Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks (CLARITY): a multicentre, single-blinded, randomised, controlled, phase 2b, non-inferiority trial

The Lancet

Volumn 389, Issue 10085, 2017, Pages 2193-2203

  Sivaprasad, Sobha ^a   Prevost, A Toby ^b   Vasconcelos, Joana C ^b   Riddell, Amy ^c   Murphy, Caroline ^c   Kelly, Joanna ^c   Bainbridge, James ^d   Tudor Edwards, Rhiannon ^e   Hopkins, David ^f   Hykin, Philip ^a   Bhatnagar, A ^g   Burton, B ^g   Chakravarthy, U ^g   Eleftheriadis, H ^g   Empeslidis, T ^g   Gale, R ^g   George, S ^g   Habib, M ^g   Kelly, S ^g   Lotery, A ^g   McKibbin, M ^g   Membrey, L ^g   Menon, G ^g   Mushtaq, B ^g   Nicholson, L ^g   Ramu, J ^g   Osoba, O ^g   Patel, J ^g   Prakash, P ^g   Purbrick, R ^g   Ross, A ^g   Stylianides, A ^g   Talks, J ^g   Harding, S ^g   Peto, T ^g   Yeo, S T ^g   Laidlaw, Alistair ^g   Amoaku, Winfried ^g   Hood, Gillian ^g   Hitman, Graham A ^g   Preece, Daniel ^g   Burns, Paul ^g   Walker, Sarah ^g   Mensah, Evelyn ^g   Karia, Niral ^g   more..

^a Moorfields Biomedical Research Centre ^*  (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e BANGOR UNIVERSITY   (United Kingdom)

^f KING'S COLLEGE HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^g NONE

Author keywords

[No Author keywords available]

Indexed keywords

AFLIBERCEPT; ANGIOGENESIS INHIBITOR; FUSION PROTEIN; VASCULOTROPIN RECEPTOR;

ABRASION; ADULT; ARTICLE; BEST CORRECTED VISUAL ACUITY; BLEPHARITIS; CATARACT; COMPARATIVE EFFECTIVENESS; CONJUNCTIVA DISEASE; CONJUNCTIVAL HEMORRHAGE; CONJUNCTIVITIS; CONTROLLED STUDY; CORNEA EROSION; CORNEA INJURY; DACRYOCYSTITIS; DIABETIC RETINOPATHY; DIPLOPIA; DRUG EFFICACY; DRUG SAFETY; ENDOPHTHALMITIS; EPIRETINAL MEMBRANE; EYE DISCOMFORT; EYE PAIN; FEMALE; HEART INFARCTION; HORDEOLUM; HUMAN; INTENTION TO TREAT ANALYSIS; INTRAOCULAR FOREIGN BODY; INTRAOCULAR HYPERTENSION; KERATITIS; LACERATION; LASER COAGULATION; MACULAR EDEMA; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTICENTER STUDY; NEOVASCULAR GLAUCOMA; NIGHT BLINDNESS; NYSTAGMUS; OPHTHALMIC LASER; PARALLEL DESIGN; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROLIFERATIVE DIABETIC RETINOPATHY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RETINA DETACHMENT; RETINA NEOVASCULARIZATION; RETINA TEAR; SINGLE BLIND PROCEDURE; TREATMENT OUTCOME; UNITED KINGDOM; UVEITIS; VISUAL DISORDER; VITREOUS BODY DETACHMENT; VITREOUS FLOATERS; VITREOUS HEMORRHAGE; AGED; CLINICAL TRIAL; COMPARATIVE STUDY; DRUG EFFECT; INTRAVITREAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PROCEDURES; SENSITIVITY AND SPECIFICITY; VISUAL ACUITY;

ADULT; AGED; ANGIOGENESIS INHIBITORS; DIABETIC RETINOPATHY; FEMALE; HUMANS; INTRAVITREAL INJECTIONS; LASER COAGULATION; MALE; MIDDLE AGED; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; SENSITIVITY AND SPECIFICITY; SINGLE-BLIND METHOD; TREATMENT OUTCOME; VISUAL ACUITY;

EID: 85018423175     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(17)31193-5     Document Type: Article

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