Genetically engineered probiotic for the treatment of phenylketonuria (PKU); Assessment of a novel treatment in vitro and in the PAHenu2 mouse model of PKU

PLoS ONE

Volumn 12, Issue 5, 2017, Pages

  Durrer, Katherine E ^a,b   Allen, Michael S ^b   Von Herbing, Ione Hunt ^a  

^a UNIVERSITY OF NORTH TEXAS   (United States)

^b UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYASE; PHENYLALANINE LYASE; PROBIOTIC AGENT; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; PHENYLALANINE; PHENYLALANINE AMMONIA LYASE;

ANABAENA VARIABILIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GENE; BACTERIUM CULTURE; CODON; CONTROLLED STUDY; DOSE RESPONSE; ENZYME BLOOD LEVEL; ENZYME DEGRADATION; ENZYME REPLACEMENT; EXPRESSION VECTOR; FECES ANALYSIS; FEMALE; FREEZE DRYING; GENE EXPRESSION; GENETIC ENGINEERING; HOMOZYGOSITY; IN VITRO STUDY; IN VIVO STUDY; LACTOBACILLUS REUTERI; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; PHENYLALANINE LYASE GENE; PHENYLKETONURIA; PROCESS OPTIMIZATION; SHUTTLE VECTOR; TREATMENT DURATION; ANIMAL; BLOOD; C57BL MOUSE; GENETICS; INTESTINE; METABOLISM; MICROBIOLOGY; PHENYLKETONURIAS;

ANABAENA VARIABILIS; ANIMALS; BACTERIAL PROTEINS; INTESTINES; LACTOBACILLUS REUTERI; MICE; MICE, INBRED C57BL; PHENYLALANINE; PHENYLALANINE AMMONIA-LYASE; PHENYLKETONURIAS; PROBIOTICS;

EID: 85019912671     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0176286     Document Type: Article

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