-
1
-
-
33846006173
-
The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
-
Drucker DJ, Nauck MA. The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006;368:1696-1705
-
(2006)
Lancet
, vol.368
, pp. 1696-1705
-
-
Drucker, D.J.1
Nauck, M.A.2
-
2
-
-
84919999219
-
Management of hyperglycemia in type 2 diabetes, 2015: A patient-centered approach: Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes
-
Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes, 2015: A patient-centered approach: Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2015; 38:140-149
-
(2015)
Diabetes Care
, vol.38
, pp. 140-149
-
-
Inzucchi, S.E.1
Bergenstal, R.M.2
Buse, J.B.3
-
3
-
-
84871238486
-
GLP-1 agonists for type 2 diabetes: Pharmacokinetic and toxicological considerations
-
Jespersen MJ, Knop FK, ChristensenM. GLP-1 agonists for type 2 diabetes: Pharmacokinetic and toxicological considerations. Expert Opin Drug Metab Toxicol 2013;9:17-29
-
(2013)
Expert Opin Drug Metab Toxicol
, vol.9
, pp. 17-29
-
-
Jespersen, M.J.1
Knop, F.K.2
Christensen, M.3
-
4
-
-
78650753885
-
Incretin-based therapies for type 2 diabetes mellitus: Properties, functions, and clinical implications
-
Nauck MA. Incretin-based therapies for type 2 diabetes mellitus: Properties, functions, and clinical implications. Am J Med 2011;124 (Suppl.):S3-S18
-
(2011)
Am J Med
, vol.124
, pp. S3-S18
-
-
Nauck, M.A.1
-
5
-
-
84929947880
-
GLP-1 receptor agonists: Nonglycemic clinical effects in weight loss and beyond
-
Ryan D, Acosta A. GLP-1 receptor agonists: Nonglycemic clinical effects in weight loss and beyond. Obesity (Silver Spring) 2015;23:1119-1129
-
(2015)
Obesity (Silver Spring)
, vol.23
, pp. 1119-1129
-
-
Ryan, D.1
Acosta, A.2
-
6
-
-
84870054636
-
GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus
-
Meier JJ. GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus. Nat Rev Endocrinol 2012;8:728-742
-
(2012)
Nat Rev Endocrinol
, vol.8
, pp. 728-742
-
-
Meier, J.J.1
-
7
-
-
77952118055
-
-
Accessed 5 November 2015
-
Annex I: Summary of product characteristics [Internet], 2014. Available from http://www .ema.europa.eu/docs/en-GB/document-library/ EPAR-Product-Information/human/002445/ WC500140401.pdf. Accessed 5 November 2015
-
(2014)
Summary of Product Characteristics
-
-
Annex, I.1
-
8
-
-
0034108646
-
Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration
-
Knudsen LB, Nielsen PF, Huusfeldt PO, et al. Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration. J Med Chem 2000; 43:1664-1669
-
(2000)
J Med Chem
, vol.43
, pp. 1664-1669
-
-
Knudsen, L.B.1
Nielsen, P.F.2
Huusfeldt, P.O.3
-
9
-
-
84986209851
-
-
Liraglutide (NN2211), Bagsværd, Denmark, Novo Nordisk A/S
-
Liraglutide (NN2211). Abbreviated Investigator's Brochure. Edition 16. Bagsværd, Denmark, Novo Nordisk A/S, 2014
-
(2014)
Abbreviated Investigator's Brochure. Edition 16
-
-
-
10
-
-
67649666737
-
Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, openlabel trial (LEAD-6)
-
LEAD-6 Study Group
-
Buse JB, Rosenstock J, Sesti G, et al.; LEAD-6 Study Group. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, openlabel trial (LEAD-6). Lancet 2009;374:39-47
-
(2009)
Lancet
, vol.374
, pp. 39-47
-
-
Buse, J.B.1
Rosenstock, J.2
Sesti, G.3
-
11
-
-
84866650686
-
Efficacy and safety of switching from the DPP-4 inhibitor sitagliptin to the human GLP-1 analog liraglutide after 52 weeks in metformin-treated patients with type 2 diabetes: A randomized, open-label trial
-
1860- LIRA-DPP-4 Study Group
-
Pratley RE, NauckMA, Bailey T, et al.; 1860- LIRA-DPP-4 Study Group. Efficacy and safety of switching from the DPP-4 inhibitor sitagliptin to the human GLP-1 analog liraglutide after 52 weeks in metformin-treated patients with type 2 diabetes: A randomized, open-label trial. Diabetes Care 2012;35:1986-1993
-
(2012)
Diabetes Care
, vol.35
, pp. 1986-1993
-
-
Pratley, R.E.1
Nauckma Bailey, T.2
-
12
-
-
59449101432
-
Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): A randomised 52-week phase III double- blind parallel-treatment trial
-
LEAD-3 (Mono) Study Group
-
Garber A, Henry R, Ratner R, et al.; LEAD-3 (Mono) Study Group. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): A randomised, 52-week, phase III, double- blind, parallel-treatment trial. Lancet 2009; 373:473-481
-
(2009)
Lancet
, vol.373
, pp. 473-481
-
-
Garber, A.1
Henry, R.2
Ratner, R.3
-
13
-
-
79951906623
-
Liraglutide, a once-daily human glucagon-like peptide 1 analogue, provides sustained improvements in glycaemic control and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetes
-
LEAD-3 (Mono) Study Group.
-
Garber A, Henry RR, Ratner R, Hale P, Chang CT, Bode B; LEAD-3 (Mono) Study Group. Liraglutide, a once-daily human glucagon-like peptide 1 analogue, provides sustained improvements in glycaemic control and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetes. Diabetes Obes Metab 2011;13:348-356
-
(2011)
Diabetes Obes Metab
, vol.13
, pp. 348-356
-
-
Garber, A.1
Henry, R.R.2
Ratner, R.3
Hale, P.4
Chang, C.T.5
Bode, B.6
-
14
-
-
62449129181
-
Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU)
-
LEAD-1 SU study group
-
Marre M, Shaw J, Brändle M, et al.; LEAD-1 SU study group. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU). Diabet Med 2009;26:268-278
-
(2009)
Diabet Med
, vol.26
, pp. 268-278
-
-
Marre, M.1
Shaw, J.2
Brändle, M.3
-
15
-
-
62449169287
-
Efficacy and safety comparison of liraglutide glimepiride and placebo all in combination with metformin in type 2 diabetes: The LEAD (Liraglutide Effect and Action in Diabetes)-2 study
-
LEAD-2 Study Group
-
NauckM, Frid A, Hermansen K, et al.; LEAD-2 Study Group. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: The LEAD (Liraglutide Effect and Action in Diabetes)-2 study. Diabetes Care 2009;32:84-90
-
(2009)
Diabetes Care
, vol.32
, pp. 84-90
-
-
Nauckm Frid, A.1
Hermansen, K.2
-
16
-
-
84873085581
-
Longterm efficacy and safety comparison of liraglutide, glimepiride and placebo, all in combination with metformin in type 2 diabetes: 2-year results from the LEAD-2 study
-
Nauck M, Frid A, Hermansen K, et al. Longterm efficacy and safety comparison of liraglutide, glimepiride and placebo, all in combination with metformin in type 2 diabetes: 2-year results from the LEAD-2 study. Diabetes Obes Metab 2013;15:204-212
-
(2013)
Diabetes Obes Metab
, vol.15
, pp. 204-212
-
-
Nauck, M.1
Frid, A.2
Hermansen, K.3
-
17
-
-
77952309372
-
Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: A 26-week, randomised, parallel-group, open-label trial
-
1860- LIRA-DPP-4 Study Group
-
Pratley RE, Nauck M, Bailey T, et al.; 1860- LIRA-DPP-4 Study Group. Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: A 26-week, randomised, parallel-group, open-label trial. Lancet 2010;375:1447-1456
-
(2010)
Lancet
, vol.375
, pp. 1447-1456
-
-
Pratley, R.E.1
Nauck, M.2
Bailey, T.3
-
18
-
-
79952755181
-
One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: A randomised, parallel-group, openlabel trial
-
1860- LIRA-DPP-4 Study Group
-
Pratley R, Nauck M, Bailey T, et al.; 1860- LIRA-DPP-4 Study Group. One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: A randomised, parallel-group, openlabel trial. Int J Clin Pract 2011;65:397-407
-
(2011)
Int J Clin Pract
, vol.65
, pp. 397-407
-
-
Pratley, R.1
Nauck, M.2
Bailey, T.3
-
19
-
-
69949117621
-
Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): A randomised controlled trial
-
Liraglutide Effect and Action in Diabetes 5 (LEAD-5) met+SU Study Group
-
Russell-Jones D, Vaag A, Schmitz O, et al.; Liraglutide Effect and Action in Diabetes 5 (LEAD-5) met+SU Study Group. Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): A randomised controlled trial. Diabetologia 2009;52:2046-2055
-
(2009)
Diabetologia
, vol.52
, pp. 2046-2055
-
-
Russell-Jones, D.1
Vaag, A.2
Schmitz, O.3
-
20
-
-
67650066860
-
Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
-
LEAD-4 Study Investigators
-
Zinman B, Gerich J, Buse JB, et al.; LEAD-4 Study Investigators. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care 2009;32: 1224-1230
-
(2009)
Diabetes Care
, vol.32
, pp. 1224-1230
-
-
Zinman, B.1
Gerich, J.2
Buse, J.B.3
-
21
-
-
77955847376
-
Pharmacological profile of lixisenatide: A new GLP-1 receptor agonist for the treatment of type 2 diabetes
-
Werner U, Haschke G, Herling AW, Kramer W. Pharmacological profile of lixisenatide: A new GLP-1 receptor agonist for the treatment of type 2 diabetes. Regul Pept 2010;164:58-64
-
(2010)
Regul Pept
, vol.164
, pp. 58-64
-
-
Werner, U.1
Haschke, G.2
Herling, A.W.3
Kramer, W.4
-
22
-
-
84908334613
-
Lixisenatide plus basal insulin in patients with type 2 diabetes mellitus: A meta-analysis
-
Charbonnel B, Bertolini M, Tinahones FJ, Domingo MP, Davies M. Lixisenatide plus basal insulin in patients with type 2 diabetes mellitus: A meta-analysis. J Diabetes Complications 2014; 28:880-886
-
(2014)
J Diabetes Complications
, vol.28
, pp. 880-886
-
-
Charbonnel, B.1
Bertolini, M.2
Tinahones, F.J.3
Domingo, M.P.4
Davies, M.5
-
23
-
-
84907429773
-
Lixisenatide as add-on to oral anti-diabetic therapy: An effective treatment for glycaemic control with body weight benefits in type 2 diabetes
-
Raccah D, Gourdy P, Sagnard L, Ceriello A. Lixisenatide as add-on to oral anti-diabetic therapy: An effective treatment for glycaemic control with body weight benefits in type 2 diabetes. Diabetes Metab Res Rev 2014;30: 742-748
-
(2014)
Diabetes Metab Res Rev
, vol.30
, pp. 742-748
-
-
Raccah, D.1
Gourdy, P.2
Sagnard, L.3
Ceriello, A.4
-
24
-
-
83255160668
-
ICH harmonised tripartite guideline
-
International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. Accessed 5 November 2015
-
International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. ICH harmonised tripartite guideline. Guideline for good clinical practice E6(R1) [Internet], 1996. Available from http://www.ich.org/ fileadmin/Public-Web-Site/ICH-Products/ Guidelines/Efficacy/E6/E6-R1-Guideline.pdf. Accessed 5 November 2015
-
(1996)
Guideline for Good Clinical Practice E6(R1)
-
-
-
26
-
-
18144388647
-
Defining and reporting hypoglycemia in diabetes: A report from the American Diabetes Association Workgroup on Hypoglycemia
-
Workgroup on Hypoglycemia, American Diabetes Association
-
Workgroup on Hypoglycemia, American Diabetes Association. Defining and reporting hypoglycemia in diabetes: A report from the American Diabetes Association Workgroup on Hypoglycemia. Diabetes Care 2005;28:1245-1249
-
(2005)
Diabetes Care
, vol.28
, pp. 1245-1249
-
-
-
27
-
-
79956328908
-
Liraglutide treatment is associated with a low frequency and magnitude of antibody formation with no apparent impact on glycemic response or increased frequency of adverse events: Results from the Liraglutide Effect and Action in Diabetes (LEAD) trials
-
Buse JB, Garber A, Rosenstock J, et al. Liraglutide treatment is associated with a low frequency and magnitude of antibody formation with no apparent impact on glycemic response or increased frequency of adverse events: Results from the Liraglutide Effect and Action in Diabetes (LEAD) trials. J Clin Endocrinol Metab 2011;96:1695-1702
-
(2011)
J Clin Endocrinol Metab
, vol.96
, pp. 1695-1702
-
-
Buse, J.B.1
Garber, A.2
Rosenstock, J.3
-
28
-
-
84878863716
-
Pharmacodynamic characteristics of lixisenatide once daily versus liraglutide once daily in patients with type 2 diabetes insufficiently controlled on metformin
-
Kapitza C, Forst T, Coester HV, Poitiers F, Ruus P, Hincelin-Méry A. Pharmacodynamic characteristics of lixisenatide once daily versus liraglutide once daily in patients with type 2 diabetes insufficiently controlled on metformin. Diabetes Obes Metab 2013;15:642-649
-
(2013)
Diabetes Obes Metab
, vol.15
, pp. 642-649
-
-
Kapitza, C.1
Forst, T.2
Coester, H.V.3
Poitiers, F.4
Ruus, P.5
Hincelin-Méry, A.6
-
29
-
-
84942374717
-
Contrasting effects of lixisenatide and liraglutide on postprandial glycemic control, gastric emptying, and safety parameters in patients with type 2 diabetes on optimized insulin glargine with or without metformin: A randomized, open-label trial
-
Meier JJ, Rosenstock J, Hincelin-Méry A, et al. Contrasting effects of lixisenatide and liraglutide on postprandial glycemic control, gastric emptying, and safety parameters in patients with type 2 diabetes on optimized insulin glargine with or without metformin: A randomized, open-label trial. Diabetes Care 2015;38: 1263-1273
-
(2015)
Diabetes Care
, vol.38
, pp. 1263-1273
-
-
Meier, J.J.1
Rosenstock, J.2
Hincelin-Méry, A.3
-
30
-
-
84872084453
-
Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): A randomised, open-label study
-
Buse JB, Nauck M, Forst T, et al. Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): A randomised, open-label study. Lancet 2013; 381:117-124
-
(2013)
Lancet
, vol.381
, pp. 117-124
-
-
Buse, J.B.1
Nauck, M.2
Forst, T.3
-
31
-
-
84908177336
-
Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): A randomised, open-label, phase 3, non-inferiority trial
-
Dungan KM, Povedano ST, Forst T, et al. Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): A randomised, open-label, phase 3, non-inferiority trial. Lancet 2014;384:1349-1357
-
(2014)
Lancet
, vol.384
, pp. 1349-1357
-
-
Dungan, K.M.1
Povedano, S.T.2
Forst, T.3
-
32
-
-
84899585635
-
Once-weekly albiglutide versus once-daily liraglutide in patients with type 2 diabetes inadequately controlled on oral drugs (HARMONY 7): A randomised open-label multicentre non-inferiority phase 3 study
-
HARMONY 7 study group
-
Pratley RE, Nauck MA, Barnett AH, et al.; HARMONY 7 study group. Once-weekly albiglutide versus once-daily liraglutide in patients with type 2 diabetes inadequately controlled on oral drugs (HARMONY 7): A randomised, open-label, multicentre, non-inferiority phase 3 study. Lancet Diabetes Endocrinol 2014;2: 289-297
-
(2014)
Lancet Diabetes Endocrinol
, vol.2
, pp. 289-297
-
-
Pratley, R.E.1
Nauck, M.A.2
Barnett, A.H.3
-
33
-
-
84899498561
-
Reductions in systolic blood pressure with liraglutide in patients with type 2 diabetes: Insights from a patient-level pooled analysis of six randomized clinical trials
-
Fonseca VA, Devries JH, Henry RR, Donsmark M, Thomsen HF, Plutzky J. Reductions in systolic blood pressure with liraglutide in patients with type 2 diabetes: Insights from a patient-level pooled analysis of six randomized clinical trials. J Diabetes Complications 2014;28: 399-405
-
(2014)
J Diabetes Complications
, vol.28
, pp. 399-405
-
-
Fonseca, V.A.1
Devries, J.H.2
Henry, R.R.3
Donsmark, M.4
Thomsen, H.F.5
Plutzky, J.6
-
34
-
-
84929289581
-
Rationale design and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome a long-term cardiovascular end point trial of lixisenatide versus placebo
-
ELIXA Investigators
-
Bentley-Lewis R, Aguilar D, Riddle MC, et al.; ELIXA Investigators. Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo. Am Heart J 2015;169: 631-638.e7
-
(2015)
Am Heart J
, vol.169
, pp. 631-631e7
-
-
Bentley-Lewis, R.1
Aguilar, D.2
Riddle, M.C.3
-
35
-
-
84948740668
-
Lixisenatide in patients with type 2 diabetes and acute coronary syndrome
-
ELIXA Investigators
-
Pfeffer MA, Claggett B, Diaz R, et al.; ELIXA Investigators. Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. N Engl J Med 2015;373:2247-2257
-
(2015)
N Engl J Med
, vol.373
, pp. 2247-2257
-
-
Pfeffer, M.A.1
Claggett, B.2
Diaz, R.3
-
36
-
-
84886946727
-
Design of the Liraglutide Effect and Action in Diabetes: Evaluation of cardiovascular outcome Results (LEADER) trial
-
Marso SP, Poulter NR, Nissen SE, et al. Design of the Liraglutide Effect and Action in Diabetes: Evaluation of cardiovascular outcome Results (LEADER) trial. Am Heart J 2013;166: 823-30.e5
-
(2013)
Am Heart J
, vol.166
, pp. 823-823e5
-
-
Marso, S.P.1
Poulter, N.R.2
Nissen, S.E.3
-
37
-
-
84916630493
-
LEADER 3-lipase and amylase activity in subjects with type 2 diabetes: Baseline data from over 9000 subjects in the LEADER Trial
-
LEADER Trial investigators
-
Steinberg WM, Nauck MA, Zinman B, et al.; LEADER Trial investigators. LEADER 3-lipase and amylase activity in subjects with type 2 diabetes: Baseline data from over 9000 subjects in the LEADER Trial. Pancreas 2014;43: 1223-1231
-
(2014)
Pancreas
, vol.43
, pp. 1223-1231
-
-
Steinberg, W.M.1
Nauck, M.A.2
Zinman, B.3
-
38
-
-
84926195839
-
LEADER 2: Baseline calcitonin in 9340 people with type 2 diabetes enrolled in the Liraglutide Effect and Action in Diabetes: Evaluation of cardiovascular outcome Results (LEADER) trial: Preliminary observations
-
LEADER Trial Investigators
-
Daniels GH, Hegedüs L, Marso SP, et al.; LEADER Trial Investigators. LEADER 2: Baseline calcitonin in 9340 people with type 2 diabetes enrolled in the Liraglutide Effect and Action in Diabetes: Evaluation of cardiovascular outcome Results (LEADER) trial: Preliminary observations. Diabetes Obes Metab 2015;17: 477-486
-
(2015)
Diabetes Obes Metab
, vol.17
, pp. 477-486
-
-
Daniels, G.H.1
Hegedüs, L.2
Marso, S.P.3
-
39
-
-
84864674632
-
Elevated amylase and lipase levels in patients using glucagonlike peptide-1 receptor agonists or dipeptidylpeptidase- 4 inhibitors in the outpatient setting
-
Lando HM, Alattar M, Dua AP. Elevated amylase and lipase levels in patients using glucagonlike peptide-1 receptor agonists or dipeptidylpeptidase- 4 inhibitors in the outpatient setting. Endocr Pract 2012;18:472-477
-
(2012)
Endocr Pract
, vol.18
, pp. 472-477
-
-
Lando, H.M.1
Alattar, M.2
Dua, A.P.3
-
40
-
-
84878493249
-
A low-grade increase of serum pancreatic exocrine enzyme levels by dipeptidyl peptidase-4 inhibitor in patients with type 2 diabetes
-
Tokuyama H, Kawamura H, Fujimoto M, et al. A low-grade increase of serum pancreatic exocrine enzyme levels by dipeptidyl peptidase-4 inhibitor in patients with type 2 diabetes. Diabetes Res Clin Pract 2013;100:e66-e69
-
(2013)
Diabetes Res Clin Pract
, vol.100
, pp. e66-e69
-
-
Tokuyama, H.1
Kawamura, H.2
Fujimoto, M.3
|