Truncating Variants in Titin Independently Predict Early Arrhythmias in Patients With Dilated Cardiomyopathy

Journal of the American College of Cardiology

Volumn 69, Issue 19, 2017, Pages 2466-2468

  Tayal, Upasana ^a   Newsome, Simon ^a   Buchan, Rachel ^a   Whiffin, Nicola ^a   Walsh, Roddy ^a   Barton, Paul J ^a   Ware, James S ^a   Cook, Stuart A ^a   Prasad, Sanjay K ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CONNECTIN;

ADULT; ATRIAL FIBRILLATION; CONGESTIVE CARDIOMYOPATHY; EXON; FAMILY HISTORY; FEMALE; GENETIC RISK; GENETIC VARIABILITY; HEART ARRHYTHMIA; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE FIBROSIS; HEART VENTRICLE TACHYCARDIA; HUMAN; LETTER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SUDDEN CARDIAC DEATH; COMPLICATION; GENETICS; METABOLISM; MIDDLE AGED; MUTATION; PROGNOSIS; TIME FACTOR;

ARRHYTHMIAS, CARDIAC; CARDIOMYOPATHY, DILATED; CONNECTIN; FEMALE; HUMANS; MALE; MIDDLE AGED; MUTATION; PROGNOSIS; TIME FACTORS;

EID: 85019097365     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2017.03.530     Document Type: Letter

References (3)

1. 1 Spezzacatene, A., Sinagra, G., Merlo, M., et al. Arrhythmogenic Phenotype in dilated cardiomyopathy: natural history and predictors of life-threatening arrhythmias. J Am Heart Assoc, 4, 2015, e002149.
2. 2 Herman, D.S., Lam, L., Taylor, M.R., et al. Truncations of titin causing dilated cardiomyopathy. N Engl J Med 366 (2012), 619–628.
3. 3 Roberts, A.M., Ware, J.S., Herman, D.S., et al. Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease. Sci Transl Med, 7, 2015, 270ra6.