Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice: Implications for Superficial Erosion

Circulation Research

Volumn 121, Issue 1, 2017, Pages 31-42

  Franck, Grégory ^a   Mawson, Thomas ^a   Sausen, Grasiele ^a   Salinas, Manuel ^a,c   Masson, Gustavo Santos ^b   Cole, Andrew ^a   Beltrami Moreira, Marina ^a   Chatzizisis, Yiannis ^a   Quillard, Thibault ^a   Tesmenitsky, Yevgenia ^a   Shvartz, Eugenia ^a   Sukhova, Galina K ^a   Swirski, Filip K ^b   Nahrendorf, Matthias ^b   Aikawa, Elena ^a   Croce, Kevin J ^a   Libby, Peter ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c NOVA SOUTHEASTERN UNIVERSITY   (United States)

Author keywords

acute coronary syndromes; disturbed flow; endothelium; neutrophils; superficial erosion

Indexed keywords

APOLIPOPROTEIN E; CHEMOATTRACTANT; HYALURONIC ACID; TOLL LIKE RECEPTOR 2; TLR2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY BLOOD FLOW; ARTERY INTIMA PROLIFERATION; ARTICLE; BLOOD CLOTTING; CAROTID ARTERY; CELL ACTIVATION; CELL ADHESION; CELL DEATH; CELL FUNCTION; CELL LOSS; CONTROLLED STUDY; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; IN VIVO STUDY; INTRACELLULAR SIGNALING; LEFT COMMON CAROTID ARTERY; MOUSE; NEOINTIMA; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BLOOD FLOW VELOCITY; BONE MARROW TRANSPLANTATION; C57BL MOUSE; CAROTID ARTERY OBSTRUCTION; CELL CULTURE; DEFICIENCY; HUMAN; KNOCKOUT MOUSE; MALE; METABOLISM; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; PHYSIOLOGY; PROCEDURES; VASCULAR ENDOTHELIUM;

ANIMALS; BLOOD FLOW VELOCITY; BONE MARROW TRANSPLANTATION; CAROTID STENOSIS; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; TOLL-LIKE RECEPTOR 2;

EID: 85018688693     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.117.310694     Document Type: Article

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