Genome-wide association study of Parkinson's disease in East Asians

Human Molecular Genetics

Volumn 26, Issue 1, 2017, Pages 226-232

  Foo, Jia Nee ^a,b   Tan, Louis C ^c   Irwan, Ishak D ^b   Au, Wing Lok ^c   Low, Hui Qi ^b   Prakash, Kumar M ^c   Ahmad Annuar, Azlina ^d   Bei, Jinxin ^e   Chan, Anne Yy ^f   Chen, Chiung Mei ^g   Chen, Yi Chun ^g   Chung, Sun Ju ^h   Deng, Hao ⁱ   Lim, Shen Yang ^d   Mok, Vincent ^f   Pang, Hao ^j   Pei, Zhong ^k   Peng, Rong ^l   Shang, Hui Fang ^l   Song, Kyuyoung ^h   Tan, Ai Huey ^d   Wu, Yih Ru ^g   Aung, Tin ^m,n   Cheng, Ching Yu ^m,n,o   Chew, Fook Tim ^p   Chew, Soo Hong ^p   Chong, Siow Ann ^q   Ebstein, Richard P ^p   Lee, Jimmy ^o,q   Saw, Seang Mei ^m,n,o   Seow, Adeline ⁿ   Subramaniam, Mythily ^q   Tai, E Shyong ⁿ   Vithana, Eranga N ^m,n,o   Wong, Tien Yin ^m,n,o   Heng, Khai Koon ^b   Meah, Wee Yang ^b   Khor, Chiea Chuen ^b,m,n   Liu, Hong ^r   Zhang, Furen ^r   Liu, Jianjun ^b   Tan, Eng King ^c,o   more..

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b GENOME INSTITUTE OF SINGAPORE   (Singapore)

^c NATIONAL NEUROSCIENCE INSTITUTE   (Singapore)

^d UNIVERSITY OF MALAYA   (Malaysia)

^e SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^f CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^g CHANG GUNG UNIVERSITY   (Taiwan)

^h University of Ulsan College of Medicine   (South Korea)

ⁱ CENTRAL SOUTH UNIVERSITY   (China)

^j CHINA MEDICAL UNIVERSITY   (China)

^k SUN YAT SEN UNIVERSITY   (China)

^l SICHUAN UNIVERSITY   (China)

^m SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

ⁿ NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^o DUKE NUS MEDICAL SCHOOL   (Singapore)

^p NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^q INSTITUTE OF MENTAL HEALTH   (Singapore)

^r SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER;

ADULT; CASE CONTROL STUDY; COMPARATIVE STUDY; ETHNIC GROUP; FAR EAST; FEMALE; GENE LOCUS; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMAN; MALE; META ANALYSIS (TOPIC); METABOLISM; MIDDLE AGED; PARKINSON DISEASE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; BIOMARKERS; CASE-CONTROL STUDIES; ETHNIC GROUPS; FAR EAST; FEMALE; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; META-ANALYSIS AS TOPIC; MIDDLE AGED; PARKINSON DISEASE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 85019650937     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddw379     Document Type: Article

References (21)

1. Nalls, M.A., Pankratz, N., Lill, C.M., Do, C.B., Hernandez, D.G., Saad, M., DeStefano, A.L., Kara, E., Bras, J., Sharma, M., et al. (2014) Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat. Genet, 46, 989-993.
2. Satake, W., Nakabayashi, Y., Mizuta, I., Hirota, Y., Ito, C., Kubo, M., Kawaguchi, T., Tsunoda, T., Watanabe, M., Takeda, A., et al. (2009) Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat. Genet, 41, 1303-1307.
3. Simon-Sanchez, J., Schulte, C., Bras, J.M., Sharma, M., Gibbs, J.R., Berg, D., Paisan-Ruiz, C., Lichtner, P., Scholz, S.W., Hernandez, D.G., et al. (2009) Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat. Genet., 41, 1308-1312.
4. Nalls, M.A., Plagnol, V., Hernandez, D.G., Sharma, M., Sheerin, U.M., Saad, M., Simon-Sanchez, J., Schulte, C., Lesage, S., Sveinbjornsdottir, S., et al. (2011) Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet, 377, 641-649.
5. International Parkinson's Disease Genomics Consortium (IPDGC); Wellcome Trust Case Control Consortium 2 (WTCCC2). (2011) A two-stage meta-analysis identifies several new loci for Parkinson's disease. PLoS. Genet., 7, e1002142.
6. Lill, C.M., Roehr, J.T., McQueen, M.B., Kavvoura, F.K., Bagade, S., Schjeide, B.M., Schjeide, L.M., Meissner, E., Zauft, U., Allen, N.C., et al. (2012) Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS. Genet., 8,. e1002548.
7. Pankratz, N., Beecham, G.W., DeStefano, A.L., Dawson, T.M., Doheny, K.F., Factor, S.A., Hamza, T.H., Hung, A.Y., Hyman, B.T., Ivinson, A.J., et al. (2012) Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. Ann. Neurol., 71, 370-384.
8. Do, C.B., Tung, J.Y., Dorfman, E., Kiefer, A.K., Drabant, E.M., Francke, U., Mountain, J.L., Goldman, S.M., Tanner, C.M., Langston, J.W., et al. (2011) Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. PLoS Genet., 7, e1002141.
9. Hamza, T.H., Zabetian, C.P., Tenesa, A., Laederach, A., Montimurro, J., Yearout, D., Kay, D.M., Doheny, K.F., Paschall, J., Pugh, E., et al. (2011) Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. Nat. Genet., 42, 781-785.
10. Pruim, R.J., Welch, R.P., Sanna, S., Teslovich, T.M., Chines, P.S., Gliedt, T.P., Boehnke, M., Abecasis, G.R. and Willer, C.J. (2010) LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics, 26, 2336-2337.
11. Auton, A., Brooks, L.D., Durbin, R.M., Garrison, E.P., Kang, H.M., Korbel, J.O., Marchini, J.L., McCarthy, S., McVean, G.A. and Abecasis, G.R. 1000 Genomes Project Consortium (2015) A global reference for human genetic variation. Nature, 526, 68-74.
12. Zhang, K., Cui, S., Chang, S., Zhang, L. and Wang, J. (2010) i-GSEA4GWAS: a web server for identification of pathways/ gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study. Nucleic Acid Res., 38, W90-W95.
13. Purcell, S., Cherny, S.S. and Sham, P.C. (2003) Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics, 19, 149-150.
14. Foo, J.N., Chung, S.J., Tan, L.C., Liany, H., Ryu, H.S., Hong, M., Koh, T.H., Irwan, I.D., Au, W.L., Prakash, K.M., et al. (2016) Linking a genome-wide association study signal to a LRRK2 coding variant in Parkinson's disease. Mov. Disord., 31, 484-487.
15. Howie, B.N., Donnelly, P. and Marchini, J. (2009) A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS. Genet., 5, e1000529.
16. Howie, B., Marchini, J. and Stephens, M. (2011) Genotype imputation with thousands of genomes. G3 (Bethesda), 1, 457-470.
17. Delaneau, O., Marchini, J. and Zagury, J.F. (2012) A linear complexity phasing method for thousands of genomes. Nat. Methods, 9, 179-181.
18. Howie, B., Fuchsberger, C., Stephens, M., Marchini, J. and Abecasis, G.R. (2012) Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat. Genet., 44, 955-959.
19. Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M.A., Bender, D., Maller, J., Sklar, P., de Bakker, P.I., Daly, M.J. and Sham, P.C. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet., 81, 559-575.
20. Price, A.L., Patterson, N.J., Plenge, R.M., Weinblatt, M.E., Shadick, N.A. and Reich, D. (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet., 38, 904-909.
21. Chen, J., Zheng, H., Bei, J.X., Sun, L., Jia, W.H., Li, T., Zhang, F., Seielstad, M., Zeng, Y.X., Zhang, X. and Liu, J. (2009) Genetic structure of the Han Chinese population revealed by genome-wide SNP variation. Am. J. Hum. Genet., 85, 775-785.