Prolonged Cold Ischemia Time Results in Local and Remote Organ Dysfunction in a Murine Model of Vascularized Composite Transplantation

American Journal of Transplantation

Volumn 17, Issue 10, 2017, Pages 2572-2579

  Datta, N ^a   Devaney, S G ^a   Busuttil, R W ^a   Azari, K ^a   Kupiec Weglinski, J W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

basic (laboratory) research science; immunobiology; organ perfusion and preservation; organ procurement and allocation; tissue injury and repair; vascularized composite and reconstructive transplantation

Indexed keywords

CD31 ANTIGEN; CREATINE KINASE; INTERLEUKIN 1ALPHA; INTERLEUKIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; AUTACOID; CYTOKINE;

ACUTE KIDNEY TUBULE NECROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; BLOOD VESSEL SHUNT; BODY WEIGHT; CELL INFILTRATION; COLD ISCHEMIA; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CRYOPRESERVATION; GRAFT RECIPIENT; GRAFT SURVIVAL; INNATE IMMUNITY; KIDNEY INJURY; LONG TERM SURVIVAL; MACROPHAGE; MALE; MOUSE; MUSCLE BIOPSY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; TIME; UREA NITROGEN BLOOD LEVEL; VASCULAR ENDOTHELIUM; VASCULARIZED COMPOSITE ALLOTRANSPLANTATION; ANIMAL; C57BL MOUSE; DISEASE MODEL; HINDLIMB; HUMAN; KIDNEY; METABOLISM; PROCEDURES; REPERFUSION INJURY; VASCULARIZATION;

ANIMALS; COLD ISCHEMIA; CYTOKINES; DISEASE MODELS, ANIMAL; HINDLIMB; HUMANS; INFLAMMATION MEDIATORS; KIDNEY; MALE; MICE; MICE, INBRED C57BL; REPERFUSION INJURY; VASCULARIZED COMPOSITE ALLOTRANSPLANTATION;

EID: 85019036499     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.14290     Document Type: Article

References (31)

1. Khalil A, Aziz F, Hall JC. Reperfusion injury. Plast Reconstr Surg 2006; 117: 1024–1033.
2. Wang WZ, Baynosa RC, Zamboni WA. Update on ischemia-reperfusion injury for the plastic surgeon: 2011. Plast Reconstr Surg 2011; 128: 685e–692e.
3. Mitchell RN. Learning from rejection: What transplantation teaches us about (other) vascular pathologies. J Autoimmun 2013; 45: 80–89.
4. Furukawa Y, Libby P, Stinn JL, Becker G, Mitchell RN. Cold ischemia induces isograft arteriopathy, but does not augment allograft arteriopathy in non- immunosuppressed hosts. Am J Pathol 2002; 160: 1077–1087.
5. Zhai Y, Petrowsky H, Hong JC, Busuttil RW, Kupiec-Weglinski JW. Ischaemia-reperfusion injury in liver transplantation–from bench to bedside. Nat Rev Gastroenterol Hepatol 2013; 10: 79–89.
6. Siemionow M, Arslan E. Ischemia/reperfusion injury: A review in relation to free tissue transfers. Microsurgery 2004; 24: 468–475.
7. Hinojosa Pérez R, Porras López M, Escoresca-Ortega AM, et al. Severe rhabdomyolysis after allogeneic transplantation of facial structures: A case report. Transplant Proc. 2010;42:3081–3082.
8. Zhai Y, Busuttil RW, Kupiec-Weglinski JW. Liver ischemia and reperfusion injury: New insights into mechanisms of innate-adaptive immune-mediated tissue inflammation. Am J Transplant 2011; 11: 1563–1569.
9. Arora S, Gullestad L. The challenge of allograft vasculopathy in cardiac transplantation. Curr Opin Organ Transplant 2014; 19: 508–514.
10. Dhaliwal A, Thohan V. Cardiac allograft vasculopathy: The Achilles’ heel of long- term survival after cardiac transplantation. Curr Atheroscler Rep 2006; 8: 119–130.
11. Türegün M, Güdemez E, Newman P, Zins J, Siemionow M. Blockade of platelet endothelial cell adhesion molecule-1 (PECAM-1) protects against ischemia- reperfusion injury in muscle flaps at microcirculatory level. Plast Reconstr Surg 1999; 104: 1033–1040.
12. Kaufman CL, Marvin MR, Chilton PM, et al. Immunobiology in VCA. Transpl Int 2016; 29: 644–654.
13. Unadkat JV, Schneeberger S, Horibe EH, et al. Composite tissue vasculopathy and degeneration following multiple episodes of acute rejection in reconstructive transplantation. Am J Transplant 2010; 10: 251–261.
14. Hautz T, Hickethier T, Blumer MJ, et al. Histomorphometric evaluation of ischemia-reperfusion injury and the effect of preservation solutions histidine-tryptophan-ketoglutarate and University of Wisconsin in limb transplantation. Transplantation 2014; 98: 713–720.
15. Sucher R, Lin CH, Zanoun R, et al. Mouse hind limb transplantation: A new composite tissue allotransplantation model using nonsuture supermicrosurgery. Transplantation 2010; 90: 1374–1380.
16. Okada M, Payne TR, Drowley L, et al. Human skeletal muscle cells with a slow adhesion rate after isolation and an enhanced stress resistance improve function of ischemic hearts. Mol Ther 2012; 20: 138–145.
17. Liapis H, Boils C, Hennigar R, Silva F. Myoglobin casts in renal biopsies: Immunohistochemistry and morphologic spectrum. Hum Pathol 2016; 54: 25–30.
18. Odeh M. The role of reperfusion-induced injury in the pathogenesis of the crush syndrome. N Engl J Med 1991; 324: 1417–1422.
19. Muller WA, Weigl SA, Deng X, Phillips DM. PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med 1993; 178: 449–460.
20. Privratsky JR, Newman DK, Newman PJ. PECAM-1: Conflicts of interest in inflammation. Life Sci 2010; 87: 69–82.
21. Mahooti S, Graesser D, Patil S, et al. PECAM-1 (CD31) expression modulates bleeding time in vivo. Am J Pathol 2000; 157: 75–81.
22. Carrithers M, Tandon S, Canosa S, Michaud M, Graesser D, Madri JA. Enhanced susceptibility to endotoxic shock and impaired STAT3 signaling in CD31-deficient mice. Am J Pathol 2005; 166: 185–196.
23. Maas M, Stapleton M, Bergom C, Mattson DL, Newman DK, Newman PJ. Endothelial cell PECAM-1 confers protection against endotoxic shock. Am J Physiol Heart Circ Physiol. 2005;288:H159–H164.
24. Winter DA. Biomechanics and motor control of human movement, 4th ed., Hoboken, NJ: John Wiley and Sons, 2005; p.82–106
25. Cohen J. The immunopathogenesis of sepsis. Nature 2002; 420: 885–891.
26. Shimizu F, Okamoto O, Katagiri K, Fujiwara S, Wei FC. Prolonged ischemia increases severity of rejection in skin flap allotransplantation in rats. Microsurgery 2010; 30: 132–137.
27. Couty JP, Rampon C, Leveque M, et al. PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells. J Neurochem 2007; 103: 793–801.
28. Goel R, Boylan B, Gruman L, Newman PJ, North PE, Newman DK. The proinflammatory phenotype of PECAM-1-deficient mice results in atherogenic diet-induced steatohepatitis. Am J Physiol Gastrointest Liver Physiol 2007; 293: G1205–G1214.
29. Khalifian S, Raimondi G, Brandacher G. The use of luminex assays to measure cytokines. J Invest Dermatol 2015; 135: e31.
30. Won JH, Goldberger O, Shen-Orr SS, Davis MM, Olshen RA. Significance analysis of xMap cytokine bead arrays. Proc Natl Acad Sci U S A 2012; 109: 2848–2853.
31. Chaturvedi AK, Kemp TJ, Pfeiffer RM, et al. Evaluation of multiplexed cytokine and inflammation marker measurements: A methodologic study. Cancer Epidemiol Biomark Prev. 2011;20:1902–1911.