Spatial molecular epidemiology of carbapenem-resistant and New Delhi metallo beta-lactamase (blaNDM)-producing Escherichia coli in the piglets of organized farms in India

Journal of Applied Microbiology

Volumn 122, Issue 6, 2017, Pages 1537-1546

  Pruthvishree, B S ^a   Vinodh Kumar, O R ^a   Sinha, D K ^a   Malik, Y P S ^a   Dubal, Z B ^a   Desingu, P A ^a   Shivakumar, M ^b   Krishnaswamy, N ^a   Singh, B R ^a  

^a INDIAN VETERINARY RESEARCH INSTITUTE   (India)

^b VETERINARY COLLEGE   (India)

Author keywords

blaNDM; carbapenemase; E. coli; India; piglets; spatial epidemiological analysis

Indexed keywords

FARMS; GENES; HEALTH RISKS; PUBLIC HEALTH; SPATIAL VARIABLES MEASUREMENT;

BLANDM; CARBAPENEMASE; CARBAPENEMS; E. COLI; EFFLUX PUMPS; INDIA; LACTAMASES; MOLECULAR EPIDEMIOLOGY; PIGLET; SPATIAL EPIDEMIOLOGICAL ANALYSE;

ESCHERICHIA COLI;

CARBAPENEM; EXTENDED SPECTRUM BETA LACTAMASE; METALLO BETA LACTAMASE; NEW DELHI METALLO BETA LACTAMASE; UNCLASSIFIED DRUG; VIRULENCE FACTOR; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE; BETA-LACTAMASE NDM-1; CARBAPENEM DERIVATIVE; CARBAPENEMASE;

ANTIBIOTIC RESISTANCE; BACTERIAL DISEASE; DIARRHEAL DISEASE; DISEASE PREVALENCE; ENZYME; EPIDEMIOLOGY; FARM; FECES; HEALTH RISK; HEALTH STATUS; PIG; RISK FACTOR; SPATIAL ANALYSIS; STATISTICAL ANALYSIS; VIRULENCE;

AGRICULTURAL LAND; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BACTERIUM ISOLATION; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DATA ANALYSIS SOFTWARE; DIARRHEA; EAE GENE; ESCHERICHIA COLI; FECES; GENOTYPE; GOVERNMENT; HEALTH STATUS; HLYA GENE; INDIA; MOLECULAR EPIDEMIOLOGY; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; PHYLOGENETIC TREE; PIGLET; POLYMERASE CHAIN REACTION; SPATIAL ANALYSIS; STX1 GENE; STX2 GENE; ANIMAL; DRUG EFFECTS; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PIG;

DELHI; INDIA; NEW DELHI;

ENTEROBACTERIACEAE; ESCHERICHIA COLI; SUIDAE;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CARBAPENEMS; CROSS-SECTIONAL STUDIES; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; FARMS; GENOTYPE; HUMANS; INDIA; MICROBIAL SENSITIVITY TESTS; MOLECULAR EPIDEMIOLOGY; SWINE; VIRULENCE FACTORS;

EID: 85018884093     PISSN: 13645072     EISSN: 13652672     Source Type: Journal    
DOI: 10.1111/jam.13455     Document Type: Article

References (46)

1. Bhardwaj, M., Singh, B.R., Murugan, M.S. and Prasannavadhana, D.S. (2015) Emergence of carbapenemase producing pathogens in animals. Pharm Anal Acta 6, 379. doi:10.4172/21532435.1000379.
2. van der Bij, A.K. and Pitout, J.D. (2012) The role of international travel in the worldwide spread of multi-resistant Enterobacteriaceae. J Antimicrob Chemother 67, 2090–2100.
3. Centre for Disease Dynamics, Economics & Policy (CDDEP). (2015) Drug resistance index and resistance map. Retrieved from http://www.cddep.org. accessed on 5 September 2016.
4. CLSI (2014) Performance Standards for Antimicrobial Susceptibility Testing. CLSI Document. Wayne, PA: Clinical and Laboratory Standard Institute, pp. M100–S124.
5. Cuzon, G., Naas, T. and Nordmann, P. (2011) Functional characterization of Tn4401, a Tn3-based transposon involved in blaKPC gene mobilization. Antimicrob Agents Chemother 55, 5370–5373.
6. ECDC and EMEA Joint Working Group (2009) ECDC. EMEA Joint Technical Report: The bacterial challenge: time to react. http://ecdc.europa.eu/en/publications/Publications/0909_TER_The_Bacterial_Challenge_Time_to_React.pdf
7. Edwards, R. and Ewing, W.M. (1972) Identification of Enterobacteriaceae, 3rd edn. Minnesota: Burgess Publishing Co.
8. EFSA (2013) Panel (EFSA Panel on Food Additives and Nutrient Sources added to Food). Scientific opinion on the re-evaluation of aspartame (E 951) as a food additive. EFSA Journal 11, 3496.
9. Fischer, J., Rodriguez, I., Schmoger, S., Friese, A., Roesler, U., Helmuth, R. and Guerra, B. (2012) Escherichia coli producing VIM-1 carbapenemase isolated on a pig farm. J Antimicrob Chemother 67, 1793–1795.
10. Galvin, S., Bergin, N., Hennessy, R., Hanahoe, B., Murphy, A.W., Cormican, M. and Vellinga, A. (2013) Exploratory spatial mapping of the occurrence of antimicrobial resistance in E. coli in the community. Antibiotics 2, 328–338.
11. Ghatak, S., Singha, A., Sen, A., Guha, C., Ahuja, A., Bhattacharjee, U., Das, S., Pradhan, N.R. et al. (2013) Detection of New Delhi metallo-beta-lactamase and extended-spectrum beta-lactamase genes in Escherichia coli isolated from mastitic milk samples. Transbound Emerg Dis 60, 385–389.
12. Gupta, E., Mohanty, S., Sood, S. and Dhawan, B. (2006) Emerging resistance to carbapenems in a tertiary care hospital in North India. Indian J Med Res 124, 95.
13. Gupta, N., Limbago, B.M., Patel, J.B. and Kallen, A.J. (2011) Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. Clin Infect Dis 53, 60–67.
14. Hornsey, M., Phee, L. and Wareham, D.W. (2011) A novel variant, NDM-5, of the New Delhi metallo beta-lactamase in a multi-drug resistant Escherichia coli ST648 isolate recovered from a patient in the United Kingdom. Antimicrob Agents Chemother 55, 5952–5954.
15. Hrabak, J., Chudackova, E. and Papagiannitsis, C.C. (2014) Detection of carbapenemases in Enterobacteriaceae: a challenge for diagnostic microbiological laboratories. Clin Microbiol Infect 20, 839–853.
16. Jia, W., Li, C., Zhang, H., Li, G., Liu, X. and Wei, J. (2015) Prevalence of genes of OXA-23 carbapenemase and AdeABC efflux pump associated with multidrug resistance of Acinetobacter baumannii isolates in the ICU of a comprehensive hospital of Northwestern China. Int J Environ Res Public Health 12, 10079–10092.
17. Kar, D., Bandyopadhyay, S., Bhattacharyya, D., Samanta, I., Mahanti, A., Nanda, P.K., Mondal, B., Dandapat, P. et al. (2015) Molecular and phylogenetic characterization of multidrug resistant extended spectrum beta-lactamase producing Escherichia coli isolated from poultry and cattle in Odisha, India. Infect Genet Evol 29, 82–90.
18. Khajuria, A., Praharaj, A.K., Kumar, M. and Grover, N. (2014) Carbapenem resistance among Enterobacter species in a tertiary care hospital in central India. Chemother Res Pract Article ID 972646, http://dx.doi.org/10.1155/2014/972646
19. Koovapra, S., Bandyopadhyay, S., Das, G., Bhattacharyya, D., Banerjee, J., Mahanti, A., Samanta, I., Nanda, P.K. et al. (2016) Molecular signature of extended spectrum β-lactamase producing Klebsiella pneumoniae isolated from bovine milk in eastern and north-eastern India. Infect Genet Evol 44, 395–402.
20. Kulldorff, M. (1997) A spatial scan statistic. Commun Stat Theory Methods 26, 1481–1496.
21. Lin, D., Xie, M., Li, R., Chen, K., Chan, E.W.C. and Chen, S. (2017) IncFII conjugative plasmid-mediated transmission of blaNDM-1 elements among animal-borne Escherichia coli strains. Antimicrob Agents Chemother 61, e02285–16.
22. Martins, M., McCusker, M.P., Viveiros, M., Couto, I., Fanning, S. and Amaral, L. (2013) A simple method for assessment of MDR bacteria for over-expressed efflux pumps. Open Microbiol J 7, 72–82.
23. Morrison, B.J. and Rubin, J.E. (2015) Carbapenemase producing bacteria in the food supply escaping detection. PLoS ONE 10, e0126717.
24. Murugan, M.S. (2015) Epidemiology of carbapenemase producing Escherichia coli isolated from calves. M.V.Sc. Thesis, Deemed University, Indian Veterinary Research Institute, Izatnagar, India.
25. Nordmann, P., Naas, T. and Poirel, L. (2011) Global spread of carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis 17, 1791–1798.
26. Nordmann, P., Dortet, L. and Poirel, L. (2012) Carbapenem resistance in Enterobacteriaceae: here is the storm!. Trends Mol Med 18, 263–272.
27. Page, S.W. and Gautier, P. (2012) Use of antimicrobial agents in livestock. Revue Scientifique et Technique-OIE 31, 145.
28. Paton, A.W. and Paton, J.C. (1998) Detection and characterization of shiga toxigenic Escherichia coli by using multiplex PCR assays for stx1, stx2, eaeA, enterohemorrhagic E. coli hlyA, rfb O111, and rfb O157s. J Clin Microbiol 36, 598–602.
29. Poirel, L., Walsh, T.R., Cuvillier, V. and Nordmann, P. (2011) Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Infect Dis 70, 119–123.
30. Queenan, A.M. and Bush, K. (2007) Carbapenemases: the versatile β-lactamases. Clin Microbiol Rev 20, 440–458.
31. Rumbo, C., Gato, E., Lopez, M., de Alegria, C.R., Fernandez-Cuenca, F., Martinez-Martinez, L., Vila, J., Pachón, J. et al. (2013) The contribution of efflux pumps, porins and β-lactamases to multi-drug resistance in clinical isolates of Acinetobacter baumannii. Antimicrob Agents Chemother 57, 5247–5257.
32. Schwaber, M.J., Klarfeld-Lidji, S., Navon-Venezia, S., Schwartz, D., Leavitt, A. and Carmeli, Y. (2008) Predictors of carbapenem-resistant Klebsiella pneumoniae acquisition among hospitalized adults and effect of acquisition on mortality. Antimicrob Agents Chemother 52, 1028–1033.
33. Shanthi, M., Sekar, U., Kamalanathan, A. and Sekar, B. (2014) Detection of New Delhi metallo beta lactamase-1 (NDM-1) carbapenemase in Pseudomonas aeruginosa in a single centre in Southern India. Indian J Med Res 140, 546.
34. Singh, B.R. (2009) Labtop for Microbiology Laboratory. Germany: Lambert Academic Publishing. EISBN: 978-3-8383-1574-40.
35. Singh, B.R. (2013) Chapter: Antimicrobial sensitivity assay and antimicrobial chemotherapy in animals: a practical approach. In Diseases of Animals: Diagnosis and Management ed. Singh, B.R. and Somvanshi, R. pp. 7–31. Uttar Pradesh, India: Indian Veterinary Research Institute.
36. Stolle, I., Prenger-Berninghoff, E., Stamm, I., Scheufen, S., Hassdenteufel, E., Guenther, S. and Ewers, C. (2013) Emergence of OXA-48 carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in dogs. J Antimicrob Chemother 68, 2802–2808.
37. Versalovic, J., Koeuth, T. and Lupski, R. (1991) Distribution of repetitive DNA sequences in eubacteria and application to finger printing of bacterial genomes. Nucleic Acids Res 19, 6823–6831.
38. VinodhKumar, O.R., Sinha, D.K. and Singh, B.R. (2016) Use of geographic information system (GIS) in veterinary science. In Book on Innovative Technology for Sustainable Management in Agriculture ed. Narain, S. and Rawat, S.K. Chapter 31 pp. 471–486. ISBN 978-81-7622-375-1. New Delhi, India: Biotech Books.
39. Viveiros, M., Jesus, A., Brito, M., Leandro, C., Martins, M. and Ordway, D. (2005) Inducement and reversal of tetracycline resistance in Escherichia coli K-12 and the expression of proton gradient dependent multidrug efflux pump genes. Antimicrob Agents Chemother 49, 3578–3582.
40. Woodford, N., Wareham, D.W., Guerra, B. and Teale, C. (2014) Carbapenemase-producing Enterobacteriaceae and non-Enterobacteriaceae from animals and the environment: an emerging public health risk of our own making? J Antimicrob Chemother 69, 287–291.
41. Xu, Y., Gu, B., Huang, M., Liu, H., Xu, T., Xia, W. and Wang, T. (2015) Epidemiology of carbapenem resistant Enterobacteriaceae (CRE) during 2000-2012 in Asia. J Thorac Dis 7, 376–385.
42. Yaqoob, M., Wang, L.P., Wang, S., Hussain, S., Memon, J., Kashif, J. and Lu, C.P. (2013) Associations between anti-microbial resistance phenotypes, anti-microbial resistance genotypes and virulence genes of Escherichia coli isolates from Pakistan and China. Transbound Emerg Dis 60, 416–424.
43. Yong, D., Toleman, M.A., Giske, C.G., Cho, H.S., Sundman, K., Lee, K. and Walsh, T.R. (2009) Characterization of a new metallo-β-lactamase gene, blaNDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother 53, 5046–5054.
44. Yousfi, M., Mairi, A., Bakour, S., Touati, A., Hassissen, L., Hadjadj, L. and Rolain, J.M. (2015) First report of NDM-5-producing Escherichia coli ST1284 isolated from dog in Bejaia, Algeria. New Microbes New Infect 8, 17–18.
45. Zhang, W.J., Lu, Z.J., Schwarz, S., Zhang, R.M., Wang, X.M. and Si, W. (2013) Complete sequence of the blaNDM-1 carrying plasmid pNDM-AB from Acinetobacter baumannii of food animal origin. J Antimicrob Chemother 68, 1681–1682.
46. Zhang, R., Yang, W., Liu, Z., Li, J., Yin, W., Lei, L., Wu, C. and Shen, J. (2015) Characterization of NDM-1-producing carbapenemase in Acinetobacter spp. and E. coli isolates from diseased pigs. Front Agr Sci Eng 2, 223–229.