Human pegivirus-1 in the CSF of patients with HIV-associated neurocognitive disorder (HAND) may be derived from blood in highly viraemic patients

Journal of Clinical Virology

Volumn 91, Issue , 2017, Pages 58-61

  Hardie, Diana ^a   Smuts, Heidi ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Cerebrospinal fluid; HIV associated neurocognitive disorder; Human pegivirus 1

Indexed keywords

5' NON CODING REGION; UNCLASSIFIED DRUG; UNTRANSLATED RNA; VIRUS RNA;

ARTICLE; BLOOD ANALYSIS; BLOOD CULTURE; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID CULTURE; CLINICAL ARTICLE; DROPLET DIGITAL POLYMERASE CHAIN REACTION; HIGH THROUGHPUT SEQUENCING; HIV ASSOCIATED DEMENTIA; HUMAN; HUMAN PEGIVIRUS 1; POLYMERASE CHAIN REACTION; POSITIVE-STRAND RNA VIRUS; PREVALENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; VIREMIA; VIRUS DETECTION; VIRUS LOAD; ADULT; BLOOD; COMPLICATION; DISORDERS OF HIGHER CEREBRAL FUNCTION; FEMALE; FLAVIVIRIDAE INFECTION; GENETICS; HEPATITIS G VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; ISOLATION AND PURIFICATION; MALE; MIDDLE AGED; PHYLOGENY; VIROLOGY;

ADULT; CEREBROSPINAL FLUID; FEMALE; FLAVIVIRIDAE INFECTIONS; GB VIRUS C; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED; NEUROCOGNITIVE DISORDERS; PHYLOGENY; POLYMERASE CHAIN REACTION; RNA, VIRAL; VIRAL LOAD; VIREMIA;

EID: 85018398313     PISSN: 13866532     EISSN: 18735967     Source Type: Journal    
DOI: 10.1016/j.jcv.2017.04.007     Document Type: Article

References (16)

1. [1] Palacios, G., Ph, D., Druce, J., et al. A new arenavirus in a cluster of transplant-associated diseases. New Engl. J. Med. 358 (2008), 991–998.
2. [2] Briese, T., Paweska, J.T., McMullan, L.K., et al. Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from Southern Africa. PLoS Pathog. 5 (2009), 1–8, 10.1371/journal.ppat.1000455.
3. [3] Van, Tan L., Van, Doorn H.R., Trung, D., et al. Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervus system infections. MBio, 4, 2013, 10.1128/mBio.00231-13 Invited, e00231-13.
4. [4] Maidana Giret, M.T., Kallas, E.G., GBV-C: state of the art and future prospects. Curr. HIV/AIDS Rep. 9 (2012), 26–33, 10.1007/s11904-011-0109-1.
5. [5] Ghai, R.R., Sibley, S.D., Lauck, M., et al. Deep sequencing identifies two genotypes and high viral genetic diversity of human pegivirus (GB virus C) in rural Ugandan patients. J. Gen. Virol. 94 (2013), 2670–2678, 10.1099/vir.0.055509-0.
6. [6] Chivero, E.T., Stapleton, J.T., Tropism of human pegivirus (formerly known as GB virus C/hepatitis G virus) and host immunomodulation: insights into a highly successful viral infection. J. Gen. Virol. 96 (2015), 1521–1532, 10.1099/vir.0.000086.
7. [7] Kriesel, J.D., Hobbs, M.R., Jones, B.B., et al. Deep sequencing for the detection of virus-like sequences in the brains of patients with multiple sclerosis: detection of GBV-C in human brain. PLoS One 7 (2012), 1–8, 10.1371/journal.pone.0031886.
8. [8] Fridholm, H., Østergaard Sørensen, L., Rosenstierne, M.W., et al. Human pegivirus detected in a patient with severe encephalitis using a metagenomic pan-virus array. J. Clin. Virol. 77 (2016), 5–8, 10.1016/j.jcv.2016.01.013.
9. [9] Liu, Z., Zhang, Y., Wei, F., et al. Detection of GB virus C genomic sequence in the cerebrospinal fluid of a HIV-infected patient in China: a case report and literature review. Epidemiol. Infect., 2015, 1–7, 10.1017/S0950268815001326.
10. [10] Feng, Y., Zhao, W., Feng, Y., et al. A novel genotype of GB virus C: its identification and predominance among injecting drug users in Yunnan, China. PLoS One 6:10 (2011), 1–10, 10.1371/journal.pone.0021151.
11. [11] Tamura, K., Stecher, G., Peterson, D., et al. MEGA6: molecular evolutionary genetics analysis version 6.0. Mol. Biol. Evol. 30 (2013), 2725–2729, 10.1093/molbev/mst197.
12. [12] Albertyn, C., Plas, H., Van Der Hardie, D., et al. FORUM Silent casualties from the measles outbreak in South Africa Case reports. S. Afr. Med. J. 101 (2011), 3–6.
13. [13] Muerhoff, A.S., Leary, T.P., Sathar, M.A., et al. African origin of GB virus C determined by phylogenetic analysis of a complete genotype 5 genome from South Africa. J. Gen. Virol. 86 (2005), 1729–1735, 10.1099/vir.0.80854-0.
14. [14] Luk, K.C., Berg, M.G., Naccache, S.N., et al. Utility of metagenomic next-generation sequencing for characterization of HIV and human pegivirus diversity. PLoS One 10 (2015), 1–20, 10.1371/journal.pone.0141723.
15. [15] Tucker, T.J., Smuts, H.E.M., Eedes, C., et al. Evidence that the GBV-C/hepatitis G virus is primarily a lymphotropic virus. J. Med. Virol. 61 (2000), 52–58, 10.1002/(SICI)1096-9071(200005)61:1<52:AID-JMV8>3.0.CO;2-L.
16. [16] Chivero, E.T., Bhattarai, N., Rydze, R.T., et al. Human pegivirus RNA is found in multiple blood mononuclear cells in vivo and serum-derived viral RNA-containing particles are infectious in vitro. J. Gen. Virol. 95 (2014), 1307–1319, 10.1099/vir.0.063016-0.