Nicotine effects on exercise performance and physiological responses in nicotine-naïve individuals: a systematic review

Clinical Physiology and Functional Imaging

Volumn 38, Issue 4, 2018, Pages 527-538

  Johnston, Robert ^a   Doma, Kenji ^a   Crowe, Melissa ^a  

^a JAMES COOK UNIVERSITY   (Australia)

Author keywords

doping; ergogenic aid; sports; supplement

Indexed keywords

GHRELIN; NICOTINE; PLACEBO; NICOTINIC AGENT; PERFORMANCE ENHANCING SUBSTANCE;

ANAEROBIC CAPACITY; BLOOD FLOW; DIASTOLIC BLOOD PRESSURE; ENDURANCE; EXERCISE; GLOMERULUS FILTRATION RATE; GRIP STRENGTH; HEART RATE; HEART RATE VARIABILITY; HEMATOCRIT; HUMAN; JUMPING; LEG EXTENSOR TORQUE; LUNG FUNCTION; LUNG MINUTE VOLUME; MEAN ARTERIAL PRESSURE; MUSCLE STRENGTH; MUSCLE SYMPATHETIC NERVE ACTIVITY; PHYSICAL PERFORMANCE; PHYSIOLOGICAL PROCESS; PHYSIOLOGICAL RESPONSE; PRIORITY JOURNAL; PULSE WAVE; REVIEW; SKIN CONDUCTANCE; SKIN TEMPERATURE; SYSTEMATIC REVIEW; SYSTOLIC BLOOD PRESSURE; TORQUE; ADULT; BIOMECHANICS; DRUG EFFECT; FEMALE; HEMODYNAMICS; MALE; MUSCLE CONTRACTION; PHYSIOLOGY; SKELETAL MUSCLE; YOUNG ADULT;

ADULT; BIOMECHANICAL PHENOMENA; EXERCISE; FEMALE; HEMODYNAMICS; HUMANS; MALE; MUSCLE CONTRACTION; MUSCLE, SKELETAL; NICOTINE; NICOTINIC AGONISTS; PERFORMANCE-ENHANCING SUBSTANCES; PHYSICAL ENDURANCE; TORQUE; YOUNG ADULT;

EID: 85020105063     PISSN: 14750961     EISSN: 1475097X     Source Type: Journal    
DOI: 10.1111/cpf.12443     Document Type: Review

References (71)

1. Adamopoulos D, Argacha JF, Gujic M, et al. Acute effects of nicotine on arterial stiffness and wave reflection in healthy young non-smokers. Clin Exp Pharmacol Physiol (2009); 36: 784–789.
2. Alaranta A, Alaranta H, Patja K, et al. Snuff use and smoking in Finnish olympic athletes. Int J Sports Med (2006); 27: 581–586. https://doi.org/10.1055/s-2005-865826.
3. Andersson K, Arner P. Systemic nicotine stimulates human adipose tissue lipolysis through local cholinergic and catecholaminergic receptors. Int J Obes Relat Metab Disord (2001); 25: 1225–1232.
4. Argacha J-F, Adamopoulos D, Gujic M, et al. Acute effects of passive smoking on peripheral vascular function. Hypertension (2008); 51: 1506–1511.
5. Astrup P. Some physiological and pathological effects of moderate carbon monoxide exposure. Br Med J (1972); 4: 447–452.
6. Bada AA, Svendsen JH, Secher NH, et al. Peripheral vasodilatation determines cardiac output in exercising humans: insight from atrial pacing. J Physiol (2012); 590: 2051–2060. https://doi.org/10.1113/jphysiol.2011.225334.
7. Baker L. Effects of dietary constituents on cognitive and motor skill performance in sports. Sports Sci Exchang (2013); 26: 1–6.
8. Baschnagel JS, Hawk LW Jr. The effects of nicotine on the attentional modification of the acoustic startle response in nonsmokers. Psychopharmacology (2008); 198: 93–101.
9. Becker J, Wu WF. Integrating biomechanical and motor control principles in elite high jumpers: a transdisciplinary approach to enhancing sport performance. J Sport Health Sci (2015); 4: 341–346.
10. Bisset L, Paungmali A, Vicenzino B, et al. A systematic review and meta-analysis of clinical trials on physical interventions for lateral epicondylalgia. Br J Sports Med (2005); 39: 411–422. https://doi.org/10.1136/bjsm.2004.016170.
11. Brody AL, Mandelkern MA, London ED, et al. Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors. Arch Gen Psychiatry (2006); 63: 907–915. https://doi.org/10.1001/archpsyc.63.8.907.
12. Carson KV, Brinn MP, Robertson TA, et al. Current and emerging pharmacotherapeutic options for smoking cessation. Subst Abuse (2013); 7: 85–105. https://doi.org/10.4137/sart.s8108.
13. Chague F, Guenancia C, Gudjoncik A, et al. Smokeless tobacco, sport and the heart. Arch Cardiovasc Dis (2015); 108: 75–83. https://doi.org/10.1016/j.acvd.2014.10.003.
14. Charkoudian N. Skin Blood Flow in Adult Human Thermoregulation: how It Works, When It Does Not, and Why. Mayo Clin Proc (2003); 78: 603–612. https://doi.org/10.4065/78.5.603.
15. Coker RH, Brown SP, Chitwood LF, et al. Nicotine use and athletic performance: a brief review. J Strength Cond Res (1996); 10: 279–282.
16. Collins N, Bisset L, McPoil T, et al. Foot orthoses in lower limb overuse conditions: a systematic review and meta-analysis. Foot Ankle Int (2007); 28: 396–412. https://doi.org/10.3113/fai.2007.0396.
17. Daanen HA, Lamberts RP, Kallen VL, et al. A systematic review on heart-rate recovery to monitor changes in training status in athletes. Int J Sports Physiol Perform (2012); 7: 251–260.
18. Fenster CP, Hicks JH, Beckman ML, et al. Desensitization of nicotinic receptors in the central nervous system. Ann N Y Acad Sci (1999); 868: 620–623. https://doi.org/10.1111/j.1749-6632.1999.tb11335.x.
19. Fishbein L, O'Brien P, Hutson A, et al. Pharmacokinetics and pharmacodynamic effects of nicotine nasal spray devices on cardiovascular and pulmonary function. J Investig Med (2000); 48: 435–440.
20. Fisher DJ, Knobelsdorf A, Jaworska N, et al. Effects of nicotine on electroencephalographic (EEG) and behavioural measures of visual working memory in non-smokers during a dual-task paradigm. Pharmacol Biochem Behav (2013); 103: 494–500.
21. Flores CM, Rogers SW, Pabreza LA, et al. A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment. Mol Pharmacol (1992); 41: 31–37.
22. Fogt DL, Levi MA, Rickards CA, et al. Effects of acute vaporized nicotine in non-tobacco users at rest and during exercise. Int J Exerc Sci (2016); 9: 607–615.
23. Fond G, Micoulaud-Franchi JA, Brunel L, et al. Innovative mechanisms of action for pharmaceutical cognitive enhancement: a systematic review. Psychiatry Res (2015); 229: 12–20. https://doi.org/S0165-1781(15)00451-5[pii]10.1016/j.psychres.2015.07.006.
24. Foulds J, McSorley K, Sneddon J, et al. Effect of subcutaneous nicotine injections of EEG alpha frequency in non-smokers: a placebo-controlled pilot study. Psychopharmacology (1994); 115: 163–166.
25. Foulds J, Stapleton JA, Bell N, et al. Mood and physiological effects of subcutaneous nicotine in smokers and never-smokers. Drug Alcohol Depend (1997); 44: 105–115.
26. French DN, Kraemer WJ, Volek JS, et al. Anticipatory responses of catecholamines on muscle force production. J Appl Physiol (2007); 102: 94–102. https://doi.org/00586.2006[pii]10.1152/japplphysiol.00586.2006.
27. Halimi J-M, Mimran A. Systemic and renal effect of nicotine in non-smokers: influence of vitamin C. J Hypertens (2000); 18: 1665–1669.
28. Hansson L, Choudry NB, Karlsson J, et al. Inhaled nicotine in humans: effect on the respiratory and cardiovascular systems. J Appl Physiol (1994); 76: 2420–2427.
29. Harte CB. Nicotine acutely inhibits erectile tumescence by altering heart rate variability. Urology (2014); 83: 1093–1098.
30. Harte CB, Meston CM. Acute effects of nicotine on physiological and subjective sexual arousal in nonsmoking men: a randomized, double-blind, placebo-controlled trial. J Sexual Med (2008); 5: 110–121.
31. Hedelin R, Bjerle P, Henriksson-Larsen K. Heart rate variability in athletes: relationship with central and peripheral performance. Med Sci Sports Exerc (2001); 33: 1394–1398.
32. Heishman SJ, Snyder FR, Henningfield JE. Performance, subjective, and physiological effects of nicotine in non-smokers. Drug Alcohol Depend (1993); 34: 11–18.
33. Heishman SJ, Kleykamp BA, Singleton EG. Meta-analysis of the acute effects of nicotine and smoking on human performance. Psychopharmacology (2010); 210: 453–469. https://doi.org/10.1007/s00213-010-1848-1.
34. Hu FB, Hedeker D, Flay BR, et al. The patterns and predictors of smokeless tobacco onset among urban public school teenagers. Am J Prev Med (1995); 12: 22–28.
35. Kamper SJ, Moseley AM, Herbert RD, et al. 15 years of tracking physiotherapy evidence on PEDro, where are we now? Br J Sports Med (2015); 49: 907–909. https://doi.org/10.1136/bjsports-2014-094468.
36. Kodaira M, Wasaka T, Motomura E, et al. Effects of acute nicotine on somatosensory change-related cortical responses. Neuroscience (2013); 229: 20–26.
37. Laughlin MH, Davis MJ, Secher NH, et al. Peripheral circulation. Comp Physiol (2012); 2: 321–447.
38. Le Houezec J, Halliday R, Benowitz NL, et al. A low dose of subcutaneous nicotine improves information processing in non-smokers. Psychopharmacology (1994); 114: 628–634.
39. Logemann H, Böcker K, Deschamps P, et al. Differences between nicotine-abstinent smokers and non-smokers in terms of visuospatial attention and inhibition before and after single-blind nicotine administration. Neuroscience (2014); 277: 375–382.
40. Marclay F, Saugy M. Determination of nicotine and nicotine metabolites in urine by hydrophilic interaction chromatography–tandem mass spectrometry: potential use of smokeless tobacco products by ice hockey players. J Chromatogr A (2010); 1217: 7528–7538. https://doi.org/10.1016/j.chroma.2010.10.005.
41. Marclay F, Grata E, Perrenoud L, et al. A one-year monitoring of nicotine use in sport: frontier between potential performance enhancement and addiction issues. Forensic Sci Int (2011); 213: 73–84.
42. Martinsen M, Sundgot-Borgen J. Adolescent elite athletes' cigarette smoking, use of snus, and alcohol. Scand J Med Sci Sports (2014); 24: 439–446. https://doi.org/10.1111/j.1600-0838.2012.01505.x.
43. Meier JN. Effect of nicotine and muscle performance using a wingate anaerobic test on collegiate football players. (2006). University of Wisconsin-Whitewater.
44. Meng KY, Zuhairi NA, Manan FA, et al. Role of gender, age and ethnicities on visual reaction time and visual anticipation time of junior athletes. Aust J Basic Appl Sci (2015); 9: 129–134.
45. Morente-Sanchez J, Zandonai T, Mateo-March M, et al. Acute effect of Snus on physical performance and perceived cognitive load on amateur footballers. Scand J Med Sci Sports (2015); 25: e423–e431. 10.1111/sms.12321.
46. Morrell HE, Cohen LM, Bacchi D, et al. Predictors of smoking and smokeless tobacco use in college students: a preliminary study using web-based survey methodology. J Am Coll Health (2005); 54: 108–115.
47. Mundal H, Gjesdal K, Hjemdahl P. Acute effects of low dose nicotine gum on platelet function in non-smoking hypertensive and normotensive men. Europ J Clin Pharmacol (1995); 47: 411–416.
48. Mündel T, Jones DA. Effect of transdermal nicotine administration on exercise endurance in men. Exp Physiol (2006); 91: 705–713. https://doi.org/10.1113/expphysiol.2006.033373.
49. Mundel T, Machal M, Cochrane DJ, et al. A randomised, placebo-controlled, crossover study investigating the effects of nicotine gum on strength, power and anaerobic performance in nicotine-naive, Active Males. Sports Med Open (2017); 3: 5. https://doi.org/10.1186/s40798-016-0074-8 [pii].
50. Myers CS, Taylor RC, Salmeron BJ, et al. Nicotine enhances alerting, but not executive, attention in smokers and nonsmokers. Nicotine Tob Res (2013); 15: 277–281.
51. Neumann DL, Fitzgerald ZT, Furedy JJ, et al. Sexually dimorphic effects of acute nicotine administration on arousal and visual-spatial ability in non-smoking human volunteers. Pharmacol Biochem Behav (2007); 86: 758–765.
52. Norberg M, Malmberg G, Ng N, et al. Who is using snus?-Time trends, socioeconomic and geographic characteristics of snus users in the ageing Swedish population. BMC Public Health (2011); 11: 929.
53. Nyberg G, Panfilov V, Sivertsson R, et al. Cardiovascular effects of nicotine chewing gum in healthy non-smokers. Europ J Clin Pharmacol (1982); 23: 303–307.
54. Perrier ET, Pavol MJ, Hoffman MA. The acute effects of a warm-up including static or dynamic stretching on countermovement jump height, reaction time, and flexibility. J Strength Cond Res (2011); 25: 1925–1931.
55. Pesta DH, Angadi SS, Burtscher M, et al. The effects of caffeine, nicotine, ethanol, and tetrahydrocannabinol on exercise performance. Nutr Metab (Lond) (2013); 10: 71. https://doi.org/1743-7075-10-71[pii].
56. Pilhatsch M, Scheuing H, Kroemer N, et al. Nicotine administration in healthy non-smokers reduces appetite but does not alter plasma ghrelin. Hum Psychopharmacol (2014); 29: 384–387.
57. Poltavski D, Petros T. Effects of transdermal nicotine on prose memory and attention in smokers and nonsmokers. Physiol Behav (2005); 83: 833–843.
58. Pysný L, Petru D, Pysná J, et al. The acute effect of nicotine intake on anaerobic exercise performance. J Phys Educ Sport (2015); 15: 103.
59. Reichart DL, Hinkle RT, Lefever FR, et al. Activation of the dopamine 1 and dopamine 5 receptors increase skeletal muscle mass and force production under non-atrophying and atrophying conditions. BMC Musculoskelet Disord (2011); 12: 27. https://doi.org/1471-2474-12-27[pii].
60. Rønnestad BR, Mujika I. Optimizing strength training for running and cycling endurance performance: a review. Scand J Med Sci Sports (2014); 24: 603–612. https://doi.org/10.1111/sms.12104.
61. Spangler JG. Smokeless tobacco and cardiovascular disease. Tob Count Health (2006); 4: 14–17.
62. Stark T, Walker B, Phillips JK, et al. Hand-held dynamometry correlation with the gold standard isokinetic dynamometry: a systematic review. PM R (2011); 3: 472–479. https://doi.org/10.1016/j.pmrj.2010.10.025.
63. Tønnessen E, Haugen T, Shalfawi SA. Reaction time aspects of elite sprinters in athletic world championships. J Strength Cond Res (2013); 27: 885–892.
64. Turino G. Effect of carbon monoxide on the cardiorespiratory system: carbon monoxide toxicity, physiology and biochemistry. Circulation (1981); 63: 253A–259A.
65. Usuki K, Kanekura T, Aradono K, et al. Effects of nicotine on peripheral cutaneous blood flow and skin temperature. J Dermatol Sci (1998); 16: 173–181.
66. Vossel S, Thiel CM, Fink GR. Behavioral and neural effects of nicotine on visuospatial attentional reorienting in non-smoking subjects. Neuropsychopharmacology (2008); 33: 731–738.
67. WADA. The 2012 Monitoring Program. (2012).
68. Whiting P, Schoepfer R, Lindstrom J, et al. Structural and pharmacological characterization of the major brain nicotinic acetylcholine receptor subtype stably expressed in mouse fibroblasts. Molecul Pharmacol (1991); 40: 463–472.
69. Wignall ND, de Wit H. Effects of nicotine on attention and inhibitory control in healthy nonsmokers. Exp Clin Psychopharmacol (2011); 19: 183–191.
70. Wolk R, Shamsuzzaman AS, Svatikova A, et al. Hemodynamic and autonomic effects of smokeless tobacco in healthy young men. J Am Coll Cardiol (2005); 45: 910–914.
71. Zevin S, Jacob P, Geppetti P, et al. Clinical pharmacology of oral cotinine. Drug Alcohol Depend (2000); 60: 13–18.