Big data and data repurposing - using existing data to answer new questions in vascular dementia research

BMC Neurology

Volumn 17, Issue 1, 2017, Pages

  Doubal, Fergus N ^a   Ali, Myzoon ^b   Batty, G David ^c   Charidimou, Andreas ^d   Eriksdotter, Maria ^e   Hofmann Apitius, Martin ^f   Kim, Yun Hee ^g   Levine, Deborah A ^h   Mead, Gillian ^a   Mucke, Hermann A M ⁱ   Ritchie, Craig W ^j   Roberts, Charlotte J ^k   Russ, Tom C ^j   Stewart, Robert ^l   Whiteley, William ^a   Quinn, Terence J ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^f FRAUNHOFER INSTITUTE FOR ALGORITHMS AND SCIENTIFIC COMPUTING SCAI   (Germany)

^g Sungkyunkwan University School of Medicine   (South Korea)

^h UNIVERSITY OF MICHIGAN   (United States)

ⁱ BioLife Science   (Austria)

^j UNIVERSITY OF EDINBURGH   (United Kingdom)

^k International Consortium for Health Outcomes Measurement (ICHOM)   (United Kingdom)

^l SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

more..

Author keywords

Big data; Clinical Trials; Cohort studies; Data; Dementia; Electronic health records; Registries; Systematic review; Vascular dementia

Indexed keywords

ARTICLE; BIG DATA; CLINICAL RESEARCH; DATA ANALYSIS; DATA EXTRACTION; DATA LINKAGE; DATA PROCESSING; DATA REPURPOSING; ELECTRONIC HEALTH RECORD; HEALTH SURVEY; HUMAN; KNOWLEDGE BASE; MEDICAL INFORMATICS; MULTIINFARCT DEMENTIA; QUALITY CONTROL; SCIENTIFIC LITERATURE; MEDICAL RESEARCH; METADATA;

BIOMEDICAL RESEARCH; DEMENTIA, VASCULAR; HUMANS; METADATA;

EID: 85018523886     PISSN: None     EISSN: 14712377     Source Type: Journal    
DOI: 10.1186/s12883-017-0841-2     Document Type: Article

References (48)

1. Langhorne P, Sandercock P, Prasad K. Evidence-based practice for stroke. Lancet. 2009;8:308-9.
2. Ritchie CW, Muniz Terrera G, Quinn TJ. Dementia trials an dementia tribulations: methodological and analytical challenges in dementia research. Alzheimer Res Therpay. 2015;7:31.
3. Ioannidis JPA, Greenland S, Hlatky MA, Khoury MJ, Macleod MR, Moher D, Schulz KF, Tibshirani R. Increasing value and reducing waste in research design, conduct and analysis. Lancet. 2014;383:166-75.
4. Deetjen U, Meyer ET, Schroeder R. "Big Data for Advancing Dementia Research: An Evaluation of Data Sharing Practices in Research on Age-related Neurodegenerative Diseases", OECD Digital Economy Papers, No. 246, 2015 OECD Publishing, Paris. doi: http://dx.doi.org/10.1787/5js4sbddf7jk-en
5. Catlett NL, Bargnesi AJ, Ungerer S, Seagaran T, Ladd W, Elliston KO, Prat D. Reverse causal reasoning: applying qualitative causal knowledge to the interpretation of high-throughput data. BMC Bioinformatics. 2013;14:340.
6. Mucke HA. Focus, medicinal chemistry, informatics: towards the pharmaceutical patentome. Pharm Pat Anal. 2012;1:229-31.
7. Jang D, Lee S, Lee J, Kim K, Lee D. Inferring new drug indications using the complementarity between clinical disease signatures and drug effects. J Biomed Inform. 2016;49:248-57.
8. Xu R, Wang Q. Comparing a knowledge-driven approach to a supervised machine learning approach in large-scale extraction of drug-side effect relationships from free-text biomedical literature. BMC Bioinformatics. 2015;16 Suppl 5:S6.
9. Chalmers I, Bracken MB, Djulbegovic B, Garattini S, Grant J, Gülmezoglu AM, Howells DW, Ioannidis JPA, Oliver S. How to increase value and reduce waste when research priorities are set. Lancet. 2014;383:156-65.
10. McCann SK, Irvine C, Mead GE, Sena ES, Currie GL, Egan KE, Macleod MR, Howells DW. Efficacy of antidepressants in animal models of ischemic stroke: a systematic review and meta-analysis. Stroke. 2014;45:3055-63.
11. Mead GE, Hsieh C-F, Lee R, Kutlubaev MA, Claxton A, Hankey GJ, Hackett ML. Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery. Cochrane Database Syst Rev. 2012;11:CD009286. doi: 10.1002/14651858.CD009286.
12. Mead G, Hackett ML, Lundström E, Murray V, Hankey GJ, Dennis M. The FOCUS, AFFINITY and EFFECTS trials studying the effect(s) of fluoxetine in patients with a recent stroke: a study protocol for three multicentre randomised controlled trials. Trials. 2015;16:369. doi: 10.1186/s13063-015-0864-1.
13. Quinn TJ, Fearon P, Noel-Storr AH, McShane R, Stott DJ. Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the diagnosis of dementia within community dwelling populations. Cochrane Database Syst Rev. 2014;4:CD010079.
14. Noel-Storr AH, McCleery JM, Richard E, Ritchie CW, Flicker L, Cullum SJ, Davis D, Quinn TJ, Hyde C, Rutjes AW, Smailagic N, Marcus S, Black S, Blennow K, Brayne C, Fiorivanti M, Johnson JK, Köpke S, Schneider LS, Simmons A, Mattsson N, Zetterberg H, Bossuyt PM, Wilcock G, McShane R. Reporting standards for studies of diagnostic test accuracy in dementia The STARDdem Initiative. Neurology. 2014;83:364-73.
15. Davis DHJ, Creavin ST, Noel-Storr A, Quinn TJ, Smailagic N, Hyde C, Brayne C, McShane R, Cullum S. Neuropsychological tests for the diagnosis of Alzheimer's Disease dementia and other dementias: a generic protocol for cross-sectional and delayed verification studies. Cochrane Database Syst Rev 2013:3:CD010460. doi: 10.1002/14651858.CD010460.
16. Rands G, Orrell M. Aspirin for vascular dementia. Cochrane Database Syst Rev. 2000;4:CD001296.
17. Hoffman T, Bennett S, Koh C, McKenna KT. Occupational therapy for cognitive impairment in stroke patients. Cochrane Database Syst Rev. 2010;4:CD006430.
18. Lees R, Fearon P, Harrison JK, Broomfield NM, Quinn TJ. Cognitive and mood assessment in stroke research: focussed review of contemporary studies. Stroke. 2012;43:1678-80.
19. Ali M, Bath P, Brady M, Davis S, Diener H-C, Donnan G, Fisher M, Hacke W, Hanley DF, Luby M, Tsivgoulis G, Wahlgren N, Warach S. Lees KR OBotVSC. Development, Expansion and Use of a Stroke Clinical Trials Resource for Novel Exploratory Analyses. Int J Stroke. 2012;7:133-8.
20. Abdul-Rahim A, Fulton RL, Sucharew H, Kleindorfer D, Khatri P, Broderick JP, Lees KR, for the VISTA Collaborators. National Institutes of health stroke scale item profiles as predictor of patient outcome external validation on independent trial data. Stroke. 2015;46:395-400.
21. Ovbiagele B, Reeves MJ, Nasiri M, Johnston SC, Bath PM, Saposnik G, for the VISTA-Acute Collaboration Steering Committee. A Simple Risk Index andThrombolytic Treatment Response in Acute Ischemic Stroke. JAMA Neurology 2014;71(7):848-54. doi: 10.1001/jamaneurol.2014.689.
22. Kerr D, Fulton RL, Lees KR, for the VISTA Collaborators. Day 7 NIHSS is a Sensitive Outcome Measure for Exploratory Clinical Trials in Acute Stroke: Evidence from the Virtual International Stroke Trials Archive (VISTA). Stroke. 2012;43:1401-3.
23. Brainin M, Tuomilehto J, Heiss WD, Bornstein NM, Bath PM, Teuschl Y, Richard E, Guekht A, Quinn T, Post Stroke Cognition Study Group. Post-stroke cognitive decline: an update and perspectives for clinical research. Eur J Neurol. 2015;22(2):229-38.
24. Arba F, Quinn TJ, Hankey GJ, Lees KR, Wardlaw JM, Ali M, Inzitari D. Enlarged perivascular spaces and cognitive impairment after stroke and transient ischaemic attack. Int J Stroke. Published online before print August 19, 2016, doi: 10.1177/1747493016666091
25. METACOHORTS consortium. METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration:An initiative of the Joint Programme for Neurodegenarative Diseae Research. Alzheimer's and Dementia. 2016;12(12):1235-49. http://dx.doi.org/10.1016/j.jalz.2016.06.004.
26. Levine DA, Galecki AT, Langa KM, Unverzaqt FW, Kabeto MU, Giordania B, Wadley VG. Trajectory of cognitive decline after incident stroke. JAMA. 2015;314:41-51.
27. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;2002(360):1903-13.
28. Danesh J, Erqou S, Walker M, Thompson SG. The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol. 2007;22:839-69.
29. Russ TC, Stamatakis E, Hamer M, Starr JM, Kivimaki M, Batty GD. Association between psychological distress and mortality: individual participant pooled analysis of 10 prospective cohort studies. BMJ. 2012;345:e4933.
30. Jokela M, Batty GD, Hintsa T, Elovainio M, Hakulinen C, Kivimaki M. Is personality associated with cancer incidence and mortality An individual-participant meta-analysis of 2156 incident cancer cases among 42,843 men and women. Br J Cancer. 2014;110:1820-4.
31. Russ TC, Kivimäki M, Starr JM, Stamatakis E, Batty GD. Height in relation to dementia death: individual-participant meta-analysis of eighteen uk prospective cohort studies. Br J Psychiatry. 2014;205:348-54.
32. Gray L, Batty DG, Craig P, Stewart C, Whyte B, Finlayson A, Leyland AH. Cohort profile: the Scottish health surveys cohort: linkage of study participants to routinely collected records for mortality, hospital discharge, cancer and offspring birth characteristics in three nationwide studies. Int J Epidemiol. 2010;39:345-50.
33. Mindell J, Biddulph JP, Hirani V, Stamatakis E, Craig R, Nunn S, Shelton N. Cohort profile: the health survey for England. Int J Epidemiol. 2012;41:1585-93.
34. Stewart R. The big case register. Acta Psychiatr Scand. 2014;130:83-6.
35. Perera G, Broadbent M, Callard F, Chang C-K, Downs J, Dutta R, Fernandes A, Hayes RD, Henderson M, Jackson R, Jewell A, Kadra G, Little R, Pritchard M, Shetty H, Tulloch A, Stewart R. Cohort profile of the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLaM BRC) Case Register: current status and recent enhancement of an Electronic Mental Health Record derived data resource. BMJ Open. 2016;6:e008721.
36. Perera G, Khondoker M, Broadbent M, Breen G, Stewart R. Factors associated with response to acetylcholinesterase inhibition in dementia: a cohort study from a secondary mental health case register in London. PLoS ONE. 2014;9:e109484.
37. Sultana J, Chang C-K, Hayes RD, Broadbent M, Stewart R, Corbett A, Ballard C. Associations between risk of mortality and atypical antipsychotic use in vascular dementia: a clinical cohort study. Int J Geriatr Psychiatry. 2014;29:1249-54.
38. Patel R, Jayatilleke N, Broadbent M, Chang C-K, Foskett N, Gorrell G, Hayes RD, Jackson R, Johnston C, Shetty H, Roberts A, McGuire P, Stewart R. Negative symptoms in schizophrenia: a study in a large clinical sample of patients using a novel automated method. BMJ Open. 2015;5:e007619.
39. Religa D, Fereshtehnejad S-M, Cermakova P, Edlund A-K, Garcia Ptacek S, Granqvist N, Hallbäck A, Kåwe K, Farahmand B, Kilander L, Mattsson U-B, Nägga K, Nordström P, Wijk H, Wimo A, Winblad B, Eriksdotter M. SveDem, the Swedish Dementia Registry - a tool for improving the quality of diagnostics, treatment and care of dementia patients in clinical practice. PLoS ONE. 2015;10(2):e0116538. doi: 10.1371/journal.pone.0116538. eCollection 2015.
40. Cermakova P, Lund LH, Fereshtehnejad S-M, Johnell K, Winblad B, Dahlström U, Eriksdotter M, Religa D. Heart failure and dementia: survival in relation to types of heart failure and different dementia disorders. Eur J Heart Fail. 2015;17(6):612-9. doi: 10.1002/ejhf.222.
41. Skillbäck T, Farahmand BY, Rosén C, Mattsson N, Nägga K, Kilander L, Religa D, Wimo A, Winblad B, Schott JM, Blennow K, Eriksdotter M, Henrik ZH. Cerebrospinal fluid tau and Aβ biomarkers in 5676 dementia patients. Brain. 2015;138:2716-31.
42. Garcia-Ptacek S, Farahmand B, Kareholt I, Religa D, Cuadrado ML, Eriksdotter M. Mortality risk after dementia diagnosis by dementia type and underlying factors: a cohort of 15,209 patients based on the Swedish Dementia Registry. JAD. 2014;41:467-77.
43. Dunn HL. Record linkage. Am J Public Health Nations Health. 1946;36:1412-6.
44. Russ TC, Batty GD, Starr JM. Cognitive and behavioural predictors of survival in Alzheimer disease: results from a sample of treated patients in a tertiary-referral memory clinic. Int J Geriatr Psychiatry. 2012;27:844-53.
45. Russ TC, Parra MA, Lim AE, Law E, Connelly PJ, Starr JM. Prediction of general hospital admission in people with dementia: cohort study. Br J Psychiatry. 2015;206:153-9.
46. Martyn CN, Pippard EC. Usefulness of mortality data in determining the geography and time trends of dementia. J Epidemiol Community Health. 1988;42:134-7.
47. Porter M. What is Value in Health Care N Engl J Med. 2010;363(26):2477-81.
48. Porter M, Lee T. Why strategy matters now. N Engl J Med. 2015;372:1681-4.