Functional overexpression of genes involved in erythritol synthesis in the yeast Yarrowia lipolytica

Biotechnology for Biofuels

Volumn 10, Issue 1, 2017, Pages

  Mirończuk, Aleksandra M ^a   Biegalska, Anna ^a   Dobrowolski, Adam ^a  

^a WROC AW UNIVERSITY OF ENVIRONMENTAL AND LIFE SCIENCES   (Poland)

Author keywords

Erythritol; Glycerol; Pentose phosphate pathway; Transketolase; Yarrowia lipolytica

Indexed keywords

ALCOHOLS; CARBON; DISSOLVED OXYGEN; ENCODING (SYMBOLS); GENES; GLYCEROL; SIGNAL ENCODING; YEAST;

6-PHOSPHOGLUCONATE DEHYDROGENASE; ERYTHRITOL; FUNCTIONAL OVEREXPRESSION; GLUCOSE-6-PHOSPHATE DEHYDROGENASE; PENTOSE PHOSPHATE PATHWAY; SHAKE-FLASK EXPERIMENTS; TRANSKETOLASE; YARROWIA LIPOLYTICA;

GENE ENCODING;

GENE EXPRESSION; PHOSPHATE; YEAST;

YARROWIA LIPOLYTICA;

EID: 85018731047     PISSN: 17546834     EISSN: None     Source Type: Journal    
DOI: 10.1186/s13068-017-0772-6     Document Type: Article

References (33)

1. Moon HJ. Biotechnological production of erythritol and its applications. Appl Microbiol Biotechnol. 2010;86:1017-25.
2. Bernt WO, et al. Erythritol: a review of biological and toxicological studies. Regul Toxicol Pharmacol. 1996;24(2 Pt 2):S191-7.
3. Oh DK, et al. Increased erythritol production in fed-batch cultures of Torula sp. by controlling glucose concentration. J Ind Microbiol Biotechnol. 2001;26(4):248-52.
4. Segueilha L. Method producing erythritol by repeated fed-batch fermentation. In: Freres R, editor. 09/337909 United States Patent. 2002.
5. Rymowicz W, Rywinska A, Marcinkiewicz M. High-yield production of erythritol from raw glycerol in fed-batch cultures of Yarrowia lipolytica. Biotechnol Lett. 2009;31(3):377-80.
6. Mirończuk AM, et al. Enhanced production of erythritol by Yarrowia lipolytica on glycerol in repeated batch cultures. J Ind Microbiol Biotechnol. 2014;41(1):57-64.
7. Park SY, Seo JH, Ryu YW. Two-stage fed-batch culture of Candida magnoliae for the production of erythritol using an industrial medium. Korean J Biotechnol Bioeng. 2003;18(4):249-54.
8. Ryu YW, Park CY, Park JB, Kim SY, Seo JH. Optimization of erythritol production by Candida magnoliae in fed-batch culture. J Ind Microbiol Biotechnol. 2000;25(2):100-3.
9. Yang L-B. A novel osmotic pressure control fed-batch fermentation strategy for improvement of erythritol production by Yarrowia lipolytica from glycerol. Bioresour Technol. 2014;151:120-7.
10. Makri A. Metabolic activities of biotechnological interest in Yarrowia lipolytica grown on glycerol in repeated batch cultures. Bioresour Technol. 2010;101:2351-8.
11. Dobrowolski A. Efficient conversion of crude glycerol from various industrial wastes into single cell oil by yeast Yarrowia lipolytica. Bioresour Technol. 2016;207:237-43.
12. Kamzolova SV, et al. The effect of oxalic and itaconic acids on threo-Ds-isocitric acid production from rapeseed oil by Yarrowia lipolytica. Bioresour Technol. 2016;206:128-33.
13. Lazar Z. Simultaneous production of citric acid and invertase by Yarrowia lipolytica SUC+ transformants. Bioresour Technol. 2011;102:6982-9.
14. Mirończuk A, Rywińska A, Rymowicz W. High-level production of erythritol by Yarrowia lipolytica MK1 from glycerol. Yeast. 2013;30(S1):97-216.
15. Otto C, et al. Variation of the by-product spectrum during alpha-ketoglutaric acid production from raw glycerol by overexpression of fumarase and pyruvate carboxylase genes in Yarrowia lipolytica. Appl Microbiol Biotechnol. 2012;95(4):905-17.
16. Rakicka M, et al. Technology of efficient continuous erythritol production from glycerol. J Clean Prod. 2016;139:905-13.
17. Rymowicz W, et al. Citric acid production from glycerol-containing waste of biodiesel industry by Yarrowia lipolytica in batch, repeated batch, and cell recycle regimes. Appl Microbiol Biotechnol. 2010;87(3):971-9.
18. Yovkova V, et al. Engineering the alpha-ketoglutarate overproduction from raw glycerol by overexpression of the genes encoding NADP(+)-dependent isocitrate dehydrogenase and pyruvate carboxylase in Yarrowia lipolytica. Appl Microbiol Biotechnol. 2014;98(5):2003-13.
19. Lee DH, et al. Molecular cloning and biochemical characterization of a novel erythrose reductase from Candida magnoliae JH110. Microb Cell Fact. 2010;9:43.
20. Sawada K, et al. Key role for transketolase activity in erythritol production by Trichosporonoides megachiliensis SN-G42. J Biosci Bioeng. 2009;108(5):385-90.
21. Mirończuk AM, et al. Newly isolated mutant of Yarrowia lipolytica MK1 as a proper host for efficient erythritol biosynthesis from glycerol. Process Biochem. 2015;50(1):61-8.
22. Sambrook J. Molecular cloning: a laboratory manual. 3rd ed. New York: Cold Spring Harbor Laboratory Press; 2001.
23. Mirończuk AM, et al. A novel strain of Yarrowia lipolytica as a platform for value-added product synthesis from glycerol. Biotechnol Biofuels. 2016;9(1):1-12.
24. Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 2008;3(6):1101-8.
25. Moon HJ, et al. Biotechnological production of erythritol and its applications. Appl Microbiol Biotechnol. 2010;86(4):1017-25.
26. Ruiz-Herrera J, Sentandreu R. Different effectors of dimorphism in Yarrowia lipolytica. Arch Microbiol. 2002;178(6):477-83.
27. Blazeck J, et al. Tuning gene expression in Yarrowia lipolytica by a hybrid promoter approach. Appl Environ Microbiol. 2011;77(22):7905-14.
28. Mirończuk AM, et al. A two-stage fermentation process of erythritol production by yeast Y. lipolytica from molasses and glycerol. Bioresour Technol. 2015;198:445-55.
29. Tomaszewska L, Rywinska A, Gladkowski W. Production of erythritol and mannitol by Yarrowia lipolytica yeast in media containing glycerol. J Ind Microbiol Biotechnol. 2012;39(9):1333-43.
30. Kim KA, et al. Optimization of culture conditions for erythritol production by Torula sp. Seoul: Korean Society for Applied Microbiology; 2000.
31. Jost B, et al. The influence of oxygen limitation for the production of succinic acid with recombinant strains of Yarrowia lipolytica. Appl Microbiol Biotechnol. 2015;99(4):1675-86.
32. Rakicka M, et al. Enhanced production of erythritol and mannitol by Yarrowia lipolytica in media containing surfactants. Braz J Microbiol. 2016;47(2):417-23.
33. Hanahan D. DNA cloning: a practical approach. In: Glover DM, editor. McLean: IRL Press; 1985.