Heparinized saline versus normal saline for maintaining peripheral venous catheter patency in China: An open-label, randomized controlled study

Journal of International Medical Research

Volumn 45, Issue 2, 2017, Pages 471-480

  Xu, Lichun ^a   Hu, Yan ^a   Huang, Xiaojin ^b   Fu, Jianguo ^b   Zhang, Jinhui ^b  

^a FUDAN UNIVERSITY   (China)

^b ZHONGSHAN HOSPITAL OF XIAMEN UNIVERSITY   (China)

Author keywords

catheter flushing; Heparin; heparinized saline; peripheral venous catheter

Indexed keywords

HEPARIN; SODIUM CHLORIDE; ANTICOAGULANT AGENT; SOLUTION AND SOLUBILITY;

ADULT; AGED; ARTICLE; CATHETER INFECTION; CATHETER OCCLUSION; CATHETER REMOVAL; CHINA; CLINICAL OUTCOME; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HUMAN; INTRAVENOUS CATHETER; MAJOR CLINICAL STUDY; MALE; OPEN STUDY; PERIPHERAL VENOUS CATHETER; PHLEBITIS; RANDOMIZED CONTROLLED TRIAL; SURGICAL WARD; TRANSPARENT DRESSING; CATHETERIZATION; INDWELLING CATHETER; MIDDLE AGED; SOLUTION AND SOLUBILITY; STATISTICS AND NUMERICAL DATA; TERTIARY CARE CENTER;

ADULT; AGED; ANTICOAGULANTS; CATHETER OBSTRUCTION; CATHETERIZATION, PERIPHERAL; CATHETERS, INDWELLING; CHINA; FEMALE; HEPARIN; HUMANS; MALE; MIDDLE AGED; PHLEBITIS; SODIUM CHLORIDE; SOLUTIONS; TERTIARY CARE CENTERS;

EID: 85018947223     PISSN: 03000605     EISSN: 14732300     Source Type: Journal    
DOI: 10.1177/0300060516685203     Document Type: Article

References (29)

1. McCallum L, Higgins D. Care of peripheral venous cannula sites. Nurs Times 2012; 108: 12, 14–15.
2. Zingg W, Pittet D. Peripheral venous catheters: an under-evaluated problem. Int J Antimicrob Agents 2009; 34(Suppl 4): S38–S42.
3. Li CY, Jing H, Li L. A survey of the status of infusion therapy in Beijing. Chinese Journal of Nursing 2009; 44: 607–609. [in Chinese].
4. Malloy MH, Cutter GR. The association of heparin exposure with intraventricular hemorrhage among very low birth weight infants. J Perinatol 1995; 15: 185–191.
5. Schindewolf M, Lindhoff-Last E, Ludwig RJ. Heparin-induced skin lesions. Lancet 2012; 380: 1867–1879.
6. Miller PL. Heparin-induced thrombocytopenia–recognition and treatment. AORN J 2003; 78: 79–86,89.
7. Rice L, Nguyen PH, Vann AR. Preventing complications in heparin-induced thrombocytopenia. Alternative anticoagulants are improving patient outcomes. Postgrad Med 2002; 112: 85–89.
8. Otoya M. Heparin safety in the neonatal intensive care unit: are we learning from mistakes of others? Newborn Infant Nurs Rev 2009; 9: 53–61.
9. Shu DJ, Min Z. Comparison of the effect of obstruction between two kinds of locking solution for PICC. International Journal of Nursing 2010; 8: 1256–1258. [in Chinese].
10. Goode CJ, Titler M, Rakel B. A meta-analysis of effects of heparin flush and saline flush: quality and cost implications. Nurs Res 1991; 40: 324–330.
11. Infusion Nursing Society. Infusion Nursing Standards of Practice. J Infus Nurs 2011; 34: S1–S34. Available at: http://engage.ahima.org/HigherLogic/System/DownloadDocumentFile.ashx?DocumentFileKey=2238ee0a-c2df-4d1a-affa-f69f2ce41856.
12. Niesen KM, Harris DY, Parkin LS. The effects of heparin versus normal saline for maintenance of peripheral intravenous locks in pregnant women. J Obstet Gynecol Neonatal Nurs 2003; 32: 503–508.
13. Bertolino G, Pitassi A, Tinelli C. Intermittent flushing with heparin versus saline for maintenance of peripheral intravenous catheters in a medical department: a pragmatic cluster-randomized controlled study. Worldviews Evid Based Nurs 2012; 9: 221–226.
14. Goode CJ, Titler M, Rakel B. A meta-analysis of effects of heparin flush and saline flush: quality and cost implications. Nurs Res 1991; 40: 324–330.
15. Thamlikitkul V, Indranoi A. Switching from heparinized saline flush to normal saline flush for maintaining peripheral venous catheter patency. Int J Qual Health Care 2006; 18: 183–185.
16. Wang R, Luo O, He L. Preservative-free 0.9% sodium chloride for flushing and locking peripheral intravenous access device: a prospective controlled trial. J Evid Based Med 2012; 5: 205–208.
17. Rickard CM, McCann D, Munnings J. Routine resite of peripheral intravenous devices every 3 days did not reduce complications compared with clinically indicated resite: a randomised controlled trial. BMC Med 2010; 8: 53–53.
18. O’Grady NP, Alexander M, Burns LA. Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis 2011; 52: e162–e193.
19. Bao ZW, Zu YL, Sha SW. Effect of the two different solution used to seal up the tube of intravenous indwelling needle in old patients. Jilin Medication 2010; 30: 3146–3147. [in Chinese].
20. Epperson EL. Efficacy of 0.9% sodium chloride injection with and without heparin for maintaining indwelling intermittent injection sites. Clin Pharm 1984; 3: 626–629.
21. Hamilton RA, Plis JM, Clay C. Heparin sodium versus 0.9% sodium chloride injection for maintaining patency of indwelling intermittent infusion devices. Clin Pharm 1988; 7: 439–443.
22. Shoaf J, Oliver S. Efficacy of normal saline injection with and without heparin for maintaining intermittent intravenous site. Appl Nurs Res 1992; 5: 9–12.
23. Arnts IJ, Heijnen JA, Wilbers HT. Effectiveness of heparin solution versus normal saline in maintaining patency of intravenous locks in neonates: a double blind randomized controlled study. J Adv Nurs 2011; 67: 2677–2685.
24. Mok E, Kwong TK, Chan MF. A randomized controlled trial for maintaining peripheral intravenous lock in children. Int J Nurs Pract 2007; 13: 33–45.
25. Zhu YM. Observation of the effect of two kinds of sealing fluid on sealing venous indwelling needle in perioperative patients. Journal of Aerospace Medicine 2015; 26: 785–786. [in Chinese].
26. Chen LJ. Comparison of two kinds of sealing liquid on venous indwelling needle in patients with pneumocardial disease. Jilin Medication 2008; 29: 795–796. [in Chinese].
27. Yang GY. Study on the effect of the different liquids of a vein detains the needle. Chinese Primary Health Care 2007; 121: 82–83. [in Chinese].
28. Xin TW, Zhi ML, Yue HZ. Effects of venous remaining needle sealing with heparin vs. Saline in China: a meta-analysis. Chin J Evid-based Med 2011; 11: 96–100. [in Chinese].
29. Meyer BA, Little CJ, Thorp JA. Heparin versus normal saline as a peripheral line flush in maintenance of intermittent intravenous lines in obstetric patients. Obstet Gynecol 1995; 85: 433–436.