Greater preclinical atherosclerosis in treated monogenic familial hypercholesterolemia vs. polygenic hypercholesterolemia

Atherosclerosis

Volumn 263, Issue , 2017, Pages 405-411

  Sharifi, Mahtab ^a,b   Higginson, Elizabeth ^c   Bos, Sven ^d   Gallivan, Angela ^b   Harvey, Darren ^b   Li, Ka Wah ^a   Abeysekera, Amali ^c   Haddon, Angela ^c   Ashby, Helen ^c   Shipman, Kate E ^c   Cooper, Jackie A ^a   Futema, Marta ^a   Roeters van Lennep, Jeanine E ^d   Sijbrands, Eric J G ^d   Labib, Mourad ^c   Nair, Devaki ^b   Humphries, Steve E ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ROYAL FREE LONDON NHS FOUNDATION TRUST   (United Kingdom)

^c RUSSELLS HALL HOSPITAL   (United Kingdom)

^d Department of Internal Medicine ^*  (Netherlands)

Author keywords

Carotid intima media thickness; Coronary artery calcification; Familial hypercholesterolemia; Polygenic hypercholesterolemia; Preclinical atherosclerosis

Indexed keywords

CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; BIOLOGICAL MARKER;

ADULT; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROSIS; B SCAN; CORONARY ARTERY CALCIUM SCORE; FAMILIAL HYPERCHOLESTEROLEMIA; FEMALE; GENE MUTATION; GENETIC ANALYSIS; GENOTYPE; HUMAN; HYPERCHOLESTEROLEMIA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; AGED; ASYMPTOMATIC DISEASE; BLOOD; CAROTID ARTERY DISEASE; CLINICAL TRIAL; COMPARATIVE STUDY; COMPLICATION; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; DIAGNOSTIC IMAGING; DNA MUTATIONAL ANALYSIS; ENGLAND; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; MULTICENTER STUDY; MULTIFACTORIAL INHERITANCE; MUTATION; NETHERLANDS; PHENOTYPE; PROCEDURES; RISK FACTOR; SEVERITY OF ILLNESS INDEX;

ADULT; AGED; ASYMPTOMATIC DISEASES; BIOMARKERS; CAROTID ARTERY DISEASES; CAROTID INTIMA-MEDIA THICKNESS; CHOLESTEROL, LDL; COMPUTED TOMOGRAPHY ANGIOGRAPHY; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; DNA MUTATIONAL ANALYSIS; ENGLAND; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERLIPOPROTEINEMIA TYPE II; MALE; MIDDLE AGED; MULTIFACTORIAL INHERITANCE; MUTATION; NETHERLANDS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 85019549572     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2017.05.015     Document Type: Article

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