Biotin interference in immunoassays mimicking subclinical Graves' disease and hyperestrogenism: A case series

Clinical Chemistry and Laboratory Medicine

Volumn 55, Issue 6, 2017, Pages e99-e103

  Batista, Marcelo C ^a   Ferreira, Carlos E S ^a,b   Faulhaber, Adriana C L ^a   Hidal, Jairo T ^a   Lottenberg, Simão A ^a   Mangueira, Cristóvão L P ^a  

^a HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

analytical interference; biotin; Graves' disease; hyperestrogenism; immunoassay

Indexed keywords

ALPHA FETOPROTEIN; BIOTIN; C PEPTIDE; CA 125 ANTIGEN; CA 15-3 ANTIGEN; CA 19-9 ANTIGEN; CA 72-4 ANTIGEN; CARCINOEMBRYONIC ANTIGEN; CYANOCOBALAMIN; ESTRADIOL; ESTROGEN; FOLIC ACID; FOLLITROPIN; HYDROCORTISONE; INSULIN; IODINE 123; LIOTHYRONINE; LUTEINIZING HORMONE; PARATHYROID HORMONE; PRASTERONE SULFATE; PROGESTERONE; PROLACTIN; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; THYROGLOBULIN; THYROGLOBULIN ANTIBODY; THYROID PEROXIDASE ANTIBODY; THYROTROPIN; THYROTROPIN RECEPTOR ANTIBODY; THYROXINE; ANTIBODY; DIAGNOSTIC KIT; THYROTROPIN RECEPTOR;

ADULT; AGED; ASYMPTOMATIC DISEASE; BREAST TENDERNESS; CLINICAL ARTICLE; CLINICAL EVALUATION; DIAGNOSTIC TEST; DISORDERS OF HORMONE METABOLISM; DOPPLER ULTRASONOGRAPHY; DRUG WITHDRAWAL; ECHOGRAPHY; ENDOCRINE FUNCTION TEST; ESTROGEN THERAPY; FEMALE; FOLLOW UP; GRANULOSA CELL TUMOR; GRAVES DISEASE; HAIR LOSS; HUMAN; HYPERESTROGENISM; IMMUNOASSAY; INGESTION; LETTER; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; MENOPAUSE; MIDDLE AGED; PELVIS RADIOGRAPHY; PHYSICAL EXAMINATION; PRIORITY JOURNAL; SIDE EFFECT; THECOMA; THYROID NODULE; THYROID SCINTISCANNING; VASCULARIZATION; VITAMIN INTAKE; VITAMIN SUPPLEMENTATION; BLOOD; CHEMISTRY; DIAGNOSTIC ERROR; DIAGNOSTIC KIT; DIETARY SUPPLEMENT; IMMUNOLOGY; METABOLISM; STANDARDS; YOUNG ADULT;

ADULT; AGED; ANTIBODIES; BIOTIN; DIAGNOSTIC ERRORS; DIETARY SUPPLEMENTS; ESTRADIOL; FEMALE; GRAVES DISEASE; HUMANS; IMMUNOASSAY; MALE; MIDDLE AGED; REAGENT KITS, DIAGNOSTIC; RECEPTORS, THYROTROPIN; YOUNG ADULT;

EID: 85019139864     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm-2016-0628     Document Type: Letter

References (10)

1. Zempleni J, Mock DM. Biotin biochemistry and human requirements. J Nutr Biochem 1999;10:128-38.
2. European Commission, Scientific Committee on Food (ECSCF). 2001. Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of Biotin. European Commission, SCF/CS/NUT/ UPPLEV/55 Final Report. Brussels. Available at: http://ec.europa.eu/food/fs/sc/scf/out106-en.pdf. Accessed: 20 Aug 2016.
3. Barbesino G. Misdiagnosis of Graves' Disease with apparent severe hyperthyroidism in a patient taking biotin megadoses. Thyroid 2016;26:860-3.
4. Elston MS, Sehgal S, Du Toit S, Yarndley T, Conaglen JV. Factitious Graves' disease due to biotin immunoassay interference-a case and review of the literature. J Clin Endocrinol Metab 2016;101:3251-5.
5. Kummer S, Hermsen D, Distelmaier F. Biotin treatment mimicking Graves' disease. N Engl J Med 2016;375:704-6.
6. Diamandis EP, Christopoulos TK. The biotin-(strept)avidin system: principles and applications in biotechnology. Clin Chem 1991;37:625-36.
7. Wijeratne NG, Doery JC, Lu ZX. Positive and negative interference in immunoassays following biotin ingestion: a pharmacokinetic study. Pathology 2012;44:674-5.
8. Kwok JS, Chan IH, Chan MH. Biotin interference on TSH and free thyroid hormone measurement. Pathology 2012; 44:278-80.
9. Meany DL, Jan de Beur SM, Bill MJ, Sokoll LJ. A case of renal osteodystrophy with unexpected serum intact parathyroid hormone concentrations. Clin Chem 2009;55:1737-41.
10. Waghray A, Milas M, Nyalakonda K, Siperstein AE. Falsely low parathyroid hormone secondary to biotin interference: a case series. Endocr Pract 2013;19:451-5.