Neutral macrocyclic factor VIIa inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 27, Issue 12, 2017, Pages 2650-2654

  Wurtz, Nicholas R ^a   Parkhurst, Brandon L ^a   DeLucca, Indawati ^a   Glunz, Peter W ^a   Jiang, Wen ^a   Zhang, Xiaojun ^a   Cheney, Daniel L ^a   Bozarth, Jeffrey M ^a   Rendina, Alan R ^a   Wei, Anzhi ^a   Harper, Tim ^a   Luettgen, Joseph M ^a   Wu, Yiming ^a   Wong, Pancras C ^a   Seiffert, Dietmar A ^a   Wexler, Ruth R ^a   Priestley, E Scott ^a  

^a BRISTOL MYERS SQUIBB RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Anticoagulant; Macrocycles; Neutral P1; TF FVIIa

Indexed keywords

BENZAMIDE; BLOOD CLOTTING FACTOR 7A INHIBITOR; MACROCYCLIC COMPOUND; SULFONE; BLOOD CLOTTING FACTOR 7A; SERINE PROTEINASE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; CELL MEMBRANE PERMEABILITY; DRUG PENETRATION; DRUG POTENCY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PROTEIN BINDING; RAT; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

DOSE-RESPONSE RELATIONSHIP, DRUG; FACTOR VIIA; HUMANS; MACROCYCLIC COMPOUNDS; MOLECULAR STRUCTURE; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85018259607     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2017.04.008     Document Type: Article

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