메뉴 건너뛰기




Volumn 77, Issue 10, 2017, Pages 1077-1089

Immunotherapy in Urothelial Cancer: Recent Results and Future Perspectives

Author keywords

[No Author keywords available]

Indexed keywords

ATEZOLIZUMAB; AVELUMAB; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DURVALUMAB; MESSENGER RNA; NIVOLUMAB; PEMBROLIZUMAB; PROGRAMMED DEATH 1 LIGAND 1; ANTINEOPLASTIC AGENT; CD274 PROTEIN, HUMAN; CTLA4 PROTEIN, HUMAN; MONOCLONAL ANTIBODY; PDCD1 PROTEIN, HUMAN; PROGRAMMED DEATH 1 RECEPTOR;

EID: 85019154217     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.1007/s40265-017-0748-7     Document Type: Review
Times cited : (69)

References (59)
  • 1
    • 84954400636 scopus 로고    scopus 로고
    • Cancer statistics, 2017
    • PID: 28055103
    • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin. 2017;67(1):7–30. doi:10.3322/caac.21387.
    • (2017) CA Cancer J Clin , vol.67 , Issue.1 , pp. 7-30
    • Siegel, R.L.1    Miller, K.D.2    Jemal, A.3
  • 2
    • 85020559867 scopus 로고    scopus 로고
    • Published May 23, 2016. Accessed December 18, 2016
    • Bladder cancer risk factors. http://www.cancer.org/cancer/bladdercancer/detailedguide/bladder-cancer-risk-factors. Published May 23, 2016. Accessed December 18, 2016.
    • Bladder cancer risk factors.
  • 3
    • 85020607884 scopus 로고    scopus 로고
    • Surveillance, Epidemiology, and End Results Program
    • Accessed December 18, 2016
    • NCI. Surveillance, Epidemiology, and End Results Program. Cancer of the Urinary Bladder—SEER Stat Fact Sheets. 2016. https://seer.cancer.gov/statfacts/html/urinb.html. Accessed December 18, 2016.
    • (2016) Cancer of the Urinary Bladder—SEER Stat Fact Sheets.
  • 4
    • 85020597513 scopus 로고    scopus 로고
    • Abstract 3622: further observation of increasing strength of the smoking-bladder cancer association: the Los Angeles Bladder Cancer Study
    • Dueker DC, Stern MC, Conti DV, Pike MC, Cortessis VK. Abstract 3622: further observation of increasing strength of the smoking-bladder cancer association: the Los Angeles Bladder Cancer Study. Cancer Res. 2013;73(8 Supplement):3622. doi:10.1158/1538-7445.am2013-3622.
    • (2013) Cancer Res , vol.73 , pp. 3622
    • Dueker, D.C.1    Stern, M.C.2    Conti, D.V.3    Pike, M.C.4    Cortessis, V.K.5
  • 5
    • 84969629955 scopus 로고    scopus 로고
    • Accessed December 18, 2016
    • Survival rates for bladder cancer. American Cancer Society. 2016. http://www.cancer.org/cancer/bladdercancer/detailedguide/bladder-cancer-survival-rates. Accessed December 18, 2016.
    • (2016) American Cancer Society.
  • 6
    • 77951626194 scopus 로고    scopus 로고
    • Prognostic factors in patients with advanced transitional cell carcinoma of the urothelial tract experiencing treatment failure with platinum-containing regimens
    • PID: 20231682
    • Bellmunt J, Choueiri TK, Fougeray R, et al. Prognostic factors in patients with advanced transitional cell carcinoma of the urothelial tract experiencing treatment failure with platinum-containing regimens. J Clin Oncol. 2010;28(11):1850–5. doi:10.1200/jco.2009.25.4599.
    • (2010) J Clin Oncol. , vol.28 , Issue.11 , pp. 1850-1855
    • Bellmunt, J.1    Choueiri, T.K.2    Fougeray, R.3
  • 7
    • 79952012493 scopus 로고    scopus 로고
    • A consensus definition of patients with metastatic urothelial carcinoma who are unfit for cisplatin-based chemotherapy
    • PID: 21376284
    • Galsky MD, Hahn NM, Rosenberg J, et al. A consensus definition of patients with metastatic urothelial carcinoma who are unfit for cisplatin-based chemotherapy. Lancet. 2011;12(3):211–4. doi:10.1016/s1470-2045(10)70275-8.
    • (2011) Lancet , vol.12 , Issue.3 , pp. 211-214
    • Galsky, M.D.1    Hahn, N.M.2    Rosenberg, J.3
  • 8
    • 79751491417 scopus 로고    scopus 로고
    • First- and second-line therapy for metastatic urothelial carcinoma of the bladder
    • PID: 21331269
    • Yafi FA, North S, Kassouf W. First- and second-line therapy for metastatic urothelial carcinoma of the bladder. Curr Oncol. 2011. doi:10.3747/co.v18i1.695.
    • (2011) Curr Oncol.
    • Yafi, F.A.1    North, S.2    Kassouf, W.3
  • 9
    • 0032887956 scopus 로고    scopus 로고
    • Long-term survival in metastatic transitional-cell carcinoma and prognostic factors predicting outcome of therapy
    • COI: 1:STN:280:DyaK1MvjvVWrtw%3D%3D, PID: 10506615
    • Bajorin DF, Dodd PM, Mazumdar M. Long-term survival in metastatic transitional-cell carcinoma and prognostic factors predicting outcome of therapy. J Clin Oncol. 1999;17(10):3173–81. doi:10.1200/jco.1999.17.10.3173.
    • (1999) J Clin Oncol. , vol.17 , Issue.10 , pp. 3173-3181
    • Bajorin, D.F.1    Dodd, P.M.2    Mazumdar, M.3
  • 10
    • 79251570870 scopus 로고    scopus 로고
    • Bacillus Calmette–Guérin treatment of non-muscle invasive bladder cancer
    • PID: 21091799
    • Sylvester RJ. Bacillus Calmette–Guérin treatment of non-muscle invasive bladder cancer. Int J Urol. 2010;18(2):113–20. doi:10.1111/j.1442-2042.2010.02678.x.
    • (2010) Int J Urol , vol.18 , Issue.2 , pp. 113-120
    • Sylvester, R.J.1
  • 11
    • 0016198025 scopus 로고
    • Immunotherapy of guinea pig cancer with BCG
    • Zbar B, Rapp HJ. Immunotherapy of guinea pig cancer with BCG. Cancer. 1974;34(S8):1532–40. doi:10.1002/1097-0142(197410)34:8.
    • (1974) Cancer , vol.34 , Issue.S8 , pp. 1532-1540
    • Zbar, B.1    Rapp, H.J.2
  • 12
    • 0036480489 scopus 로고    scopus 로고
    • Intracavitary bacillus Calmette–Guerin in the treatment of superficial bladder tumors
    • COI: 1:STN:280:DC%2BD387nt1Kguw%3D%3D, PID: 11905917, (reprint of J Urol. 1976;116:180–183)
    • Morales A, Eidinger D, Bruce A. Intracavitary bacillus Calmette–Guerin in the treatment of superficial bladder tumors. J Urol. 2002;167(2):891–4. doi:10.1016/s0022-5347(02)80294-4. (reprint of J Urol. 1976;116:180–183)
    • (2002) J Urol , vol.167 , Issue.2 , pp. 891-894
    • Morales, A.1    Eidinger, D.2    Bruce, A.3
  • 13
    • 36749051886 scopus 로고    scopus 로고
    • History of bacillus Calmette–Guerin and bladder cancer: an immunotherapy success story
    • PID: 17997439
    • Herr HW, Morales A. History of bacillus Calmette–Guerin and bladder cancer: an immunotherapy success story. J Urol. 2008;179(1):53–6. doi:10.1016/j.juro.2007.08.122.
    • (2008) J Urol , vol.179 , Issue.1 , pp. 53-56
    • Herr, H.W.1    Morales, A.2
  • 14
    • 0034105381 scopus 로고    scopus 로고
    • Maintenance bacillus Calmette–Guerin immunotherapy for recurrent Ta, T1 and carcinoma in situ transitional cell carcinoma of the bladder: a randomized Southwest Oncology Group Study
    • COI: 1:STN:280:DC%2BD3c7pvFOnsw%3D%3D, PID: 10737480
    • Lamm DL, Blumenstein BA, Crissman JD, et al. Maintenance bacillus Calmette–Guerin immunotherapy for recurrent Ta, T1 and carcinoma in situ transitional cell carcinoma of the bladder: a randomized Southwest Oncology Group Study. J Urol. 2000;163(4):1124–9. doi:10.1016/s0022-5347(05)67707-5.
    • (2000) J Urol , vol.163 , Issue.4 , pp. 1124-1129
    • Lamm, D.L.1    Blumenstein, B.A.2    Crissman, J.D.3
  • 15
    • 0026004545 scopus 로고
    • A randomized trial of intravesical doxorubicin and immunotherapy with bacille Calmette–Guérin for transitional-cell carcinoma of the bladder
    • COI: 1:STN:280:DyaK38%2FhvVSgtg%3D%3D, PID: 1922207
    • Lamm DL, Blumenstein BA, Crawford ED, et al. A randomized trial of intravesical doxorubicin and immunotherapy with bacille Calmette–Guérin for transitional-cell carcinoma of the bladder. N Engl J Med. 1991;325(17):1205–9. doi:10.1056/nejm199110243251703.
    • (1991) N Engl J Med , vol.325 , Issue.17 , pp. 1205-1209
    • Lamm, D.L.1    Blumenstein, B.A.2    Crawford, E.D.3
  • 16
    • 85020567588 scopus 로고    scopus 로고
    • Accessed December 18, 2016
    • TICE BCG. 2016. http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm134033.htm. Accessed December 18, 2016.
    • (2016)
  • 17
    • 85020597529 scopus 로고    scopus 로고
    • Published 2016. Accessed November 30, 2016
    • Bladder Cancer. Cancer Research Institute. http://www.cancerresearch.org/cancer-immunotherapy/impacting-all-cancers/bladder-cancer. Published 2016. Accessed November 30, 2016.
    • (2016) Cancer Research Institute.
  • 18
    • 79960899604 scopus 로고    scopus 로고
    • Camouflage and sabotage: tumor escape from the immune system
    • COI: 1:CAS:528:DC%2BC3MXpt1Oqtr4%3D, PID: 21626032
    • Poschke I, Mougiakakos D, Kiessling R. Camouflage and sabotage: tumor escape from the immune system. Cancer Immunol Immunother. 2011;60(8):1161–71.
    • (2011) Cancer Immunol Immunother , vol.60 , Issue.8 , pp. 1161-1171
    • Poschke, I.1    Mougiakakos, D.2    Kiessling, R.3
  • 19
    • 0037307930 scopus 로고    scopus 로고
    • Blockade of programmed death ligands on dendritic cells enhances T cell activation and cytokine production
    • COI: 1:CAS:528:DC%2BD3sXnvVOmtQ%3D%3D, PID: 12538684
    • Brown JA, Dorfman DM, Ma FR, et al. Blockade of programmed death ligands on dendritic cells enhances T cell activation and cytokine production. J Immunol. 2003;170(3):1257–66. doi:10.4049/jimmunol.170.3.1257.
    • (2003) J Immunol. , vol.170 , Issue.3 , pp. 1257-1266
    • Brown, J.A.1    Dorfman, D.M.2    Ma, F.R.3
  • 20
    • 84989918072 scopus 로고    scopus 로고
    • Safety and efficacy of durvalumab (MEDI4736), an anti-programmed cell death ligand-1 immune checkpoint inhibitor, in patients with advanced urothelial bladder cancer
    • COI: 1:CAS:528:DC%2BC28XhvFertrzP, PID: 27269937
    • Massard C, Gordon MS, Sharma S, et al. Safety and efficacy of durvalumab (MEDI4736), an anti-programmed cell death ligand-1 immune checkpoint inhibitor, in patients with advanced urothelial bladder cancer. J Clin Oncol. 2016;34(26):3119–25. doi:10.1200/jco.2016.67.9761.
    • (2016) J Clin Oncol. , vol.34 , Issue.26 , pp. 3119-3125
    • Massard, C.1    Gordon, M.S.2    Sharma, S.3
  • 21
    • 33847611968 scopus 로고    scopus 로고
    • Programmed cell death 1 ligand 1 and tumor-infiltrating CD8 T lymphocytes are prognostic factors of human ovarian cancer
    • COI: 1:CAS:528:DC%2BD2sXjtVWlt7s%3D, PID: 17360651
    • Hamanishi J, Mandai M, Iwasaki M, et al. Programmed cell death 1 ligand 1 and tumor-infiltrating CD8 T lymphocytes are prognostic factors of human ovarian cancer. Proc Natl Acad Sci USA. 2007;104(9):3360–5. doi:10.1073/pnas.0611533104.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.9 , pp. 3360-3365
    • Hamanishi, J.1    Mandai, M.2    Iwasaki, M.3
  • 22
    • 84957839638 scopus 로고    scopus 로고
    • CTLA-4 and PD-1 pathways: similarities, differences, and implications of their inhibition
    • COI: 1:CAS:528:DC%2BC28XhsVGru7s%3D, PID: 26558876
    • Buchbinder EI, Desai A. CTLA-4 and PD-1 pathways: similarities, differences, and implications of their inhibition. Am J Clin Oncol. 2016;39(1):98–106.
    • (2016) Am J Clin Oncol , vol.39 , Issue.1 , pp. 98-106
    • Buchbinder, E.I.1    Desai, A.2
  • 23
    • 84939161466 scopus 로고    scopus 로고
    • Anti-PD-1 and PD-L1 therapy for bladder cancer: what is on the horizon?
    • COI: 1:CAS:528:DC%2BC2MXhtlSnsbvJ, PID: 26260808
    • Sundararajan S, Vogelzang NJ. Anti-PD-1 and PD-L1 therapy for bladder cancer: what is on the horizon? Future Oncol. 2015;11(16):2299–306. doi:10.2217/fon.15.162.
    • (2015) Future Oncol. , vol.11 , Issue.16 , pp. 2299-2306
    • Sundararajan, S.1    Vogelzang, N.J.2
  • 24
    • 84873140820 scopus 로고    scopus 로고
    • Balance of CD8+ CD28+/CD8+ CD28− T lymphocytes is vital for patients with ulcerative colitis
    • PID: 22851040
    • Dai S-X, Wu G, Zou Y, et al. Balance of CD8+ CD28+/CD8+ CD28− T lymphocytes is vital for patients with ulcerative colitis. Dig Dis Sci. 2012;58(1):88–96. doi:10.1007/s10620-012-2327-9.
    • (2012) Dig Dis Sci , vol.58 , Issue.1 , pp. 88-96
    • Dai, S.-X.1    Wu, G.2    Zou, Y.3
  • 25
    • 33845748319 scopus 로고    scopus 로고
    • CD8+ CD28− regulatory T lymphocytes prevent experimental inflammatory bowel disease in mice
    • Ménager-Marcq I, Pomié C, Romagnoli P, Meerwijk JPV. CD8+ CD28− regulatory T lymphocytes prevent experimental inflammatory bowel disease in mice. Gastroenterol. 2006;131(6):1775–85. doi:10.1053/j.gastro.2006.09.008.
    • (2006) Gastroenterol. , vol.131 , Issue.6 , pp. 1775-1785
    • Ménager-Marcq, I.1    Pomié, C.2    Romagnoli, P.3    Meerwijk, J.P.V.4
  • 26
    • 0031054242 scopus 로고    scopus 로고
    • CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics
    • PID: 9053440
    • Merwe PAVD, Bodian DL, Daenke S, Linsley P, Davis SJ. CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. J Exp Med. 1997;185(3):393–404. doi:10.1084/jem.185.3.393.
    • (1997) J Exp Med , vol.185 , Issue.3 , pp. 393-404
    • Merwe, P.A.V.D.1    Bodian, D.L.2    Daenke, S.3    Linsley, P.4    Davis, S.J.5
  • 27
    • 0027403299 scopus 로고
    • The role of the CD28 receptor during T cell responses to antigen
    • COI: 1:CAS:528:DyaK3sXktVKmu7s%3D, PID: 8386518
    • Linsley PS, Ledbetter JA. The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol. 1993;11(1):191–212. doi:10.1146/annurev.iy.11.040193.001203.
    • (1993) Annu Rev Immunol , vol.11 , Issue.1 , pp. 191-212
    • Linsley, P.S.1    Ledbetter, J.A.2
  • 28
    • 68149155982 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
    • COI: 1:CAS:528:DC%2BD1MXps1enu7w%3D
    • Peggs KS, Quezada SA, Chambers CA, Korman AJ, Allison JP. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J Expl Med. 2009;206(8):1717–25. doi:10.1084/jem.20082492.
    • (2009) J Expl Med. , vol.206 , Issue.8 , pp. 1717-1725
    • Peggs, K.S.1    Quezada, S.A.2    Chambers, C.A.3    Korman, A.J.4    Allison, J.P.5
  • 29
    • 0042971650 scopus 로고    scopus 로고
    • Molecular interactions mediating T cell antigen recognition
    • PID: 12615890
    • van der Merwe PA, Davis SJ. Molecular interactions mediating T cell antigen recognition. Annu Rev Immunol. 2001;21:659–84. doi:10.1146/annurev.immunol.21.120601.141036.
    • (2001) Annu Rev Immunol , vol.21 , pp. 659-684
    • van der Merwe, P.A.1    Davis, S.J.2
  • 30
    • 0034254301 scopus 로고    scopus 로고
    • CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression
    • COI: 1:STN:280:DC%2BD3cvgsFejtQ%3D%3D, PID: 10903737
    • Carreno BM, Bennett F, Chau TA, et al. CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression. J Immunol. 2000;165(3):1352–6. doi:10.4049/jimmunol.165.3.1352.
    • (2000) J Immunol. , vol.165 , Issue.3 , pp. 1352-1356
    • Carreno, B.M.1    Bennett, F.2    Chau, T.A.3
  • 31
    • 84923078390 scopus 로고    scopus 로고
    • MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
    • COI: 1:CAS:528:DC%2BC2cXitFamsrjE, PID: 25428503
    • Powles T, Eder JP, Fine GD, et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature. 2014;515(7528):558–62. doi:10.1038/nature13904.
    • (2014) Nature , vol.515 , Issue.7528 , pp. 558-562
    • Powles, T.1    Eder, J.P.2    Fine, G.D.3
  • 32
    • 85020564820 scopus 로고    scopus 로고
    • Published October 19, 2016. Accessed December 18, 2016
    • FDA approves Roche’s cancer immunotherapy TECENTRIQ (atezolizumab) for people with a specific type of metastatic lung cancer. M2 Presswire. http://search.proquest.com.ezproxy.library.tufts.edu/docview/1830015330/abstract/5E40FDE609A84CF7PQ/1?accountid=14434. Published October 19, 2016. Accessed December 18, 2016.
    • (2016) M2 Presswire
  • 33
    • 84999820156 scopus 로고    scopus 로고
    • Published June 7, 2016 Accessed December 18, 2016
    • FDA approves new immunotherapy drug for bladder cancer. National Cancer Institute. https://www.cancer.gov/news-events/cancer-currents-blog/2016/fda-atezolizumab-bladder. Published June 7, 2016. Accessed December 18, 2016.
    • (2016) National Cancer Institute
  • 34
    • 85007564166 scopus 로고    scopus 로고
    • Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial
    • COI: 1:CAS:528:DC%2BC28XitVyjt7jM, PID: 27939400
    • Balar AV, Galsky MD, Rosenberg JE, et al. Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial. Lancet. 2017;389(10064):67–76. doi:10.1016/s0140-6736(16)32455-2.
    • (2017) Lancet. , vol.389 , pp. 67-76
    • Balar, A.V.1    Galsky, M.D.2    Rosenberg, J.E.3
  • 35
    • 84959577118 scopus 로고    scopus 로고
    • Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial
    • COI: 1:CAS:528:DC%2BC28XjslGmu7w%3D, PID: 26952546
    • Rosenberg JE, Hoffman-Censits J, Powles T, et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet. 2016;387(10031):1909–20. doi:10.1016/s0140-6736(16)00561-4.
    • (2016) Lancet , vol.387 , pp. 1909-1920
    • Rosenberg, J.E.1    Hoffman-Censits, J.2    Powles, T.3
  • 36
    • 84990852158 scopus 로고    scopus 로고
    • Nivolumab monotherapy in recurrent metastatic urothelial carcinoma (CheckMate 032): a multicentre, open-label, two-stage, multi-arm, phase 1/2 trial
    • COI: 1:CAS:528:DC%2BC28Xhs1GnsbjM, PID: 27733243
    • Sharma P, Callahan MK, Bono P, et al. Nivolumab monotherapy in recurrent metastatic urothelial carcinoma (CheckMate 032): a multicentre, open-label, two-stage, multi-arm, phase 1/2 trial. Lancet Oncol. 2016;17(11):1590–8. doi:10.1016/s1470-2045(16)30496-x.
    • (2016) Lancet Oncol , vol.17 , Issue.11 , pp. 1590-1598
    • Sharma, P.1    Callahan, M.K.2    Bono, P.3
  • 37
    • 85010904121 scopus 로고    scopus 로고
    • Nivolumab in metastatic urothelial carcinoma after platinum therapy (275): a multicentre, single-arm, phase 2 trial
    • COI: 1:CAS:528:DC%2BC2sXhs1KntLs%3D, PID: 28131785
    • Sharma P, Retz M, Siefker-Radtke A, et al. Nivolumab in metastatic urothelial carcinoma after platinum therapy (275): a multicentre, single-arm, phase 2 trial. Lancet Oncol. 2017;18(3):312–22. doi:10.1016/s1470-2045(17)30065-7.
    • (2017) Lancet Oncol , vol.18 , Issue.3 , pp. 312-322
    • Sharma, P.1    Retz, M.2    Siefker-Radtke, A.3
  • 38
    • 85020611538 scopus 로고    scopus 로고
    • Pembrolizumab (Pembro; MK-3475) for advanced urothelial cancer: results of a phase IB study. [supplement no. 7; abstract no. 296]
    • O’Donnell PH, Plimack ER, Bellmunt J, et al. Pembrolizumab (Pembro; MK-3475) for advanced urothelial cancer: results of a phase IB study. [supplement no. 7; abstract no. 296]. In: ASCO Genitourinary Cancers Symposium; 2015.
    • (2015) ASCO Genitourinary Cancers Symposium
    • O’Donnell, P.H.1    Plimack, E.R.2    Bellmunt, J.3
  • 39
    • 85020600400 scopus 로고    scopus 로고
    • Pembrolizumab (MK-3475) for advanced urothelial cancer: updated results and biomarker analysis from KEYNOTE-012. [supplement; abstract no. 4502]
    • Plimack ER, Bellmunt J, Gupta S, et al. Pembrolizumab (MK-3475) for advanced urothelial cancer: updated results and biomarker analysis from KEYNOTE-012. [supplement; abstract no. 4502]. In: ASCO Annual Meeting; 2015.
    • (2015) ASCO Annual Meeting
    • Plimack, E.R.1    Bellmunt, J.2    Gupta, S.3
  • 40
    • 85015755043 scopus 로고    scopus 로고
    • Pembrolizumab as second-line therapy for advanced urothelial carcinoma
    • PID: 28212060
    • Bellmunt J, Wit RD, Vaughn DJ, et al. Pembrolizumab as second-line therapy for advanced urothelial carcinoma. N Engl J Med. 2017;376(11):1015–26. doi:10.1056/nejmoa1613683.
    • (2017) N Engl J Med , vol.376 , Issue.11 , pp. 1015-1026
    • Bellmunt, J.1    Wit, R.D.2    Vaughn, D.J.3
  • 43
    • 85020609662 scopus 로고    scopus 로고
    • Avelumab, an anti-programmed death-ligand 1 antibody, in patients with refractory metastatic urothelial carcinoma: results from a multicenter, phase Ib study
    • PID: 28375787
    • Apolo AB, Infante JR, Balmanoukian A, et al. Avelumab, an anti-programmed death-ligand 1 antibody, in patients with refractory metastatic urothelial carcinoma: results from a multicenter, phase Ib study. J Clin Oncol. 2017. doi:10.1200/jco.2016.71.6795.
    • (2017) J Clin Oncol
    • Apolo, A.B.1    Infante, J.R.2    Balmanoukian, A.3
  • 44
    • 0033857218 scopus 로고    scopus 로고
    • Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study
    • PID: 11001674
    • von der Maase H, Hansen SW, Roberts JT, et al. Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study. J Clin Oncol. 2000;18(17):3068–77. doi:10.1200/JCO.2000.18.17.3068.
    • (2000) J Clin Oncol. , vol.18 , Issue.17 , pp. 3068-3077
    • von der Maase, H.1    Hansen, S.W.2    Roberts, J.T.3
  • 45
    • 0035873915 scopus 로고    scopus 로고
    • Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor vs. classic MVAC in advanced urothelial tract tumors: European Organization for Research and Treatment of Cancer Protocol No. 30924
    • COI: 1:CAS:528:DC%2BD3MXkt1Omu78%3D, PID: 11352955
    • Sternberg CN, Mulder PHD, Schornagel JH, et al. Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor vs. classic MVAC in advanced urothelial tract tumors: European Organization for Research and Treatment of Cancer Protocol No. 30924. J Clin Oncol. 2001;19(10):2638–46. doi:10.1200/jco.2001.19.10.2638.
    • (2001) J Clin Oncol , vol.19 , Issue.10 , pp. 2638-2646
    • Sternberg, C.N.1    Mulder, P.H.D.2    Schornagel, J.H.3
  • 46
    • 84863897662 scopus 로고    scopus 로고
    • Randomized phase III study comparing paclitaxel/cisplatin/gemcitabine and gemcitabine/cisplatin in patients with locally advanced or metastatic urothelial cancer without prior systemic therapy: EORTC intergroup study 30987
    • COI: 1:CAS:528:DC%2BC38XntVOqtb0%3D
    • Bellmunt J, Maase HVD, Mead GM, et al. Randomized phase III study comparing paclitaxel/cisplatin/gemcitabine and gemcitabine/cisplatin in patients with locally advanced or metastatic urothelial cancer without prior systemic therapy: EORTC intergroup study 30987. J Clin Onc. 2012;30(10):1107–13. doi:10.1200/jco.2011.38.6979.
    • (2012) J Clin Onc. , vol.30 , Issue.10 , pp. 1107-1113
    • Bellmunt, J.1    Maase, H.V.D.2    Mead, G.M.3
  • 47
    • 84855583390 scopus 로고    scopus 로고
    • Randomized phase II/III trial assessing gemcitabine/carboplatin and methotrexate/carboplatin/vinblastine in patients with advanced urothelial cancer who are unfit for cisplatin-based chemotherapy: EORTC Study 30986
    • PID: 22162575
    • Santis MD, Bellmunt J, Mead G, et al. Randomized phase II/III trial assessing gemcitabine/carboplatin and methotrexate/carboplatin/vinblastine in patients with advanced urothelial cancer who are unfit for cisplatin-based chemotherapy: EORTC Study 30986. J Clin Oncol. 2011;30(2):191–9. doi:10.1200/jco.2011.37.3571.
    • (2011) J Clin Oncol. , vol.30 , Issue.2 , pp. 191-199
    • Santis, M.D.1    Bellmunt, J.2    Mead, G.3
  • 48
    • 84959923381 scopus 로고    scopus 로고
    • Vinflunine–gemcitabine vs. vinflunine–carboplatin as first-line chemotherapy in cisplatin-unfit patients with advanced urothelial carcinoma: results of an international randomized phase II trial (JASINT1)
    • PID: 26673352
    • Santis MD, Wiechno PJ, Bellmunt J, et al. Vinflunine–gemcitabine vs. vinflunine–carboplatin as first-line chemotherapy in cisplatin-unfit patients with advanced urothelial carcinoma: results of an international randomized phase II trial (JASINT1). Ann Oncol. 2015;27(3):449–54. doi:10.1093/annonc/mdv609.
    • (2015) Ann Oncol , vol.27 , Issue.3 , pp. 449-454
    • Santis, M.D.1    Wiechno, P.J.2    Bellmunt, J.3
  • 49
    • 75149128685 scopus 로고    scopus 로고
    • Phase III trial of vinflunine plus best supportive care compared with best supportive care alone after a platinum-containing regimen in patients with advanced transitional cell carcinoma of the urothelial tract
    • COI: 1:CAS:528:DC%2BD1MXhtlCnsrfI, PID: 19687335
    • Bellmunt J, Theodore C, Demkov T, et al. Phase III trial of vinflunine plus best supportive care compared with best supportive care alone after a platinum-containing regimen in patients with advanced transitional cell carcinoma of the urothelial tract. J Clin Oncol. 2009;27(27):4454–61. doi:10.1200/jco.2008.20.5534.
    • (2009) J Clin Oncol. , vol.27 , Issue.27 , pp. 4454-4461
    • Bellmunt, J.1    Theodore, C.2    Demkov, T.3
  • 50
    • 85020600312 scopus 로고    scopus 로고
    • Pembrolizumab as first-line therapy in cisplatin-ineligible advanced urothelial cancer: results from the total KEYNOTE-052 study population. [abstract no. 284]
    • Balar AV, Castellano DE, O’Donnell PH, et al. Pembrolizumab as first-line therapy in cisplatin-ineligible advanced urothelial cancer: results from the total KEYNOTE-052 study population. [abstract no. 284]. In: ASCO Genitourinary Cancers Symposium, 2017.
    • (2017) ASCO Genitourinary Cancers Symposium
    • Balar, A.V.1    Castellano, D.E.2    O’Donnell, P.H.3
  • 51
    • 84925969186 scopus 로고    scopus 로고
    • Association of PD-L1 expression on tumor-infiltrating mononuclear cells and overall survival in patients with urothelial carcinoma
    • COI: 1:STN:280:DC%2BC2MvnsFOjug%3D%3D, PID: 25600565
    • Bellmunt J, Mullane SA, Werner L, et al. Association of PD-L1 expression on tumor-infiltrating mononuclear cells and overall survival in patients with urothelial carcinoma. Ann Oncol. 2015;26(4):812–7. doi:10.1093/annonc/mdv009.
    • (2015) Ann Oncol , vol.26 , Issue.4 , pp. 812-817
    • Bellmunt, J.1    Mullane, S.A.2    Werner, L.3
  • 52
    • 84897022815 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of urothelial bladder carcinoma
    • COI: 1:CAS:528:DC%2BC2cXks1Wjtbo%3D
    • Weinstein JN, Akbani R, Broom BM, et al. Comprehensive molecular characterization of urothelial bladder carcinoma. Nature. 2014;507(7492):315–22. doi:10.1038/nature12965.
    • (2014) Nature , vol.507 , Issue.7492 , pp. 315-322
    • Weinstein, J.N.1    Akbani, R.2    Broom, B.M.3
  • 53
    • 84979763259 scopus 로고    scopus 로고
    • Molecular drivers of the non-T-cell-inflamed tumor microenvironment in urothelial bladder cancer
    • COI: 1:CAS:528:DC%2BC28XhtVyitLnK, PID: 27197067
    • Sweis RF, Spranger S, Bao R, et al. Molecular drivers of the non-T-cell-inflamed tumor microenvironment in urothelial bladder cancer. Cancer Immunol Res. 2016;4(7):563–8. doi:10.1158/2326-6066.cir-15-0274.
    • (2016) Cancer Immunol Res , vol.4 , Issue.7 , pp. 563-568
    • Sweis, R.F.1    Spranger, S.2    Bao, R.3
  • 54
    • 85020597554 scopus 로고    scopus 로고
    • PD-L1 expression, Cancer Genome Atlas (TCGA) subtype, and mutational load as independent predictors of response to atezolizumab (atezo) in metastatic urothelial carcinoma (mUC, IMvigor210). [supplement; abstract no. 104]
    • Rosenberg JE, Petrylak DP, Van Der Heijden MS, et al. PD-L1 expression, Cancer Genome Atlas (TCGA) subtype, and mutational load as independent predictors of response to atezolizumab (atezo) in metastatic urothelial carcinoma (mUC, IMvigor210). [supplement; abstract no. 104]. In: ASCO Annual Meeting; 2016.
    • (2016) ASCO Annual Meeting
    • Rosenberg, J.E.1    Petrylak, D.P.2    Van Der Heijden, M.S.3
  • 55
    • 84946615376 scopus 로고    scopus 로고
    • Comprehensive cancer-gene panels can be used to estimate mutational load and predict clinical benefit to PD-1 blockade in clinical practice
    • PID: 26439694
    • Campesato LF, Barroso-Sousa R, Jimenez L, et al. Comprehensive cancer-gene panels can be used to estimate mutational load and predict clinical benefit to PD-1 blockade in clinical practice. Oncotarget. 2015;6(33):34221–7. doi:10.18632/oncotarget.5950.
    • (2015) Oncotarget. , vol.6 , Issue.33 , pp. 34221-34227
    • Campesato, L.F.1    Barroso-Sousa, R.2    Jimenez, L.3
  • 56
    • 84936821508 scopus 로고    scopus 로고
    • Association of response to programmed death receptor 1 (PD-1) blockade with pembrolizumab (MK-3475) with an interferon-inflammatory immune gene signature. [supplement; abstract no. 3001]
    • Ribas A, Robert C, Hodi FS, et al. Association of response to programmed death receptor 1 (PD-1) blockade with pembrolizumab (MK-3475) with an interferon-inflammatory immune gene signature. [supplement; abstract no. 3001]. In: ASCO Annual Meeting; 2015.
    • (2015) ASCO Annual Meeting
    • Ribas, A.1    Robert, C.2    Hodi, F.S.3
  • 57
    • 85009701352 scopus 로고    scopus 로고
    • Pembrolizumab (pembro) as first-line therapy for advanced/unresectable or metastatic urothelial cancer: preliminary results from the phase 2 KEYNOTE-052 study
    • Balar A, Bellmunt J, O’Donnell PH, et al. Pembrolizumab (pembro) as first-line therapy for advanced/unresectable or metastatic urothelial cancer: preliminary results from the phase 2 KEYNOTE-052 study. In: ESMO Annual Meeting; 2016.
    • (2016) ESMO Annual Meeting
    • Balar, A.1    Bellmunt, J.2    O’Donnell, P.H.3
  • 58
    • 85021763091 scopus 로고    scopus 로고
    • Efficacy and safety of nivolumab plus ipilimumab in previously treated metastatic urothelial carcinoma: first results from the phase I/II Check Mate 032 study
    • Sharma P, Callahan MK, Calvo E et al. Efficacy and safety of nivolumab plus ipilimumab in previously treated metastatic urothelial carcinoma: first results from the phase I/II Check Mate 032 study. In: 2016 SITC Annual Meeting; November 9–13, 2016.
    • (2016) 2016 SITC Annual Meeting; November , pp. 9-13
    • Sharma, P.1    Callahan, M.K.2    Calvo, E.3
  • 59
    • 85020564741 scopus 로고    scopus 로고
    • Cancer.gov. Published June 7 2016
    • FDA approves new immunotherapy drug for bladder cancer. Cancer.gov. https://www.cancer.gov/news-events/cancer-currents-blog/2016/fda-atezolizumab-bladder. Published June 7 2016.
    • (2016) FDA approves new immunotherapy drug for bladder cancer.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.