Use of Preventive Medication in Patients With Limited Life Expectancy: A Systematic Review

Journal of Pain and Symptom Management

Volumn 53, Issue 6, 2017, Pages 1097-1110.e1

  Poudel, Arjun ^a   Yates, Patsy ^a   Rowett, Debra ^b   Nissen, Lisa M ^a  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^b REPATRIATION GENERAL HOSPITAL   (Australia)

Author keywords

Limited life expectancy; optimal prescribing; preventive medication; symptomatic treatment

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIBIOTIC AGENT; ANTICOAGULANT AGENT; ANTIDEPRESSANT AGENT; ANTILIPEMIC AGENT; ANTIPARKINSON AGENT; ANTITHROMBOCYTIC AGENT; ANTIULCER AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BRONCHODILATING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARDIOVASCULAR AGENT; CORTICOSTEROID; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; GASTROINTESTINAL AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN DERIVATIVE; IRON; LAXATIVE; NEUROLEPTIC AGENT; NITRIC ACID DERIVATIVE; NOOTROPIC AGENT; ORAL ANTIDIABETIC AGENT; UNINDEXED DRUG; VITAMIN; VITAMIN D; WARFARIN;

CARDIOVASCULAR DISEASE; COGNITIVE DEFECT; COMMUNITY CARE; DEMENTIA; HOSPITAL CARE; HUMAN; LIFE EXPECTANCY; MALIGNANT NEOPLASM; MULTICENTER STUDY (TOPIC); NURSING HOME; PALLIATIVE THERAPY; PROPHYLAXIS; REVIEW; SYSTEMATIC REVIEW; HEALTH SERVICE; INAPPROPRIATE PRESCRIBING; POLYPHARMACY; PRESCRIPTION; PREVENTIVE HEALTH SERVICE; PROCEDURES; TERMINAL CARE;

DRUG PRESCRIPTIONS; HUMANS; INAPPROPRIATE PRESCRIBING; LIFE EXPECTANCY; MEDICAL OVERUSE; NURSING HOMES; PALLIATIVE CARE; POLYPHARMACY; PREVENTIVE HEALTH SERVICES; TERMINAL CARE;

EID: 85019679842     PISSN: 08853924     EISSN: 18736513     Source Type: Journal    
DOI: 10.1016/j.jpainsymman.2016.12.350     Document Type: Review

References (41)

1. Larcher, V., Craig, F., Bhogal, K., Wilkinson, D., Brierley, J., Making decisions to limit treatment in life-limiting and life-threatening conditions in children: a framework for practice. Arch Dis Child 100 (2015), s3–s23.
2. Stevenson, J., Abernethy, A.P., Miller, C., Currow, D.C., Managing comorbidities in patients at the end of life. BMJ 329 (2004), 909–912.
3. Holmes, H.M., Rational prescribing for patients with a reduced life expectancy. Clin Pharmacol Ther 85 (2009), 103–107.
4. Maddison, A.R., Fisher, J., Johnston, G., Preventive medication use among persons with limited life expectancy. Prog Palliat Care 19 (2011), 15–21.
5. Holmes, H.M., Hayley, D.C., Alexander, G.C., Sachs, G.A., Reconsidering medication appropriateness for patients late in life. Arch Intern Med 166 (2006), 605–609.
6. Lee, S.J., Leipzig, R.M., Walter, L.C., Incorporating lag time to benefit into prevention decisions for older adults. JAMA 310 (2013), 2609–2610.
7. Todd, A., Husband, A., Andrew, I., et al. Inappropriate prescribing of preventative medication in patients with life-limiting illness: a systematic review. BMJ Support Palliat Care, 2016 [Epub ahead of print].
8. Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA Statement. Ann Intern Med 151 (2009), 264–269.
9. Barcelo, M., Torres, O., Ruiz, D., Casademont, J., Appropriateness of medications prescribed to elderly patients with advanced heart failure and limited life expectancy who died during hospitalization. Drugs Aging 31 (2014), 541–546.
10. Blass, D.M., Black, B.S., Phillips, H., et al. Medication use in nursing home residents with advanced dementia. Int J Geriatr Psychiatry 23 (2008), 490–496.
11. Currow, D.C., Stevenson, J.P., Abernethy, A.P., Plummer, J., Shelby-James, T.M., Prescribing in palliative care as death approaches. J Am Geriatr Soc 55 (2007), 590–595.
12. Evans, N., Pasman, H.R.W., Donker, G.A., et al. End-of-life care in general practice: a cross-sectional, retrospective survey of ‘cancer’, ‘organ failure’ and ‘old-age/dementia’ patients. Palliat Med 28 (2014), 965–975.
13. Fede, A., Miranda, M., Antonangelo, D., et al. Use of unnecessary medications by patients with advanced cancer: cross-sectional survey. Support Care Cancer 19 (2011), 1313–1318.
14. Heppenstall, C.P., Broad, J.B., Boyd, M., et al. Medication use and potentially inappropriate medications in those with limited prognosis living in residential aged care. Australas J Ageing 35 (2016), E18–E24.
15. Kutner, J.S., Blatchford, P.J., Taylor, D.H. Jr., et al. Safety and benefit of discontinuing statin therapy in the setting of advanced, life-limiting illness: a randomized clinical trial. JAMA Intern Med 175 (2015), 691–700.
16. Lindsay, J., Dooley, M., Martin, J., et al. The development and evaluation of an oncological palliative care deprescribing guideline: the ‘OncPal deprescribing guideline’. Support Care Cancer 23 (2015), 71–78.
17. McLean, S., Sheehy-Skeffington, B., O'Leary, N., O'Gorman, A., Pharmacological management of co-morbid conditions at the end of life: is less more?. Ir J Med Sci 182 (2013), 107–112.
18. Min, L.C., Wenger, N.S., Fung, C., et al. Multimorbidity is associated with better quality of care among vulnerable elders. Med Care 45 (2007), 480–488.
19. Onder, G., Liperoti, R., Foebel, A., et al. Polypharmacy and mortality among nursing home residents with advanced cognitive impairment: results from the SHELTER study. J Am Med Dir Assoc 14 (2013), 450.e7–450.e12.
20. Riechelmann, R.P., Krzyzanowska, M.K., Zimmermann, C., Futile medication use in terminally ill cancer patients. Support Care Cancer 17 (2009), 745–748.
21. Russell, B.J., Rowett, D., Abernethy, A.P., Currow, D.C., Prescribing for comorbid disease in a palliative population: focus on the use of lipid-lowering medications. Intern Med J 44 (2014), 177–184.
22. Sera, L., McPherson, M.L., Holmes, H.M., Commonly prescribed medications in a population of hospice patients. Am J Hosp Palliat Care 31 (2014), 126–131.
23. Silveira, M.J., Kazanis, A.S., Shevrin, M.P., Statins in the last six months of life: a recognizable, life-limiting condition does not decrease their use. J Palliat Med 11 (2008), 685–693.
24. Stavrou, E.P., Buckley, N., Olivier, J., Pearson, S.A., Discontinuation of statin therapy in older people: does a cancer diagnosis make a difference? An observational cohort study using data linkage. BMJ Open, 2, 2012, e000880.
25. Tjia, J., Cutrona, S.L., Peterson, D., et al. Statin discontinuation in nursing home residents with advanced dementia. J Am Geriatr Soc 62 (2014), 2095–2101.
26. LeBlanc, T.W., McNeil, M.J., Kamal, A.H., Currow, D.C., Abernethy, A.P., Polypharmacy in patients with advanced cancer and the role of medication discontinuation. Lancet Oncol 16 (2015), e333–341.
27. Alexander, G.C., Sayla, M.A., Holmes, H.M., Sachs, G.A., Prioritizing and stopping prescription medicines. CMAJ 174 (2006), 1083–1084.
28. Sergi, G., De Rui, M., Sarti, S., Manzato, E., Polypharmacy in the elderly: can comprehensive geriatric assessment reduce inappropriate medication use?. Drugs Aging 28 (2011), 509–518.
29. Campanelli, C.M., American Geriatrics Society updated beers criteria for potentially inappropriate medication use in older adults: the American Geriatrics Society 2012 Beers Criteria Update Expert Panel. J Am Geriatr Soc, 60, 2012, 616.
30. O'Mahony, D., O'Sullivan, D., Byrne, S., et al. STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing 44 (2015), 213–218.
31. Knight, E.L., Avorn, J., Quality indicators for appropriate medication use in vulnerable elders. Ann Intern Med 135 (2001), 703–710.
32. McLeod, P.J., Huang, A.R., Tamblyn, R.M., Gayton, D.C., Defining inappropriate practices in prescribing for elderly people: a national consensus panel. Can Med Assoc J 156 (1997), 385–391.
33. Basger, B.J., Chen, T.F., Moles, R.J., Inappropriate medication use and prescribing indicators in elderly Australians. Drugs Aging 25 (2008), 777–793.
34. Hanlon, J.T., Schmader, K.E., Samsa, G.P., et al. A method for assessing drug therapy appropriateness. J Clin Epidemiol 45 (1992), 1045–1051.
35. Poudel, A., Hubbard, R.E., Nissen, L., Mitchell, C., Frailty: a key indicator to minimize inappropriate medication in older people. QJM 106 (2013), 969–975.
36. Poudel, A., Peel, N.M., Nissen, L., et al. A systematic review of prescribing criteria to evaluate appropriateness of medications in frail older people. Rev Clin Gerontol 24 (2014), 304–318.
37. Greene, B., Transformative advance care planning: the Honoring Choices Minnesota experience. Creat Nurs 19 (2013), 200–204.
38. Steinhauser, K.E., Christakis, N.A., Clipp, E.C., et al. Factors considered important at the end of life by patients, family, physicians, and other care providers. JAMA 284 (2000), 2476–2482.
39. Scott, I.A., Hilmer, S.N., Reeve, E., et al. Reducing inappropriate polypharmacy: the process of deprescribing. JAMA Intern Med 175 (2015), 827–834.
40. Payne, R.A., Abel, G.A., Avery, A.J., Mercer, S.W., Roland, M.O., Is polypharmacy always hazardous? A retrospective cohort analysis using linked electronic health records from primary and secondary care. Br J Clin Pharmacol 77 (2014), 1073–1082.
41. Todd, A., Holmes, H.M., Recommendations to support deprescribing medications late in life. Int J Clin Pharm 37 (2015), 678–681.