Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort

Genetics in Medicine

Volumn 19, Issue 9, 2017, Pages 1007-1012

  Maas, Iris Lianne ^a   Brüggemann, Petra ^a   Requena, Teresa ^b   Bulla, Jan ^c   Edvall, Niklas K ^d   Hjelmborg, Jacob V B ^e   Szczepek, Agnieszka J ^a   Canlon, Barbara ^d   Mazurek, Birgit ^a   Lopez Escamez, Jose A ^b   Cederroth, Christopher R ^d  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF GRANADA   (Spain)

^c UNIVERSITY OF BERGEN   (Norway)

^d KAROLINSKA INSTITUTE   (Sweden)

^e UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

concordance; gender; heritability; tinnitus; twins

Indexed keywords

ADULT; AGED; ARTICLE; CROSS-SECTIONAL STUDY; DIZYGOTIC TWINS; ENVIRONMENTAL FACTOR; FEMALE; GENETIC SUSCEPTIBILITY; HEREDITY; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOZYGOTIC TWINS; PHENOTYPE; SELF REPORT; SWEDISH CITIZEN; TINNITUS; TWIN CONCORDANCE; ADOLESCENT; COHORT ANALYSIS; GENETIC PREDISPOSITION; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; HEALTH SURVEY; INHERITANCE; MIDDLE AGED; REGISTER; RISK; SWEDEN; TWINS; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; COHORT STUDIES; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INHERITANCE PATTERNS; MALE; MIDDLE AGED; POPULATION SURVEILLANCE; REGISTRIES; RISK; SWEDEN; TINNITUS; TWINS; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC; YOUNG ADULT;

EID: 85019542899     PISSN: 10983600     EISSN: 15300366     Source Type: Journal    
DOI: 10.1038/gim.2017.4     Document Type: Article

References (40)

1. Dobie RA. Depression and tinnitus. Otolaryngol Clin North Am 2003;36:383-388.
2. Heller AJ. Classification and epidemiology of tinnitus. Otolaryngol Clin North Am 2003;36:239-248.
3. Cederroth CR, Canlon B, Langguth B. Hearing loss and tinnitus-are funders and industry listening Nat Biotechnol 2013;31:972-974.
4. Lopez-Escamez JA, Bibas T, Cima RF, et al. Genetics of tinnitus: an emerging area for molecular diagnosis and drug development. Front Neurosci 2016;10:377.
5. Baguley D, McFerran D, Hall D. Tinnitus. Lancet 2013;382:1600-1607.
6. Langguth B, Kreuzer PM, Kleinjung T, De Ridder D. Tinnitus: causes and clinical management. Lancet Neurol 2013;12:920-930.
7. Kvestad E, Czajkowski N, Engdahl B, Hoffman HJ, Tambs K. Low heritability of tinnitus: results from the second Nord-Trøndelag health study. Arch Otolaryngol Head Neck Surg 2010;136:178-182.
8. Hendrickx JJ, Huyghe JR, Demeester K, et al. Familial aggregation of tinnitus: a European multicentre study. B-ENT 2007;3(suppl 7):51-60.
9. Lichtenstein P, Sullivan PF, Cnattingius S, et al. The Swedish Twin Registry in the third millennium: an update. Twin Res Hum Genet 2006;9:875-882.
10. Magnusson PK, Almqvist C, Rahman I, et al. The Swedish Twin Registry: establishment of a biobank and other recent developments. Twin Res Hum Genet 2013;16:317-329.
11. Lichtenstein P, De Faire U, Floderus B, Svartengren M, Svedberg P, Pedersen NL. The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies. J Intern Med 2002;252:184-205.
12. Neale MC, Cardon LR. Methodology for Genetic Studies of Twins and Families. Kluwer Academic Publishers: Dordrecht, The Netherlands, 1992.
13. Sham P. Statistics in Human Genetics. John Wiley & Sons: Chichester, UK, 1998.
14. Bell AE. Heritability in retrospect. J Hered 1977;68:297-300.
15. Kang KW, Christian JC, Norton JA Jr. Heritability estimates from twin studies. I. Formulae of heritability estimates. Acta Genet Med Gemellol (Roma) 1978;27:39-44.
16. McCormack A, Edmondson-Jones M, Somerset S, Hall D. A systematic review of the reporting of tinnitus prevalence and severity. Hear Res 2016;337:70-79.
17. Gopinath B, McMahon CM, Rochtchina E, Karpa MJ, Mitchell P. Incidence, persistence, and progression of tinnitus symptoms in older adults: the Blue Mountains Hearing Study. Ear Hear 2010;31:407-412.
18. Shargorodsky J, Curhan GC, Farwell WR. Prevalence and characteristics of tinnitus among US adults. Am J Med 2010;123:711-718.
19. Park B, Choi HG, Lee HJ, et al. Analysis of the prevalence of and risk factors for tinnitus in a young population. Otol Neurotol 2014;35:1218-1222.
20. van Dongen J, Slagboom PE, Draisma HH, Martin NG, Boomsma DI. The continuing value of twin studies in the omics era. Nat Rev Genet 2012;13:640-653.
21. CONVERGE consortium. Sparse whole-genome sequencing identifies two loci for major depressive disorder. Nature 2015;523:588-591.
22. Forsberg LA, Rasi C, Razzaghian HR, et al. Age-related somatic structural changes in the nuclear genome of human blood cells. Am J Hum Genet 2012;90:217-228.
23. Ryan BC, Vandenbergh JG. Intrauterine position effects. Neurosci Biobehav Rev 2002;26:665-678.
24. vom Saal FS, Grant WM, McMullen CW, Laves KS. High fetal estrogen concentrations: correlation with increased adult sexual activity and decreased aggression in Male mice. Science 1983;220:1306-1309.
25. Vom Saal FS, Dhar MG. Blood flow in the uterine loop artery and loop vein is bidirectional in the mouse: implications for transport of steroids between fetuses. Physiol Behav 1992;52:163-171.
26. Vandenberg LN, Colborn T, Hayes TB, et al. Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocr Rev 2012;33:378-455.
27. Cederroth CR, Nef S. Fetal programming of adult glucose homeostasis in mice. PLoS One 2009;4:e7281.
28. vom Saal FS, Timms BG, Montano MM, et al. Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses. Proc Natl Acad Sci USA 1997;94:2056-2061.
29. Resnick SM, Gottesman II, McGue M. Sensation seeking in opposite-sex twins: an effect of prenatal hormones Behav Genet 1993;23:323-329.
30. Hsieh CC, Lan SJ, Ekbom A, Petridou E, Adami HO, Trichopoulos D. Twin membership and breast cancer risk. Am J Epidemiol 1992;136:1321-1326.
31. McFadden D. A masculinizing effect on the auditory systems of human females having Male co-twins. Proc Natl Acad Sci USA 1993;90:11900-11904.
32. McFadden D, Loehlin JC, Pasanen EG. Additional findings on heritability and prenatal masculinization of cochlear mechanisms: click-evoked otoacoustic emissions. Hear Res 1996;97:102-119.
33. Scheike TH, Hjelmborg JB, Holst KK. Estimating twin pair concordance for age of onset. Behav Genet 2015;45:573-580.
34. Holst KK, Scheike TH, Hjelmborg JB. The liability threshold model for censored twin data. Computational statistics and Data Analysis. 2016;93:324-335.
35. Yano T, Nishio SY, Usami S; Deafness Gene Study Consortium. Frequency of mitochondrial mutations in non-syndromic hearing loss as well as possibly responsible variants found by whole mitochondrial genome screening. J Hum Genet 2014;59:100-106.
36. Verstreken M, Declau F, Wuyts FL, et al. Hereditary otovestibular dysfunction and Ménière's disease in a large Belgian family is caused by a missense mutation in the COCH gene. Otol Neurotol 2001;22:874-881.
37. Lopez-Escamez JA, Dlugaiczyk J, Jacobs J, et al. Accompanying symptoms overlap during attacks in Menière's disease and vestibular migraine. Front Neurol 2014;5:265.
38. Schaette R. Tinnitus in men, mice (as well as other rodents), and machines. Hear Res 2014;311:63-71.
39. Schaette R, McAlpine D. Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model. J Neurosci 2011;31:13452-13457.
40. Rüttiger L, Singer W, Panford-Walsh R, et al. The reduced cochlear output and the failure to adapt the central auditory response causes tinnitus in noise exposed rats. PLoS One 2013;8:e57247.