Mcr-1 colistin resistance in ESBL-producing Klebsiella pneumoniae, France

Emerging Infectious Diseases

Volumn 23, Issue 5, 2017, Pages 874-876

  Caspar, Yvan ^a   Maillet, Mylène ^a   Pavese, Patricia ^a   Francony, Gilles ^a   Brion, Jean Paul ^a   Mallaret, Marie Reine ^a   Bonnet, Richard ^b,c,d,e,f   Robin, Frédéric ^b,c,d,e,f   Beyrouthy, Racha ^b,c,d,e,f   Maurin, Max ^a  

^a GRENOBLE UNIVERSITY HOSPITAL   (France)

^b UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

^c Centre National de Référence de la Résistance Aux Antibiotiques   (France)

^d UNIVERSITÉ CLERMONT AUVERGNE   (France)

^e INSERM   (France)

^f CEMAGREF   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANAKINRA; CLINDAMYCIN; COLISTIN; COTRIMOXAZOLE; FLUCYTOSINE; MEROPENEM; METHYLPREDNISOLONE; TRIMETHOPRIM; VANCOMYCIN; ANTIINFECTIVE AGENT; BETA LACTAMASE;

ABSCESS; ADULT; ANTIBIOTIC RESISTANCE; ASPERGILLUS FUMIGATUS; BACTERIAL GROWTH; BACTERIUM IDENTIFICATION; BRAIN VASOSPASM; BROTH DILUTION; CASE REPORT; DISEASE ASSOCIATION; EPSILOMETER TEST; EXTENDED SPECTRUM BETA LACTAMASE PRODUCING KLEBSIELLA PNEUMONIAE; FRANCE; FUNGAL MENINGITIS; GENE MUTATION; HUMAN; HYDROCEPHALUS; LETTER; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; THYROID DISEASE; WHOLE GENOME SEQUENCING; BACTERIAL GENE; BACTERIAL GENOME; BIOSYNTHESIS; COMBINATION DRUG THERAPY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HIGH THROUGHPUT SEQUENCING; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PLASMID; TREATMENT OUTCOME;

ADULT; ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; COLISTIN; DRUG RESISTANCE, BACTERIAL; DRUG THERAPY, COMBINATION; FRANCE; GENES, BACTERIAL; GENOME, BACTERIAL; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MICROBIAL SENSITIVITY TESTS; PLASMIDS; TREATMENT OUTCOME;

EID: 85018660751     PISSN: 10806040     EISSN: 10806059     Source Type: Journal    
DOI: 10.3201/eid2305.161942     Document Type: Letter

References (10)

1. Baron S, Hadjadj L, Rolain J-M, Olaitan AO. Molecular mechanisms of polymyxin resistance: knowns and unknowns. Int J Antimicrob Agents. 2016;48:583–91. http://dx.doi.org/10.1016/j.ijantimicag.2016.06.023
2. Liu Y-Y, Wang Y, Walsh TR, Yi L-X, Zhang R, Spencer J, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2016;16:161–8. http://dx.doi.org/10.1016/S1473-3099(15)00424-7
3. Schwarz S, Johnson AP. Transferable resistance to colistin: a new but old threat. J Antimicrob Chemother. 2016;71:2066–70. http://dx.doi.org/10.1093/jac/dkw274
4. Di Pilato V, Arena F, Tascini C, Cannatelli A, Henrici De Angelis L, Fortunato S, et al. mcr-1.2, a new mcr variant carried on a transferable plasmid from a colistin-resistant KPC carbapenemase-producing Klebsiella pneumoniae strain of sequence type 512. Antimicrob Agents Chemother. 2016;60:5612–5. http://dx.doi.org/10.1128/AAC.01075-16
5. Cannatelli A, D’Andrea MM, Giani T, Di Pilato V, Arena F, Ambretti S, et al. In vivo emergence of colistin resistance in Klebsiella pneumoniae producing KPC-type carbapenemases mediated by insertional inactivation of the PhoQ/PhoP mgrB regulator. Antimicrob Agents Chemother. 2013;57:5521–6. http://dx.doi.org/10.1128/AAC.01480-13
6. Nordmann P, Jayol A, Poirel L. A universal culture medium for screening polymyxin-resistant gram-negative isolates. J Clin Microbiol. 2016;54:1395–9. http://dx.doi.org/10.1128/JCM.00446-16
7. Nordmann P, Jayol A, Poirel L. Rapid detection of polymyxin resistance in Enterobacteriaceae. Emerg Infect Dis. 2016;22:1038– 43. http://dx.doi.org/10.3201/eid2206.151840
8. Nijhuis RH, Veldman KT, Schelfaut J, Van Essen-Zandbergen A, Wessels E, Claas EC, et al. Detection of the plasmid-mediated colistin-resistance gene mcr-1 in clinical isolates and stool specimens obtained from hospitalized patients using a newly developed real-time PCR assay. J Antimicrob Chemother. 2016;71:2344–6. http://dx.doi.org/10.1093/jac/dkw192
9. Bontron S, Poirel L, Nordmann P. Real-time PCR for detection of plasmid-mediated polymyxin resistance (mcr-1) from cultured bacteria and stools. J Antimicrob Chemother. 2016;71:2318–20. http://dx.doi.org/10.1093/jac/dkw139
10. Haenni M, Métayer V, Gay E, Madec J-Y. Increasing trends in mcr-1 prevalence among ESBL-producing E. coli in French calves despite decreasing exposure to colistin. Antimicrob Agents Chemother. 2016;60:6433–4. http://dx.doi.org/10.1128/AAC.01147-16