Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases

EBioMedicine

Volumn 20, Issue , 2017, Pages 27-38

  Matsuhashi, Tetsuro ^a   Sato, Takeya ^a   Kanno, Shin ichiro ^b   Suzuki, Takehiro ^a,b   Matsuo, Akihiro ^a   Oba, Yuki ^a   Kikusato, Motoi ^b   Ogasawara, Emi ^c   Kudo, Tai ^d   Suzuki, Kosuke ^a   Ohara, Osamu ^e   Shimbo, Hiroko ^f   Nanto, Fumika ^a   Yamaguchi, Hiroaki ^g   Saigusa, Daisuke ^b   Mukaiyama, Yasuno ^a   Watabe, Akiko ^a   Kikuchi, Koichi ^a   Shima, Hisato ^a   Mishima, Eikan ^a   Akiyama, Yasutoshi ^a   Oikawa, Yoshitsugu ^a   Hsin Jung, H O ^a,b   Akiyama, Yukako ^a   Suzuki, Chitose ^a   Uematsu, Mitsugu ^a   Ogata, Masaki ^a   Kumagai, Naonori ^a   Toyomizu, Masaaki ^b   Hozawa, Atsushi ^b   Mano, Nariyasu ^g   Owada, Yuji ^a   Aiba, Setsuya ^a   Yanagisawa, Teruyuki ^a   Tomioka, Yoshihisa ^b   Kure, Shigeo ^a   Ito, Sadayoshi ^a   Nakada, Kazuto ^c   Hayashi, Ken ichiro ^h   Osaka, Hitoshi ⁱ   Abe, Takaaki ^a,b   more..

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d Primetech Corporation   (Japan)

^e KAZUSA DNA RESEARCH INSTITUTE   (Japan)

^f KANAGAWA CHILDREN'S MEDICAL CENTER   (Japan)

^g TOHOKU UNIVERSITY HOSPITAL   (Japan)

^h OKAYAMA UNIVERSITY OF SCIENCE   (Japan)

ⁱ JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

ATPase dimer formation; GDF 15; MA 5; Mitochondrial disease; Supercomplex

Indexed keywords

GROWTH DIFFERENTIATION FACTOR 15; 4-(2,4-DIFLUOROPHENYL)-2-(1H-INDOL-3-YL)-4-OXOBUTANOIC ACID; ADENOSINE TRIPHOSPHATE; ARYLBUTYRIC ACID DERIVATIVE; BIOLOGICAL MARKER; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 21; INDOLEACETIC ACID DERIVATIVE; MITOCHONDRIAL DNA; MULTIPROTEIN COMPLEX; PROTECTIVE AGENT; PROTEIN BINDING; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ADOLESCENT; ADULT; AGED; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CHILD; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE MUTATION; HETEROPLASMY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; INFANT; LEIGH DISEASE; MASS SPECTROMETRY; MIDDLE AGED; MITOCHONDRIAL BIOGENESIS; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; OLIGOMERIZATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SIZE EXCLUSION CHROMATOGRAPHY; WESTERN BLOTTING; ANIMAL; CELL LINE; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; FIBROBLAST; GENETICS; METABOLISM; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MUTATION; ORGANELLE BIOGENESIS; PROGNOSIS; PROTEIN MULTIMERIZATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; BIOMARKERS; CELL LINE; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DNA, MITOCHONDRIAL; FIBROBLAST GROWTH FACTORS; FIBROBLASTS; GROWTH DIFFERENTIATION FACTOR 15; HUMANS; INDOLEACETIC ACIDS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; MULTIPROTEIN COMPLEXES; MUTATION; ORGANELLE BIOGENESIS; PHENYLBUTYRATES; PROGNOSIS; PROTECTIVE AGENTS; PROTEIN BINDING; PROTEIN MULTIMERIZATION;

EID: 85020007376     PISSN: None     EISSN: 23523964     Source Type: Journal    
DOI: 10.1016/j.ebiom.2017.05.016     Document Type: Article

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