Cryo-EM Structure of a Relaxase Reveals the Molecular Basis of DNA Unwinding during Bacterial Conjugation

Cell

Volumn 169, Issue 4, 2017, Pages 708-721.e12

  Ilangovan, Aravindan ^a   Kay, Christopher W M ^b   Roier, Sandro ^c   El Mkami, Hassane ^d   Salvadori, Enrico ^b   Zechner, Ellen L ^c   Zanetti, Giulia ^a   Waksman, Gabriel ^a,b  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF GRAZ   (Austria)

^d UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

bacterial conjugation; cryo electron microscopy; relaxase; structural biology; TraI; type IV secretion system

Indexed keywords

ESTERASE; HELICASE; RELAXASE; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; BACTERIAL DNA; DNA HELICASE; ESCHERICHIA COLI PROTEIN; TRAI PROTEIN, E COLI;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL GENOME; BACTERIUM CONJUGATION; BINDING SITE; CRYOELECTRON MICROSCOPY; DNA DENATURATION; DNA STRAND; DNA TRANSFER; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME STRUCTURE; HORIZONTAL GENE TRANSFER; INVERTED REPEAT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECONDARY STRUCTURE; CHEMISTRY; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; METABOLISM; MOLECULAR MODEL; ULTRASTRUCTURE;

CONJUGATION, GENETIC; CRYOELECTRON MICROSCOPY; DNA HELICASES; DNA, BACTERIAL; DNA, SINGLE-STRANDED; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MODELS, MOLECULAR;

EID: 85018171488     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.04.010     Document Type: Article

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