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Volumn 40, Issue 4, 2017, Pages 614-624

Insulin and glucagon-like peptide 1 receptor agonist combination therapy in type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials

Author keywords

[No Author keywords available]

Indexed keywords

ALBIGLUTIDE; DULAGLUTIDE; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; HEMOGLOBIN A1C; INSULIN; INSULIN DEGLUDEC; INSULIN DEGLUDEC PLUS LIRAGLUTIDE; INSULIN DETEMIR; INSULIN GLARGINE PLUS LIXISENATIDE; LIRAGLUTIDE; LIXISENATIDE; ANTIDIABETIC AGENT; GLP1R PROTEIN, HUMAN; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN;

EID: 85019557315     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc16-1957     Document Type: Review
Times cited : (106)

References (46)
  • 1
    • 84919999219 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes, 2015: A patient-centered approach: Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2015; 38:140-149
    • (2015) Diabetes Care , vol.38 , pp. 140-149
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 2
    • 84960189946 scopus 로고    scopus 로고
    • Approaches to glycemic treatment. Sec. 7 in Standards of Medical Care in Diabetesd2016
    • American Diabetes Association
    • American Diabetes Association. Approaches to glycemic treatment. Sec. 7. In Standards of Medical Care in Diabetesd2016. Diabetes Care 2016;39(Suppl. 1):S52-S59
    • (2016) Diabetes Care , vol.39 , pp. S52-S59
  • 4
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: A patient-centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • Inzucchi SE, Bergenstal RM, Buse JB, et al.; American Diabetes Association (ADA); European Association for the Study of Diabetes (EASD). Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2012;35:1364-1379
    • (2012) Diabetes Care , vol.35 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 5
    • 84919344081 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonist and basal insulin combination treatment for the management of type 2 diabetes: A systematic review and meta-analysis
    • Eng C, Kramer CK, Zinman B, Retnakaran R. Glucagon-like peptide-1 receptor agonist and basal insulin combination treatment for the management of type 2 diabetes: a systematic review and meta-analysis. Lancet 2014;384: 2228-2234
    • (2014) Lancet , vol.384 , pp. 2228-2234
    • Eng, C.1    Kramer, C.K.2    Zinman, B.3    Retnakaran, R.4
  • 6
    • 69149107727 scopus 로고    scopus 로고
    • The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration
    • Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med 2009;151:W65-W94
    • (2009) Ann Intern Med , vol.151 , pp. W65-W94
    • Liberati, A.1    Altman, D.G.2    Tetzlaff, J.3
  • 7
    • 84859001212 scopus 로고    scopus 로고
    • The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
    • Higgins JP, Altman DG, Gøtzsche PC, et al.; Cochrane BiasMethods Group; Cochrane Statistical Methods Group. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011;343:d5928
    • (2011) BMJ , vol.343 , pp. d5928
    • Higgins, J.P.1    Altman, D.G.2    Gøtzsche, P.C.3
  • 8
    • 0029914622 scopus 로고    scopus 로고
    • Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
    • Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996;17:1-12
    • (1996) Control Clin Trials , vol.17 , pp. 1-12
    • Jadad, A.R.1    Moore, R.A.2    Carroll, D.3
  • 10
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-634
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Davey Smith, G.2    Schneider, M.3    Minder, C.4
  • 11
    • 0033934949 scopus 로고    scopus 로고
    • Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis
    • Duval S, Tweedie R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 2000;56:455-463
    • (2000) Biometrics , vol.56 , pp. 455-463
    • Duval, S.1    Tweedie, R.2
  • 12
    • 79551615182 scopus 로고    scopus 로고
    • Use of twice-daily exenatide in basal insulin-treated patients with type 2 diabetes: A randomized, controlled trial
    • Buse JB, Bergenstal RM, Glass LC, et al. Use of twice-daily exenatide in basal insulin-treated patients with type 2 diabetes: a randomized, controlled trial. Ann Intern Med 2011;154: 103-112
    • (2011) Ann Intern Med , vol.154 , pp. 103-112
    • Buse, J.B.1    Bergenstal, R.M.2    Glass, L.C.3
  • 13
    • 84862903186 scopus 로고    scopus 로고
    • Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets
    • DeVries JH, Bain SC, Rodbard HW, et al.; Liraglutide-Detemir Study Group. Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets. Diabetes Care 2012;35:1446-1454
    • (2012) Diabetes Care , vol.35 , pp. 1446-1454
    • DeVries, J.H.1    Bain, S.C.2    Rodbard, H.W.3
  • 14
    • 84865979163 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia)
    • Seino Y, Min KW, Niemoeller E, Takami A; EFC10887 GETGOAL-L Asia Study Investigators. Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia). Diabetes Obes Metab 2012;14:910-917
    • (2012) Diabetes Obes Metab , vol.14 , pp. 910-917
    • Seino, Y.1    Min, K.W.2    Niemoeller, E.3    Takami, A.4
  • 15
    • 84878592117 scopus 로고    scopus 로고
    • Adding once-daily lixisenatide for type 2 diabetes inadequately controlled by established basal insulin: A 24-week, randomized, placebocontrolled comparison (GetGoal-L)
    • Riddle MC, Aronson R, Home P, et al. Adding once-daily lixisenatide for type 2 diabetes inadequately controlled by established basal insulin: a 24-week, randomized, placebocontrolled comparison (GetGoal-L). Diabetes Care 2013;36:2489-2496
    • (2013) Diabetes Care , vol.36 , pp. 2489-2496
    • Riddle, M.C.1    Aronson, R.2    Home, P.3
  • 16
    • 84878603672 scopus 로고    scopus 로고
    • Adding once-daily lixisenatide for type 2 diabetes inadequately controlled with newly initiated and continuously titrated basal insulin glargine: A 24-week, randomized, placebo-controlled study (GetGoal-Duo 1)
    • RiddleMC, Forst T, Aronson R, et al. Adding once-daily lixisenatide for type 2 diabetes inadequately controlled with newly initiated and continuously titrated basal insulin glargine: a 24-week, randomized, placebo-controlled study (GetGoal-Duo 1). Diabetes Care 2013;36:2497-2503
    • (2013) Diabetes Care , vol.36 , pp. 2497-2503
    • Riddle, M.C.1    Forst, T.2    Aronson, R.3
  • 17
    • 84945492252 scopus 로고    scopus 로고
    • Efficacy and safety of liraglutide versus placebo added to basal insulin analogues (with or without metformin) in patients with type 2 diabetes: A randomized placebo-controlled trial
    • Ahmann A, Rodbard HW, Rosenstock J, et al.; NN2211-3917 Study Group. Efficacy and safety of liraglutide versus placebo added to basal insulin analogues (with or without metformin) in patients with type 2 diabetes: a randomized, placebo-controlled trial. Diabetes Obes Metab 2015;17:1056-1064
    • (2015) Diabetes Obes Metab , vol.17 , pp. 1056-1064
    • Ahmann, A.1    Rodbard, H.W.2    Rosenstock, J.3
  • 18
    • 84948158921 scopus 로고    scopus 로고
    • Liraglutide in people treated for type 2 diabetes with multiple daily insulin injections: Randomised clinical trial (MDI Liraglutide trial)
    • Lind M, Hirsch IB, Tuomilehto J, et al. Liraglutide in people treated for type 2 diabetes with multiple daily insulin injections: randomised clinical trial (MDI Liraglutide trial). BMJ 2015;351: h5364
    • (2015) BMJ , vol.351 , pp. h5364
    • Lind, M.1    Hirsch, I.B.2    Tuomilehto, J.3
  • 19
    • 84974678872 scopus 로고    scopus 로고
    • Effect of adding insulin degludec to treatment in patients with type 2 diabetes inadequately controlled with metformin and liraglutide: A double-blind randomized controlled trial (BEGIN: ADD to GLP-1 Study)
    • Aroda VR, Bailey TS, Cariou B, et al. Effect of adding insulin degludec to treatment in patients with type 2 diabetes inadequately controlled with metformin and liraglutide: a double-blind randomized controlled trial (BEGIN: ADD TO GLP-1 Study). Diabetes Obes Metab 2016;18: 663-670
    • (2016) Diabetes Obes Metab , vol.18 , pp. 663-670
    • Aroda, V.R.1    Bailey, T.S.2    Cariou, B.3
  • 20
    • 84977567493 scopus 로고    scopus 로고
    • Combination therapy with liraglutide and insulin in Japanese patients with type 2 diabetes: A 36-week, randomized, double-blind, parallelgroup trial
    • Seino Y, Kaneko S, Fukuda S, et al. Combination therapy with liraglutide and insulin in Japanese patients with type 2 diabetes: a 36-week, randomized, double-blind, parallelgroup trial. J Diabetes Investig 2016;7:565-573
    • (2016) J Diabetes Investig , vol.7 , pp. 565-573
    • Seino, Y.1    Kaneko, S.2    Fukuda, S.3
  • 21
    • 84979034798 scopus 로고    scopus 로고
    • Effect of adding liraglutide vs placebo to a high-dose insulin regimen in patients with type 2 diabetes: A randomized clinical trial
    • Vanderheiden A, Harrison L, Warshauer J, Li X, Adams-Huet B, Lingvay I. Effect of adding liraglutide vs placebo to a high-dose insulin regimen in patients with type 2 diabetes: a randomized clinical trial. JAMA Intern Med 2016;176: 939-947
    • (2016) JAMA Intern Med , vol.176 , pp. 939-947
    • Vanderheiden, A.1    Harrison, L.2    Warshauer, J.3    Li, X.4    Adams-Huet, B.5    Lingvay, I.6
  • 22
    • 84868700326 scopus 로고    scopus 로고
    • Efficacy and safety comparison between liraglutide as add-on therapy to insulin and insulin dose-increase in Chinese subjects with poorly controlled type 2 diabetes and abdominal obesity
    • Li CJ, Li J, Zhang QM, et al. Efficacy and safety comparison between liraglutide as add-on therapy to insulin and insulin dose-increase in Chinese subjects with poorly controlled type 2 diabetes and abdominal obesity. Cardiovasc Diabetol 2012;11:142
    • (2012) Cardiovasc Diabetol , vol.11 , pp. 142
    • Li, C.J.1    Li, J.2    Zhang, Q.M.3
  • 23
    • 84905580879 scopus 로고    scopus 로고
    • Liraglutide reverses pronounced insulin-associated weight gain, improves glycaemic control and decreases insulin dose in patients with type 2 diabetes: A 26 week, randomised clinical trial (ELEGANT)
    • de Wit HM, Vervoort GM, Jansen HJ, de Grauw WJ, de Galan BE, Tack CJ. Liraglutide reverses pronounced insulin-associated weight gain, improves glycaemic control and decreases insulin dose in patients with type 2 diabetes: a 26 week, randomised clinical trial (ELEGANT). Diabetologia 2014;57:1812-1819
    • (2014) Diabetologia , vol.57 , pp. 1812-1819
    • De Wit, H.M.1    Vervoort, G.M.2    Jansen, H.J.3    De Grauw, W.J.4    De Galan, B.E.5    Tack, C.J.6
  • 24
    • 84905729436 scopus 로고    scopus 로고
    • The effect of addition of liraglutide to high-dose intensive insulin therapy: A randomized prospective trial
    • LaneW, Weinrib S, Rappaport J, Hale C. The effect of addition of liraglutide to high-dose intensive insulin therapy: a randomized prospective trial. Diabetes Obes Metab 2014;16:827-832
    • (2014) Diabetes Obes Metab , vol.16 , pp. 827-832
    • Lane, E.1    Weinrib, S.2    Rappaport, J.3    Hale, C.4
  • 25
    • 84903121563 scopus 로고    scopus 로고
    • A comparison of adding liraglutide versus a single daily dose of insulin aspart to insulin degludec in subjectswith type 2 diabetes (BEGIN: VICTOZA ADD-ON)
    • Mathieu C, Rodbard HW, Cariou B, et al.; BEGIN: VICTOZA ADD-ON (NN1250-3948) study group. A comparison of adding liraglutide versus a single daily dose of insulin aspart to insulin degludec in subjectswith type 2 diabetes (BEGIN: VICTOZA ADD-ON). Diabetes Obes Metab 2014;16:636-644
    • (2014) Diabetes Obes Metab , vol.16 , pp. 636-644
    • Mathieu, C.1    Rodbard, H.W.2    Cariou, B.3
  • 26
    • 84980385742 scopus 로고    scopus 로고
    • Prandial options to advance basal insulin glargine therapy: Testing lixisenatide plus basal insulin versus insulin glulisine either as basal-plus or basal-bolus in type 2 diabetes: The GetGoal Duo-2 Trial
    • Rosenstock J, Guerci B, Hanefeld M, et al.; GetGoal Duo-2 Trial Investigators. Prandial options to advance basal insulin glargine therapy: testing lixisenatide plus basal insulin versus insulin glulisine either as basal-plus or basal-bolus in type 2 diabetes: the GetGoal Duo-2 Trial. Diabetes Care 2016;39:1318-1328
    • (2016) Diabetes Care , vol.39 , pp. 1318-1328
    • Rosenstock, J.1    Guerci, B.2    Hanefeld, M.3
  • 27
    • 84907345097 scopus 로고    scopus 로고
    • Benefits of exenatide on obesity and non-alcoholic fatty liver disease with elevated liver enzymes in patients with type 2 diabetes
    • Shao N, Kuang HY, Hao M, Gao XY, Lin WJ, Zou W. Benefits of exenatide on obesity and non-alcoholic fatty liver disease with elevated liver enzymes in patients with type 2 diabetes. Diabetes Metab Res Rev 2014;30:521-529
    • (2014) Diabetes Metab Res Rev , vol.30 , pp. 521-529
    • Shao, N.1    Kuang, H.Y.2    Hao, M.3    Gao, X.Y.4    Lin, W.J.5    Zou, W.6
  • 28
    • 84904977278 scopus 로고    scopus 로고
    • Advancing basal insulin replacement in type 2 diabetes inadequately controlled with insulin glargine plus oral agents: A comparison of adding albiglutide a weekly GLP-1 receptor agonist versus thrice-daily prandial insulin lispro
    • Rosenstock J, Fonseca VA, Gross JL, et al.; Harmony 6 Study Group. Advancing basal insulin replacement in type 2 diabetes inadequately controlled with insulin glargine plus oral agents: a comparison of adding albiglutide, a weekly GLP-1 receptor agonist, versus thrice-daily prandial insulin lispro. Diabetes Care 2014;37: 2317-2325
    • (2014) Diabetes Care , vol.37 , pp. 2317-2325
    • Rosenstock, J.1    Fonseca, V.A.2    Gross, J.L.3
  • 29
    • 84908164432 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor agonist or bolus insulin with optimized basal insulin in type 2 diabetes
    • Diamant M, Nauck MA, Shaginian R, et al.; 4B Study Group. Glucagon-like peptide 1 receptor agonist or bolus insulin with optimized basal insulin in type 2 diabetes. Diabetes Care 2014; 37:2763-2773
    • (2014) Diabetes Care , vol.37 , pp. 2763-2773
    • Diamant, M.1    Nauck, M.A.2    Shaginian, R.3
  • 30
    • 84930074468 scopus 로고    scopus 로고
    • Onceweekly dulaglutide versus bedtime insulin glargine, both in combination with prandial insulin lispro, in patients with type 2 diabetes (AWARD-4): A randomised, open-label, phase 3, non-inferiority study
    • Blonde L, Jendle J, Gross J, et al. Onceweekly dulaglutide versus bedtime insulin glargine, both in combination with prandial insulin lispro, in patients with type 2 diabetes (AWARD-4): a randomised, open-label, phase 3, non-inferiority study. Lancet 2015;385:2057-2066
    • (2015) Lancet , vol.385 , pp. 2057-2066
    • Blonde, L.1    Jendle, J.2    Gross, J.3
  • 31
    • 84971350162 scopus 로고    scopus 로고
    • Glucose variability in a 26-week randomized comparison of mealtime treatment with rapid-acting insulin versus GLP-1 agonist in participants with type 2 diabetes at high cardiovascular risk
    • FLAT-SUGAR Trial Investigators. Glucose variability in a 26-week randomized comparison of mealtime treatment with rapid-acting insulin versus GLP-1 agonist in participants with type 2 diabetes at high cardiovascular risk. Diabetes Care 2016;39:973-981
    • (2016) Diabetes Care , vol.39 , pp. 973-981
  • 32
    • 84910049684 scopus 로고    scopus 로고
    • Contribution of liraglutide in the fixed-ratio combination of insulin degludec and liraglutide (IDegLira)
    • Buse JB, Vilsbøll T, Thurman J, et al.; NN9068-3912 (DUAL-II) Trial Investigators. Contribution of liraglutide in the fixed-ratio combination of insulin degludec and liraglutide (IDegLira). Diabetes Care 2014;37:2926-2933
    • (2014) Diabetes Care , vol.37 , pp. 2926-2933
    • Buse, J.B.1    Vilsbøll, T.2    Thurman, J.3
  • 33
    • 84922519772 scopus 로고    scopus 로고
    • Efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with its components given alone: Results of a phase 3 open-label randomised 26-week treat-to-target trial in insulin-naive patients with type 2 diabetes
    • Gough SC, Bode B, Woo V, et al.; NN9068-3697 (DUAL-I) trial investigators. Efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with its components given alone: results of a phase 3, open-label, randomised, 26-week, treat-to-target trial in insulin-naive patients with type 2 diabetes. Lancet Diabetes Endocrinol 2014;2:885-893
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 885-893
    • Gough, S.C.1    Bode, B.2    Woo, V.3
  • 34
    • 84959284398 scopus 로고    scopus 로고
    • Effect of insulin glargine up-titration vs insulin degludec/liraglutide on glycated hemoglobin levels in patients with uncontrolled type 2 diabetes: The DUAL v randomized clinical trial
    • Lingvay I, Pérez Manghi F, García-Hernández P, et al.; DUAL V Investigators. Effect of insulin glargine up-titration vs insulin degludec/liraglutide on glycated hemoglobin levels in patients with uncontrolled type 2 diabetes: the DUAL V randomized clinical trial. JAMA 2016; 315:898-907
    • (2016) JAMA , vol.315 , pp. 898-907
    • Lingvay, I.1    Pérez Manghi, F.2    García-Hernández, P.3
  • 35
    • 84994235673 scopus 로고    scopus 로고
    • Efficacy and safety of LixiLan, a titratable fixed-ratio combination of insulin glargine plus lixisenatide in type 2 diabetes inadequately controlled on basal insulin and metformin: The LixiLan-L randomized trial
    • Aroda VR, Rosenstock J, Wysham C, et al.; LixiLan-L Trial Investigators. LixiLan-L Trial Investigators. Efficacy and safety of LixiLan, a titratable fixed-ratio combination of insulin glargine plus lixisenatide in type 2 diabetes inadequately controlled on basal insulin and metformin: the LixiLan-L randomized trial. Diabetes Care 2016; 39:1972-1980
    • (2016) Diabetes Care , vol.39 , pp. 1972-1980
    • Aroda, V.R.1    Rosenstock, J.2    Wysham, C.3
  • 36
    • 84982820694 scopus 로고    scopus 로고
    • Efficacy and safety of LixiLan a titratable fixed-ratio combination of lixisenatide and insulin glargine versus insulin glargine in type 2 diabetes inadequately controlled on metformin monotherapy: The LixiLan proof-of-concept randomized trial
    • Rosenstock J, Diamant M, Aroda VR, et al.; LixiLan PoC Study Group. Efficacy and safety of LixiLan, a titratable fixed-ratio combination of lixisenatide and insulin glargine, versus insulin glargine in type 2 diabetes inadequately controlled on metformin monotherapy: the LixiLan proof-of-concept randomized trial. Diabetes Care 2016;39:1579-1586
    • (2016) Diabetes Care , vol.39 , pp. 1579-1586
    • Rosenstock, J.1    Diamant, M.2    Aroda, V.R.3
  • 37
    • 84994234273 scopus 로고    scopus 로고
    • Benefits of LixiLan a titratable fixed-ratio combination of insulin glargine plus lixisenatide versus insulin glargine and lixisenatide monocomponents in type 2 diabetes inadequately controlled with oral agents: The LixiLan-O randomized trial
    • Rosenstock J, Aronson R, Grunberger G, et al.; LixiLan-O Trial Investigators. Benefits of LixiLan, a titratable fixed-ratio combination of insulin glargine plus lixisenatide, versus insulin glargine and lixisenatide monocomponents in type 2 diabetes inadequately controlled with oral agents: the LixiLan-O randomized trial. Diabetes Care 2016;39:2026-2035
    • (2016) Diabetes Care , vol.39 , pp. 2026-2035
    • Rosenstock, J.1    Aronson, R.2    Grunberger, G.3
  • 38
    • 84960090337 scopus 로고    scopus 로고
    • Clinical inertia with regard to intensifying therapy in people with type 2 diabetes treated with basal insulin
    • Khunti K, Nikolajsen A, Thorsted BL, Andersen M, Davies MJ, Paul SK. Clinical inertia with regard to intensifying therapy in people with type 2 diabetes treated with basal insulin. Diabetes Obes Metab 2016;18:401-409
    • (2016) Diabetes Obes Metab , vol.18 , pp. 401-409
    • Khunti, K.1    Nikolajsen, A.2    Thorsted, B.L.3    Andersen, M.4    Davies, M.J.5    Paul, S.K.6
  • 39
    • 84955296052 scopus 로고    scopus 로고
    • How much is too much? Outcomes in patients using high-dose insulin glargine
    • Reid T, Gao L, Gill J, et al. How much is too much? Outcomes in patients using high-dose insulin glargine. Int J Clin Pract 2016;70:56-65
    • (2016) Int J Clin Pract , vol.70 , pp. 56-65
    • Reid, T.1    Gao, L.2    Gill, J.3
  • 40
    • 84942374717 scopus 로고    scopus 로고
    • Contrasting effects of lixisenatide and liraglutide on postprandial glycemic control, gastric emptying, and safety parameters in patients with type 2 diabetes on optimized insulin glargine with or without metformin: A randomized, open-label trial
    • Meier JJ, Rosenstock J, Hincelin-Méry A, et al. Contrasting effects of lixisenatide and liraglutide on postprandial glycemic control, gastric emptying, and safety parameters in patients with type 2 diabetes on optimized insulin glargine with or without metformin: a randomized, open-label trial. Diabetes Care 2015;38:1263-1273
    • (2015) Diabetes Care , vol.38 , pp. 1263-1273
    • Meier, J.J.1    Rosenstock, J.2    Hincelin-Méry, A.3
  • 41
    • 84944517749 scopus 로고    scopus 로고
    • Efficacy and safety of once-weekly glucagon-like peptide 1 receptor agonists for the management of type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials
    • Karagiannis T, Liakos A, Bekiari E, et al. Efficacy and safety of once-weekly glucagon-like peptide 1 receptor agonists for the management of type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Diabetes Obes Metab 2015;17:1065-1074
    • (2015) Diabetes Obes Metab , vol.17 , pp. 1065-1074
    • Karagiannis, T.1    Liakos, A.2    Bekiari, E.3
  • 42
    • 84857029848 scopus 로고    scopus 로고
    • Proportion of patients at HbA1c target, 7% with eight classes of antidiabetic drugs in type 2 diabetes: Systematic review of 218 randomized controlled trials with 78 945 patients
    • Esposito K, Chiodini P, Bellastella G, Maiorino MI, Giugliano D. Proportion of patients at HbA1c target, 7% with eight classes of antidiabetic drugs in type 2 diabetes: systematic review of 218 randomized controlled trials with 78 945 patients. Diabetes Obes Metab 2012;14:228-233
    • (2012) Diabetes Obes Metab , vol.14 , pp. 228-233
    • Esposito, K.1    Chiodini, P.2    Bellastella, G.3    Maiorino, M.I.4    Giugliano, D.5
  • 43
    • 84986229303 scopus 로고    scopus 로고
    • Once-daily liraglutide versus lixisenatide as add-on to metformin in type 2 diabetes: A 26-week randomized controlled clinical trial
    • Nauck M, Rizzo M, Johnson A, Bosch-Traberg H, Madsen J, Cariou B. Once-daily liraglutide versus lixisenatide as add-on to metformin in type 2 diabetes: a 26-week randomized controlled clinical trial. Diabetes Care 2016; 39:1501-1509
    • (2016) Diabetes Care , vol.39 , pp. 1501-1509
    • Nauck, M.1    Rizzo, M.2    Johnson, A.3    Bosch-Traberg, H.4    Madsen, J.5    Cariou, B.6
  • 44
    • 84995543386 scopus 로고    scopus 로고
    • Safety and efficacy of insulin degludec/liraglutide (IDegLira) added to sulphonylurea alone or to sulphonylurea and metformin in insulin-naïve people with type 2 diabetes: The DUAL IV trial
    • Rodbard HW, Bode BW, Harris SB, et al.; Dual Action of Liraglutide and insulin degludec (DUAL) IV trial investigators. Safety and efficacy of insulin degludec/liraglutide (IDegLira) added to sulphonylurea alone or to sulphonylurea and metformin in insulin-naïve people with type 2 diabetes: the DUAL IV trial. Diabet Med 2017; 34:189-196
    • (2017) Diabet Med , vol.34 , pp. 189-196
    • Rodbard, H.W.1    Bode, B.W.2    Harris, S.B.3
  • 45
    • 0038726233 scopus 로고    scopus 로고
    • Adjusting for publication bias in the presence of heterogeneity
    • Terrin N, Schmid CH, Lau J, Olkin I. Adjusting for publication bias in the presence of heterogeneity. Stat Med 2003;22:2113-2126
    • (2003) Stat Med , vol.22 , pp. 2113-2126
    • Terrin, N.1    Schmid, C.H.2    Lau, J.3    Olkin, I.4
  • 46
    • 84978976076 scopus 로고    scopus 로고
    • Comparison of clinical outcomes and adverse events associated with glucose-lowering drugs in patients with type 2 diabetes: A meta-analysis
    • Palmer SC, Mavridis D, Nicolucci A, et al. Comparison of clinical outcomes and adverse events associated with glucose-lowering drugs in patients with type 2 diabetes: a meta-analysis. JAMA 2016;316:313-324
    • (2016) JAMA , vol.316 , pp. 313-324
    • Palmer, S.C.1    Mavridis, D.2    Nicolucci, A.3


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