Inappropriate medication use and prescribing indicators in elderly Australians: Development of a prescribing indicators tool

Drugs and Aging

Volumn 25, Issue 9, 2008, Pages 777-793

  Basger, Benjamin J ^a   Chen, Timothy F ^a   Moles, Rebekah J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Elderly; Prescribing

Indexed keywords

ARTICLE; AUSTRALIA; DRUG CONTRAINDICATION; DRUG INDICATION; DRUG USE; ELDERLY CARE; PRESCRIPTION; PRIORITY JOURNAL;

AGED; AUSTRALIA; HUMANS; MEDICATION ERRORS; PHARMACEUTICAL PREPARATIONS; PHYSICIAN'S PRACTICE PATTERNS; PRESCRIPTIONS; QUALITY ASSURANCE, HEALTH CARE; QUALITY INDICATORS, HEALTH CARE;

EID: 50249083293     PISSN: 1170229X     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002512-200825090-00004     Document Type: Article

References (96)

1. Commonwealth of Australia. The national strategy for quality use of medicines: plain English edition [online]. Available from URL: http://www.health.gov.au/internet/main/Publishing.nsf/Content/ CA777524C860DFF2CA256F1800468B61/$File/natstrateng.pdf [Accessed 2008 Mar 27]
2. Australian Commission on Safety and Quality in Health Care. Charting the safety and quality of health care in Australia [online]. Available from URL: http://www.safetyandquality.org/internet/safety/publishing.nsf/Content/ F1AB7CD29C037EFBCA25716F00033691/$File/chartbk.pdf [Accessed 2008 Mar 27]
3. Roughead EE, Lexchin J. Adverse drug events: counting is not enough, action is needed. Med J Aust 2006; 184 (7): 315-6
4. Harris MF, Zwar NA. Care of patients with chronic disease: the challenge for general practice. Med J Aust 2007; 187: 104-7
5. Miller GC, Britt HC, Valenti L. Adverse drug events in general practice patients in Australia. Med J Aust 2006; 184 (7): 321-4
6. Chan M, Nicklason F, Vial JH. Adverse drug events as a cause of hospital admission in the elderly. Int Med J 2001; 31 (4): 199-205
7. Pirmohamed M, James S, Meakin S, et al. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ 2004; 329 (7456): 15-9
8. Routledge PA, O'Mahony MS, Woodhouse KW. Adverse drug reactions in elderly patients. Br J Clin Pharmacol 2004; 57 (2): 121-6
9. Merle L, Laroche ML, Dantoine T, et al. Predicting and prevent ing adverse drug reactions in the very old. Drugs Aging 2005; 22 (5): 375-92
10. Gallagher P, Barry P, O'Mahony D. Inappropriate prescribing in the elderly. J Clin Pharm Ther 2007; 32: 113-21
11. Elliott RA. Problems with medication use in the elderly: an Australian perspective. J Pharm Pract Res 2006; 36 (1): 58-66
12. Burgess CL, Holman CD, Satti AG. Adverse drug reactions in older Australians, 1981-2002. Med J Aust 2005; 182 (6): 267-70
13. Zhang M, Holman CD, Preen DB, et al. Repeat adverse drug reactions causing hospitalization in older Australians: a population-based longitudinal study 1980-2003. Br J Clin Pharmacol 2007; 63 (2): 163-70
14. Buchan H. Turning knowledge into action. Australian Prescriber 2007; 30 (5): 114-5
15. Hanlon JT, Schmader KE, Samsa GP, et al. A method for assessing drug therapy appropriateness. J Clin Epidemiol 1992; 45 (10): 1045-51
16. Lipton HL, Bero LA, Bird JA, et al. The impact of clinical pharmacists' consultations on physicians' geriatric drug prescribing: a randomized controlled trial. Med Care 1992; 30 (7): 646-58
17. Lipton HL, Bird JA, Bero LA, et al. Assessing the appropriateness of physician prescribing for geriatric outpatients: development and testing of an instrument. J Pharm Technol 1993; 9 (3): 107-13
18. Tamblyn RM, McLeod PJ, Abrahamowicz M, et al. Questionable prescribing for elderly patients in Quebec. CMAJ 1994; 150 (11): 1801-9
19. Newton PF, Levinson W, Maslen D. The geriatric medication algorithm: a pilot study. J Gen Intern Med 1994; 9 (3): 164-7
20. Oborne CA, Batty GM, Maskrey V, et al. Development of prescribing indicators for elderly medical inpatients. Br J Clin Pharmacol 1997; 43 (1): 91-7
21. Beers MH. Explicit criteria for determining potentially inappropriate medication use by the elderly: an update. Arch Intern Med 1997; 157 (14): 1531-6
22. McLeod PJ, Huang AR, Tamblyn RM, et al. Defining inappropriate practices in prescribing for elderly people: a national consensus panel. CMAJ 1997; 156 (3): 385-91
23. Parkes AJ, Coper LC. Inappropriate use of medications in the veteran community: how much do doctors and pharmacists contribute? Aust N Z J Public Health. 1997; 21 (5): 469-76
24. Brown NJ, Griffin MR, Ray WA, et al. A model for improving medication use in home health care patients. J Am Pharm Assoc (Wash) 1998; 38 (6): 696-702
25. NSW Therapeutic Assessment Group. Manual of indicators for drug use in Australian hospitals [online]. Available from URL: http://www.ciap.health.nsw. gov.au/nswtag/publications/otherdocs/Manual%20of%20Indicators.pdf [Accessed 2008 Mar 27]
26. Knight EL, Avorn J. Quality indicators for appropriate medication use in vulnerable elders. Ann Intern Med 2001; 135 (8 Pt 2): 703-10
27. Zhan C, Sangl J, Bierman AS, et al. Potentially inappropriate medication use in the community-dwelling elderly: findings from the 1996 Medical Expenditure Panel Survey. JAMA 2001; 286 (22): 2823-9
28. Mackinnon NJ, Hepler CD. Preventable drug-related morbidity in older adults: 1. Indicator development. J Manag Care Pharm 2002; 8 (5): 365-71
29. Robertson HA, MacKinnon NJ. Development of a list of consensus-approved clinical indicators of preventable drug-related morbidity in older adults. Clin Ther 2002; 24 (10): 1595-613
30. Morris CJ, Cantrill JA, Hepler CD, et al. Preventing drug-related morbidity: determining valid indicators. Int J Qual Health Care 2002; 14 (3): 183-98
31. Morris CJ, Cantrill J. Preventing drug-related morbidity: the development of quality indicators. J Clin Pharm Ther 2003; 28 (4): 295-305
32. Hajjar ER, Hanlon JT, Artz MB, et al. Adverse drug reaction risk factors in older outpatients. Am J Geriatr Pharmacotherapy 2003; 1 (2): 82-9
33. Evidence-practice gaps report. Vol. 1. Melbourne (VIC): National Institute of Clinical Studies, 2003 [online]. Available from URL: http://www.nhmrc.gov.au/nics/asp/index.asp?page=materials/ materials_year_article&cid=5212&id=406 [Accessed 2008 Jul 18]
34. Evidence-practice gaps report. Vol. 2. Melbourne (VIC): National Institute of Clinical Studies, 2005 [online]. Available from URL: http://www.nhmrc.gov.au/nics/asp/index.asp?page=materials/ materials_year_article&cid=5212&id=405 [Accessed 2008 Jul 18]
35. Fick DM, Cooper JW, Wade WE, et al. Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Int Med 2003; 163 (22): 2716-24
36. Byles JE, Heinze R, Nair BK, et al. Medication use among older Australian veterans and war widows. Int Med J 2003; 33 (8): 388-92
37. Higashi T, Shekelle PG, Solomon DH, et al. The quality of pharmacologic care for vulnerable older patients. Ann Intern Med 2004; 140 (9): 714-20
38. Tully MP, Cantrill JA. The validity of explicit indicators of prescribing appropriateness. Int J Qual Health Care 2006; 18 (2): 87-94
39. Okechukwu I, Bennett K, Feely J. General practitioners' ranking of evidence-based prescribing quality indicators: a comparative study with a prescription database. Br J Clin Pharmacol 2006; 62 (2): 218-24
40. National Prescribing Service. Indicators of quality prescribing in Australian general practice: a manual for users [online]. Available from URL: http://www.nps.org.au/resources/quality_prescribing_indicators/indicators_full. pdf [Accessed 2008 Mar 27]
41. Allenet B, Bedouch P, Rose FX, et al. Validation of an instrument for the documentation of clinical pharmacists' interventions. Pharm World Sci 2006; 28 (4): 181-8
42. Laroche ML, Charmes JP, Merle L. Potentially inappropriate medications in the elderly: a French consensus panel list. Eur J Clin Pharmacol 2007; 63: 725-31
43. Naugler CT, Brymer C, Stolee P, et al. Development and validation of an improving prescribing in the elderly tool. Can J Clin Pharmacol 2000; 7 (2): 103-7
44. Elliott RA, Woodward MC, Oborne CA. Indicators of prescribing quality for elderly hospital inpatients. Aust J Hosp Pharm 2001; 31 (1): 19-25
45. Gallagher P, Ryan C, Byrne S, et al. STOPP (screening tool of older person's prescriptions) and START (screening tool to alert doctors to right treatment): consensus validation. Int J Clin Pharmacol Ther 2008; 46 (2): 72-83
46. Beers MH, Ouslander JG, Rollingher I, et al. Explicit criteria for determining inappropriate medication use in nursing home residents: UCLA Division of Geriatric Medicine. Arch Intern Med 1991; 151 (9): 1825-32
47. O'Halloran J, Britt H, Valenti L, et al. Older patients attending general practice in Australia 2000-02: General Practice Series no. 12, General Practice Statistics and Classification Unit [online]. Canberra (ACT): Australian Institute of Health and Welfare, 2003: 1-147. Available from URL: http://www.aihw.gov.au/publications/gep/opagpa/opagpa00-02.pdf [Accessed 2008 Mar 27]
48. Australian Institute of Health and Welfare. Australia's health 2006: report no.: AIHW cat. no. AUS 73. Canberra (ACT): AIHW, 2006
49. Department of Health and Ageing, Australian Government. Expenditure and prescriptions twelve months to 30 June 2006 [online]. Available from URL: http://www.health.gov.au/internet/wcms/publishing.nsf/Content/ A58720844CBFCB47CA257218000D91C7/$File/complete.pdf [Accessed 2008 Mar 27]
50. Rossi S, editor. Australian medicines handbook 2008. Adelaide (SA): Australian Medicines Handbook Pty Ltd, 2008
51. Australian medicines handbook drug choice companion: aged care. 2nd ed. Adelaide (SA): Australian Medicines Handbook Pty Ltd, 2006
52. Therapeutic Goods Administration. Australian adverse drug reactions bulletin [online]. Available from URL: http://www.tga.gov.au/adr/aadrb.htm [Accessed 2008 Mar 27]
53. eTG complete [CD-ROM]. Melbourne (VIC): Therapeutic Guidelines, 2006 Jan
54. National Prescribing Service Limited. Prescribing practice review [online]. Available from URL: http://www.nps.org.au/site.php?.page = 1&content = /html/resource.php&id = 8 [Accessed 2008 Mar 27]
55. National Prescribing Service Limited. National Prescribing Service newsletter [online]. Available from URL: http://www.nps.org.au/site.php?.page= 1&content=/html/resource.php&id=7 [Accessed 2008 Mar 27]
56. Mallet L, Spinewine A, Huang A. The challenge of managing drug interactions in elderly people. Lancet 2007; 370: 185-91
57. The Australian pharmaceutical formulary and handbook. 20th ed. Canberra (ACT): The Pharmaceutical Society of Australia, 2006
58. Medicines and older people: an accident waiting to happen? National Prescribing Service newsletter 34, National Prescribing Service Limited; 2004 [online]. Available from URL: http://www.nps.org.au/site.php?content=/html/news. php&news=/resources/NPS_News/news34 [Accessed 2008 Jun 12]
59. Managing dyslipidaemia. Prescribing Practice Review 17, National Prescribing Service Limited; 2002 [online]. Available from URL: http://www.nps.org.au/site.php?content=/html/ppr.php&ppr=/resources/ Prescribing_Practice_Reviews/ppr17 [Accessed 2008 Jul 16]
60. Reducing risk in type 2 diabetes. Prescribing Practice Review 29, National Prescribing Service Limited; 2005 [online]. Available from URL: http://www.nps.org.au/site.php?content=/html/ppr.php&ppr=/resources/ Prescribing_Practice_Reviews/ppr29 [Accessed 2008 Jul 16]
61. Ischaemic heart disease. Prescribing Practice Review 31, National Prescribing Service Limited; 2005 [online]. Available from URL: http://www.nps.org.au/site.php?content=/html/ppr.php&ppr=/resources/ Prescribing_Practice_Reviews/ppr31 [Accessed 2008 Jul 16]
62. Treating dyslipidaemia. NPS News 20, National Prescribing Service Limited; 2002 [online]. Available from URL: http://www.nps.org.au/site.php? content=/html/news.php&news=/resources/NPS_News/news20 [Accessed 2008 Jul 16]
63. Targeting ischaemic heart disease: improving health outcomes with multiple medications. NPS News 41, National Prescribing Service Limited; 2005 [online]. Available from URL: http://www.nps.org.au/site.php?content=/html/news. php&news=/resources/NPS_News/news41 [Accessed 2008 Jul 16]
64. Amabile CM, Spencer AP. Keeping your patients with heart failure safe: a review of potentially dangerous medications. Arch Intern Med 2004; 164: 709-20
65. Improving outcomes for heart failure patients. Prescribing Practice Review 28, National Prescribing Service Limited; 2004 [online]. Available from URL: http://www.nps.org.au/site.php?content=/html/ppr.php&ppr=/resources/ Prescribing_Practice_Reviews/ppr28 [Accessed 2008 Jul 16]
66. Risk factors for myopathy and rhabdomyolysis with the statins. Australian Adverse Drug Reactions Bulletin 2004; 23 (1) [online]. Available from URL: http://www.tga.gov.au/adr/aadrb/aadr0402.htm [Accessed 2008 Jul 16]
67. Analgesic choices in persistent pain. Prescribing Practice Review 35, National Prescribing Service Limited; 2006 [online]. Available from URL: http://www.nps.org.au/site.php?content=/html/ppr.php&ppr=/resources/ Prescribing_Practice_Reviews/ppr35 [Accessed 2008 Jul 16]
68. Proton pump inhibitors. NPS News 46, National Prescribing Service Limited; 2006 [online]. Available from URL: http://www.nps.org.au/site.php? content=/html/news.php&news=/resources/NPS_News/news46 [Accessed 2008 Jul 16]
69. Maintaining bone health to prevent osteoporotic fractures. NPS News 53, National Prescribing Service Limited; 2007 [online]. Available from URL: http://www.nps.org.au/site.php?content=/html/news.php&news=/resources/ NPS_News/news53 [Accessed 2008 Jul 16]
70. Preventing osteoporosis and reducing fracture risk. Prescribing Practice Review 39, National Prescribing Service Limited; 2007 [online]. Available from URL: http://www.nps.org.au/site.php?content=/html/ppr.php&ppr=/resources/ Prescribing_Practice_Reviews/ppr39 [Accessed 2008 Jul 16]
71. Beware the triple whammy! Australian Adverse Medication Reactions Bulletin 2006; 25 (5) [online]. Available from URL: http://www.tga.gov.au/adr/ aadrb/aadr0610.htm [Accessed 2008 Jul 18]
72. McGavock H. Prescription-related illness: a scandalous pandemic. J Eval Clin Pract 2004; 10 (4): 491-7
73. Jano E, Aparasu RR. Healthcare outcomes associated with Beers' criteria: a systematic review. Ann Pharmacother 2007; 41 (3): 438-47
74. Hanlon JT, Schmader KE, Ruby CM, et al. Suboptimal prescribing in older inpatients and outpatients. J Am Geriatr Soc 2001; 49 (2): 200-9
75. Spinewine A, Schmader KE, Barber N, et al. Appropriate prescribing in elderly people: how well can it be measured and optimised? Lancet 2007; 370: 173-84
76. Shelton PS, Fritsch MA, Scott MA. Assessing medication appropriateness in the elderly: a review of available measures. Drugs Aging 2000; 16 (6): 437-50
77. Department of Health and Ageing, Australian Government. Home medicines review [online]. Available from URL: http://www.health.gov.au/internet/wcms/ publishing.nsf/Content/health-epc-dmmr.htm/dollar;FILE/homereview.pdf [Accessed 2008 Mar 27]
78. Stowasser DA, Allinson YM, O'Leary KM. Understanding the medicines management pathway. J Pharm Pract Res 2004; 34: 293-6
79. NSW Therapeutic Advisory Group. Indicators for quality use of medicines in Australian hospitals [online]. Available from URL: http://www.ciap.health. nsw.gov.au/nswtag/publications/QUMIndicators/Manual.pdf [Accessed 2008 Mar 28]
80. King MA, Roberts MS. The influence of the Pharmaceutical Benefits Scheme (PBS) on inappropriate prescribing in Australian nursing homes. Pharm World Sci 2007; 29: 39-42
81. Sloane PD, Zimmerman S, Brown LC, et al. Inappropriate medication prescribing in residential care/assisted living facilities. J Am Geriatr Soc 2002; 50 (6): 1001-11
82. Gray SL, Hedrick SC, Rhinard EE, et al. Potentially inapproprimedication use in community residential care facilities. Ann Pharmacother 2003; 37 (7-8): 988-93
83. Klarin I, Wimo A, Fastbom J. The association of inappropriate drug use with hospitalisation and mortality: a population-based study of the very old. Drugs Aging 2005; 22 (1): 69-82
84. O'Mahony D, Gallagher PF. Inappropriate prescribing in the older population: need for new criteria. Age Ageing 2008; 37: 138-41
85. Sorensen L, King MA, Peck R, et al. In-home medication reviews for war veterans: early experience in Australia. J Pharm Pract Res 2004; 34 (2): 122-4
86. Roughead EE, Anderson B, Gilbert AL. Potentially inappropriate prescribing among Australian veterans and war widows/widowers. Int Med J 2007; 37: 402-5
87. Elliott RA, Woodward MC, Oborne CA. Antithrombotic prescribing in atrial fibrillation: application of a prescribing indicator and multidisciplinary feedback to improve prescribing. Age Ageing 2002; 31: 391-6
88. Elliott RA, Woodward MC, Oborne CA. Quality of prescribing for elderly inpatients at nine hospitals in Victoria, Australia. J Pharm Pract Res 2003; 33 (2): 101-5
89. Department of Health and Ageing, Commonwealth of Australia. Australian statistics on medicines 2003 [online]. Available from URL: http://www.health. gov.au/internet/wcms/publishing.nsf/Content/872454E0BDD67CA5CA257110000A95FD/ $File/Stats%20on%20Medicines.pdf [Accessed 2008 Mar 27]
90. Thompson PD, Clarkson P, Karas RH. Statin-associated myopathy. JAMA 2003; 289: 657-9
91. Hilmer SN. The dilemma of polypharmacy. Australian Prescriber 2008; 31 (1): 2-3
92. Barry PJ, Gallagher P, Ryan C, et al. START (screening tool to alert doctors to the right treatment): an evidence-based screening tool to detect prescribing omissions in elderly patients. Age Ageing 2007; 36: 632-8
93. Adverse Drug Reactions Advisory Committee (ADRAC). Evidence-based medicine: pitfalls of overlooking safety. Australian Adverse Drug Reactions Bulletin 2005; 24 (2) [online]. Available from URL: http://www.tga.gov.au/adr/ aadrb/aadr0504.htm#a4 [Accessed 2008 Jun 12]
94. Guthrie B, Inkster M, Fahey T. Tackling therapeutic inertia: role of treatment data in quality indicators. BMJ 2007; 335 (7619): 542-4
95. Swagerty D, Brickley R; American Medical Directors Associa tion; American Society of Consultant Pharmacists. American Medical Directors Association and American Society of Consultant Pharmacists joint position statement on the Beers List of Potentially Inappropriate Medications in Older Adults. J Am Med Dir Assoc 2005; 6 (1): 80-6
96. Chutka DS, Takahashi PY, Hoel RW. Inappropriate medications for elderly patients. Mayo Clinic Proc 2004; 79: 122-39