Nicotine administration in healthy non-smokers reduces appetite but does not alter plasma ghrelin

Human Psychopharmacology

Volumn 29, Issue 4, 2014, Pages 384-387

  Pilhatsch, Maximilian ^a   Scheuing, Hannah ^a   Kroemer, Nils ^a   Kobiella, Andrea ^a   Bidlingmaier, Martin ^b   Farger, Gisbert ^c   Smolka, Michael N ^a   Zimmermann, Ulrich S ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

appetite; blood pressure; ghrelin; nicotine

Indexed keywords

GHRELIN; NICOTINE; CHEWING GUM; NICOTINIC AGENT;

ARTICLE; BLOOD LEVEL; DECREASED APPETITE; ELEVATED BLOOD PRESSURE; HORMONE RELEASE; HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SMOKING; SMOKING CESSATION; WEIGHT CHANGE; APPETITE; BLOOD; BLOOD PRESSURE; CHEWING GUM; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; FEMALE; MALE; PHYSIOLOGY; SELF REPORT; TIME; YOUNG ADULT;

APPETITE; BLOOD PRESSURE; CHEWING GUM; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; GHRELIN; HUMANS; MALE; NICOTINE; NICOTINIC AGONISTS; SELF REPORT; TIME FACTORS; YOUNG ADULT;

EID: 84903955172     PISSN: 08856222     EISSN: 10991077     Source Type: Journal    
DOI: 10.1002/hup.2405     Document Type: Article

References (17)

1. Bouros D, Tzouvelekis A, Anevlavis S, et al,. 2006. Smoking acutely increases plasma ghrelin concentrations. Clin Chem 52: 777-778.
2. Bullen C, McRobbie H, Thornley S, Glover M, Lin R, Laugesen M,. 2010. Effect of an electronic nicotine delivery device (e cigarette) on desire to smoke and withdrawal, user preferences and nicotine delivery: randomised cross-over trial. Tob Control 19: 98-103.
3. Cosgrove KP, Batis J, Bois F, et al,. 2009. Beta(2)-nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking. Arch Gen Psychiatry 66: 666-676.
4. Cummings DE, Naleid AM, Lattemann DPF,. 2007. Ghrelin: a link between energy homeostasis and drug abuse? Addict Biol 12: 1-5.
5. Flint A, Raben A, Blundell JE, Astrup A,. 2000. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes 24: 38-48
6. Grouselle D, Chaillou E, Caraty A, et al,. 2008. Pulsatile cerebrospinal fluid and plasma ghrelin in relation to growth hormone secretion and food intake in the sheep. J Neuroendocrinol 20: 1138-1146.
7. Jerlhag E, Engel JA,. 2011. Ghrelin receptor antagonism attenuates nicotine-induced locomotor stimulation, accumbal dopamine release and conditioned place preference in mice. Drug Alcohol Depend 117 (2-3): 126-131.
8. Jo YH, Talmage DA, Role LW,. 2002. Nicotinic receptor-mediated effects on appetite and food intake. J Neurobiol 53 (4): 618-632.
9. Kokkinos A, Tentolouris N, Kyriakaki E, et al,. 2007. Differentiation in the short- and long-term effects, of smoking on plasma total ghrelin concentrations between mare non-smokers and habitual smokers. Metabolism 56: 523-527.
10. Kroemer NB, Krebs L, Kobiella A, et al,. 2012. (Still) longing for food: insulin reactivity modulates response to food pictures. Hum Brain Mapp. doi: 10.1002/hbm.22071. [Epub ahead of print]
11. Leggio L, Ferrulli A, Cardone S, et al,. 2011. Ghrelin system in alcohol-dependent subjects: role of plasma ghrelin levels in alcohol drinking and craving. Addict Biol 17 (2): 452-464.
12. Lippl F, Erdmann J, Steiger A, et al,. 2012. Low-dose ghrelin infusion-evidence against a hormonal role in food intake. Regul Pept 174 (1-3): 26-31.
13. Mutschler J, Graf N, Spanaus KS, et al,. 2012. Circulating ghrelin levels are not associated with craving and withdrawal symptoms in acute nicotine withdrawal. Psychiatr Danub 24 (2): 229-230.
14. Soares JB, Leite-Moreira AF,. 2008. Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle. Peptides 29: 1255-1270.
15. Staes E, Absil PA, Lins L, et al,. 2010. Acylated and unacylated ghrelin binding to membranes and to ghrelin receptor: towards a better understanding of the underlying mechanisms. Bioch Biophys Acta 1798: 2102-2113.
16. Tonnesen P,. 2009. Smoking cessation: how compelling is the evidence? A review. Health Policy 91: S15-S25.
17. Von der Goltz C, Koopmann A, Dinter C, et al,. 2010. Orexin and leptin are associated with nicotine craving: a link between smoking, appetite and reward. Psychoneuroendocrinology 35 (4): 570-577.