False biochemical diagnosis of hyperthyroidism in streptavidin-biotin-based immunoassays: The problem of biotin intake and related interferences

Clinical Chemistry and Laboratory Medicine

Volumn 55, Issue 6, 2017, Pages 780-788

  Piketty, Marie Liesse ^a   Polak, Michel ^a   Flechtner, Isabelle ^a   Gonzales Briceño, Laura ^a   Souberbielle, Jean Claude ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

anti streptavidin antibody; biotin; immunoassay; interference

Indexed keywords

BIOTIN; C PEPTIDE; CHORIONIC GONADOTROPIN; INSULIN; LIOTHYRONINE; LIOTRIX; PARATHYROID HORMONE; SOMATOMEDIN C; STREPTAVIDIN; STREPTAVIDIN ANTIBODY; THYROGLOBULIN; THYROTROPIN; THYROTROPIN RECEPTOR; THYROXINE; UNCLASSIFIED DRUG;

ANALYTICAL ERROR; ANTIBODY COMBINING SITE; ANTIGEN ANTIBODY COMPLEX; DIAGNOSTIC ERROR; DIETARY INTAKE; DOSE RESPONSE; FALSE NEGATIVE RESULT; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; HORMONE DETERMINATION; HUMAN; HYPERTHYROIDISM; IMMUNOASSAY; PRIORITY JOURNAL; PROTEIN INTERACTION; REVIEW; STEREOSPECIFICITY; FALSE POSITIVE RESULT; IMMUNOLOGY; METABOLISM; PROCEDURES;

BIOTIN; FALSE NEGATIVE REACTIONS; FALSE POSITIVE REACTIONS; HUMANS; HYPERTHYROIDISM; IMMUNOASSAY; STREPTAVIDIN;

EID: 85019154885     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm-2016-0606     Document Type: Review

References (23)

1. Decoudier B, Delemer B, Maarouf A, Tourbah A, Marot D. Une hyperthyroidie enigmatique ⋯ de l'importance des interferences dans les dosages hormonaux. 32e SFE congress. oct 2015, Poster P172. Ann Endocrinol 2015;76:428.
2. Barbesino G. Misdiagnosis of Graves' disease with apparent severe hyperthyroidism in a patient taking biotin megadoses. Thyroid 2016;26:860-3.
3. Elston MS, Sehgal S, Du Toit S, Yarndley T, Conaglen JV. Facticious Graves' disease due to biotin immunoassay interference-a case and review of the literature. J Clin Endocrinol Metab 2016;101:3251-5.
4. Khieng V, Stevens C. Vitamin D toxicity? a case study. NZ J Med Lab Sci 2010;64:44-50.
5. Meany DL, Jan De Beur SM, Bill MJ, Sokoll LJ. A case of renal osteodystrophy with unexpected serum intact parathyroid hormone concentrations. Clin Chem 2009;55:1737-41.
6. Simo-Guerrero O, Gimenez-Perez G, Recsens-Garci A, Villa-Blasco C, Castells-Fuste I. False overt hyperthyroidism by interference in immunoassays. Endocrinol Nutr 2016;63:431-2.
7. Waghray A, Milas M, Nyalakonda K, Siperstein AE. Falsely low parathyroid hormone secondary to biotin interference: a case series. Endocr Pract 2013;19:451-5.
8. Seaborg E. Thyroid month January 2016: beware of biotin. In endocrine news. Washington, USA: Endocrine society, 2016:42. Available at: http://endocrinenews.endocrine.org/January-2016-thyroid-month-beware-of-biotin.
9. National Research Council. Dietary reference intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic acid, Biotin, and Choline. National Academy of Sciences. Washington, DC: National Academy press, 1998:374-89.
10. Zempleni J, Wijeratne SS, Hassan YI. Biotin. Biofactors 2009;35:36-46.
11. Kwok JS, Chan IH, Chan MH. Biotin interference on TSH and free thyroid hormone measurement. Pathology 2012;44:278-80.
12. Henry JG, Sobki S, Arafat N. Interference by biotin therapy on measurement of TSH and FT4 by enzymeimmunoassay on Boehringer Mannheim ES700 analyser. Ann Clin Biochem 1996;33:162-3.
13. Wijeratne NG, Doery JC, Lu ZX. Positive and negative interference in immunoassays following biotin ingestion: a pharmacokinetic study. Pathology 2012;44:674-5.
14. Sedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study. Mult Scler relat Disord 2015;4:159-69.
15. Peyro Saint Paul L, Debruyne D, Bernard D, Mock DM, Defer GL. Pharmacokinetics and pharmacodynamics of MD1003 (high dose biotin) in the treatment of progressive multiple sclerosis. Expert Opin Drug Metab Toxicol 2016;12:327-44.
16. Rulander NJ, Cardamome D, Senior M, Snyder PJ, Master S. Interference from anti-streptavidin antibody. Arch Pathol Lab Med 2013;137:1141-6.
17. Peltier L, Massart C, Moineau MP, Delhostal A, Roudaut N. Antistreptavidin interferences in Roche Thyroid immunoassays: a case report [letter]. Clin Chem Lab Med 2016;54:e11-4.
18. Selby C. Interference in immunoassay. Ann Clin Biochem 1999;36:704-21.
19. Tate J, Ward G. Interferences in immunoassay. Clin Biochem Rev 2004;25:105-19.
20. Gulbahar O, Degertekin CK, Akturk M, Yalcin MM, Kalan I, Atikeler GF, et al. A case with immunoassay interferences in the measurement of multiple hormones. J Clin Endocrinol Metab 2015;100:2147-53.
21. Mongolu S, Armston AE, Mozley E, Nasruddin A. Heterophilic antibody interference affecting multiple hormone assays: is it due to rheumatoid factor? Scand J Clin Lab Invest 2016;76:240-2.
22. Faix JD. Principles and pitfalls of free hormone measurements. Best Pract Res Clin Endocrinol Metab 2013;27:631-45.
23. Ohba K, Noh JY, Unno T, Satoh T, Iwahara K, Matsushita A, et al. Falsely elevated thyroid hormone levels caused by antiruthenium interference in the Elecsys assay resembling the syndrome of inappropriate secretion of thyrotropin. Endocr J 2012;59:663-7.