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Volumn 13, Issue 7, 2017, Pages 385-399

Insulin analogues in type 1 diabetes mellitus: Getting better all the time

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN ASPART; INSULIN ASPART PLUS INSULIN DEGLUDEC; INSULIN DEGLUDEC; INSULIN DERIVATIVE; INSULIN DETEMIR; INSULIN GLARGINE; INSULIN GLULISINE; INSULIN LISPRO; INSULIN PEGLISPRO; INSULIN ZINC SUSPENSION; ISOPHANE INSULIN; PIG INSULIN; ANTIDIABETIC AGENT; INSULIN; LONG ACTING INSULIN;

EID: 85018278053     PISSN: 17595029     EISSN: 17595037     Source Type: Journal    
DOI: 10.1038/nrendo.2017.39     Document Type: Review
Times cited : (174)

References (138)
  • 2
    • 85020581250 scopus 로고    scopus 로고
    • Insulin - pharmacology, therapeutic regimens and principles of intensive insulin therapy
    • Donner, T. Insulin - pharmacology, therapeutic regimens and principles of intensive insulin therapy. Endotext https://www.ncbi.nlm.nih.gov/books/NBK278938/ (2000).
    • (2000) Endotext
    • Donner, T.1
  • 3
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329, 977-986 (1993).
    • (1993) N. Engl. J. Med. , vol.329 , pp. 977-986
  • 4
    • 84892408228 scopus 로고    scopus 로고
    • The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: Overview
    • Nathan, D. M. & DCCT/EDIC Research Group. The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: overview. Diabetes Care 37, 9-16 (2014).
    • (2014) Diabetes Care , vol.37 , pp. 9-16
    • Nathan, D.M.1
  • 5
    • 84864331174 scopus 로고    scopus 로고
    • The pharmacokinetics and pharmacodynamics of rapid-acting insulin analogues and their clinical consequences
    • Home, P. D. The pharmacokinetics and pharmacodynamics of rapid-acting insulin analogues and their clinical consequences. Diabetes Obes. Metab. 14, 780-788 (2012).
    • (2012) Diabetes Obes. Metab. , vol.14 , pp. 780-788
    • Home, P.D.1
  • 6
    • 84860873383 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of high-dose human regular U-500 insulin versus human regular U-100 insulin in healthy obese subjects
    • de la Pena, A. et al. Pharmacokinetics and pharmacodynamics of high-dose human regular U-500 insulin versus human regular U-100 insulin in healthy obese subjects. Diabetes Care 34, 2496-2501 (2011).
    • (2011) Diabetes Care , vol.34 , pp. 2496-2501
    • De La-Pena, A.1
  • 7
    • 2542576404 scopus 로고    scopus 로고
    • Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetes
    • Heise, T. et al. Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetes. Diabetes 53, 1614-1620 (2004).
    • (2004) Diabetes , vol.53 , pp. 1614-1620
    • Heise, T.1
  • 8
    • 34547908855 scopus 로고    scopus 로고
    • Towards peakless, reproducible and long-acting insulins. An assessment of the basal analogues based on isoglycaemic clamp studies
    • Heise, T. & Pieber, T. R. Towards peakless, reproducible and long-acting insulins. An assessment of the basal analogues based on isoglycaemic clamp studies. Diabetes Obes. Metab. 9, 648-659 (2007).
    • (2007) Diabetes Obes. Metab. , vol.9 , pp. 648-659
    • Heise, T.1    Pieber, T.R.2
  • 9
    • 80052003991 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of therapeutic doses of basal insulins NPH, glargine, and detemir after 1 week of daily administration at bedtime in type 2 diabetic subjects: A randomized cross-over study
    • Lucidi, P. et al. Pharmacokinetics and pharmacodynamics of therapeutic doses of basal insulins NPH, glargine, and detemir after 1 week of daily administration at bedtime in type 2 diabetic subjects: a randomized cross-over study. Diabetes Care 34, 1312-1314 (2011).
    • (2011) Diabetes Care , vol.34 , pp. 1312-1314
    • Lucidi, P.1
  • 10
    • 0025078913 scopus 로고
    • Monomeric insulins and their experimental and clinical implications
    • Brange, J., Owens, D. R., Kang, S. & Volund, A. Monomeric insulins and their experimental and clinical implications. Diabetes Care 13, 923-954 (1990).
    • (1990) Diabetes Care , vol.13 , pp. 923-954
    • Brange, J.1    Owens, D.R.2    Kang, S.3    Volund, A.4
  • 11
    • 0030055378 scopus 로고    scopus 로고
    • Prandial glycaemia after a carbohydrate-rich meal in type I diabetic patients: Using the rapid acting insulin analogue [Lys(B28), pro(B29)] human insulin
    • Heinemann, L. et al. Prandial glycaemia after a carbohydrate-rich meal in type I diabetic patients: using the rapid acting insulin analogue [Lys(B28), Pro(B29)] human insulin. Diabet. Med. 13, 625-629 (1996).
    • (1996) Diabet. Med. , vol.13 , pp. 625-629
    • Heinemann, L.1
  • 12
    • 0029958430 scopus 로고    scopus 로고
    • Injection site effects on the pharmacokinetics and glucodynamics of insulin lispro and regular insulin
    • ter Braak, E. W. et al. Injection site effects on the pharmacokinetics and glucodynamics of insulin lispro and regular insulin. Diabetes Care 19, 1437-1440 (1996).
    • (1996) Diabetes Care , vol.19 , pp. 1437-1440
    • Ter Braak, E.W.1
  • 13
    • 0034788515 scopus 로고    scopus 로고
    • Glycaemic control in type 1 diabetic patients using optimised insulin aspart or human insulin in a randomised multinational study
    • Tamas, G. et al. Glycaemic control in type 1 diabetic patients using optimised insulin aspart or human insulin in a randomised multinational study. Diabetes Res. Clin. Pract. 54, 105-114 (2001).
    • (2001) Diabetes Res. Clin. Pract. , vol.54 , pp. 105-114
    • Tamas, G.1
  • 14
    • 0034976371 scopus 로고    scopus 로고
    • Italian multicentre study of intensive therapy with insulin lispro in 1184 patients with type 1 diabetes
    • Valle, D., Santoro, D., Bates, P., Scarpa, L. & Italian Multicentre Lispro Study Group. Italian multicentre study of intensive therapy with insulin lispro in 1184 patients with type 1 diabetes. Diabetes Nutr. Metab. 14, 126-132 (2001).
    • (2001) Diabetes Nutr. Metab. , vol.14 , pp. 126-132
    • Valle, D.1    Santoro, D.2    Bates, P.3    Scarpa, L.4
  • 15
    • 0032896693 scopus 로고    scopus 로고
    • Improved postprandial glycemic control with insulin aspart. A randomized double-blind cross-over trial in type 1 diabetes
    • Lindholm, A., McEwen, J. & Riis, A. P. Improved postprandial glycemic control with insulin aspart. A randomized double-blind cross-over trial in type 1 diabetes. Diabetes Care 22, 801-805 (1999).
    • (1999) Diabetes Care , vol.22 , pp. 801-805
    • Lindholm, A.1    McEwen, J.2    Riis, A.P.3
  • 16
    • 0033060426 scopus 로고    scopus 로고
    • Comparative pharmacokinetics and pharmacodynamics of the novel rapid-acting insulin analogue, insulin aspart, in healthy volunteers
    • Home, P. D., Barriocanal, L. & Lindholm, A. Comparative pharmacokinetics and pharmacodynamics of the novel rapid-acting insulin analogue, insulin aspart, in healthy volunteers. Eur. J. Clin. Pharmacol. 55, 199-203 (1999).
    • (1999) Eur. J. Clin. Pharmacol. , vol.55 , pp. 199-203
    • Home, P.D.1    Barriocanal, L.2    Lindholm, A.3
  • 17
    • 0036833902 scopus 로고    scopus 로고
    • A direct comparison of insulin aspart and insulin lispro in patients with type 1 diabetes
    • Plank, J. et al. A direct comparison of insulin aspart and insulin lispro in patients with type 1 diabetes. Diabetes Care 25, 2053-2057 (2002).
    • (2002) Diabetes Care , vol.25 , pp. 2053-2057
    • Plank, J.1
  • 18
    • 1542787613 scopus 로고    scopus 로고
    • Comparison of insulin aspart and lispro: Pharmacokinetic and metabolic effects
    • Homko, C., Deluzio, A., Jimenez, C., Kolaczynski, J. W. & Boden, G. Comparison of insulin aspart and lispro: pharmacokinetic and metabolic effects. Diabetes Care 26, 2027-2031 (2003).
    • (2003) Diabetes Care , vol.26 , pp. 2027-2031
    • Homko, C.1    Deluzio, A.2    Jimenez, C.3    Kolaczynski, J.W.4    Boden, G.5
  • 19
    • 57349185245 scopus 로고    scopus 로고
    • Better postprandial glucose stability during continuous subcutaneous infusion with insulin aspart compared with insulin lispro in patients with type 1 diabetes
    • Bartolo, P. D. et al. Better postprandial glucose stability during continuous subcutaneous infusion with insulin aspart compared with insulin lispro in patients with type 1 diabetes. Diabetes Technol. Ther. 10, 495-498 (2008).
    • (2008) Diabetes Technol. Ther. , vol.10 , pp. 495-498
    • Bartolo, P.D.1
  • 20
    • 0036514611 scopus 로고    scopus 로고
    • Comparison of insulin aspart with buffered regular insulin and insulin lispro in continuous subcutaneous insulin infusion: A randomized study in type 1 diabetes
    • Bode, B. et al. Comparison of insulin aspart with buffered regular insulin and insulin lispro in continuous subcutaneous insulin infusion: a randomized study in type 1 diabetes. Diabetes Care 25, 439-444 (2002).
    • (2002) Diabetes Care , vol.25 , pp. 439-444
    • Bode, B.1
  • 21
    • 29144461567 scopus 로고    scopus 로고
    • Efficacy and safety of insulin glulisine in patients with type 1 diabetes
    • Dreyer, M. et al. Efficacy and safety of insulin glulisine in patients with type 1 diabetes. Horm. Metab. Res. 37, 702-707 (2005).
    • (2005) Horm. Metab. Res. , vol.37 , pp. 702-707
    • Dreyer, M.1
  • 22
    • 0034537104 scopus 로고    scopus 로고
    • Insulin aspart versus human insulin in the management of long-term blood glucose control in type 1 diabetes mellitus: A randomized controlled trial
    • Home, P. D., Lindholm, A., Riis, A. & European Insulin Aspart Study Group. Insulin aspart versus human insulin in the management of long-term blood glucose control in type 1 diabetes mellitus: a randomized controlled trial. Diabet. Med. 17, 762-770 (2000).
    • (2000) Diabet. Med. , vol.17 , pp. 762-770
    • Home, P.D.1    Lindholm, A.2    Riis, A.3
  • 23
    • 0034109079 scopus 로고    scopus 로고
    • Use of insulin aspart, a fast-acting insulin analog, as the mealtime insulin in the management of patients with type 1 diabetes
    • Raskin, P., Guthrie, R. A., Leiter, L., Riis, A. & Jovanovic, L. Use of insulin aspart, a fast-acting insulin analog, as the mealtime insulin in the management of patients with type 1 diabetes. Diabetes Care 23, 583-588 (2000).
    • (2000) Diabetes Care , vol.23 , pp. 583-588
    • Raskin, P.1    Guthrie, R.A.2    Leiter, L.3    Riis, A.4    Jovanovic, L.5
  • 24
    • 25444468590 scopus 로고    scopus 로고
    • Insulin glulisine, a new rapid-acting insulin analogue, displays a rapid time-action profile in obese non-diabetic subjects
    • Becker, R. H., Frick, A. D., Burger, F., Potgieter, J. H. & Scholtz, H. Insulin glulisine, a new rapid-acting insulin analogue, displays a rapid time-action profile in obese non-diabetic subjects. Exp. Clin. Endocrinol. Diabetes 113, 435-443 (2005).
    • (2005) Exp. Clin. Endocrinol. Diabetes , vol.113 , pp. 435-443
    • Becker, R.H.1    Frick, A.D.2    Burger, F.3    Potgieter, J.H.4    Scholtz, H.5
  • 25
    • 84900530439 scopus 로고    scopus 로고
    • Stability and performance of rapid-acting insulin analogs used for continuous subcutaneous insulin infusion: A systematic review
    • Kerr, D., Wizemann, E., Senstius, J., Zacho, M. & Ampudia-Blasco, F. J. Stability and performance of rapid-acting insulin analogs used for continuous subcutaneous insulin infusion: a systematic review. J. Diabetes Sci. Technol. 7, 1595-1606 (2013).
    • (2013) J. Diabetes Sci. Technol. , vol.7 , pp. 1595-1606
    • Kerr, D.1    Wizemann, E.2    Senstius, J.3    Zacho, M.4    Ampudia-Blasco, F.J.5
  • 26
    • 34547879624 scopus 로고    scopus 로고
    • Insulin glulisine: A faster onset of action compared with insulin lispro
    • Heise, T. et al. Insulin glulisine: a faster onset of action compared with insulin lispro. Diabetes Obes. Metab. 9, 746-753 (2007).
    • (2007) Diabetes Obes. Metab. , vol.9 , pp. 746-753
    • Heise, T.1
  • 27
    • 77958144693 scopus 로고    scopus 로고
    • Insulin glulisine has a faster onset of action compared with insulin aspart in healthy volunteers
    • Arnolds, S. et al. Insulin glulisine has a faster onset of action compared with insulin aspart in healthy volunteers. Exp. Clin. Endocrinol. Diabetes 118, 662-664 (2010).
    • (2010) Exp. Clin. Endocrinol. Diabetes , vol.118 , pp. 662-664
    • Arnolds, S.1
  • 28
    • 38349087531 scopus 로고    scopus 로고
    • A comparison of preprandial insulin glulisine versus insulin lispro in people with type 2 diabetes over a 12-h period
    • Luzio, S., Peter, R., Dunseath, G. J., Mustafa, L. & Owens, D. R. A comparison of preprandial insulin glulisine versus insulin lispro in people with type 2 diabetes over a 12-h period. Diabetes Res. Clin. Pract. 79, 269-275 (2008).
    • (2008) Diabetes Res. Clin. Pract. , vol.79 , pp. 269-275
    • Luzio, S.1    Peter, R.2    Dunseath, G.J.3    Mustafa, L.4    Owens, D.R.5
  • 29
    • 78851472325 scopus 로고    scopus 로고
    • Comparative pharmacodynamic and pharmacokinetic characteristics of subcutaneous insulin glulisine and insulin aspart prior to a standard meal in obese subjects with type 2 diabetes
    • Bolli, G. B. et al. Comparative pharmacodynamic and pharmacokinetic characteristics of subcutaneous insulin glulisine and insulin aspart prior to a standard meal in obese subjects with type 2 diabetes. Diabetes Obes. Metab. 13, 251-257 (2011).
    • (2011) Diabetes Obes. Metab. , vol.13 , pp. 251-257
    • Bolli, G.B.1
  • 30
    • 18144419604 scopus 로고    scopus 로고
    • Optimized basal-bolus insulin regimens in type 1 diabetes: Insulin glulisine versus regular human insulin in combination with basal insulin glargine
    • Garg, S. K., Rosenstock, J. & Ways, K. Optimized basal-bolus insulin regimens in type 1 diabetes: insulin glulisine versus regular human insulin in combination with basal insulin glargine. Endocr. Pract. 11, 11-17 (2005).
    • (2005) Endocr. Pract. , vol.11 , pp. 11-17
    • Garg, S.K.1    Rosenstock, J.2    Ways, K.3
  • 31
    • 84977606171 scopus 로고    scopus 로고
    • Short-acting insulin analogues versus regular human insulin for adults with type 1 diabetes mellitus
    • Fullerton, B. et al. Short-acting insulin analogues versus regular human insulin for adults with type 1 diabetes mellitus. Cochrane Database Syst. Rev. 6, CD012161 (2016).
    • (2016) Cochrane Database Syst. Rev. , vol.6 , pp. CD012161
    • Fullerton, B.1
  • 32
    • 85020601911 scopus 로고    scopus 로고
    • Fast-acting insulin aspart improves glycemic control in basal-bolus treatment for type 1 diabetes: Results of a 26-week multicenter, active-controlled, treat-to-target, randomized, parallel-group trial (Onset 1)
    • Russell-Jones, D. et al. Fast-acting insulin aspart improves glycemic control in basal-bolus treatment for type 1 diabetes: Results of a 26-week multicenter, active-controlled, treat-to-target, randomized, parallel-group trial (Onset 1). Diabetes Care http://dx.doi.org/10.2337/dc16-1771 (2017).
    • (2017) Diabetes Care
    • Russell-Jones, D.1
  • 33
    • 0037799202 scopus 로고    scopus 로고
    • A randomized trial of insulin aspart with intensified basal NPH insulin supplementation in people with type 1 diabetes
    • DeVries, J. H. et al. A randomized trial of insulin aspart with intensified basal NPH insulin supplementation in people with type 1 diabetes. Diabet. Med. 20, 312-318 (2003).
    • (2003) Diabet. Med. , vol.20 , pp. 312-318
    • DeVries, J.H.1
  • 34
    • 84991593769 scopus 로고    scopus 로고
    • Systematic review of the cost effectiveness of insulin analogues in type 1 and type 2 diabetes mellitus
    • Shafie, A. A., Ng, C. H., Tan, Y. P. & Chaiyakunapruk, N. Systematic review of the cost effectiveness of insulin analogues in type 1 and type 2 diabetes mellitus. Pharmacoeconomics 35, 141-162 (2017).
    • (2017) Pharmacoeconomics , vol.35 , pp. 141-162
    • Shafie, A.A.1    Ng, C.H.2    Tan, Y.P.3    Chaiyakunapruk, N.4
  • 35
    • 84978700559 scopus 로고    scopus 로고
    • Short-term cost-effectiveness of insulin detemir and insulin aspart in people with type 1 diabetes who are prone to recurrent severe hypoglycemia
    • Pedersen-Bjergaard, U. et al. Short-term cost-effectiveness of insulin detemir and insulin aspart in people with type 1 diabetes who are prone to recurrent severe hypoglycemia. Curr. Med. Res. Opin. 32, 1719-1725 (2016).
    • (2016) Curr. Med. Res. Opin. , vol.32 , pp. 1719-1725
    • Pedersen-Bjergaard, U.1
  • 36
    • 85009168575 scopus 로고    scopus 로고
    • 8. Pharmacologic approaches to glycemic treatment
    • American Diabetes Association. 8. Pharmacologic approaches to glycemic treatment. Diabetes Care 40, S64-S74 (2017).
    • (2017) Diabetes Care , vol.40 , pp. S64-S74
  • 37
    • 80052075211 scopus 로고    scopus 로고
    • Glycemic control and pregnancy outcomes in women with type 1 diabetes mellitus using lispro versus regular insulin: A systematic review and meta-analysis
    • Gonzalez Blanco, C., Chico Ballesteros, A., Gich Saladich, I. & Corcoy Pla, R. Glycemic control and pregnancy outcomes in women with type 1 diabetes mellitus using lispro versus regular insulin: a systematic review and meta-analysis. Diabetes Technol. Ther. 13, 907-911 (2011).
    • (2011) Diabetes Technol. Ther. , vol.13 , pp. 907-911
    • Gonzalez Blanco, C.1    Chico Ballesteros, A.2    Gich Saladich, I.3    Corcoy Pla, R.4
  • 38
    • 34147093269 scopus 로고    scopus 로고
    • Maternal glycemic control and hypoglycemia in type 1 diabetic pregnancy: A randomized trial of insulin aspart versus human insulin in 322 pregnant women
    • Mathiesen, E. R. et al. Maternal glycemic control and hypoglycemia in type 1 diabetic pregnancy: a randomized trial of insulin aspart versus human insulin in 322 pregnant women. Diabetes Care 30, 771-776 (2007).
    • (2007) Diabetes Care , vol.30 , pp. 771-776
    • Mathiesen, E.R.1
  • 39
    • 84953837663 scopus 로고    scopus 로고
    • Continuous subcutaneous insulin infusion in diabetes: Patient populations, safety, efficacy, and pharmacoeconomics
    • Pozzilli, P. et al. Continuous subcutaneous insulin infusion in diabetes: patient populations, safety, efficacy, and pharmacoeconomics. Diabetes Metab. Res. Rev. 32, 21-39 (2016).
    • (2016) Diabetes Metab. Res. Rev. , vol.32 , pp. 21-39
    • Pozzilli, P.1
  • 40
    • 77956139107 scopus 로고    scopus 로고
    • Laboratory-based non-clinical comparison of occlusion rates using three rapid-acting insulin analogs in continuous subcutaneous insulin infusion catheters using low flow rates
    • Kerr, D., Morton, J., Whately-Smith, C., Everett, J. & Begley, J. P. Laboratory-based non-clinical comparison of occlusion rates using three rapid-acting insulin analogs in continuous subcutaneous insulin infusion catheters using low flow rates. J. Diabetes Sci. Technol. 2, 450-455 (2008).
    • (2008) J. Diabetes Sci. Technol. , vol.2 , pp. 450-455
    • Kerr, D.1    Morton, J.2    Whately-Smith, C.3    Everett, J.4    Begley, J.P.5
  • 41
    • 0034011079 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic properties of long-acting insulin analogue NN304 in comparison to NPH insulin in humans
    • Brunner, G. A. et al. Pharmacokinetic and pharmacodynamic properties of long-acting insulin analogue NN304 in comparison to NPH insulin in humans. Exp. Clin. Endocrinol. Diabetes 108, 100-105 (2000).
    • (2000) Exp. Clin. Endocrinol. Diabetes , vol.108 , pp. 100-105
    • Brunner, G.A.1
  • 42
    • 80054084342 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of basal insulins
    • Porcellati, F., Bolli, G. B. & Fanelli, C. G. Pharmacokinetics and pharmacodynamics of basal insulins. Diabetes Technol. Ther. 13 (Suppl. 1), S15-S24 (2011).
    • (2011) Diabetes Technol. Ther. , vol.13 , pp. S15-S24
    • Porcellati, F.1    Bolli, G.B.2    Fanelli, C.G.3
  • 43
    • 0033865137 scopus 로고    scopus 로고
    • U.S. Insulin glargine (HOE 901) type 1 diabetes investigator group. Basal insulin glargine (HOE 901) versus NPH insulin in patients with type 1 diabetes on multiple daily insulin regimens
    • Rosenstock, J., Park, G., Zimmerman, J. & U.S. Insulin Glargine (HOE 901) Type 1 Diabetes Investigator Group. Basal insulin glargine (HOE 901) versus NPH insulin in patients with type 1 diabetes on multiple daily insulin regimens. Diabetes Care 23, 1137-1142 (2000).
    • (2000) Diabetes Care , vol.23 , pp. 1137-1142
    • Rosenstock, J.1    Park, G.2    Zimmerman, J.3
  • 44
    • 0842311525 scopus 로고    scopus 로고
    • Efficacy of conversion from bedtime NPH insulin injection to once- or twice-daily injections of insulin glargine in type 1 diabetic patients using basal/bolus therapy
    • Albright, E. S., Desmond, R. & Bell, D. S. Efficacy of conversion from bedtime NPH insulin injection to once- or twice-daily injections of insulin glargine in type 1 diabetic patients using basal/bolus therapy. Diabetes Care 27, 632-633 (2004).
    • (2004) Diabetes Care , vol.27 , pp. 632-633
    • Albright, E.S.1    Desmond, R.2    Bell, D.S.3
  • 45
    • 0034033028 scopus 로고    scopus 로고
    • Less hypoglycemia with insulin glargine in intensive insulin therapy for type 1 diabetes. U.S. Study group of insulin glargine in type 1 diabetes
    • Ratner, R. E. et al. Less hypoglycemia with insulin glargine in intensive insulin therapy for type 1 diabetes. U.S. study group of insulin glargine in type 1 diabetes. Diabetes Care 23, 639-643 (2000).
    • (2000) Diabetes Care , vol.23 , pp. 639-643
    • Ratner, R.E.1
  • 46
    • 33847046362 scopus 로고    scopus 로고
    • Safety and efficacy of insulin detemir in clinical practice: 14-week follow-up data from type 1 and type 2 diabetes patients in the PREDICTIVE european cohort
    • Dornhorst, A. et al. Safety and efficacy of insulin detemir in clinical practice: 14-week follow-up data from type 1 and type 2 diabetes patients in the PREDICTIVE European cohort. Int. J. Clin. Pract. 61, 523-528 (2007).
    • (2007) Int. J. Clin. Pract. , vol.61 , pp. 523-528
    • Dornhorst, A.1
  • 47
    • 72549093542 scopus 로고    scopus 로고
    • Observational, open-label study of type 1 and type 2 diabetes patients switching from human insulin to insulin analogue basal-bolus regimens: Insights from the PREDICTIVE study
    • Hermansen, K., Dornhorst, A. & Sreenan, S. Observational, open-label study of type 1 and type 2 diabetes patients switching from human insulin to insulin analogue basal-bolus regimens: insights from the PREDICTIVE study. Curr. Med. Res. Opin. 25, 2601-2608 (2009).
    • (2009) Curr. Med. Res. Opin. , vol.25 , pp. 2601-2608
    • Hermansen, K.1    Dornhorst, A.2    Sreenan, S.3
  • 48
    • 85020574458 scopus 로고    scopus 로고
    • Top 50 pharmaceutical products by global sales
    • [No authors listed]
    • [No authors listed.] Top 50 pharmaceutical products by global sales. PMLiVE http://www.pmlive.com/top-pharma-list/Top-50-pharmaceutical-products-by-global-sales (2017).
    • (2017) PMLiVE
  • 49
    • 0033661254 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro
    • Lepore, M. et al. Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro. Diabetes 49, 2142-2148 (2000).
    • (2000) Diabetes , vol.49 , pp. 2142-2148
    • Lepore, M.1
  • 50
    • 34247611906 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of the long-acting insulin analog glargine after 1 week of use compared with its first administration in subjects with type 1 diabetes
    • Porcellati, F. et al. Pharmacokinetics and pharmacodynamics of the long-acting insulin analog glargine after 1 week of use compared with its first administration in subjects with type 1 diabetes. Diabetes Care 30, 1261-1263 (2007).
    • (2007) Diabetes Care , vol.30 , pp. 1261-1263
    • Porcellati, F.1
  • 51
    • 0001521925 scopus 로고
    • Controlling insulin bioavailability by crystal contact engineering
    • Hilgenfeld, R. et al. Controlling insulin bioavailability by crystal contact engineering. Diabetologia 35, A193 (1992).
    • (1992) Diabetologia , vol.35 , pp. A193
    • Hilgenfeld, R.1
  • 52
    • 33947644300 scopus 로고    scopus 로고
    • Albumin-bound basal insulin analogues (insulin detemir and NN344): Comparable time-action profiles but less variability than insulin glargine in type 2 diabetes
    • Klein, O. et al. Albumin-bound basal insulin analogues (insulin detemir and NN344): comparable time-action profiles but less variability than insulin glargine in type 2 diabetes. Diabetes Obes. Metab. 9, 290-299 (2007).
    • (2007) Diabetes Obes. Metab. , vol.9 , pp. 290-299
    • Klein, O.1
  • 53
    • 33645058907 scopus 로고    scopus 로고
    • Optimal timing of injection of once-daily insulin glargine in people with type 1 diabetes using insulin lispro at meal-times
    • Ashwell, S. G., Gebbie, J. & Home, P. D. Optimal timing of injection of once-daily insulin glargine in people with type 1 diabetes using insulin lispro at meal-times. Diabet. Med. 23, 46-52 (2006).
    • (2006) Diabet. Med. , vol.23 , pp. 46-52
    • Ashwell, S.G.1    Gebbie, J.2    Home, P.D.3
  • 54
    • 4344701890 scopus 로고    scopus 로고
    • The mechanism of protraction of insulin detemir, a long-acting, acylated analog of human insulin
    • Havelund, S. et al. The mechanism of protraction of insulin detemir, a long-acting, acylated analog of human insulin. Pharm. Res. 21, 1498-1504 (2004).
    • (2004) Pharm. Res. , vol.21 , pp. 1498-1504
    • Havelund, S.1
  • 55
    • 0038114440 scopus 로고    scopus 로고
    • Duration of action, pharmacodynamic profile and between-subject variability of insulin detemir in subjects with type 1 diabetes
    • Pieber, T. R. et al. Duration of action, pharmacodynamic profile and between-subject variability of insulin detemir in subjects with type 1 diabetes. Diabetes 51, A53 (2002).
    • (2002) Diabetes , vol.51 , pp. A53
    • Pieber, T.R.1
  • 56
    • 34249297061 scopus 로고    scopus 로고
    • Comparison of insulin detemir and insulin glargine in subjects with type 1 diabetes using intensive insulin therapy
    • Pieber, T. R. et al. Comparison of insulin detemir and insulin glargine in subjects with type 1 diabetes using intensive insulin therapy. Diabet. Med. 24, 635-642 (2007).
    • (2007) Diabet. Med. , vol.24 , pp. 635-642
    • Pieber, T.R.1
  • 57
    • 71549116382 scopus 로고    scopus 로고
    • Comparison of insulin detemir and insulin glargine in a basal-bolus regimen, with insulin aspart as the mealtime insulin, in patients with type 1 diabetes: A 52-week, multinational, randomized, open-label, parallel-group, treat to target noninferiority trial
    • Heller, S., Koenen, C. & Bode, B. Comparison of insulin detemir and insulin glargine in a basal-bolus regimen, with insulin aspart as the mealtime insulin, in patients with type 1 diabetes: a 52-week, multinational, randomized, open-label, parallel-group, treat to target noninferiority trial. Clin. Ther. 31, 2086-2097 (2009).
    • (2009) Clin. Ther. , vol.31 , pp. 2086-2097
    • Heller, S.1    Koenen, C.2    Bode, B.3
  • 58
    • 20944432717 scopus 로고    scopus 로고
    • A double-blind, randomized, dose-response study investigating the pharmacodynamic and pharmacokinetic properties of the long-acting insulin analog detemir
    • Plank, J. et al. A double-blind, randomized, dose-response study investigating the pharmacodynamic and pharmacokinetic properties of the long-acting insulin analog detemir. Diabetes Care 28, 1107-1112 (2005).
    • (2005) Diabetes Care , vol.28 , pp. 1107-1112
    • Plank, J.1
  • 59
    • 84890560109 scopus 로고    scopus 로고
    • Pharmacodynamics of the long-acting insulin analogues detemir and glargine following single-doses and under steady-state conditions in patients with type 1 diabetes
    • Koehler, G. et al. Pharmacodynamics of the long-acting insulin analogues detemir and glargine following single-doses and under steady-state conditions in patients with type 1 diabetes. Diabetes Obes. Metab. 16, 57-62 (2014).
    • (2014) Diabetes Obes. Metab. , vol.16 , pp. 57-62
    • Koehler, G.1
  • 60
    • 56649117255 scopus 로고    scopus 로고
    • Insulin detemir is characterized by a more reproducible pharmacokinetic profile than insulin glargine in children and adolescents with type 1 diabetes: Results from a randomized, double-blind, controlled trial
    • Danne, T. et al. Insulin detemir is characterized by a more reproducible pharmacokinetic profile than insulin glargine in children and adolescents with type 1 diabetes: results from a randomized, double-blind, controlled trial. Pediatr. Diabetes 9, 554-560 (2008).
    • (2008) Pediatr. Diabetes , vol.9 , pp. 554-560
    • Danne, T.1
  • 61
    • 12744274867 scopus 로고    scopus 로고
    • Insulin detemir used in basal-bolus therapy in people with type 1 diabetes is associated with a lower risk of nocturnal hypoglycaemia and less weight gain over 12 months in comparison to NPH insulin
    • De Leeuw, I. et al. Insulin detemir used in basal-bolus therapy in people with type 1 diabetes is associated with a lower risk of nocturnal hypoglycaemia and less weight gain over 12 months in comparison to NPH insulin. Diabetes Obes. Metab. 7, 73-82 (2005).
    • (2005) Diabetes Obes. Metab. , vol.7 , pp. 73-82
    • De Leeuw, I.1
  • 62
    • 84907504686 scopus 로고    scopus 로고
    • Safety, effectiveness, and cost effectiveness of long acting versus intermediate acting insulin for patients with type 1 diabetes: Systematic review and network meta-analysis
    • Tricco, A. C. et al. Safety, effectiveness, and cost effectiveness of long acting versus intermediate acting insulin for patients with type 1 diabetes: systematic review and network meta-analysis. BMJ 349, g5459 (2014).
    • (2014) BMJ , vol.349 , pp. g5459
    • Tricco, A.C.1
  • 63
    • 84885311416 scopus 로고    scopus 로고
    • A comparison of insulin detemir and neutral protamine hagedorn (isophane) insulin in the treatment of diabetes: A systematic review
    • Frier, B. M., Russell-Jones, D. & Heise, T. A comparison of insulin detemir and neutral protamine Hagedorn (isophane) insulin in the treatment of diabetes: a systematic review. Diabetes Obes. Metab. 15, 978-986 (2013).
    • (2013) Diabetes Obes. Metab. , vol.15 , pp. 978-986
    • Frier, B.M.1    Russell-Jones, D.2    Heise, T.3
  • 64
    • 39049105019 scopus 로고    scopus 로고
    • A randomised, 52 week, treat to target trial comparing insulin detemir with insulin glargine when administered as add-on to glucose-lowering drugs in insulin-naive people with type 2 diabetes
    • Rosenstock, J. et al. A randomised, 52 week, treat to target trial comparing insulin detemir with insulin glargine when administered as add-on to glucose-lowering drugs in insulin-naive people with type 2 diabetes. Diabetologia 51, 408-416 (2008).
    • (2008) Diabetologia , vol.51 , pp. 408-416
    • Rosenstock, J.1
  • 65
    • 23844452771 scopus 로고    scopus 로고
    • Insulin detemir, does a new century bring a better basal insulin?
    • Hordern, S. V. & Russell-Jones, D. L. Insulin detemir, does a new century bring a better basal insulin? Int. J. Clin. Pract. 59, 730-739 (2005).
    • (2005) Int. J. Clin. Pract. , vol.59 , pp. 730-739
    • Hordern, S.V.1    Russell-Jones, D.L.2
  • 66
    • 84944592167 scopus 로고    scopus 로고
    • Effect of subcutaneous insulin detemir on glucose flux, lipolysis and electroencephalography in type 1 diabetes
    • Herring, R. et al. Effect of subcutaneous insulin detemir on glucose flux, lipolysis and electroencephalography in type 1 diabetes. Diabetes Obes. Metab. 17, 1100-1103 (2015).
    • (2015) Diabetes Obes. Metab. , vol.17 , pp. 1100-1103
    • Herring, R.1
  • 67
    • 78751559448 scopus 로고    scopus 로고
    • Safety of insulin glargine use in pregnancy: A systematic review and meta-analysis
    • Pollex, E., Moretti, M. E., Koren, G. & Feig, D. S. Safety of insulin glargine use in pregnancy: a systematic review and meta-analysis. Ann. Pharmacother. 45, 9-16 (2011).
    • (2011) Ann. Pharmacother. , vol.45 , pp. 9-16
    • Pollex, E.1    Moretti, M.E.2    Koren, G.3    Feig, D.S.4
  • 68
    • 84887465724 scopus 로고    scopus 로고
    • Diabetes and pregnancy: An endocrine society clinical practice guideline
    • Blumer, I. et al. Diabetes and pregnancy: an endocrine society clinical practice guideline. J. Clin. Endocrinol. Metab. 98, 4227-4249 (2013).
    • (2013) J. Clin. Endocrinol. Metab. , vol.98 , pp. 4227-4249
    • Blumer, I.1
  • 69
    • 84866653669 scopus 로고    scopus 로고
    • Maternal efficacy and safety outcomes in a randomized, controlled trial comparing insulin detemir with NPH insulin in 310 pregnant women with type 1 diabetes
    • Mathiesen, E. R. et al. Maternal efficacy and safety outcomes in a randomized, controlled trial comparing insulin detemir with NPH insulin in 310 pregnant women with type 1 diabetes. Diabetes Care 35, 2012-2017 (2012).
    • (2012) Diabetes Care , vol.35 , pp. 2012-2017
    • Mathiesen, E.R.1
  • 70
    • 3142755690 scopus 로고    scopus 로고
    • Initiation of insulin glargine in children and adolescents with type 1 diabetes
    • Tan, C. Y., Wilson, D. M. & Buckingham, B. Initiation of insulin glargine in children and adolescents with type 1 diabetes. Pediatr. Diabetes 5, 80-86 (2004).
    • (2004) Pediatr. Diabetes , vol.5 , pp. 80-86
    • Tan, C.Y.1    Wilson, D.M.2    Buckingham, B.3
  • 71
    • 80055064859 scopus 로고    scopus 로고
    • Treatment with insulin detemir or NPH insulin in children aged 2-5 yr with type 1 diabetes mellitus
    • Thalange, N., Bereket, A., Larsen, J., Hiort, L. C. & Peterkova, V. Treatment with insulin detemir or NPH insulin in children aged 2-5 yr with type 1 diabetes mellitus. Pediatr. Diabetes 12, 632-641 (2011).
    • (2011) Pediatr. Diabetes , vol.12 , pp. 632-641
    • Thalange, N.1    Bereket, A.2    Larsen, J.3    Hiort, L.C.4    Peterkova, V.5
  • 72
    • 85059816553 scopus 로고    scopus 로고
    • Type 1 diabetes in adults: Diagnosis and management
    • National Institute for Health and Care Excellence
    • National Institute for Health and Care Excellence. Type 1 diabetes in adults: diagnosis and management. NICE https://www.nice.org.uk/guidance/ng17 (2015).
    • (2015) NICE
  • 73
    • 33645054809 scopus 로고    scopus 로고
    • Improved glycaemic control with insulin glargine plus insulin lispro: A multicentre, randomized, cross-over trial in people with type 1 diabetes
    • Ashwell, S. G. et al. Improved glycaemic control with insulin glargine plus insulin lispro: a multicentre, randomized, cross-over trial in people with type 1 diabetes. Diabet. Med. 23, 285-292 (2006).
    • (2006) Diabet. Med. , vol.23 , pp. 285-292
    • Ashwell, S.G.1
  • 74
    • 84903792623 scopus 로고    scopus 로고
    • Effect of insulin analogues on risk of severe hypoglycaemia in patients with type 1 diabetes prone to recurrent severe hypoglycaemia (HypoAna trial): A prospective, randomised, open-label, blinded-endpoint crossover trial
    • Pedersen-Bjergaard, U. et al. Effect of insulin analogues on risk of severe hypoglycaemia in patients with type 1 diabetes prone to recurrent severe hypoglycaemia (HypoAna trial): a prospective, randomised, open-label, blinded-endpoint crossover trial. Lancet Diabetes Endocrinol. 2, 553-561 (2014).
    • (2014) Lancet Diabetes Endocrinol. , vol.2 , pp. 553-561
    • Pedersen-Bjergaard, U.1
  • 75
    • 77954453975 scopus 로고    scopus 로고
    • Analysis of 24-hour glycemic excursions in patients with type 1 diabetes by using continuous glucose monitoring
    • Taki, K. et al. Analysis of 24-hour glycemic excursions in patients with type 1 diabetes by using continuous glucose monitoring. Diabetes Technol. Ther. 12, 523-528 (2010).
    • (2010) Diabetes Technol. Ther. , vol.12 , pp. 523-528
    • Taki, K.1
  • 76
    • 33845229243 scopus 로고    scopus 로고
    • Efficacy of continuous glucose monitoring system (CGMS) to detect postprandial hyperglycemia and unrecognized hypoglycemia in type 1 diabetic patients
    • Maia, F. F. & Araujo, L. R. Efficacy of continuous glucose monitoring system (CGMS) to detect postprandial hyperglycemia and unrecognized hypoglycemia in type 1 diabetic patients. Diabetes Res. Clin. Pract. 75, 30-34 (2007).
    • (2007) Diabetes Res. Clin. Pract. , vol.75 , pp. 30-34
    • Maia, F.F.1    Araujo, L.R.2
  • 77
    • 85020579085 scopus 로고    scopus 로고
    • Abasaglar (previously abasria)
    • European Medicines Agency. Abasaglar (previously Abasria). EMA http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/002835/human-med-001790.jsp&mid=WC0b01ac058001d124 (2014).
    • (2014) EMA
  • 78
    • 84964070186 scopus 로고    scopus 로고
    • FDA approves basaglar, the first "follow-on" insulin glargine product to treat diabetes
    • US Food and Drug Administration. FDA approves Basaglar, the first "follow-on" insulin glargine product to treat diabetes. FDA https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm477734.htm (2015).
    • (2015) FDA
  • 79
    • 84962360228 scopus 로고    scopus 로고
    • Comparison of the pharmacokinetics and pharmacodynamics of LY2963016 insulin glargine and EU- and US approved versions of lantus insulin glargine in healthy subjects: Three randomized euglycemic clamp studies
    • Linnebjerg, H. et al. Comparison of the pharmacokinetics and pharmacodynamics of LY2963016 insulin glargine and EU- and US approved versions of lantus insulin glargine in healthy subjects: three randomized euglycemic clamp studies. Diabetes Care 38, 2226-2233 (2015).
    • (2015) Diabetes Care , vol.38 , pp. 2226-2233
    • Linnebjerg, H.1
  • 80
    • 84962711009 scopus 로고    scopus 로고
    • Pharmacokinetics of the long-acting basal insulin LY2605541 in subjects with varying degrees of renal function
    • Linnebjerg, H. et al. Pharmacokinetics of the long-acting basal insulin LY2605541 in subjects with varying degrees of renal function. Clin. Pharmacol. Drug Dev. 5, 216-224 (2016).
    • (2016) Clin. Pharmacol. Drug Dev. , vol.5 , pp. 216-224
    • Linnebjerg, H.1
  • 81
    • 84956873259 scopus 로고    scopus 로고
    • Evaluation of immunogenicity of LY2963016 insulin glargine compared with lantus® insulin glargine in patients with type 1 or type 2 diabetes mellitus
    • Ilag, L. L. et al. Evaluation of immunogenicity of LY2963016 insulin glargine compared with Lantus® insulin glargine in patients with type 1 or type 2 diabetes mellitus. Diabetes Obes. Metab. 18, 159-168 (2016).
    • (2016) Diabetes Obes. Metab. , vol.18 , pp. 159-168
    • Ilag, L.L.1
  • 82
    • 84959919994 scopus 로고    scopus 로고
    • Efficacy and safety of LY2963016 insulin glargine in patients with type 1 and type 2 diabetes previously treated with insulin glargine
    • Hadjiyianni, I. et al. Efficacy and safety of LY2963016 insulin glargine in patients with type 1 and type 2 diabetes previously treated with insulin glargine. Diabetes Obes. Metab. 18, 425-429 (2016).
    • (2016) Diabetes Obes. Metab. , vol.18 , pp. 425-429
    • Hadjiyianni, I.1
  • 83
    • 85006873283 scopus 로고    scopus 로고
    • Duration of action of two insulin glargine products, LY2963016 insulin glargine and lantus insulin glargine, in subjects with type 1 diabetes mellitus
    • Linnebjerg, H. et al. Duration of action of two insulin glargine products, LY2963016 insulin glargine and Lantus insulin glargine, in subjects with type 1 diabetes mellitus. Diabetes Obes. Metab. 19, 33-39 (2016).
    • (2016) Diabetes Obes. Metab. , vol.19 , pp. 33-39
    • Linnebjerg, H.1
  • 84
    • 0028296760 scopus 로고
    • Effect of insulin concentration, subcutaneous fat thickness and skin temperature on subcutaneous insulin absorption in healthy subjects
    • Sindelka, G., Heinemann, L., Berger, M., Frenck, W. & Chantelau, E. Effect of insulin concentration, subcutaneous fat thickness and skin temperature on subcutaneous insulin absorption in healthy subjects. Diabetologia 37, 377-380 (1994).
    • (1994) Diabetologia , vol.37 , pp. 377-380
    • Sindelka, G.1    Heinemann, L.2    Berger, M.3    Frenck, W.4    Chantelau, E.5
  • 85
    • 84964262352 scopus 로고    scopus 로고
    • Low within- and between-day variability in exposure to new insulin glargine 300 U/ml
    • Becker, R. H., Nowotny, I., Teichert, L., Bergmann, K. & Kapitza, C. Low within- and between-day variability in exposure to new insulin glargine 300 U/ml. Diabetes Obes. Metab. 17, 261-267 (2015).
    • (2015) Diabetes Obes. Metab. , vol.17 , pp. 261-267
    • Becker, R.H.1    Nowotny, I.2    Teichert, L.3    Bergmann, K.4    Kapitza, C.5
  • 87
    • 85019629780 scopus 로고    scopus 로고
    • Comparison of insulin glargine 300 U/mL and 100 U/mL in adults with type 1 diabetes: Continuous glucose monitoring profiles and variability using morning or evening injections
    • Bergenstal, R. M. et al. Comparison of insulin glargine 300 U/mL and 100 U/mL in adults with type 1 diabetes: continuous glucose monitoring profiles and variability using morning or evening injections. Diabetes Care 40, 554-560 (2017).
    • (2017) Diabetes Care , vol.40 , pp. 554-560
    • Bergenstal, R.M.1
  • 88
    • 84994553389 scopus 로고    scopus 로고
    • Sustained glycaemic control and less nocturnal hypoglycaemia with insulin glargine 300U/mL compared with glargine 100U/mL in Japanese adults with type 1 diabetes (EDITION JP 1 randomised 12-month trial including 6-month extension)
    • Matsuhisa, M. et al. Sustained glycaemic control and less nocturnal hypoglycaemia with insulin glargine 300U/mL compared with glargine 100U/mL in Japanese adults with type 1 diabetes (EDITION JP 1 randomised 12-month trial including 6-month extension). Diabetes Res. Clin. Pract. 122, 133-140 (2016).
    • (2016) Diabetes Res. Clin. Pract. , vol.122 , pp. 133-140
    • Matsuhisa, M.1
  • 89
    • 84962432685 scopus 로고    scopus 로고
    • New insulin glargine 300 units/mL versus glargine 100 units/mL in people with type 1 diabetes: A randomized, phase 3a, open-label clinical trial (EDITION 4)
    • Home, P. D. et al. New insulin glargine 300 Units/mL versus glargine 100 Units/mL in people with type 1 diabetes: a randomized, phase 3a, open-label clinical trial (EDITION 4). Diabetes Care 38, 2217-2225 (2015).
    • (2015) Diabetes Care , vol.38 , pp. 2217-2225
    • Home, P.D.1
  • 90
    • 84961158501 scopus 로고    scopus 로고
    • A meta-analysis of rate ratios for nocturnal confirmed hypoglycaemia with insulin degludec versus insulin glargine using different definitions for hypoglycaemia
    • Heller, S., Mathieu, C., Kapur, R., Wolden, M. L. & Zinman, B. A meta-analysis of rate ratios for nocturnal confirmed hypoglycaemia with insulin degludec versus insulin glargine using different definitions for hypoglycaemia. Diabet. Med. 33, 478-487 (2016).
    • (2016) Diabet. Med. , vol.33 , pp. 478-487
    • Heller, S.1    Mathieu, C.2    Kapur, R.3    Wolden, M.L.4    Zinman, B.5
  • 91
    • 84874858316 scopus 로고    scopus 로고
    • Efficacy and safety of insulin degludec in a flexible dosing regimen versus insulin glargine in patients with type 1 diabetes (BEGIN: Flex T1): A 26-week randomized, treat-to-target trial with a 26 week extension
    • Mathieu, C. et al. Efficacy and safety of insulin degludec in a flexible dosing regimen versus insulin glargine in patients with type 1 diabetes (BEGIN: Flex T1): a 26-week randomized, treat-to-target trial with a 26 week extension. J. Clin. Endocrinol. Metab. 98, 1154-1162 (2013).
    • (2013) J. Clin. Endocrinol. Metab. , vol.98 , pp. 1154-1162
    • Mathieu, C.1
  • 92
    • 84871937855 scopus 로고    scopus 로고
    • Hypoglycaemia risk with insulin degludec compared with insulin glargine in type 2 and type 1 diabetes: A pre-planned meta-analysis of phase 3 trials
    • Ratner, R. E. et al. Hypoglycaemia risk with insulin degludec compared with insulin glargine in type 2 and type 1 diabetes: a pre-planned meta-analysis of phase 3 trials. Diabetes Obes. Metab. 15, 175-184 (2013).
    • (2013) Diabetes Obes. Metab. , vol.15 , pp. 175-184
    • Ratner, R.E.1
  • 93
    • 84937111272 scopus 로고    scopus 로고
    • Comparison of the pharmacokinetic and pharmacodynamic profiles of insulin degludec and insulin glargine
    • Heise, T. et al. Comparison of the pharmacokinetic and pharmacodynamic profiles of insulin degludec and insulin glargine. Expert Opin. Drug Metab. Toxicol. 11, 1193-1201 (2015).
    • (2015) Expert Opin. Drug Metab. Toxicol. , vol.11 , pp. 1193-1201
    • Heise, T.1
  • 94
    • 79956136690 scopus 로고    scopus 로고
    • A new-generation ultra-long-acting basal insulin with a bolus boost compared with insulin glargine in insulin-naive people with type 2 diabetes: A randomized, controlled trial
    • Heise, T. et al. A new-generation ultra-long-acting basal insulin with a bolus boost compared with insulin glargine in insulin-naive people with type 2 diabetes: a randomized, controlled trial. Diabetes Care 34, 669-674 (2011).
    • (2011) Diabetes Care , vol.34 , pp. 669-674
    • Heise, T.1
  • 95
    • 84865972844 scopus 로고    scopus 로고
    • Ultra-long-acting insulin degludec has a flat and stable glucose-lowering effect in type 2 diabetes
    • Heise, T., Nosek, L., Bottcher, S. G., Hastrup, H. & Haahr, H. Ultra-long-acting insulin degludec has a flat and stable glucose-lowering effect in type 2 diabetes. Diabetes Obes. Metab. 14, 944-950 (2012).
    • (2012) Diabetes Obes. Metab. , vol.14 , pp. 944-950
    • Heise, T.1    Nosek, L.2    Bottcher, S.G.3    Hastrup, H.4    Haahr, H.5
  • 96
    • 84892724602 scopus 로고    scopus 로고
    • Insulin stacking versus therapeutic accumulation: Understanding the differences
    • Heise, T. & Meneghini, L. F. Insulin stacking versus therapeutic accumulation: understanding the differences. Endocr. Pract. 20, 75-83 (2014).
    • (2014) Endocr. Pract. , vol.20 , pp. 75-83
    • Heise, T.1    Meneghini, L.F.2
  • 97
    • 84859896417 scopus 로고    scopus 로고
    • Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN basal-bolus type 1): A phase 3, randomised, open-label, treat-to-target non-inferiority trial
    • Heller, S. et al. Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trial. Lancet 379, 1489-1497 (2012).
    • (2012) Lancet , vol.379 , pp. 1489-1497
    • Heller, S.1
  • 98
    • 85020556709 scopus 로고    scopus 로고
    • Switch1: Reduced hypoglycaemia with insulin degludec (IDeg) vs. Insulin glargine (IGlar), both U100, in patients with T1D at high risk of hypoglycaemia: A randomized, double-blind, crossover trial [abstract LB 87]
    • Lane, W. S. et al. Switch1: reduced hypoglycaemia with insulin degludec (IDeg) vs. insulin glargine (IGlar), both U100, in patients with T1D at high risk of hypoglycaemia: a randomized, double-blind, crossover trial [abstract LB 87]. American Diabetes Association (2016).
    • (2016) American Diabetes Association
    • Lane, W.S.1
  • 99
    • 84994804587 scopus 로고    scopus 로고
    • Switching from twice-daily glargine or detemir to once-daily degludec improves glucose control in type 1 diabetes. An observational study
    • Galasso, S. et al. Switching from twice-daily glargine or detemir to once-daily degludec improves glucose control in type 1 diabetes. An observational study. Nutr. Metab. Cardiovasc. Dis. 26, 1112-1119 (2016).
    • (2016) Nutr. Metab. Cardiovasc. Dis. , vol.26 , pp. 1112-1119
    • Galasso, S.1
  • 100
    • 84879814052 scopus 로고    scopus 로고
    • A comparison of the steady-state pharmacokinetic and pharmacodynamic profiles of 100 and 200 U/mL formulations of ultra-long-acting insulin degludec
    • Korsatko, S. et al. A comparison of the steady-state pharmacokinetic and pharmacodynamic profiles of 100 and 200 U/mL formulations of ultra-long-acting insulin degludec. Clin. Drug Investig. 33, 515-521 (2013).
    • (2013) Clin. Drug Investig. , vol.33 , pp. 515-521
    • Korsatko, S.1
  • 101
    • 84864460325 scopus 로고    scopus 로고
    • Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin
    • Jonassen, I. et al. Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin. Pharm. Res. 29, 2104-2114 (2012).
    • (2012) Pharm. Res. , vol.29 , pp. 2104-2114
    • Jonassen, I.1
  • 102
    • 84920991726 scopus 로고    scopus 로고
    • A review of the pharmacological properties of insulin degludec and their clinical relevance
    • Haahr, H. & Heise, T. A review of the pharmacological properties of insulin degludec and their clinical relevance. Clin. Pharmacokinet. 53, 787-800 (2014).
    • (2014) Clin. Pharmacokinet. , vol.53 , pp. 787-800
    • Haahr, H.1    Heise, T.2
  • 103
    • 84926218961 scopus 로고    scopus 로고
    • Insulin degludec in combination with bolus insulin aspart is safe and effective in children and adolescents with type 1 diabetes
    • Thalange, N. et al. Insulin degludec in combination with bolus insulin aspart is safe and effective in children and adolescents with type 1 diabetes. Pediatr. Diabetes 16, 164-176 (2015).
    • (2015) Pediatr. Diabetes , vol.16 , pp. 164-176
    • Thalange, N.1
  • 104
    • 85016993505 scopus 로고    scopus 로고
    • Cost-effectiveness of insulin degludec versus insulin glargine in adults with type 1 and type 2 diabetes mellitus
    • Evans, M., Chubb, B. & Gundgaard, J. Cost-effectiveness of insulin degludec versus insulin glargine in adults with type 1 and type 2 diabetes mellitus. Diabetes Ther. http://dx.doi.org/10.1007/s13300-017-0236-9 (2017).
    • (2017) Diabetes Ther.
    • Evans, M.1    Chubb, B.2    Gundgaard, J.3
  • 105
    • 85009986826 scopus 로고    scopus 로고
    • Cost-effectiveness of switching to insulin degludec from other basal insulins: Evidence from swedish real-world data
    • Landstedt-Hallin, L., Gundgaard, J., Ericsson, A. & Ellfors-Zetterlund, S. Cost-effectiveness of switching to insulin degludec from other basal insulins: evidence from Swedish real-world data. Curr. Med. Res. Opin. http://dx.doi.org/10.1080/03007995.2016.1277194 (2017).
    • (2017) Curr. Med. Res. Opin.
    • Landstedt-Hallin, L.1    Gundgaard, J.2    Ericsson, A.3    Ellfors-Zetterlund, S.4
  • 106
    • 84906691684 scopus 로고    scopus 로고
    • Basal insulin peglispro demonstrates preferential hepatic versus peripheral action relative to insulin glargine in healthy subjects
    • Henry, R. R. et al. Basal insulin peglispro demonstrates preferential hepatic versus peripheral action relative to insulin glargine in healthy subjects. Diabetes Care 37, 2609-2615 (2014).
    • (2014) Diabetes Care , vol.37 , pp. 2609-2615
    • Henry, R.R.1
  • 107
    • 84900825441 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics and glucodynamics of the novel, long-acting basal insulin LY2605541 in healthy subjects
    • Sinha, V. P. et al. Single-dose pharmacokinetics and glucodynamics of the novel, long-acting basal insulin LY2605541 in healthy subjects. J. Clin. Pharmacol. 54, 792-799 (2014).
    • (2014) J. Clin. Pharmacol. , vol.54 , pp. 792-799
    • Sinha, V.P.1
  • 108
    • 84898776737 scopus 로고    scopus 로고
    • PEGylated insulin lispro, (LY2605541) - A new basal insulin analogue
    • Caparrotta, T. M. & Evans, M. PEGylated insulin lispro, (LY2605541) - a new basal insulin analogue. Diabetes Obes. Metab. 16, 388-395 (2014).
    • (2014) Diabetes Obes. Metab. , vol.16 , pp. 388-395
    • Caparrotta, T.M.1    Evans, M.2
  • 109
    • 84962129833 scopus 로고    scopus 로고
    • Randomized clinical trial comparing basal insulin peglispro and insulin glargine in patients with type 2 diabetes previously treated with basal insulin: IMAGINE 5
    • Buse, J. B. et al. Randomized clinical trial comparing basal insulin peglispro and insulin glargine in patients with type 2 diabetes previously treated with basal insulin: IMAGINE 5. Diabetes Care 39, 92-100 (2016).
    • (2016) Diabetes Care , vol.39 , pp. 92-100
    • Buse, J.B.1
  • 110
    • 84990202423 scopus 로고    scopus 로고
    • A randomized clinical trial comparing basal insulin peglispro and insulin glargine, in combination with prandial insulin lispro, in patients with type 1 diabetes: IMAGINE 1
    • Garg, S. et al. A randomized clinical trial comparing basal insulin peglispro and insulin glargine, in combination with prandial insulin lispro, in patients with type 1 diabetes: IMAGINE 1. Diabetes Obes. Metab. 18 (Suppl. 2), 25-33 (2016).
    • (2016) Diabetes Obes. Metab. , vol.18 , pp. 25-33
    • Garg, S.1
  • 111
    • 85020575444 scopus 로고    scopus 로고
    • 1c reduction with basal insulin peglispro (BIL) versus insulin glargine (GL) in an open-label, randomised study in type 1 diabetic patients: IMAGINE 1 [abstract 3]
    • 1c reduction with basal insulin peglispro (BIL) versus insulin glargine (GL) in an open-label, randomised study in type 1 diabetic patients: IMAGINE 1 [abstract 3]. Diabetologia 58 (Suppl. 1), S2 (2015).
    • (2015) Diabetologia , vol.58 , pp. S2
    • Garg, S.1
  • 112
    • 84990179399 scopus 로고    scopus 로고
    • Randomized, double-blind clinical trial comparing basal insulin peglispro and insulin glargine, in combination with prandial insulin lispro, in patients with type 1 diabetes: IMAGINE 3
    • Bergenstal, R. M. et al. Randomized, double-blind clinical trial comparing basal insulin peglispro and insulin glargine, in combination with prandial insulin lispro, in patients with type 1 diabetes: IMAGINE 3. Diabetes Obes. Metab. 18, 1081-1088 (2016).
    • (2016) Diabetes Obes. Metab. , vol.18 , pp. 1081-1088
    • Bergenstal, R.M.1
  • 113
    • 84990210189 scopus 로고    scopus 로고
    • Different effects of basal insulin peglispro and insulin glargine on liver enzymes and liver fat content in patients with type 1 and type 2 diabetes
    • Cusi, K. et al. Different effects of basal insulin peglispro and insulin glargine on liver enzymes and liver fat content in patients with type 1 and type 2 diabetes. Diabetes Obes. Metab. 18 (Suppl. 2), 50-58 (2016).
    • (2016) Diabetes Obes. Metab. , vol.18 , pp. 50-58
    • Cusi, K.1
  • 114
    • 85012188199 scopus 로고    scopus 로고
    • How can a good idea fail? Basal insulin peglispro [LY2605541] for the treatment of type 2 diabetes
    • Munoz-Garach, A., Molina-Vega, M. & Tinahones, F. J. How can a good idea fail? Basal insulin peglispro [LY2605541] for the treatment of type 2 diabetes. Diabetes Ther. 8, 9-22 (2017).
    • (2017) Diabetes Ther. , vol.8 , pp. 9-22
    • Munoz-Garach, A.1    Molina-Vega, M.2    Tinahones, F.J.3
  • 115
    • 84945190388 scopus 로고    scopus 로고
    • Insulin degludec and insulin aspart: Novel insulins for the management of diabetes mellitus
    • Atkin, S., Javed, Z. & Fulcher, G. Insulin degludec and insulin aspart: novel insulins for the management of diabetes mellitus. Ther. Adv. Chronic Dis. 6, 375-388 (2015).
    • (2015) Ther. Adv. Chronic Dis. , vol.6 , pp. 375-388
    • Atkin, S.1    Javed, Z.2    Fulcher, G.3
  • 116
    • 84920936584 scopus 로고    scopus 로고
    • Distinct prandial and basal glucose-lowering effects of insulin degludec/insulin aspart (IDegAsp) at steady state in subjects with type 1 diabetes mellitus
    • Heise, T. et al. Distinct prandial and basal glucose-lowering effects of insulin degludec/insulin aspart (IDegAsp) at steady state in subjects with type 1 diabetes mellitus. Diabetes Ther. 5, 255-265 (2014).
    • (2014) Diabetes Ther. , vol.5 , pp. 255-265
    • Heise, T.1
  • 117
    • 84975749523 scopus 로고    scopus 로고
    • Safety and efficacy of insulin degludec/insulin aspart with bolus mealtime insulin aspart compared with standard basal-bolus treatment in people with type 1 diabetes: 1-year results from a randomized clinical trial (BOOST(R) T1)
    • Hirsch, I. B., Franek, E., Mersebach, H., Bardtrum, L. & Hermansen, K. Safety and efficacy of insulin degludec/insulin aspart with bolus mealtime insulin aspart compared with standard basal-bolus treatment in people with type 1 diabetes: 1-year results from a randomized clinical trial (BOOST(R) T1). Diabet. Med. 34, 167-173 (2017).
    • (2017) Diabet. Med. , vol.34 , pp. 167-173
    • Hirsch, I.B.1    Franek, E.2    Mersebach, H.3    Bardtrum, L.4    Hermansen, K.5
  • 118
    • 84931956619 scopus 로고    scopus 로고
    • Faster-acting insulin aspart: Earlier onset of appearance and greater early pharmacokinetic and pharmacodynamic effects than insulin aspart
    • Heise, T. et al. Faster-acting insulin aspart: earlier onset of appearance and greater early pharmacokinetic and pharmacodynamic effects than insulin aspart. Diabetes Obes. Metab. 17, 682-688 (2015).
    • (2015) Diabetes Obes. Metab. , vol.17 , pp. 682-688
    • Heise, T.1
  • 119
    • 84954528476 scopus 로고    scopus 로고
    • Bioequivalence and comparative pharmacodynamics of insulin lispro 200 U/mL relative to insulin lispro (Humalog®) 100 U/mL
    • de la Pena, A. et al. Bioequivalence and comparative pharmacodynamics of insulin lispro 200 U/mL relative to insulin lispro (Humalog®) 100 U/mL. Clin. Pharmacol. Drug Dev. 5, 69-75 (2016).
    • (2016) Clin. Pharmacol. Drug Dev. , vol.5 , pp. 69-75
    • De La-Pena, A.1
  • 120
    • 77955505940 scopus 로고    scopus 로고
    • Review of the mechanism of action and clinical efficacy of recombinant human hyaluronidase coadministration with current prandial insulin formulations
    • Muchmore, D. B. & Vaughn, D. E. Review of the mechanism of action and clinical efficacy of recombinant human hyaluronidase coadministration with current prandial insulin formulations. J. Diabetes Sci. Technol. 4, 419-428 (2010).
    • (2010) J. Diabetes Sci. Technol. , vol.4 , pp. 419-428
    • Muchmore, D.B.1    Vaughn, D.E.2
  • 121
    • 84873115674 scopus 로고    scopus 로고
    • Accelerating and improving the consistency of rapid-acting analog insulin absorption and action for both subcutaneous injection and continuous subcutaneous infusion using recombinant human hyaluronidase
    • Muchmore, D. B. & Vaughn, D. E. Accelerating and improving the consistency of rapid-acting analog insulin absorption and action for both subcutaneous injection and continuous subcutaneous infusion using recombinant human hyaluronidase. J. Diabetes Sci. Technol. 6, 764-772 (2012).
    • (2012) J. Diabetes Sci. Technol. , vol.6 , pp. 764-772
    • Muchmore, D.B.1    Vaughn, D.E.2
  • 122
    • 84873191592 scopus 로고    scopus 로고
    • A review of a family of ultra-rapid-acting insulins: Formulation development
    • Krasner, A. et al. A review of a family of ultra-rapid-acting insulins: formulation development. J. Diabetes Sci. Technol. 6, 786-796 (2012).
    • (2012) J. Diabetes Sci. Technol. , vol.6 , pp. 786-796
    • Krasner, A.1
  • 123
    • 84870713727 scopus 로고    scopus 로고
    • Design of non-standard insulin analogs for the treatment of diabetes mellitus
    • Pandyarajan, V. & Weiss, M. A. Design of non-standard insulin analogs for the treatment of diabetes mellitus. Curr. Diab. Rep. 12, 697-704 (2012).
    • (2012) Curr. Diab. Rep. , vol.12 , pp. 697-704
    • Pandyarajan, V.1    Weiss, M.A.2
  • 124
    • 85020613786 scopus 로고    scopus 로고
    • Faster onset and greater early exposure and glucose-lowering effect with faster-acting insulin aspart versus insulin aspart: A pooled analysis in subjects with type 1 diabetes [abstract 929 P]
    • Heise, T., Pieber, R. R., Danne, T., Erlichsen, L. & Haahr, H. Faster onset and greater early exposure and glucose-lowering effect with faster-acting insulin aspart versus insulin aspart: a pooled analysis in subjects with type 1 diabetes [abstract 929 P]. American Diabetes Association (2016).
    • (2016) American Diabetes Association
    • Heise, T.1    Pieber, R.R.2    Danne, T.3    Erlichsen, L.4    Haahr, H.5
  • 125
    • 84996484005 scopus 로고    scopus 로고
    • A comparison of pharmacokinetic and pharmacodynamic properties between faster-acting insulin aspart and insulin aspart in elderly subjects with type 1 diabetes mellitus
    • Heise, T. et al. A comparison of pharmacokinetic and pharmacodynamic properties between faster-acting insulin aspart and insulin aspart in elderly subjects with type 1 diabetes mellitus. Drugs Aging 34, 29-38 (2017).
    • (2017) Drugs Aging , vol.34 , pp. 29-38
    • Heise, T.1
  • 126
    • 85012906465 scopus 로고    scopus 로고
    • Faster-acting insulin aspart provides faster onset and greater early exposure versus insulin aspart in children and adolescents with type 1 diabetes mellitus
    • Fath, M. et al. Faster-acting insulin aspart provides faster onset and greater early exposure versus insulin aspart in children and adolescents with type 1 diabetes mellitus. Pediatr. Diabetes http://dx.doi.org/10.1111/pedi.12506 (2017).
    • (2017) Pediatr. Diabetes
    • Fath, M.1
  • 127
    • 85006511291 scopus 로고    scopus 로고
    • Pharmacological properties of faster-acting insulin aspart versus insulin aspart in patients with type 1 diabetes using continuous subcutaneous insulin infusion: A randomised, double-blind, crossover trial
    • Heise, T., Zijlstra, E., Nosek, L., Rikte, T. & Haahr, H. Pharmacological properties of faster-acting insulin aspart versus insulin aspart in patients with type 1 diabetes using continuous subcutaneous insulin infusion: a randomised, double-blind, crossover trial. Diabetes Obes. Metab. 19, 208-215 (2017).
    • (2017) Diabetes Obes. Metab. , vol.19 , pp. 208-215
    • Heise, T.1    Zijlstra, E.2    Nosek, L.3    Rikte, T.4    Haahr, H.5
  • 128
    • 85010008881 scopus 로고    scopus 로고
    • Improved postprandial glycemic control with faster-acting insulin aspart in patients with type 1 diabetes using continuous subcutaneous insulin infusion
    • Bode, B. W., Johnson, J. A., Hyveled, L., Tamer, S. C. & Demissie, M. Improved postprandial glycemic control with faster-acting insulin aspart in patients with type 1 diabetes using continuous subcutaneous insulin infusion. Diabetes Technol. Ther. 19, 25-33 (2017).
    • (2017) Diabetes Technol. Ther. , vol.19 , pp. 25-33
    • Bode, B.W.1    Johnson, J.A.2    Hyveled, L.3    Tamer, S.C.4    Demissie, M.5
  • 129
    • 85020606238 scopus 로고    scopus 로고
    • Fiasp
    • European Medicines Agency. Fiasp. EMA http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/004046/human-med-002063.jsp&mid=WC0b01ac058001d124 (2017).
    • (2017) EMA
  • 132
    • 84899057025 scopus 로고    scopus 로고
    • Proinsulin-transferrin fusion protein as a novel long-acting insulin analog for the inhibition of hepatic glucose production
    • Wang, Y., Shao, J., Zaro, J. L. & Shen, W. C. Proinsulin-transferrin fusion protein as a novel long-acting insulin analog for the inhibition of hepatic glucose production. Diabetes 63, 1779-1788 (2014).
    • (2014) Diabetes , vol.63 , pp. 1779-1788
    • Wang, Y.1    Shao, J.2    Zaro, J.L.3    Shen, W.C.4
  • 133
    • 84865117076 scopus 로고    scopus 로고
    • Insulin fibrillation and protein design: Topological resistance of single-chain analogs to thermal degradation with application to a pump reservoir
    • Phillips, N. B., Whittaker, J., Ismail-Beigi, F. & Weiss, M. A. Insulin fibrillation and protein design: topological resistance of single-chain analogs to thermal degradation with application to a pump reservoir. J. Diabetes Sci. Technol. 6, 277-288 (2012).
    • (2012) J. Diabetes Sci. Technol. , vol.6 , pp. 277-288
    • Phillips, N.B.1    Whittaker, J.2    Ismail-Beigi, F.3    Weiss, M.A.4
  • 134
    • 84923567695 scopus 로고    scopus 로고
    • Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates
    • Chou, D. H. et al. Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates. Proc. Natl Acad. Sci. USA 112, 2401-2406 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. 2401-2406
    • Chou, D.H.1
  • 135
    • 84913599401 scopus 로고    scopus 로고
    • Cell factories for insulin production
    • Baeshen, N. A. et al. Cell factories for insulin production. Microb. Cell Fact. 13, 141 (2014).
    • (2014) Microb. Cell Fact. , vol.13 , pp. 141
    • Baeshen, N.A.1
  • 136
    • 84906936347 scopus 로고    scopus 로고
    • Inhaled insulin: A breath of fresh air? A review of inhaled insulin
    • Santos Cavaiola, T. & Edelman, S. Inhaled insulin: a breath of fresh air? A review of inhaled insulin. Clin. Ther. 36, 1275-1289 (2014).
    • (2014) Clin. Ther. , vol.36 , pp. 1275-1289
    • Santos Cavaiola, T.1    Edelman, S.2
  • 137
    • 84928801214 scopus 로고    scopus 로고
    • Insulin pens and new ways of insulin delivery
    • Heinemann, L. Insulin pens and new ways of insulin delivery. Diabetes Technol. Ther. 16 (Suppl. 1), S44-S55 (2014).
    • (2014) Diabetes Technol. Ther. , vol.16 , pp. S44-S55
    • Heinemann, L.1


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