Short communication: Small-molecule CD4 mimetics sensitize HIV-1-infected cells to antibody-dependent cellular cytotoxicity by antibodies elicited by multiple envelope glycoprotein immunogens in nonhuman primates

AIDS Research and Human Retroviruses

Volumn 33, Issue 5, 2017, Pages 428-431

  Ding, Shilei ^a,b   Verly, Myriam M ^a,c   Princiotto, Amy ^d,e   Melillo, Bruno ^f   Moody, Anthony M ^g   Bradley, Todd ^g   Easterhoff, David ^g   Roger, Michel ^a,b   Hahn, Beatrice H ^h   Madani, Navid ^d,e   Smith, Amos B ^f   Haynes, Barton F ^g   Sodroski, Joseph ^d,e,i   Finzi, Andrés ^a,b,c  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

^g DUKE UNIVERSITY MEDICAL CENTER   (United States)

^h UNIVERSITY OF PENNSYLVANIA   (United States)

ⁱ HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

ADCC; CD4 mimetics; Env; HIV 1; Neutralization; Nonneutralizing antibodies

Indexed keywords

ANTIBODY; ANTIGEN; GLYCOPROTEIN; CD4 ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; ASSAY; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; NONHUMAN; PRIMATE; PRIORITY JOURNAL; VIRUS NEUTRALIZATION; VIRUS PARTICLE; ANIMAL; BIOMIMETICS; FLOW CYTOMETRY; IMMUNOLOGY; METABOLISM; RHESUS MONKEY; VIROLOGY;

ANIMALS; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; BIOMIMETICS; CD4 ANTIGENS; CD4-POSITIVE T-LYMPHOCYTES; FLOW CYTOMETRY; HIV ANTIBODIES; HIV-1; MACACA MULATTA;

EID: 85019133998     PISSN: 08892229     EISSN: 19318405     Source Type: Journal    
DOI: 10.1089/aid.2016.0246     Document Type: Article

References (9)

1. Veillette M, Coutu M, Richard J, et al.: The HIV-1 gp120 CD4-Bound conformation is preferentially targeted by antibody-dependent cellular cytotoxicity-mediating antibodies in sera from HIV-1-infected individuals. J Virol 2015;89: 545-551.
2. Veillette M, Desormeaux A, Medjahed H, et al.: Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicity. J Virol 2014;88: 2633-2644.
3. Ding S, Veillette M, Coutu M, et al.: A highly conserved residue of the HIV-1 gp120 inner domain is important for antibody-dependent cellular cytotoxicity responses mediated by anti-cluster A antibodies. J Virol 2016;90: 2127-2134.
4. Richard J, Veillette M, Brassard N, et al.: CD4 mimetics sensitize HIV-1-infected cells to ADCC. Proc Natl Acad Sci U S A 2015;112: E2687-E2694.
5. Richard J, Veillette M, Ding S, et al.: Small CD4 mimetics prevent HIV-1 uninfected bystander CD4 + T cell killing mediated by antibody-dependent cell-mediated cytotoxicity. EBioMedicine 2016;3: 122-134.
6. Madani N, Princiotto AM, Easterhoff D, et al.: Antibodies elicited by multiple envelope glycoprotein immunogens in primates neutralize primary human immunodeficiency viruses (HIV-1) sensitized by CD4-mimetic compounds. J Virol 2016;90: 5031-5046.
7. Wiehe K, Easterhoff D, Luo K, et al.: Antibody light-chainrestricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved. Immunity 2014;41: 909-918.
8. Melillo B, Liang S, Park J, et al.: Small-molecule CD4-mimics: Structure-based optimization of HIV-1 entry inhibition. ACS Med Chem Lett 2016;7: 330-334.
9. Richard J, Veillette M, Batraville LA, et al.: Flow cytometrybased assay to study HIV-1 gp120 specific antibody-dependent cellular cytotoxicity responses. J Virol Methods 2014;208: 107-114.