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Volumn 53, Issue 1, 2017, Pages 73-84

Intentional Misuse and Abuse of Loperamide: A New Look at a Drug with “Low Abuse Potential”

Author keywords

drug abuse; loperamide; opioid dependence; P glycoprotein

Indexed keywords

LOPERAMIDE; OPIATE; NARCOTIC ANALGESIC AGENT;

EID: 85019090288     PISSN: 07364679     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jemermed.2017.03.018     Document Type: Article
Times cited : (28)

References (39)
  • 1
    • 0024651845 scopus 로고
    • Dinner with De Quincey. Loperamide overdose
    • Mack, R.B., Dinner with De Quincey. Loperamide overdose. NC Med J 50 (1989), 204–206.
    • (1989) NC Med J , vol.50 , pp. 204-206
    • Mack, R.B.1
  • 2
    • 37849050550 scopus 로고    scopus 로고
    • Loperamide: a pharmacological review
    • Baker, D.E., Loperamide: a pharmacological review. Rev Gastroenterol Disord 7 (2007), S11–S18.
    • (2007) Rev Gastroenterol Disord , vol.7 , pp. S11-S18
    • Baker, D.E.1
  • 3
    • 0016261115 scopus 로고
    • Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 5: the pharmacokinetics of loperamide in rats and man
    • Heykants, J., Michiels, M., Knaeps, A., Brugmans, J., Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 5: the pharmacokinetics of loperamide in rats and man. Arzneimittelforschung 24 (1974), 1649–1653.
    • (1974) Arzneimittelforschung , vol.24 , pp. 1649-1653
    • Heykants, J.1    Michiels, M.2    Knaeps, A.3    Brugmans, J.4
  • 4
    • 0029145596 scopus 로고
    • Bioequivalence evaluation of 2 different oral formulations of loperamide (Diarex-Lactab vs Imodium capsules)
    • Doser, K., Meyer, B., Nitsche, V., Binkert-Graber, P., Bioequivalence evaluation of 2 different oral formulations of loperamide (Diarex-Lactab vs Imodium capsules). Int J Clin Pharmacol Ther 33 (1995), 431–436.
    • (1995) Int J Clin Pharmacol Ther , vol.33 , pp. 431-436
    • Doser, K.1    Meyer, B.2    Nitsche, V.3    Binkert-Graber, P.4
  • 5
    • 0017723118 scopus 로고
    • Studies on the elimination rate of loperamide in man after administration of increasing oral doses of Imodium
    • Weintraub, H.S., Killinger, J.M., Heykants, J., Kanzler, M., Jaffe, J.H., Studies on the elimination rate of loperamide in man after administration of increasing oral doses of Imodium. Curr Ther Res 21 (1977), 867–876.
    • (1977) Curr Ther Res , vol.21 , pp. 867-876
    • Weintraub, H.S.1    Killinger, J.M.2    Heykants, J.3    Kanzler, M.4    Jaffe, J.H.5
  • 6
    • 1642579542 scopus 로고    scopus 로고
    • Variable modulation of opioid brain uptake by P-glycoprotein in mice
    • Dagenais, C., Graff, C.L., Pollack, G.M., Variable modulation of opioid brain uptake by P-glycoprotein in mice. Biochem Pharmacol 67 (2004), 269–276.
    • (2004) Biochem Pharmacol , vol.67 , pp. 269-276
    • Dagenais, C.1    Graff, C.L.2    Pollack, G.M.3
  • 7
    • 85026797811 scopus 로고    scopus 로고
    • Drug interactions with digoxin: the role of P-glycoprotein. Pharmacy Times 2004. Available at: Accessed March 26
    • Horn JR, Hansten PD. Drug interactions with digoxin: the role of P-glycoprotein. Pharmacy Times 2004. Available at: http://www.pharmacytimes.com/publications/issue/2004/2004-10/2004-10-4618. Accessed March 26, 2017.
    • (2017)
    • Horn, J.R.1    Hansten, P.D.2
  • 8
    • 0031042571 scopus 로고    scopus 로고
    • Surveillance of loperamide ingestions: an analysis of 216 poison center reports
    • Litovitz, T., Clancy, C., Korberly, B., Temple, A.R., Mann, K.V., Surveillance of loperamide ingestions: an analysis of 216 poison center reports. J Toxicol Clin Toxicol 35 (1997), 11–19.
    • (1997) J Toxicol Clin Toxicol , vol.35 , pp. 11-19
    • Litovitz, T.1    Clancy, C.2    Korberly, B.3    Temple, A.R.4    Mann, K.V.5
  • 9
    • 0025092206 scopus 로고
    • Loperamide poisoning in children
    • Bhutta, T.I., Tahir, K.I., Loperamide poisoning in children. Lancet, 335, 1990, 363.
    • (1990) Lancet , vol.335 , pp. 363
    • Bhutta, T.I.1    Tahir, K.I.2
  • 10
    • 0018893134 scopus 로고
    • Loperamide in “toddler diarrhoea”
    • Marcovitch, H., Loperamide in “toddler diarrhoea”. Lancet, 1, 1980, 1413.
    • (1980) Lancet , vol.1 , pp. 1413
    • Marcovitch, H.1
  • 11
    • 84980271066 scopus 로고
    • Loperamide toxicity in an infant
    • Tan, S.H., Loperamide toxicity in an infant. Aust Paediatr J, 19, 1983, 55.
    • (1983) Aust Paediatr J , vol.19 , pp. 55
    • Tan, S.H.1
  • 12
    • 0021091350 scopus 로고
    • Loperamide intoxication in a baby
    • Tan, S.H., Loperamide intoxication in a baby. Singapore Med J 24 (1983), 227–228.
    • (1983) Singapore Med J , vol.24 , pp. 227-228
    • Tan, S.H.1
  • 13
    • 84923400734 scopus 로고    scopus 로고
    • Ventricular tachycardia storm – can it be a side effect from over the counter anti-diarrheal? (Abstract #1204)
    • Boppana, V.S., Kahlon, A., Bhatta, L., Ventricular tachycardia storm – can it be a side effect from over the counter anti-diarrheal? (Abstract #1204). Crit Care Med 40 (2012), 1–328.
    • (2012) Crit Care Med , vol.40 , pp. 1-328
    • Boppana, V.S.1    Kahlon, A.2    Bhatta, L.3
  • 14
    • 84893784190 scopus 로고    scopus 로고
    • Loperamide overdose-induced catatonia: potential role of brain opioid system and P-glycoprotein
    • Di Rosa, E., Di Rosa, A.E., Loperamide overdose-induced catatonia: potential role of brain opioid system and P-glycoprotein. Acta Neuropsychiatrica 26 (2014), 58–60.
    • (2014) Acta Neuropsychiatrica , vol.26 , pp. 58-60
    • Di Rosa, E.1    Di Rosa, A.E.2
  • 15
    • 84964692757 scopus 로고    scopus 로고
    • Loperamide abuse associated with cardiac dysrhythmia and death
    • Eggleston, W., Clark, K.H., Marraffa, J.M., Loperamide abuse associated with cardiac dysrhythmia and death. Ann Emerg Med 69 (2017), 83–86.
    • (2017) Ann Emerg Med , vol.69 , pp. 83-86
    • Eggleston, W.1    Clark, K.H.2    Marraffa, J.M.3
  • 17
    • 84960373922 scopus 로고    scopus 로고
    • Ventricular dysrhythmias from loperamide misuse
    • Lasoff, D.R., Schneir, A., Ventricular dysrhythmias from loperamide misuse. J Emerg Med 50 (2016), 508–509.
    • (2016) J Emerg Med , vol.50 , pp. 508-509
    • Lasoff, D.R.1    Schneir, A.2
  • 18
    • 84910039997 scopus 로고    scopus 로고
    • Cardiac conduction disturbance after loperamide abuse
    • Marraffa, J.M., Holland, M.G., Sullivan, R.W., et al. Cardiac conduction disturbance after loperamide abuse. Clin Toxicol (Phila) 52 (2014), 952–957.
    • (2014) Clin Toxicol (Phila) , vol.52 , pp. 952-957
    • Marraffa, J.M.1    Holland, M.G.2    Sullivan, R.W.3
  • 19
    • 85026810072 scopus 로고    scopus 로고
    • Syncope and recurrent polymorphic ventricular tachycardia following loperamide misuse (Abstract # 174)
    • Marraffa, J.M., Holland, M.G., Sullivan, R.W., Seabury, R., Hodgman, M.J., Syncope and recurrent polymorphic ventricular tachycardia following loperamide misuse (Abstract # 174). Clin Toxicol (Phila), 51, 2013, 653.
    • (2013) Clin Toxicol (Phila) , vol.51 , pp. 653
    • Marraffa, J.M.1    Holland, M.G.2    Sullivan, R.W.3    Seabury, R.4    Hodgman, M.J.5
  • 21
    • 84923426197 scopus 로고    scopus 로고
    • Ventricular tachycardia associated with high-dose chronic loperamide use
    • Spinner, H.L., Lonardo, N.W., Mulamalla, R., Stehlik, J., Ventricular tachycardia associated with high-dose chronic loperamide use. Pharmacotherapy 35 (2015), 234–238.
    • (2015) Pharmacotherapy , vol.35 , pp. 234-238
    • Spinner, H.L.1    Lonardo, N.W.2    Mulamalla, R.3    Stehlik, J.4
  • 23
    • 20844434515 scopus 로고    scopus 로고
    • Impact of gastric acid suppressants on cytochrome P450 3A4 and P-glycoprotein: consequences for FK506 assimilation
    • Lemahieu, W.P., Maes, B.D., Verbeke, K., Vanrenterghem, Y., Impact of gastric acid suppressants on cytochrome P450 3A4 and P-glycoprotein: consequences for FK506 assimilation. Kidney Int 67 (2005), 1152–1160.
    • (2005) Kidney Int , vol.67 , pp. 1152-1160
    • Lemahieu, W.P.1    Maes, B.D.2    Verbeke, K.3    Vanrenterghem, Y.4
  • 24
    • 84871890217 scopus 로고    scopus 로고
    • 2011 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 29th Annual Report
    • Bronstein, A.C., Spyker, D.A., Cantilena, L.R. Jr., Rumack, B.H., Dart, R.C., 2011 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 29th Annual Report. Clin Toxicol (Phila) 50 (2012), 911–1164.
    • (2012) Clin Toxicol (Phila) , vol.50 , pp. 911-1164
    • Bronstein, A.C.1    Spyker, D.A.2    Cantilena, L.R.3    Rumack, B.H.4    Dart, R.C.5
  • 25
    • 84894450063 scopus 로고    scopus 로고
    • 2012 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 30th Annual Report
    • Mowry, J.B., Spyker, D.A., Cantilena, L.R. Jr., Bailey, J.E., Ford, M., 2012 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 30th Annual Report. Clin Toxicol (Phila) 51 (2013), 949–1229.
    • (2013) Clin Toxicol (Phila) , vol.51 , pp. 949-1229
    • Mowry, J.B.1    Spyker, D.A.2    Cantilena, L.R.3    Bailey, J.E.4    Ford, M.5
  • 26
    • 84923006251 scopus 로고    scopus 로고
    • 2013 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 31st Annual Report
    • Mowry, J.B., Spyker, D.A., Cantilena, L.R. Jr., McMillan, N., Ford, M., 2013 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 31st Annual Report. Clin Toxicol (Phila) 52 (2014), 1032–1283.
    • (2014) Clin Toxicol (Phila) , vol.52 , pp. 1032-1283
    • Mowry, J.B.1    Spyker, D.A.2    Cantilena, L.R.3    McMillan, N.4    Ford, M.5
  • 27
    • 84948734595 scopus 로고    scopus 로고
    • 2014 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 32nd Annual Report
    • Mowry, J.B., Spyker, D.A., Brooks, D.E., McMillan, N., Schauben, J.L., 2014 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 32nd Annual Report. Clin Toxicol (Phila) 53 (2015), 962–1147.
    • (2015) Clin Toxicol (Phila) , vol.53 , pp. 962-1147
    • Mowry, J.B.1    Spyker, D.A.2    Brooks, D.E.3    McMillan, N.4    Schauben, J.L.5
  • 28
    • 73949122010 scopus 로고    scopus 로고
    • 2008 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 26th Annual Report
    • Bronstein, A.C., Spyker, D.A., Cantilena, L.R. Jr., Green, J.L., Rumack, B.H., Giffin, S.L., 2008 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 26th Annual Report. Clin Toxicol (Phila) 47 (2009), 911–1084.
    • (2009) Clin Toxicol (Phila) , vol.47 , pp. 911-1084
    • Bronstein, A.C.1    Spyker, D.A.2    Cantilena, L.R.3    Green, J.L.4    Rumack, B.H.5    Giffin, S.L.6
  • 29
    • 78650932261 scopus 로고    scopus 로고
    • 2009 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 27th Annual Report
    • Bronstein, A.C., Spyker, D.A., Cantilena, L.R. Jr., Green, J.L., Rumack, B.H., Giffin, S.L., 2009 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 27th Annual Report. Clin Toxicol (Phila) 48 (2010), 979–1178.
    • (2010) Clin Toxicol (Phila) , vol.48 , pp. 979-1178
    • Bronstein, A.C.1    Spyker, D.A.2    Cantilena, L.R.3    Green, J.L.4    Rumack, B.H.5    Giffin, S.L.6
  • 30
    • 83655193152 scopus 로고    scopus 로고
    • 2010 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 28th Annual Report
    • Bronstein, A.C., Spyker, D.A., Cantilena, L.R., Green, J.L., Rumack, B.H., Dart, R.C., 2010 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 28th Annual Report. Clin Toxicol (Phila) 49 (2011), 910–941.
    • (2011) Clin Toxicol (Phila) , vol.49 , pp. 910-941
    • Bronstein, A.C.1    Spyker, D.A.2    Cantilena, L.R.3    Green, J.L.4    Rumack, B.H.5    Dart, R.C.6
  • 31
    • 85021127474 scopus 로고    scopus 로고
    • Cardiac conduction disturbances secondary to chronic abuse of loperamide: an initial case report
    • [Abstract]
    • Audi, J., Layher, I., Morgan, B., Cardiac conduction disturbances secondary to chronic abuse of loperamide: an initial case report. [Abstract] Clin Toxicol (Phila), 42, 2004, 722.
    • (2004) Clin Toxicol (Phila) , vol.42 , pp. 722
    • Audi, J.1    Layher, I.2    Morgan, B.3
  • 32
    • 85016252106 scopus 로고    scopus 로고
    • Loperamide induced torsades de pointes: a case report and review of the literature
    • Mukarram, O., Hindi, Y., Catalasan, G., Ward, J., Loperamide induced torsades de pointes: a case report and review of the literature. Case Rep Med, 2016, 2016, 4061980.
    • (2016) Case Rep Med , vol.2016 , pp. 4061980
    • Mukarram, O.1    Hindi, Y.2    Catalasan, G.3    Ward, J.4
  • 33
    • 85018405684 scopus 로고    scopus 로고
    • Adverse event detection using the FDA post-marketing drug safety surveillance system: cardiotoxicity associated with loperamide abuse and misuse
    • Swank, K.A., Wu, E., Kortepeter, C., McAninch, J., Levin, R.L., Adverse event detection using the FDA post-marketing drug safety surveillance system: cardiotoxicity associated with loperamide abuse and misuse. J Am Pharm Assoc 2003 57 (2017), S63–S67.
    • (2017) J Am Pharm Assoc 2003 , vol.57 , pp. S63-S67
    • Swank, K.A.1    Wu, E.2    Kortepeter, C.3    McAninch, J.4    Levin, R.L.5
  • 34
    • 84982097917 scopus 로고    scopus 로고
    • Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic
    • Kang, J., Compton, D.R., Vaz, R.J., Rampe, D., Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic. Naunyn Schmiedebergs Arch Pharmacol 389 (2016), 1133–1137.
    • (2016) Naunyn Schmiedebergs Arch Pharmacol , vol.389 , pp. 1133-1137
    • Kang, J.1    Compton, D.R.2    Vaz, R.J.3    Rampe, D.4
  • 35
    • 84877014785 scopus 로고    scopus 로고
    • “I just wanted to tell you that loperamide WILL WORK”: a web-based study of extra-medical use of loperamide
    • Daniulaityte, R., Carlson, R., Falck, R., et al. “I just wanted to tell you that loperamide WILL WORK”: a web-based study of extra-medical use of loperamide. Drug Alcohol Depend 130 (2013), 241–244.
    • (2013) Drug Alcohol Depend , vol.130 , pp. 241-244
    • Daniulaityte, R.1    Carlson, R.2    Falck, R.3
  • 36
    • 0033833430 scopus 로고    scopus 로고
    • Increased drug delivery to the brain by P-glycoprotein inhibition
    • Sadeque, A.J., Wandel, C., He, H., Shah, S., Wood, A.J., Increased drug delivery to the brain by P-glycoprotein inhibition. Clin Pharmacol Ther 68 (2000), 231–237.
    • (2000) Clin Pharmacol Ther , vol.68 , pp. 231-237
    • Sadeque, A.J.1    Wandel, C.2    He, H.3    Shah, S.4    Wood, A.J.5
  • 37
    • 84925355263 scopus 로고    scopus 로고
    • Vaccine-related Internet search activity predicts H1N1 and HPV vaccine coverage: implications for vaccine acceptance
    • Kalichman, S.C., Kegler, C., Vaccine-related Internet search activity predicts H1N1 and HPV vaccine coverage: implications for vaccine acceptance. J Health Commun 20 (2015), 259–265.
    • (2015) J Health Commun , vol.20 , pp. 259-265
    • Kalichman, S.C.1    Kegler, C.2
  • 39
    • 85026276223 scopus 로고    scopus 로고
    • Evaluating Google, Twitter, and Wikipedia as tools for influenza surveillance using Bayesian change point analysis: a comparative analysis
    • Sharpe, J.D., Hopkins, R.S., Cook, R.L., Striley, C.W., Evaluating Google, Twitter, and Wikipedia as tools for influenza surveillance using Bayesian change point analysis: a comparative analysis. JMIR Public Health Surveill, 2, 2016, e161.
    • (2016) JMIR Public Health Surveill , vol.2 , pp. e161
    • Sharpe, J.D.1    Hopkins, R.S.2    Cook, R.L.3    Striley, C.W.4


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