Flavonoids and Tannins from Smilax China L. Rhizome Induce Apoptosis Via Mitochondrial Pathway and MDM2-p53 Signaling in Human Lung Adenocarcinoma Cells

American Journal of Chinese Medicine

Volumn 45, Issue 2, 2017, Pages 369-384

  Fu, San ^a   Yang, Yanfang ^a   Liu, Dan ^a   Luo, Yan ^a   Ye, Xiaochuan ^a   Liu, Yanwen ^a   Chen, Xin ^a   Wang, Song ^a   Wu, Hezhen ^a   Wang, Yuhang ^b   Hu, Qiwei ^b   You, Pengtao ^a  

^a HUBEI UNIVERSITY OF CHINESE MEDICINE   (China)

^b WUHAN INSTITUTE OF TECHNOLOGY   (China)

Author keywords

A549 Cell; Apoptosis; MDM2; Mitochondrial Pathway; p53; SCR Extracts

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; FLAVONOID; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MDM2; PROTEIN P53; TANNIN DERIVATIVE; CASPASE; MDM2 PROTEIN, HUMAN; TP53 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL PROLIFERATION; CELL VIABILITY; CHINA; CHINESE MEDICINE; CONTROLLED STUDY; ENZYME ACTIVATION; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LUNG ADENOCARCINOMA; LUNG CANCER CELL LINE; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RHIZOME; SARSAPARILLA; SMILAX CHINA; WESTERN BLOTTING; ADENOCARCINOMA; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ISOLATION AND PURIFICATION; LUNG TUMOR; METABOLISM; MITOCHONDRION; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE;

ADENOCARCINOMA; APOPTOSIS; CASPASES; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; HUMANS; LUNG NEOPLASMS; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-MDM2; SIGNAL TRANSDUCTION; SMILAX; TANNINS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85018512668     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X17500239     Document Type: Article

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