Factitious Graves' disease due to biotin immunoassay interference-A case and review of the literature

Journal of Clinical Endocrinology and Metabolism

Volumn 101, Issue 9, 2016, Pages 3251-3255

  Elston, Marianne S ^a,b   Sehgal, Shekhar ^a   Toit, Stephen Du ^a   Yarndley, Tania ^a   Conaglen, John V ^b  

^a WAIKATO HOSPITAL   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTIN; THYROTROPIN RECEPTOR ANTIBODY; THYROXINE;

ABNORMAL LABORATORY RESULT; ADULT; CASE REPORT; CLINICAL EXAMINATION; CLINICAL FEATURE; DIAGNOSTIC ERROR; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG MEGADOSE; DRUG WITHDRAWAL; EUTHYROIDISM; FACTITIOUS DISEASE; FATIGUE; FEMALE; GRAVES DISEASE; HALF LIFE TIME; HUMAN; IMMUNOASSAY; INGESTION; MIDDLE AGED; MULTIPLE SCLEROSIS; NEW ZEALAND; PRIORITY JOURNAL; REFERENCE VALUE; REVIEW; SYSTEMATIC REVIEW; THYROID FUNCTION TEST; THYROTOXICOSIS; BLOOD; IMMUNOLOGY; PROGNOSIS; STANDARDS;

BIOTIN; FEMALE; GRAVES DISEASE; HUMANS; IMMUNOASSAY; MIDDLE AGED; NEW ZEALAND; PROGNOSIS; THYROID FUNCTION TESTS;

EID: 84988931320     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2016-1971     Document Type: Review

References (16)

1. Institute of Medicine. Biotin. In: Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline, a report of the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline and Subcommittee on Upper Reference Levels of Nutrients, Food and Nutrition Board, Institute of Medicine. Chap 11. Washington DC: National Academies Press; 1998:374-389
2. Maebashi M, Makino Y, Furukawa Y, Ohinata K, Kimura S, Sato T. Therapeutic evaluation of the effect of biotin on hyperglycemia in patients with non-insulin dependent diabetes mellitus. J Clin Biochem Nutr. 1993;14:211-218
3. Sedel F, Bernard D, Mock DM, Tourbah A. Targeting demyelination and virtual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis [published online September 5, 2015]. Neuropharmacology. doi:10.1016/j.neuropharm.2015.08.028
4. Sedel F, Papeix C, Bellanger A, et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study. Mult Scler Relat Disord. 2015;4:159-169
5. Diamandis EP, Christopoulos TK. The biotin-(strept)avidin system: principles and applications in biotechnology. Clin Chem. 1991;37: 625-636
6. Henry JG, Sobki S, Arafat N. Interference by biotin therapy on measurement of TSH and FT4 by enzyme immunoassay on Boehringer Mannheim ES700 analyser. Ann Clin Biochem. 1996;33: 162-163
7. Meany DL, Jan de Beur SM, Bill MJ, Sokoll LJ. A case of renal osteodystrophy with unexpected serum intact parathyroid hormone concentrations. Clin Chem. 2009;55:1737-1739
8. Kwok JS, Chan IH, Chan MH. Biotin interference on TSH and free thyroid hormone measurement. Pathology. 2012;44:278-280
9. Wijeratne NG, Doery JC, Lu ZX. Positive and negative interference in immunoassays following biotin ingestion: a pharmacokinetic study. Pathology. 2012;44:674-675
10. Waghray A, Milas M, Nyalakonda K, Siperstein AE. Falsely low parathyroid hormone secondary to biotin interference: a case series. Endocr Pract. 2013;19:451-455
11. Barbesino G. Misdiagnosis of Graves' disease with apparent severe hyperthyroidism in a patient taking biotin megadoses. Thyroid. 2016;26:860-863
12. Seaborg E. January 2016: Thyroid Month: Beware of Biotin. In: Endocrine News. Washington DC: Endocrine Society; 2016;42
13. Cobas FT4 II assay [package insert]. Mannheim, Germany; Roche Diagnostics GmbH; 2013
14. Cobas TSH assay [package insert]. Mannheim, Germany; Roche Diagnostics GmbH; 2014
15. Rulander NJ, Cardamone D, Senior M, Snyder PJ, Master SR. Interference from anti-streptavidin antibody. Arch Pathol Lab Med. 2013;137:1141-1146
16. Chen T, Hedman L, Mattila PS, et al. Biotin IgM antibodies in human blood: a previously unknown factor eliciting false results in biotinylation-based immunoassays. PLoS One. 2012;7: e42376