메뉴 건너뛰기




Volumn 39, Issue 9, 2016, Pages 1501-1509

Once-daily liraglutide versus lixisenatide as Add-on to Metformin in type 2 diabetes: A 26-week randomized controlled clinical trial

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN A1C; LIRAGLUTIDE; LIXISENATIDE; METFORMIN; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; PEPTIDE;

EID: 84986229303     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc15-2479     Document Type: Article
Times cited : (89)

References (40)
  • 1
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker DJ, Nauck MA. The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006;368:1696-1705
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 2
    • 84919999219 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes, 2015: A patient-centered approach: Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes, 2015: A patient-centered approach: Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2015; 38:140-149
    • (2015) Diabetes Care , vol.38 , pp. 140-149
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 3
    • 84871238486 scopus 로고    scopus 로고
    • GLP-1 agonists for type 2 diabetes: Pharmacokinetic and toxicological considerations
    • Jespersen MJ, Knop FK, ChristensenM. GLP-1 agonists for type 2 diabetes: Pharmacokinetic and toxicological considerations. Expert Opin Drug Metab Toxicol 2013;9:17-29
    • (2013) Expert Opin Drug Metab Toxicol , vol.9 , pp. 17-29
    • Jespersen, M.J.1    Knop, F.K.2    Christensen, M.3
  • 4
    • 78650753885 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus: Properties, functions, and clinical implications
    • Nauck MA. Incretin-based therapies for type 2 diabetes mellitus: Properties, functions, and clinical implications. Am J Med 2011;124 (Suppl.):S3-S18
    • (2011) Am J Med , vol.124 , pp. S3-S18
    • Nauck, M.A.1
  • 5
    • 84929947880 scopus 로고    scopus 로고
    • GLP-1 receptor agonists: Nonglycemic clinical effects in weight loss and beyond
    • Ryan D, Acosta A. GLP-1 receptor agonists: Nonglycemic clinical effects in weight loss and beyond. Obesity (Silver Spring) 2015;23:1119-1129
    • (2015) Obesity (Silver Spring) , vol.23 , pp. 1119-1129
    • Ryan, D.1    Acosta, A.2
  • 6
    • 84870054636 scopus 로고    scopus 로고
    • GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus
    • Meier JJ. GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus. Nat Rev Endocrinol 2012;8:728-742
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 728-742
    • Meier, J.J.1
  • 7
    • 77952118055 scopus 로고    scopus 로고
    • Accessed 5 November 2015
    • Annex I: Summary of product characteristics [Internet], 2014. Available from http://www .ema.europa.eu/docs/en-GB/document-library/ EPAR-Product-Information/human/002445/ WC500140401.pdf. Accessed 5 November 2015
    • (2014) Summary of Product Characteristics
    • Annex, I.1
  • 8
    • 0034108646 scopus 로고    scopus 로고
    • Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration
    • Knudsen LB, Nielsen PF, Huusfeldt PO, et al. Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration. J Med Chem 2000; 43:1664-1669
    • (2000) J Med Chem , vol.43 , pp. 1664-1669
    • Knudsen, L.B.1    Nielsen, P.F.2    Huusfeldt, P.O.3
  • 9
    • 84986209851 scopus 로고    scopus 로고
    • Liraglutide (NN2211), Bagsværd, Denmark, Novo Nordisk A/S
    • Liraglutide (NN2211). Abbreviated Investigator's Brochure. Edition 16. Bagsværd, Denmark, Novo Nordisk A/S, 2014
    • (2014) Abbreviated Investigator's Brochure. Edition 16
  • 10
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, openlabel trial (LEAD-6)
    • LEAD-6 Study Group
    • Buse JB, Rosenstock J, Sesti G, et al.; LEAD-6 Study Group. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, openlabel trial (LEAD-6). Lancet 2009;374:39-47
    • (2009) Lancet , vol.374 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3
  • 11
    • 84866650686 scopus 로고    scopus 로고
    • Efficacy and safety of switching from the DPP-4 inhibitor sitagliptin to the human GLP-1 analog liraglutide after 52 weeks in metformin-treated patients with type 2 diabetes: A randomized, open-label trial
    • 1860- LIRA-DPP-4 Study Group
    • Pratley RE, NauckMA, Bailey T, et al.; 1860- LIRA-DPP-4 Study Group. Efficacy and safety of switching from the DPP-4 inhibitor sitagliptin to the human GLP-1 analog liraglutide after 52 weeks in metformin-treated patients with type 2 diabetes: A randomized, open-label trial. Diabetes Care 2012;35:1986-1993
    • (2012) Diabetes Care , vol.35 , pp. 1986-1993
    • Pratley, R.E.1    Nauckma Bailey, T.2
  • 12
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): A randomised 52-week phase III double- blind parallel-treatment trial
    • LEAD-3 (Mono) Study Group
    • Garber A, Henry R, Ratner R, et al.; LEAD-3 (Mono) Study Group. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): A randomised, 52-week, phase III, double- blind, parallel-treatment trial. Lancet 2009; 373:473-481
    • (2009) Lancet , vol.373 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3
  • 13
    • 79951906623 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human glucagon-like peptide 1 analogue, provides sustained improvements in glycaemic control and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetes
    • LEAD-3 (Mono) Study Group.
    • Garber A, Henry RR, Ratner R, Hale P, Chang CT, Bode B; LEAD-3 (Mono) Study Group. Liraglutide, a once-daily human glucagon-like peptide 1 analogue, provides sustained improvements in glycaemic control and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetes. Diabetes Obes Metab 2011;13:348-356
    • (2011) Diabetes Obes Metab , vol.13 , pp. 348-356
    • Garber, A.1    Henry, R.R.2    Ratner, R.3    Hale, P.4    Chang, C.T.5    Bode, B.6
  • 14
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU)
    • LEAD-1 SU study group
    • Marre M, Shaw J, Brändle M, et al.; LEAD-1 SU study group. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU). Diabet Med 2009;26:268-278
    • (2009) Diabet Med , vol.26 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brändle, M.3
  • 15
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide glimepiride and placebo all in combination with metformin in type 2 diabetes: The LEAD (Liraglutide Effect and Action in Diabetes)-2 study
    • LEAD-2 Study Group
    • NauckM, Frid A, Hermansen K, et al.; LEAD-2 Study Group. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: The LEAD (Liraglutide Effect and Action in Diabetes)-2 study. Diabetes Care 2009;32:84-90
    • (2009) Diabetes Care , vol.32 , pp. 84-90
    • Nauckm Frid, A.1    Hermansen, K.2
  • 16
    • 84873085581 scopus 로고    scopus 로고
    • Longterm efficacy and safety comparison of liraglutide, glimepiride and placebo, all in combination with metformin in type 2 diabetes: 2-year results from the LEAD-2 study
    • Nauck M, Frid A, Hermansen K, et al. Longterm efficacy and safety comparison of liraglutide, glimepiride and placebo, all in combination with metformin in type 2 diabetes: 2-year results from the LEAD-2 study. Diabetes Obes Metab 2013;15:204-212
    • (2013) Diabetes Obes Metab , vol.15 , pp. 204-212
    • Nauck, M.1    Frid, A.2    Hermansen, K.3
  • 17
    • 77952309372 scopus 로고    scopus 로고
    • Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: A 26-week, randomised, parallel-group, open-label trial
    • 1860- LIRA-DPP-4 Study Group
    • Pratley RE, Nauck M, Bailey T, et al.; 1860- LIRA-DPP-4 Study Group. Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: A 26-week, randomised, parallel-group, open-label trial. Lancet 2010;375:1447-1456
    • (2010) Lancet , vol.375 , pp. 1447-1456
    • Pratley, R.E.1    Nauck, M.2    Bailey, T.3
  • 18
    • 79952755181 scopus 로고    scopus 로고
    • One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: A randomised, parallel-group, openlabel trial
    • 1860- LIRA-DPP-4 Study Group
    • Pratley R, Nauck M, Bailey T, et al.; 1860- LIRA-DPP-4 Study Group. One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: A randomised, parallel-group, openlabel trial. Int J Clin Pract 2011;65:397-407
    • (2011) Int J Clin Pract , vol.65 , pp. 397-407
    • Pratley, R.1    Nauck, M.2    Bailey, T.3
  • 19
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): A randomised controlled trial
    • Liraglutide Effect and Action in Diabetes 5 (LEAD-5) met+SU Study Group
    • Russell-Jones D, Vaag A, Schmitz O, et al.; Liraglutide Effect and Action in Diabetes 5 (LEAD-5) met+SU Study Group. Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): A randomised controlled trial. Diabetologia 2009;52:2046-2055
    • (2009) Diabetologia , vol.52 , pp. 2046-2055
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3
  • 20
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
    • LEAD-4 Study Investigators
    • Zinman B, Gerich J, Buse JB, et al.; LEAD-4 Study Investigators. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care 2009;32: 1224-1230
    • (2009) Diabetes Care , vol.32 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.B.3
  • 21
    • 77955847376 scopus 로고    scopus 로고
    • Pharmacological profile of lixisenatide: A new GLP-1 receptor agonist for the treatment of type 2 diabetes
    • Werner U, Haschke G, Herling AW, Kramer W. Pharmacological profile of lixisenatide: A new GLP-1 receptor agonist for the treatment of type 2 diabetes. Regul Pept 2010;164:58-64
    • (2010) Regul Pept , vol.164 , pp. 58-64
    • Werner, U.1    Haschke, G.2    Herling, A.W.3    Kramer, W.4
  • 23
    • 84907429773 scopus 로고    scopus 로고
    • Lixisenatide as add-on to oral anti-diabetic therapy: An effective treatment for glycaemic control with body weight benefits in type 2 diabetes
    • Raccah D, Gourdy P, Sagnard L, Ceriello A. Lixisenatide as add-on to oral anti-diabetic therapy: An effective treatment for glycaemic control with body weight benefits in type 2 diabetes. Diabetes Metab Res Rev 2014;30: 742-748
    • (2014) Diabetes Metab Res Rev , vol.30 , pp. 742-748
    • Raccah, D.1    Gourdy, P.2    Sagnard, L.3    Ceriello, A.4
  • 24
    • 83255160668 scopus 로고    scopus 로고
    • ICH harmonised tripartite guideline
    • International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. Accessed 5 November 2015
    • International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. ICH harmonised tripartite guideline. Guideline for good clinical practice E6(R1) [Internet], 1996. Available from http://www.ich.org/ fileadmin/Public-Web-Site/ICH-Products/ Guidelines/Efficacy/E6/E6-R1-Guideline.pdf. Accessed 5 November 2015
    • (1996) Guideline for Good Clinical Practice E6(R1)
  • 26
    • 18144388647 scopus 로고    scopus 로고
    • Defining and reporting hypoglycemia in diabetes: A report from the American Diabetes Association Workgroup on Hypoglycemia
    • Workgroup on Hypoglycemia, American Diabetes Association
    • Workgroup on Hypoglycemia, American Diabetes Association. Defining and reporting hypoglycemia in diabetes: A report from the American Diabetes Association Workgroup on Hypoglycemia. Diabetes Care 2005;28:1245-1249
    • (2005) Diabetes Care , vol.28 , pp. 1245-1249
  • 27
    • 79956328908 scopus 로고    scopus 로고
    • Liraglutide treatment is associated with a low frequency and magnitude of antibody formation with no apparent impact on glycemic response or increased frequency of adverse events: Results from the Liraglutide Effect and Action in Diabetes (LEAD) trials
    • Buse JB, Garber A, Rosenstock J, et al. Liraglutide treatment is associated with a low frequency and magnitude of antibody formation with no apparent impact on glycemic response or increased frequency of adverse events: Results from the Liraglutide Effect and Action in Diabetes (LEAD) trials. J Clin Endocrinol Metab 2011;96:1695-1702
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 1695-1702
    • Buse, J.B.1    Garber, A.2    Rosenstock, J.3
  • 28
    • 84878863716 scopus 로고    scopus 로고
    • Pharmacodynamic characteristics of lixisenatide once daily versus liraglutide once daily in patients with type 2 diabetes insufficiently controlled on metformin
    • Kapitza C, Forst T, Coester HV, Poitiers F, Ruus P, Hincelin-Méry A. Pharmacodynamic characteristics of lixisenatide once daily versus liraglutide once daily in patients with type 2 diabetes insufficiently controlled on metformin. Diabetes Obes Metab 2013;15:642-649
    • (2013) Diabetes Obes Metab , vol.15 , pp. 642-649
    • Kapitza, C.1    Forst, T.2    Coester, H.V.3    Poitiers, F.4    Ruus, P.5    Hincelin-Méry, A.6
  • 29
    • 84942374717 scopus 로고    scopus 로고
    • Contrasting effects of lixisenatide and liraglutide on postprandial glycemic control, gastric emptying, and safety parameters in patients with type 2 diabetes on optimized insulin glargine with or without metformin: A randomized, open-label trial
    • Meier JJ, Rosenstock J, Hincelin-Méry A, et al. Contrasting effects of lixisenatide and liraglutide on postprandial glycemic control, gastric emptying, and safety parameters in patients with type 2 diabetes on optimized insulin glargine with or without metformin: A randomized, open-label trial. Diabetes Care 2015;38: 1263-1273
    • (2015) Diabetes Care , vol.38 , pp. 1263-1273
    • Meier, J.J.1    Rosenstock, J.2    Hincelin-Méry, A.3
  • 30
    • 84872084453 scopus 로고    scopus 로고
    • Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): A randomised, open-label study
    • Buse JB, Nauck M, Forst T, et al. Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): A randomised, open-label study. Lancet 2013; 381:117-124
    • (2013) Lancet , vol.381 , pp. 117-124
    • Buse, J.B.1    Nauck, M.2    Forst, T.3
  • 31
    • 84908177336 scopus 로고    scopus 로고
    • Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): A randomised, open-label, phase 3, non-inferiority trial
    • Dungan KM, Povedano ST, Forst T, et al. Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): A randomised, open-label, phase 3, non-inferiority trial. Lancet 2014;384:1349-1357
    • (2014) Lancet , vol.384 , pp. 1349-1357
    • Dungan, K.M.1    Povedano, S.T.2    Forst, T.3
  • 32
    • 84899585635 scopus 로고    scopus 로고
    • Once-weekly albiglutide versus once-daily liraglutide in patients with type 2 diabetes inadequately controlled on oral drugs (HARMONY 7): A randomised open-label multicentre non-inferiority phase 3 study
    • HARMONY 7 study group
    • Pratley RE, Nauck MA, Barnett AH, et al.; HARMONY 7 study group. Once-weekly albiglutide versus once-daily liraglutide in patients with type 2 diabetes inadequately controlled on oral drugs (HARMONY 7): A randomised, open-label, multicentre, non-inferiority phase 3 study. Lancet Diabetes Endocrinol 2014;2: 289-297
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 289-297
    • Pratley, R.E.1    Nauck, M.A.2    Barnett, A.H.3
  • 33
    • 84899498561 scopus 로고    scopus 로고
    • Reductions in systolic blood pressure with liraglutide in patients with type 2 diabetes: Insights from a patient-level pooled analysis of six randomized clinical trials
    • Fonseca VA, Devries JH, Henry RR, Donsmark M, Thomsen HF, Plutzky J. Reductions in systolic blood pressure with liraglutide in patients with type 2 diabetes: Insights from a patient-level pooled analysis of six randomized clinical trials. J Diabetes Complications 2014;28: 399-405
    • (2014) J Diabetes Complications , vol.28 , pp. 399-405
    • Fonseca, V.A.1    Devries, J.H.2    Henry, R.R.3    Donsmark, M.4    Thomsen, H.F.5    Plutzky, J.6
  • 34
    • 84929289581 scopus 로고    scopus 로고
    • Rationale design and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome a long-term cardiovascular end point trial of lixisenatide versus placebo
    • ELIXA Investigators
    • Bentley-Lewis R, Aguilar D, Riddle MC, et al.; ELIXA Investigators. Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo. Am Heart J 2015;169: 631-638.e7
    • (2015) Am Heart J , vol.169 , pp. 631-631e7
    • Bentley-Lewis, R.1    Aguilar, D.2    Riddle, M.C.3
  • 35
    • 84948740668 scopus 로고    scopus 로고
    • Lixisenatide in patients with type 2 diabetes and acute coronary syndrome
    • ELIXA Investigators
    • Pfeffer MA, Claggett B, Diaz R, et al.; ELIXA Investigators. Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. N Engl J Med 2015;373:2247-2257
    • (2015) N Engl J Med , vol.373 , pp. 2247-2257
    • Pfeffer, M.A.1    Claggett, B.2    Diaz, R.3
  • 36
    • 84886946727 scopus 로고    scopus 로고
    • Design of the Liraglutide Effect and Action in Diabetes: Evaluation of cardiovascular outcome Results (LEADER) trial
    • Marso SP, Poulter NR, Nissen SE, et al. Design of the Liraglutide Effect and Action in Diabetes: Evaluation of cardiovascular outcome Results (LEADER) trial. Am Heart J 2013;166: 823-30.e5
    • (2013) Am Heart J , vol.166 , pp. 823-823e5
    • Marso, S.P.1    Poulter, N.R.2    Nissen, S.E.3
  • 37
    • 84916630493 scopus 로고    scopus 로고
    • LEADER 3-lipase and amylase activity in subjects with type 2 diabetes: Baseline data from over 9000 subjects in the LEADER Trial
    • LEADER Trial investigators
    • Steinberg WM, Nauck MA, Zinman B, et al.; LEADER Trial investigators. LEADER 3-lipase and amylase activity in subjects with type 2 diabetes: Baseline data from over 9000 subjects in the LEADER Trial. Pancreas 2014;43: 1223-1231
    • (2014) Pancreas , vol.43 , pp. 1223-1231
    • Steinberg, W.M.1    Nauck, M.A.2    Zinman, B.3
  • 38
    • 84926195839 scopus 로고    scopus 로고
    • LEADER 2: Baseline calcitonin in 9340 people with type 2 diabetes enrolled in the Liraglutide Effect and Action in Diabetes: Evaluation of cardiovascular outcome Results (LEADER) trial: Preliminary observations
    • LEADER Trial Investigators
    • Daniels GH, Hegedüs L, Marso SP, et al.; LEADER Trial Investigators. LEADER 2: Baseline calcitonin in 9340 people with type 2 diabetes enrolled in the Liraglutide Effect and Action in Diabetes: Evaluation of cardiovascular outcome Results (LEADER) trial: Preliminary observations. Diabetes Obes Metab 2015;17: 477-486
    • (2015) Diabetes Obes Metab , vol.17 , pp. 477-486
    • Daniels, G.H.1    Hegedüs, L.2    Marso, S.P.3
  • 39
    • 84864674632 scopus 로고    scopus 로고
    • Elevated amylase and lipase levels in patients using glucagonlike peptide-1 receptor agonists or dipeptidylpeptidase- 4 inhibitors in the outpatient setting
    • Lando HM, Alattar M, Dua AP. Elevated amylase and lipase levels in patients using glucagonlike peptide-1 receptor agonists or dipeptidylpeptidase- 4 inhibitors in the outpatient setting. Endocr Pract 2012;18:472-477
    • (2012) Endocr Pract , vol.18 , pp. 472-477
    • Lando, H.M.1    Alattar, M.2    Dua, A.P.3
  • 40
    • 84878493249 scopus 로고    scopus 로고
    • A low-grade increase of serum pancreatic exocrine enzyme levels by dipeptidyl peptidase-4 inhibitor in patients with type 2 diabetes
    • Tokuyama H, Kawamura H, Fujimoto M, et al. A low-grade increase of serum pancreatic exocrine enzyme levels by dipeptidyl peptidase-4 inhibitor in patients with type 2 diabetes. Diabetes Res Clin Pract 2013;100:e66-e69
    • (2013) Diabetes Res Clin Pract , vol.100 , pp. e66-e69
    • Tokuyama, H.1    Kawamura, H.2    Fujimoto, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.