Nasal high flow reduces dead space

Journal of Applied Physiology

Volumn 122, Issue 1, 2017, Pages 191-197

  Möller, Winfried ^a,b   Feng, Sheng ^c   Domanski, Ulrike ^d   Franke, Karl Josef ^d   Celik, Gülnaz ^a,b   Bartenstein, Peter ^e   Becker, Sven ^e   Meyer, Gabriele ^f   Schmid, Otmar ^a,b   Eickelberg, Oliver ^a,b,e   Tatkov, Stanislav ^c   Nilius, Georg ^d  

^a German Center for Lung Research   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c Fisher and Paykel Healthcare Limited   (New Zealand)

^d UNIVERSITY OF WITTEN HERDECKE   (Germany)

^e LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^f ASKLEPIOS FACHKLINIKEN MÜNCHEN GAUTING   (Germany)

Author keywords

Dead space; Krypton; Nasal high flow; Rebreathing; Respiratory support; Upper airways

Indexed keywords

CARBON DIOXIDE; OXYGEN;

BREATHING; CONTROLLED STUDY; CROSSOVER PROCEDURE; FEMALE; HUMAN; LUNG DEAD SPACE; LUNG VENTILATION; MALE; METABOLISM; MIDDLE AGED; NOSE; NOSE CAVITY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; TIDAL VOLUME; TRACHEA;

CARBON DIOXIDE; CROSS-OVER STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; NASAL CAVITY; NOSE; OXYGEN; PULMONARY VENTILATION; RESPIRATION; RESPIRATORY DEAD SPACE; TIDAL VOLUME; TRACHEA;

EID: 85018957454     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00584.2016     Document Type: Article

References (29)

1. Bräunlich J, Beyer D, Mai D, Hammerschmidt S, Seyfarth HJ, Wirtz H. Effects of nasal high flow on ventilation in volunteers, COPD and idiopathic pulmonary fibrosis patients. Respiration 85: 319–325, 2013. doi:10.1159/000342027.
2. Budweiser S, Baur T, Jörres RA, Kollert F, Pfeifer M, Heinemann F. Predictors of successful decannulation using a tracheostomy retainer in patients with prolonged weaning and persisting respiratory failure. Respiration 84: 469–476, 2012. doi:10.1159/000335740.
3. Cretikos MA, Bellomo R, Hillman K, Chen J, Finfer S, Flabouris A. Respiratory rate: the neglected vital sign. Med J Aust 188: 657–659, 2008.
4. Dysart K, Miller TL, Wolfson MR, Shaffer TH. Research in high flow therapy: mechanisms of action. Respir Med 103: 1400–1405, 2009. doi:10.1016/j.rmed.2009.04.007.
5. Fraser JF, Spooner AJ, Dunster KR, Anstey CM, Corley A. Nasal high flow oxygen therapy in patients with COPD reduces respiratory rate and tissue carbon dioxide while increasing tidal and end-expiratory lung volumes: a randomised crossover trial. Thorax 71: 759 –761, 2016. doi: 10.1136/thoraxjnl-2015-207962.
6. Frat J-P, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, Prat G, Boulain T, Morawiec E, Cottereau A, Devaquet J, Nseir S, Razazi K, Mira J-P, Argaud L, Chakarian J-C, Ricard J-D, Wittebole X, Chevalier S, Herbland A, Fartoukh M, Constantin J-M, Tonnelier J-M, Pierrot M, Mathonnet A, Béduneau G, Delétage-Métreau C, Richard J-CM, Brochard L, Robert R; FLORALI Study Group; REVA Network. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 372: 2185–2196, 2015. doi:10.1056/ NEJMoa1503326.
7. Frizzola M, Miller TL, Rodriguez ME, Zhu Y, Rojas J, Hesek A, Stump A, Shaffer TH, Dysart K. High-flow nasal cannula: impact on oxygenation and ventilation in an acute lung injury model. Pediatr Pulmonol 46: 67–74, 2011. doi:10.1002/ppul.21326.
8. Hart MC, Orzalesi MM, Cook CD, Relation between anatomic respiratory dead space and body size and lung volume. J Appl Physiol 18: 519–522, 1963.
9. Hutchings FA, Hilliard TN, Davis PJ. Heated humidified high-flow nasal cannula therapy in children. Arch Dis Child 100: 571–575, 2015. doi:10.1136/archdischild-2014-306590.
10. Kallet RH, Zhuo H, Liu KD, Calfee CS, Matthay MA; National Heart Lung and Blood Institute ARDS Network Investigators. The association between physiologic dead-space fraction and mortality in subjects with ARDS enrolled in a prospective multi-center clinical trial. Respir Care 59: 1611–1618, 2014. doi:10.4187/respcare.02593.
11. Kharitonov SA, Barnes PJ. Nasal contribution to exhaled nitric oxide during exhalation against resistance or during breath holding. Thorax 52: 540–544, 1997. doi:10.1136/thx.52.6.540.
12. Lee JH, Rehder KJ, Williford L, Cheifetz IM, Turner DA. Use of high flow nasal cannula in critically ill infants, children, and adults: a critical review of the literature. Intensive Care Med 39: 247–257, 2013. doi:10. 1007/s00134-012-2743-5.
13. Leino K, Nunes S, Valta P, Takala J. Validation of a new respiratory inductive plethysmograph. Acta Anaesthesiol Scand 45: 104–111, 2001. doi:10.1034/j.1399-6576.2001.450116.x.
14. Lewis S, Martin CJ. Characteristics of the washout dead space. Respir Physiol 36: 51–63, 1979. doi:10.1016/0034-5687(79)90014-8.
15. Maggiore SM, Idone FA, Vaschetto R, Festa R, Cataldo A, Antonicelli F, Montini L, De Gaetano A, Navalesi P, Antonelli M. Nasal high-flow versus Venturi mask oxygen therapy after extubation: effects on oxygenation, comfort, and clinical outcome. Am J Respir Crit Care Med 190: 282–288, 2014. doi:10.1164/rccm.201402-0364OC.
16. Manley BJ, Owen LS, Doyle LW, Andersen CC, Cartwright DW, Pritchard MA, Donath SM, Davis PG. High-flow nasal cannulae in very preterm infants after extubation. N Engl J Med 369: 1425–1433, 2013. doi:10.1056/NEJMoa1300071.
17. Mayfield S, Bogossian F, O’Malley L, Schibler A. High-flow nasal cannula oxygen therapy for infants with bronchiolitis: pilot study. J Paediatr Child Health 50: 373–378, 2014. doi:10.1111/jpc.12509.
18. McGinley BM, Patil SP, Kirkness JP, Smith PL, Schwartz AR, Schneider H. A nasal cannula can be used to treat obstructive sleep apnea. Am J Respir Crit Care Med 176: 194 –200, 2007. doi:10.1164/rccm. 200609-1336OC.
19. Möller W, Celik G, Feng S, Bartenstein P, Meyer G, Eickelberg O, Schmid O, Tatkov S. Nasal high flow clears anatomical dead space in upper airway models. J Appl Physiol (1985) 118: 1525–1532, 2015. doi:10.1152/japplphysiol.00934.2014.
20. Mündel T, Feng S, Tatkov S, Schneider H. Mechanisms of nasal high flow on ventilation during wakefulness and sleep. J Appl Physiol (1985) 114: 1058–1065, 2013. doi:10.1152/japplphysiol.01308.2012.
21. Nilius G, Franke K-J, Domanski U, Rühle K-H, Kirkness J, Schneider H. Effects of nasal insufflation on arterial gas exchange and breathing pattern in patients with chronic obstructive pulmonary disease and hypercapnic respiratory failure. In: Respiratory Regulation: Clinical Advances, edited by Pokorski M. New York: Springer, 2013, p. 27–34.
22. Nilius G, Wessendorf T, Maurer J, Stoohs R, Patil SP, Schubert N, Schneider H. Predictors for treating obstructive sleep apnea with an open nasal cannula system (transnasal insufflation). Chest 137: 521–528, 2010. doi:10.1378/chest.09-0357.
23. Ricard JD. High flow nasal oxygen in acute respiratory failure. Minerva Anestesiol 78: 836–841, 2012.
24. Sotello D, Rivas M, Mulkey Z, Nugent K. High-flow nasal cannula oxygen in adult patients: a narrative review. Am J Med Sci 349: 179 –185, 2015. doi:10.1097/MAJ.0000000000000345.
25. Spoletini G, Alotaibi M, Blasi F, Hill NS. Heated humidified high-flow nasal oxygen in adults: mechanisms of action and clinical implications. Chest 148: 253–261, 2015. doi:10.1378/chest.14-2871.
26. Stéphan F, Barrucand B, Petit P, Rézaiguia-Delclaux S, Médard A, Delannoy B, Cosserant B, Flicoteaux G, Imbert A, Pilorge C, Bérard L; BiPOP Study Group. High-flow nasal oxygen vs noninvasive positive airway pressure in hypoxemic patients after cardiothoracic surgery: a randomized clinical trial. JAMA 313: 2331–2339, 2015. doi:10.1001/jama. 2015.5213.
27. Sztrymf B, Messika J, Mayot T, Lenglet H, Dreyfuss D, Ricard J-D. Impact of high-flow nasal cannula oxygen therapy on intensive care unit patients with acute respiratory failure: a prospective observational study. J Crit Care 27: 324.e9–324.e13, 2012. doi:10.1016/j.jcrc.2011.07.075.
28. Theilade D. Nasal CPAP employing a jet device for creating positive pressure. Intensive Care Med 4: 145–148, 1978. doi:10.1007/ BF01700256.
29. Vargas F, Saint-Leger M, Boyer A, Bui NH, Hilbert G. Physiologic effects of high-flow nasal cannula oxygen in critical care subjects. Respir Care 60: 1369–1376, 2015. doi:10.4187/respcare.03814.