2017), S4–S17.
-
(2017)
Am J Cardiol
, vol.130
, pp. S4-S17
-
-
Thrasher, J.1
-
15
-
-
85020459778
-
EMPA-REG OUTCOME: the nephrologist's point of view
-
Wanner, C., EMPA-REG OUTCOME: the nephrologist's point of view. Am J Cardiol 130 (2017), S63–S72.
-
(2017)
Am J Cardiol
, vol.130
, pp. S63-S72
-
-
Wanner, C.1
-
16
-
-
85020040943
-
Cardiovascular protection by sodium glucose cotransporter 2 inhibitors: potential mechanisms of action
-
Staels, B., Cardiovascular protection by sodium glucose cotransporter 2 inhibitors: potential mechanisms of action. Am J Cardiol 130 (2017), S30–S39.
-
(2017)
Am J Cardiol
, vol.130
, pp. S30-S39
-
-
Staels, B.1
-
17
-
-
84994180780
-
Empagliflozin and progression of kidney disease in type 2 diabetes
-
Wanner, C., Inzucchi, S.E., Lachin, J.M., et al. Empagliflozin and progression of kidney disease in type 2 diabetes. N Engl J Med 375 (2016), 323–334.
-
(2016)
N Engl J Med
, vol.375
, pp. 323-334
-
-
Wanner, C.1
Inzucchi, S.E.2
Lachin, J.M.3
-
18
-
-
84982124800
-
Years of life gained by multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: 21 years follow-up on the Steno-2 randomised trial
-
Gaede, P., Oellgaard, J., Carstensen, B., et al. Years of life gained by multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: 21 years follow-up on the Steno-2 randomised trial. Diabetologia 59 (2016), 2298–2307.
-
(2016)
Diabetologia
, vol.59
, pp. 2298-2307
-
-
Gaede, P.1
Oellgaard, J.2
Carstensen, B.3
-
19
-
-
84964773926
-
SGLT2 inhibitors and cardiovascular risk: lessons learned from the EMPA-REG OUTCOME study
-
Abdul-Ghani, M., Del Prato, S., Chilton, R., DeFronzo, R.A., SGLT2 inhibitors and cardiovascular risk: lessons learned from the EMPA-REG OUTCOME study. Diabetes Care 39 (2016), 717–725.
-
(2016)
Diabetes Care
, vol.39
, pp. 717-725
-
-
Abdul-Ghani, M.1
Del Prato, S.2
Chilton, R.3
DeFronzo, R.A.4
-
20
-
-
85007019116
-
Cardiovascular outcomes of new medications for type 2 diabetes
-
Trujillo, J.M., Wettergreen, S.A., Nuffer, W.A., Ellis, S.L., McDermott, M.T., Cardiovascular outcomes of new medications for type 2 diabetes. Diabetes Technol Ther 18 (2016), 749–758.
-
(2016)
Diabetes Technol Ther
, vol.18
, pp. 749-758
-
-
Trujillo, J.M.1
Wettergreen, S.A.2
Nuffer, W.A.3
Ellis, S.L.4
McDermott, M.T.5
-
21
-
-
4344683381
-
Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial
-
Colhoun, H.M., Betteridge, D.J., Durrington, P.N., et al. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet 364 (2004), 685–696.
-
(2004)
Lancet
, vol.364
, pp. 685-696
-
-
Colhoun, H.M.1
Betteridge, D.J.2
Durrington, P.N.3
-
22
-
-
38049033935
-
Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis
-
Kearney, P.M., Blackwell, L., Collins, R., et al. Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis. Lancet 371 (2008), 117–125.
-
(2008)
Lancet
, vol.371
, pp. 117-125
-
-
Kearney, P.M.1
Blackwell, L.2
Collins, R.3
-
23
-
-
49649100471
-
Cost-effectiveness of intensified versus conventional multifactorial intervention in type 2 diabetes: results and projections from the Steno-2 study
-
Gaede, P., Valentine, W.J., Palmer, A.J., et al. Cost-effectiveness of intensified versus conventional multifactorial intervention in type 2 diabetes: results and projections from the Steno-2 study. Diabetes Care 31 (2008), 1510–1515.
-
(2008)
Diabetes Care
, vol.31
, pp. 1510-1515
-
-
Gaede, P.1
Valentine, W.J.2
Palmer, A.J.3
-
24
-
-
0034814619
-
Metoprolol controlled release/extended release in patients with severe heart failure: analysis of the experience in the MERIT-HF study
-
Goldstein, S., Fagerberg, B., Hjalmarson, A., et al. Metoprolol controlled release/extended release in patients with severe heart failure: analysis of the experience in the MERIT-HF study. J Am Coll Cardiol 38 (2001), 932–938.
-
(2001)
J Am Coll Cardiol
, vol.38
, pp. 932-938
-
-
Goldstein, S.1
Fagerberg, B.2
Hjalmarson, A.3
-
25
-
-
0037159310
-
Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study
-
Packer, M., Fowler, M.B., Roecker, E.B., et al. Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study. Circulation 106 (2002), 2194–2199.
-
(2002)
Circulation
, vol.106
, pp. 2194-2199
-
-
Packer, M.1
Fowler, M.B.2
Roecker, E.B.3
-
26
-
-
84869417804
-
Mineralocorticoid receptor antagonists for heart failure with reduced ejection fraction: integrating evidence into clinical practice
-
Zannad, F., Gattis Stough, W., Rossignol, P., et al. Mineralocorticoid receptor antagonists for heart failure with reduced ejection fraction: integrating evidence into clinical practice. Eur Heart J 33 (2012), 2782–2795.
-
(2012)
Eur Heart J
, vol.33
, pp. 2782-2795
-
-
Zannad, F.1
Gattis Stough, W.2
Rossignol, P.3
-
28
-
-
84960469140
-
Heart failure: SGLT2 inhibitors and heart failure – clinical implications
-
Raz, I., Cahn, A., Heart failure: SGLT2 inhibitors and heart failure – clinical implications. Nat Rev Cardiol 13 (2016), 185–186.
-
(2016)
Nat Rev Cardiol
, vol.13
, pp. 185-186
-
-
Raz, I.1
Cahn, A.2
-
29
-
-
85020395878
-
EMPA-REG OUTCOME: the cardiologist's point of view
-
Pham, S.V., Chilton, R., EMPA-REG OUTCOME: the cardiologist's point of view. Am J Cardiol 130 (2017), S57–S62.
-
(2017)
Am J Cardiol
, vol.130
, pp. S57-S62
-
-
Pham, S.V.1
Chilton, R.2
-
30
-
-
84951814585
-
The EMPA-REG study: what has it told us? A diabetologist's perspective
-
DeFronzo, R.A., The EMPA-REG study: what has it told us? A diabetologist's perspective. J Diabetes Complications 30 (2016), 1–2.
-
(2016)
J Diabetes Complications
, vol.30
, pp. 1-2
-
-
DeFronzo, R.A.1
-
31
-
-
84975853831
-
CV protection in the EMPA-REG OUTCOME trial: a “thrifty substrate” hypothesis
-
Ferrannini, E., Mark, M., Mayoux, E., CV protection in the EMPA-REG OUTCOME trial: a “thrifty substrate” hypothesis. Diabetes Care 39 (2016), 1108–1114.
-
(2016)
Diabetes Care
, vol.39
, pp. 1108-1114
-
-
Ferrannini, E.1
Mark, M.2
Mayoux, E.3
-
32
-
-
84975840750
-
Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis
-
Mudaliar, S., Alloju, S., Henry, R.R., Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis. Diabetes Care 39 (2016), 1115–1122.
-
(2016)
Diabetes Care
, vol.39
, pp. 1115-1122
-
-
Mudaliar, S.1
Alloju, S.2
Henry, R.R.3
-
33
-
-
84893872877
-
Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients
-
Ferrannini, E., Muscelli, E., Frascerra, S., et al. Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. J Clin Invest 124 (2014), 499–508.
-
(2014)
J Clin Invest
, vol.124
, pp. 499-508
-
-
Ferrannini, E.1
Muscelli, E.2
Frascerra, S.3
-
34
-
-
84964608804
-
Shift to fatty substrate utilization in response to sodium-glucose cotransporter 2 inhibition in subjects without diabetes and patients with type 2 diabetes
-
Ferrannini, E., Baldi, S., Frascerra, S., et al. Shift to fatty substrate utilization in response to sodium-glucose cotransporter 2 inhibition in subjects without diabetes and patients with type 2 diabetes. Diabetes 65 (2016), 1190–1195.
-
(2016)
Diabetes
, vol.65
, pp. 1190-1195
-
-
Ferrannini, E.1
Baldi, S.2
Frascerra, S.3
-
35
-
-
84878466943
-
Ketone body metabolism and cardiovascular disease
-
Cotter, D.G., Schugar, R.C., Crawford, P.A., Ketone body metabolism and cardiovascular disease. Am J Physiol Heart Circ Physiol 304 (2013), H1060–H1076.
-
(2013)
Am J Physiol Heart Circ Physiol
, vol.304
, pp. H1060-H1076
-
-
Cotter, D.G.1
Schugar, R.C.2
Crawford, P.A.3
-
36
-
-
84904383437
-
Role of beta-hydroxybutyrate, its polymer poly-beta-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease
-
Dedkova, E.N., Blatter, L.A., Role of beta-hydroxybutyrate, its polymer poly-beta-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease. Front Physiol, 5, 2014, 260.
-
(2014)
Front Physiol
, vol.5
, pp. 260
-
-
Dedkova, E.N.1
Blatter, L.A.2
-
37
-
-
85065599284
-
Standards of Medical Care in Diabetes-2017
-
American Diabetes Association. Standards of Medical Care in Diabetes-2017. Diabetes Care 40 (2017), S4–S5.
-
(2017)
Diabetes Care
, vol.40
, pp. S4-S5
-
-
-
38
-
-
85017020764
-
Defining the potential “real-world” impact of the EMPA-REG OUTCOME trial on improving cardiovascular outcomes: observations from the Diabetes Collaborative Registry (DCR)
-
Abstract #729
-
Arnold, S.V., Inzucchi, S.E., Maddox, T.M., et al. Defining the potential “real-world” impact of the EMPA-REG OUTCOME trial on improving cardiovascular outcomes: observations from the Diabetes Collaborative Registry (DCR). Diabetologia, 59(Suppl 1), 2016 Abstract #729.
-
(2016)
Diabetologia
, vol.59
-
-
Arnold, S.V.1
Inzucchi, S.E.2
Maddox, T.M.3
-
39
-
-
85098743727
-
® (empagliflozin) tablets, for oral use
-
Available at: Accessed December 19, 2016
-
® (empagliflozin) tablets, for oral use. Available at: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/204629s008lbl.pdf Accessed December 19, 2016.
-
-
-
-
40
-
-
84880924263
-
Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS)–a randomized placebo-controlled trial
-
Neal, B., Perkovic, V., de Zeeuw, D., et al. Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS)–a randomized placebo-controlled trial. Am Heart J 166 (2013), 217–223e11.
-
(2013)
Am Heart J
, vol.166
, pp. 217-223e11
-
-
Neal, B.1
Perkovic, V.2
de Zeeuw, D.3
-
41
-
-
84862556665
-
FDA drug safety communication: interim clinical trial results find increased risk of leg and foot amputations, mostly affecting the toes, with the diabetes medicine canagliflozin (Invokana, Invokamet); FDA to investigate
-
Available at: Accessed June 1, 2016
-
Food and Drug Administration. FDA drug safety communication: interim clinical trial results find increased risk of leg and foot amputations, mostly affecting the toes, with the diabetes medicine canagliflozin (Invokana, Invokamet); FDA to investigate. Available at: http://www.fda.gov/Drugs/DrugSafety/ucm500965.htm Accessed June 1, 2016.
-
-
-
-
42
-
-
84954564720
-
Evaluation of bone mineral density and bone biomarkers in patients with type 2 diabetes treated with canagliflozin
-
Bilezikian, J.P., Watts, N.B., Usiskin, K., et al. Evaluation of bone mineral density and bone biomarkers in patients with type 2 diabetes treated with canagliflozin. J Clin Endocrinol Metab 101 (2016), 44–51.
-
(2016)
J Clin Endocrinol Metab
, vol.101
, pp. 44-51
-
-
Bilezikian, J.P.1
Watts, N.B.2
Usiskin, K.3
-
43
-
-
85098745631
-
® (canagliflozin) tablets, for oral use
-
Available at: Accessed April 11, 2017
-
® (canagliflozin) tablets, for oral use. Available at: https://www.invokanahcp.com/sites/www.invokanahcp.com/files/prescribing-information-invokana.pdf Accessed April 11, 2017.
-
-
-
-
44
-
-
85098743804
-
® (dapagliflozin) tablets, for oral use
-
Available at: Accessed April 11, 2017
-
® (dapagliflozin) tablets, for oral use. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/202293s011lbl.pdf Accessed April 11, 2017.
-
-
-
|