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Volumn 11, Issue 1, 2017, Pages 53-59

Post-induction adalimumab concentration is associated with short-term mucosal healing in patients with ulcerative colitis

Author keywords

Adalimumab; Mucosal healing; Therapeutic drug monitoring; Ulcerative colitis

Indexed keywords

ADALIMUMAB; INFLIXIMAB; ANTIINFLAMMATORY AGENT;

EID: 85018197345     PISSN: 18739946     EISSN: 18764479     Source Type: Journal    
DOI: 10.1093/ecco-jcc/jjw122     Document Type: Article
Times cited : (63)

References (44)
  • 1
    • 79955859430 scopus 로고    scopus 로고
    • Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis: results of a randomised controlled trial
    • Reinisch W, Sandborn WJ, Hommes DW, et al. Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis: results of a randomised controlled trial. Gut 2011;60:780-7
    • (2011) Gut , vol.60 , pp. 780-787
    • Reinisch, W.1    Sandborn, W.J.2    Hommes, D.W.3
  • 2
    • 84856163835 scopus 로고    scopus 로고
    • Adalimumab induces and maintains clinical remission in patients with moderate-to-severe ulcerative colitis
    • Sandborn WJ, Van Assche G, Reinisch W, et al. Adalimumab induces and maintains clinical remission in patients with moderate-to-severe ulcerative colitis. Gastroenterology 2012;142:257-65
    • (2012) Gastroenterology , vol.142 , pp. 257-265
    • Sandborn, W.J.1    Van Assche, G.2    Reinisch, W.3
  • 3
    • 84908890256 scopus 로고    scopus 로고
    • Four-year maintenance treatment with adalimumab in patients with moderately to severely active ulcerative colitis: data from ULTRA 1, 2, and 3
    • Colombel JF, Sandborn WJ, Ghosh S, et al. Four-year maintenance treatment with adalimumab in patients with moderately to severely active ulcerative colitis: data from ULTRA 1, 2, and 3. Am J Gastroenterol 2014;109:1771-80
    • (2014) Am J Gastroenterol , vol.109 , pp. 1771-1780
    • Colombel, J.F.1    Sandborn, W.J.2    Ghosh, S.3
  • 4
    • 84909647171 scopus 로고    scopus 로고
    • Prior response to infliximab and early serum drug concentrations predict effects of adalimumab in ulcerative colitis
    • Baert F, Vande Casteele N, Tops S, et al. Prior response to infliximab and early serum drug concentrations predict effects of adalimumab in ulcerative colitis. Aliment Pharmacol Ther 2014;40:1324-32
    • (2014) Aliment Pharmacol Ther , vol.40 , pp. 1324-1332
    • Baert, F.1    Vande Casteele, N.2    Tops, S.3
  • 5
    • 84963724543 scopus 로고    scopus 로고
    • Efficacy and safety of adalimumab in ulcerative colitis refractory to conventional therapy in routine clinical practice
    • Bálint A, Farkas K, Palatka K, et al. Efficacy and safety of adalimumab in ulcerative colitis refractory to conventional therapy in routine clinical practice. J Crohns Colitis 2016;10:26-30
    • (2016) J Crohns Colitis , vol.10 , pp. 26-30
    • Bálint, A.1    Farkas, K.2    Palatka, K.3
  • 6
    • 70449727863 scopus 로고    scopus 로고
    • Open-label study of adalimumab in patients with ulcerative colitis including those with prior loss of response or intolerance to infliximab
    • Afif W, Leighton JA, Hanauer SB, et al. Open-label study of adalimumab in patients with ulcerative colitis including those with prior loss of response or intolerance to infliximab. Inflamm Bowel Dis 2009;15:1302-7
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 1302-1307
    • Afif, W.1    Leighton, J.A.2    Hanauer, S.B.3
  • 7
    • 84925260231 scopus 로고    scopus 로고
    • Effectiveness of adalimumab for ambulatory ulcerative colitis patients after failure of infliximab treatment: a first 'real-life' experience in primary gastroenterology centers in Italy
    • Tursi A, Elisei W, Picchio M, et al. Effectiveness of adalimumab for ambulatory ulcerative colitis patients after failure of infliximab treatment: a first 'real-life' experience in primary gastroenterology centers in Italy. Ann Gastroenterol 2014;27:369-73
    • (2014) Ann Gastroenterol , vol.27 , pp. 369-373
    • Tursi, A.1    Elisei, W.2    Picchio, M.3
  • 8
    • 84907874543 scopus 로고    scopus 로고
    • The role of mucosal healing in the treatment of patients with inflammatory bowel disease
    • Vaughn BP, Shah S, Cheifetz AS. The role of mucosal healing in the treatment of patients with inflammatory bowel disease. Curr Treat Options Gastroenterol 2014;12:103-17
    • (2014) Curr Treat Options Gastroenterol , vol.12 , pp. 103-117
    • Vaughn, B.P.1    Shah, S.2    Cheifetz, A.S.3
  • 9
    • 84941260661 scopus 로고    scopus 로고
    • Selecting therapeutic targets in inflammatory bowel disease (stride): determining therapeutic goals for treat-to-target
    • Peyrin-Biroulet L, Sandborn W, Sands BE, et al. Selecting therapeutic targets in inflammatory bowel disease (stride): determining therapeutic goals for treat-to-target. Am J Gastroenterol 2015;110:1324-38
    • (2015) Am J Gastroenterol , vol.110 , pp. 1324-1338
    • Peyrin-Biroulet, L.1    Sandborn, W.2    Sands, B.E.3
  • 10
    • 84906790163 scopus 로고    scopus 로고
    • Treating beyond symptoms with a view to improving patient outcomes in inflammatory bowel diseases
    • Sandborn WJ, Hanauer S, Van Assche G, et al. Treating beyond symptoms with a view to improving patient outcomes in inflammatory bowel diseases. J Crohns Colitis 2014;8:927-35
    • (2014) J Crohns Colitis , vol.8 , pp. 927-935
    • Sandborn, W.J.1    Hanauer, S.2    Van Assche, G.3
  • 11
    • 84919455017 scopus 로고    scopus 로고
    • Mucosal healing in the era of biologic agents in treatment of inflammatory bowel disease
    • Florholmen J. Mucosal healing in the era of biologic agents in treatment of inflammatory bowel disease. Scand J Gastroenterol 2015;50:43-52
    • (2015) Scand J Gastroenterol , vol.50 , pp. 43-52
    • Florholmen, J.1
  • 12
    • 80053133374 scopus 로고    scopus 로고
    • Results from the 2nd Scientific Workshop of the ECCO. I: Impact of mucosal healing on the course of inflammatory bowel disease
    • Peyrin-Biroulet L, Ferrante M, Magro F, et al. Results from the 2nd Scientific Workshop of the ECCO. I: Impact of mucosal healing on the course of inflammatory bowel disease. J Crohns Colitis 2011;5:477-83
    • (2011) J Crohns Colitis , vol.5 , pp. 477-483
    • Peyrin-Biroulet, L.1    Ferrante, M.2    Magro, F.3
  • 13
    • 84922890759 scopus 로고    scopus 로고
    • Converging goals of treatment of inflammatory bowel disease from clinical trials and practice
    • Levesque BG, Sandborn WJ, Ruel J, et al. Converging goals of treatment of inflammatory bowel disease from clinical trials and practice. Gastroenterology 2015;148:37-51
    • (2015) Gastroenterology , vol.148 , pp. 37-51
    • Levesque, B.G.1    Sandborn, W.J.2    Ruel, J.3
  • 14
    • 84925320962 scopus 로고    scopus 로고
    • A panel to predict longterm outcome of infliximab therapy for patients with ulcerative colitis
    • Arias MT, Vande Casteele N, Vermeire S, et al. A panel to predict longterm outcome of infliximab therapy for patients with ulcerative colitis. Clin Gastroenterol Hepatol 2015;13:531-8
    • (2015) Clin Gastroenterol Hepatol , vol.13 , pp. 531-538
    • Arias, M.T.1    Vande Casteele, N.2    Vermeire, S.3
  • 15
    • 84876486013 scopus 로고    scopus 로고
    • Impact of mucosal healing on longterm outcomes in ulcerative colitis treated with infliximab: a multicentre experience
    • Laharie D, Filippi J, Roblin X, et al. Impact of mucosal healing on longterm outcomes in ulcerative colitis treated with infliximab: a multicentre experience. Aliment Pharmacol Ther 2013;37:998-1004
    • (2013) Aliment Pharmacol Ther , vol.37 , pp. 998-1004
    • Laharie, D.1    Filippi, J.2    Roblin, X.3
  • 16
    • 80053130407 scopus 로고    scopus 로고
    • Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis
    • Colombel JF, Rutgeerts P, Reinisch W, et al. Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis. Gastroenterology 2011;141:1194-201
    • (2011) Gastroenterology , vol.141 , pp. 1194-1201
    • Colombel, J.F.1    Rutgeerts, P.2    Reinisch, W.3
  • 17
    • 84878705859 scopus 로고    scopus 로고
    • Clinical study of the relation between mucosal healing and long-term outcomes in ulcerative colitis
    • Yokoyama K, Kobayashi K, Mukae M, et al. Clinical study of the relation between mucosal healing and long-term outcomes in ulcerative colitis. Gastroenterol Res Pract 2013;2013:192794
    • (2013) Gastroenterol Res Pract , vol.2013
    • Yokoyama, K.1    Kobayashi, K.2    Mukae, M.3
  • 18
    • 84996843166 scopus 로고    scopus 로고
    • Mucosal healing is associated with improved long-term outcomes of patients with ulcerative colitis: a systematic review and meta-analysis
    • [Epub ahead of print]
    • Shah SC, Colombel JF, Sands BE, et al. Mucosal healing is associated with improved long-term outcomes of patients with ulcerative colitis: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 2016;pii:S1542-3565(16)00107-5. doi: 10.1016/j.cgh.2016.01.015. [Epub ahead of print]
    • (2016) Clin Gastroenterol Hepatol
    • Shah, S.C.1    Colombel, J.F.2    Sands, B.E.3
  • 19
    • 84930015437 scopus 로고    scopus 로고
    • Trough concentrations of infliximab guide dosing for patients with inflammatory bowel disease
    • Vande Casteele N, Ferrante M, Van Assche G, et al. Trough concentrations of infliximab guide dosing for patients with inflammatory bowel disease. Gastroenterology 2015;148:1320-9.e3
    • (2015) Gastroenterology , vol.148 , pp. 1320-1329
    • Vande Casteele, N.1    Ferrante, M.2    Van Assche, G.3
  • 20
    • 84894640694 scopus 로고    scopus 로고
    • Therapeutic drug monitoring in inflammatory bowel disease: current state and future perspectives
    • Vande Casteele N, Feagan BG, Gils A, et al. Therapeutic drug monitoring in inflammatory bowel disease: current state and future perspectives. Curr Gastroenterol Rep 2014;16:378
    • (2014) Curr Gastroenterol Rep , vol.16 , pp. 378
    • Vande Casteele, N.1    Feagan, B.G.2    Gils, A.3
  • 21
    • 84925776153 scopus 로고    scopus 로고
    • Role for therapeutic drug monitoring during induction therapy with TNF antagonists in IBD: evolution in the definition and management of primary nonresponse
    • Papamichael K, Gils A, Rutgeerts P, et al. Role for therapeutic drug monitoring during induction therapy with TNF antagonists in IBD: evolution in the definition and management of primary nonresponse. Inflamm Bowel Dis 2015;21:182-97
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 182-197
    • Papamichael, K.1    Gils, A.2    Rutgeerts, P.3
  • 22
    • 84925623006 scopus 로고    scopus 로고
    • Proactive therapeutic concentration monitoring of infliximab may improve outcomes for patients with inflammatory bowel disease: results from a pilot observational study
    • Vaughn BP, Martinez-Vazquez M, Patwardhan VR, et al. Proactive therapeutic concentration monitoring of infliximab may improve outcomes for patients with inflammatory bowel disease: results from a pilot observational study. Inflamm Bowel Dis 2014;20:1996-2003
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 1996-2003
    • Vaughn, B.P.1    Martinez-Vazquez, M.2    Patwardhan, V.R.3
  • 23
    • 73449088039 scopus 로고    scopus 로고
    • Trough serum infliximab: a predictive factor of clinical outcome for infliximab treatment in acute ulcerative colitis
    • Seow CH, Newman A, Irwin SP, et al. Trough serum infliximab: a predictive factor of clinical outcome for infliximab treatment in acute ulcerative colitis. Gut 2010;59:49-54
    • (2010) Gut , vol.59 , pp. 49-54
    • Seow, C.H.1    Newman, A.2    Irwin, S.P.3
  • 24
    • 84890219983 scopus 로고    scopus 로고
    • Association between pharmacokinetics of adalimumab and mucosal healing in patients with inflammatory bowel diseases
    • Roblin X, Marotte H, Rinaudo M, et al. Association between pharmacokinetics of adalimumab and mucosal healing in patients with inflammatory bowel diseases. Clin Gastroenterol Hepatol 2014;12:80-4
    • (2014) Clin Gastroenterol Hepatol , vol.12 , pp. 80-84
    • Roblin, X.1    Marotte, H.2    Rinaudo, M.3
  • 25
    • 84913534923 scopus 로고    scopus 로고
    • Association between serum concentration of infliximab and efficacy in adult patients with ulcerative colitis
    • Adedokun OJ, Sandborn WJ, Feagan BG, et al. Association between serum concentration of infliximab and efficacy in adult patients with ulcerative colitis. Gastroenterology 2014;147:1296-307
    • (2014) Gastroenterology , vol.147 , pp. 1296-1307
    • Adedokun, O.J.1    Sandborn, W.J.2    Feagan, B.G.3
  • 26
    • 84899955509 scopus 로고    scopus 로고
    • Relationship between serum infliximab trough levels and endoscopic activities in patients with Crohn's disease under scheduled maintenance treatment
    • Imaeda H, Bamba S, Takahashi K, et al. Relationship between serum infliximab trough levels and endoscopic activities in patients with Crohn's disease under scheduled maintenance treatment. J Gastroenterol 2014;49:674-82
    • (2014) J Gastroenterol , vol.49 , pp. 674-682
    • Imaeda, H.1    Bamba, S.2    Takahashi, K.3
  • 27
    • 84895075749 scopus 로고    scopus 로고
    • Clinical utility of newly developed immunoassays for serum concentrations of adalimumab and antiadalimumab antibodies in patients with Crohn's disease
    • Imaeda H, Takahashi K, Fujimoto T, et al. Clinical utility of newly developed immunoassays for serum concentrations of adalimumab and antiadalimumab antibodies in patients with Crohn's disease. J Gastroenterol 2014;49:100-9
    • (2014) J Gastroenterol , vol.49 , pp. 100-109
    • Imaeda, H.1    Takahashi, K.2    Fujimoto, T.3
  • 28
    • 84975709025 scopus 로고    scopus 로고
    • First trough level of infliximab at week 2 predicts future outcomes of induction therapy in ulcerative colitisresults from a multicenter prospective randomized controlled trial and its post hoc analysis
    • Kobayashi T, Suzuki Y, Motoya S, et al. First trough level of infliximab at week 2 predicts future outcomes of induction therapy in ulcerative colitisresults from a multicenter prospective randomized controlled trial and its post hoc analysis. J Gastroenterol 2016;51:241-51
    • (2016) J Gastroenterol , vol.51 , pp. 241-251
    • Kobayashi, T.1    Suzuki, Y.2    Motoya, S.3
  • 29
    • 84905496301 scopus 로고    scopus 로고
    • Pharmacokinetics of adalimumab in inflammatory bowel diseases: a systematic review and meta-analysis
    • Paul S, Moreau AC, Del Tedesco E, et al. Pharmacokinetics of adalimumab in inflammatory bowel diseases: a systematic review and meta-analysis. Inflamm Bowel Dis 2014;20:1288-95
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 1288-1295
    • Paul, S.1    Moreau, A.C.2    Del Tedesco, E.3
  • 30
    • 84960799161 scopus 로고    scopus 로고
    • Optimizing anti-TNFa therapy: serum levels of infliximab and adalimumab associate with mucosal healing in patients with inflammatory bowel diseases
    • Ungar B, Levy I, Yavne Y, et al. Optimizing anti-TNFa therapy: serum levels of infliximab and adalimumab associate with mucosal healing in patients with inflammatory bowel diseases. Clin Gastroenterol Hepatol 2016;14:550-7
    • (2016) Clin Gastroenterol Hepatol , vol.14 , pp. 550-557
    • Ungar, B.1    Levy, I.2    Yavne, Y.3
  • 31
    • 84982193743 scopus 로고    scopus 로고
    • Higher adalimumab drug levels are associated with mucosal healing in patients with Crohn's disease
    • Zittan E, Kabakchiev B, Milgrom R, et al. Higher adalimumab drug levels are associated with mucosal healing in patients with Crohn's disease. J Crohn's Colitis 2016;10:507-9
    • (2016) J Crohn's Colitis , vol.10 , pp. 507-509
    • Zittan, E.1    Kabakchiev, B.2    Milgrom, R.3
  • 32
    • 84973911417 scopus 로고    scopus 로고
    • Antibodies to adalimumab are associated with future inflammation in Crohn's patients receiving mainte-nance adalimumab therapy: a post hoc analysis of the Karmiris trial
    • Baert F, Kondragunta V, Lockton S, et al. Antibodies to adalimumab are associated with future inflammation in Crohn's patients receiving mainte-nance adalimumab therapy: a post hoc analysis of the Karmiris trial. Gut 2016;65:1126-31
    • (2016) Gut , vol.65 , pp. 1126-1131
    • Baert, F.1    Kondragunta, V.2    Lockton, S.3
  • 33
    • 84960864810 scopus 로고    scopus 로고
    • Infliximab concentration thresholds during induction therapy are associated with short-term mucosal healing in patients with ulcerative colitis
    • Papamichael K, Van Stappen T, Casteele NV, et al. Infliximab concentration thresholds during induction therapy are associated with short-term mucosal healing in patients with ulcerative colitis. Clin Gastroenterol Hepatol 2016;14:543-9
    • (2016) Clin Gastroenterol Hepatol , vol.14 , pp. 543-549
    • Papamichael, K.1    Van Stappen, T.2    Casteele, N.V.3
  • 34
    • 84938090411 scopus 로고    scopus 로고
    • Loss of infliximab into feces is associated with lack of response to therapy in patients with severe ulcerative colitis
    • Brandse JF, van den Brink GR, Wildenberg ME, et al. Loss of infliximab into feces is associated with lack of response to therapy in patients with severe ulcerative colitis. Gastroenterology 2015;149:350-5
    • (2015) Gastroenterology , vol.149 , pp. 350-355
    • Brandse, J.F.1    van den Brink, G.R.2    Wildenberg, M.E.3
  • 35
    • 84959010224 scopus 로고    scopus 로고
    • Pharmacokinetic features and presence of antidrug antibodies associate with response to infliximab induction therapy in patients with moderate to severe ulcerative colitis
    • Brandse JF, Mathôt RA, van der Kleij D, et al. Pharmacokinetic features and presence of antidrug antibodies associate with response to infliximab induction therapy in patients with moderate to severe ulcerative colitis. Clin Gastroenterol Hepatol 2016;14:251-8.e1-2
    • (2016) Clin Gastroenterol Hepatol , vol.14
    • Brandse, J.F.1    Mathôt, R.A.2    van der Kleij, D.3
  • 36
    • 84946423531 scopus 로고    scopus 로고
    • Are anti-tumor necrosis factor trough levels predictive of mucosal healing in patients with inflammatory bowel disease?: a systematic review and meta-analysis
    • Oct 31. [Epub ahead of print]
    • Barnes EL, Allegretti JR. Are anti-tumor necrosis factor trough levels predictive of mucosal healing in patients with inflammatory bowel disease?: a systematic review and meta-analysis. J Clin Gastroenterol 2015 Oct 31. [Epub ahead of print]. doi:10.1097/MCG.0000000000000441
    • (2015) J Clin Gastroenterol
    • Barnes, E.L.1    Allegretti, J.R.2
  • 37
    • 84855197296 scopus 로고    scopus 로고
    • Early serial trough and antidrug antibody level measurements predict clinical outcome of infliximab and adalimumab treatment
    • author reply 322
    • Vande Casteele N, Ballet V, Van Assche G, et al. Early serial trough and antidrug antibody level measurements predict clinical outcome of infliximab and adalimumab treatment. Gut 2012;61:321; author reply 322
    • (2012) Gut , vol.61 , pp. 321
    • Vande Casteele, N.1    Ballet, V.2    Van Assche, G.3
  • 38
    • 84955604767 scopus 로고    scopus 로고
    • Higher adalimumab levels are associated with histologic and endoscopic remission in patients with Crohn's disease and ulcerative colitis
    • Yarur AJ, Jain A, Hauenstein SI, et al. Higher adalimumab levels are associated with histologic and endoscopic remission in patients with Crohn's disease and ulcerative colitis. Inflamm Bowel Dis 2016;22:409-15
    • (2016) Inflamm Bowel Dis , vol.22 , pp. 409-415
    • Yarur, A.J.1    Jain, A.2    Hauenstein, S.I.3
  • 39
    • 84929119171 scopus 로고    scopus 로고
    • Review article: applying pharmacokinetics to optimise dosing of anti-TNF biologics in acute severe ulcerative colitis
    • Rosen MJ, Minar P, Vinks AA. Review article: applying pharmacokinetics to optimise dosing of anti-TNF biologics in acute severe ulcerative colitis. Aliment Pharmacol Ther 2015;41:1094-103
    • (2015) Aliment Pharmacol Ther , vol.41 , pp. 1094-1103
    • Rosen, M.J.1    Minar, P.2    Vinks, A.A.3
  • 40
    • 84927697296 scopus 로고    scopus 로고
    • An accelerated infliximab induction regimen reduces the need for early colectomy in patients with acute severe ulcerative colitis
    • Gibson DJ, Heetun ZS, Redmond CE, et al. An accelerated infliximab induction regimen reduces the need for early colectomy in patients with acute severe ulcerative colitis. Clin Gastroenterol Hepatol 2015;13:330-5
    • (2015) Clin Gastroenterol Hepatol , vol.13 , pp. 330-335
    • Gibson, D.J.1    Heetun, Z.S.2    Redmond, C.E.3
  • 41
    • 84958840838 scopus 로고    scopus 로고
    • The association of tissue anti-TNF drug levels with serological and endoscopic disease activity in inflammatory bowel disease: the ATLAS study
    • Yarur AJ, Jain A, Sussman DA, et al. The association of tissue anti-TNF drug levels with serological and endoscopic disease activity in inflammatory bowel disease: the ATLAS study. Gut 2016;65:249-55
    • (2016) Gut , vol.65 , pp. 249-255
    • Yarur, A.J.1    Jain, A.2    Sussman, D.A.3
  • 42
    • 84925759693 scopus 로고    scopus 로고
    • Patient factors that increase infliximab clearance and shorten half-life in inflammatory bowel disease: a population pharmacokinetic study
    • Dotan I, Ron Y, Yanai H, et al. Patient factors that increase infliximab clearance and shorten half-life in inflammatory bowel disease: a population pharmacokinetic study. Inflamm Bowel Dis 2014;20:2247-59
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 2247-2259
    • Dotan, I.1    Ron, Y.2    Yanai, H.3
  • 43
    • 84923359740 scopus 로고    scopus 로고
    • Pharmacokinetics of anti-TNF monoclonal antibodies in inflammatory bowel disease: adding value to current practice
    • Vande Casteele N, Gils A. Pharmacokinetics of anti-TNF monoclonal antibodies in inflammatory bowel disease: adding value to current practice. J Clin Pharmacol 2015;55 Suppl 3:S39-50
    • (2015) J Clin Pharmacol , vol.55 , pp. S39-S50
    • Vande Casteele, N.1    Gils, A.2
  • 44
    • 84982193743 scopus 로고    scopus 로고
    • Higher adalimumab drug levels are associated with mucosal healing in patients with Crohn's Disease
    • Papamichael K, Cheifetz AS. Higher adalimumab drug levels are associated with mucosal healing in patients with Crohn's Disease. J Crohns Colitis 2016;10:507-9
    • (2016) J Crohns Colitis , vol.10 , pp. 507-509
    • Papamichael, K.1    Cheifetz, A.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.