Overexpression of SmeDEF efflux pump decreases aminoglycoside resistance in Stenotrophomonas maltophilia

Antimicrobial Agents and Chemotherapy

Volumn 61, Issue 5, 2017, Pages

  Huang, Yi Wei ^a   Lin, Cheng Wen ^b   Ning, Hsiao Chen ^c,d   Lin, Yi Tsung ^a,e   Chang, Yi Chih ^b   Yang, Tsuey Ching ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^d CHANG GUNG UNIVERSITY   (Taiwan)

^e TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Antibiotic resistance; Bacteria; Efflux pump; Two component regulatory system

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; CHLORAMPHENICOL; CIPROFLOXACIN; ERYTHROMYCIN; GENTAMICIN; KANAMYCIN; MACROLIDE; NALIDIXIC ACID; AMINOGLYCOSIDE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; CARRIER PROTEIN; SMED PROTEIN, STENOTROPHOMONAS MALTOPHILIA; SMEE PROTEIN, STENOTROPHOMONAS MALTOPHILIA; SMEF PROTEIN, STENOTROPHOMONAS MALTOPHILIA;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; DELETION MUTANT; DOWN REGULATION; GENE; GENE INACTIVATION; GENE OVEREXPRESSION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; SMEDEF GENE; SMEYZ GENE; STENOTROPHOMONAS MALTOPHILIA; BIOSYNTHESIS; DRUG EFFECTS; GENETICS; MULTIDRUG RESISTANCE;

AMIKACIN; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CHLORAMPHENICOL; CIPROFLOXACIN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ERYTHROMYCIN; GENTAMICINS; KANAMYCIN; MEMBRANE TRANSPORT PROTEINS; STENOTROPHOMONAS MALTOPHILIA;

EID: 85018171146     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02685-16     Document Type: Article

References (18)

1. Li XZ, Nikaido H. 2009. Efflux-mediated drug resistance in bacteria: An update. Drugs 69:1555-1623. https://doi. org/10. 2165/11317030-000000000-00000.
2. Gotoh N, Tsujimoto H, Tsuda M, Okamoto K, Nomura A, Wada T, Nakahashi M, Nishino T. 1998. Characterization of the MexC-MexD-OprJ multidrug efflux system in mexA-mexB-oprM mutants of Pseudomonas aeruginosa. Antimicrob Agents Chemother 42:1938-1943.
3. Chen CH, Huang CC, Chung TC, Hu RM, Huang YW, Yang TC. 2011. Contribution of resistance-nodulation-division efflux pump operon smeU1-V-W-U2-X to multidrug resistance of Stenotrophomonas maltophilia. Antimicrob Agents Chemother 55:5826-5833. https://doi. org/10. 1128/AAC. 00317-11.
4. Brooke JS. 2012. Stenotrophomonas maltophilia: An emerging global opportunistic pathogen. Clin Microbiol Rev 25:2-41. https://doi. org/10. 1128/CMR. 00019-11.
5. Crossman LC, Gould VC, Dow JM, Vernikos GS, Okazaki A, Sebaihia M, Saunders D, Arrowsmith C, Carver T, Peters N, Adlem E, Kerhornou A, Lord A, Murphy L, Seeger K, Squares R, Rutter S, Quail MA, Rajandream MA, Harris D, Churcher C, Bentley SD, Parkhill J, Thomson NR, Avison MB. 2008. The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants. Gen Biol 9:R74. https://doi. org/10. 1186/ gb-2008-9-4-r74.
6. Sanchez P, Alonso A, Martinez JL. 2002. Cloning and characterization of SmeT, a regulator of the Stenotrophomonas maltophilia multidrug efflux pump SmeDEF. Antimicrob Agents Chemother 46:3386-3393. https:// doi. org/10. 1128/AAC. 46. 11. 3386-3393. 2002.
7. Alonso A, Martinez JL. 2000. Cloning and characterization of SmeDEF, a novel multidrug efflux pump from Stenotrophomonas maltophilia. Antimicrob Agents Chemother 44:3079-3086. https://doi. org/10. 1128/AAC. 44. 11. 3079-3086. 2000.
8. Lin YT, Huang YW, Chen SJ, Chang CW, Yang TC. 2015. The SmeYZ efflux pump of Stenotrophomonas maltophilia contributes to drug resistance, virulence-related characteristics, and virulence in mice. Antimicrob Agents Chemother 59:4067-4073. https://doi. org/10. 1128/AAC. 00372-15.
9. Wu CJ, Huang YW, Lin YT, Ning HC, Yang TC. 2016. Inactivation of SmeSyRy two-component regulatory system inversely regulates the expression of SmeYZ and SmeDEF efflux pumps in Stenotrophomonas maltophilia. PLoS One 11:e0160943. https://doi. org/10. 1371/journal. pone. 0160943.
10. Li XZ, Li Z, Poole K. 2002. SmeC, an outer membrane multidrug efflux protein of Stenotrophomonas maltophilia. Antimicrob Agents Chemother 46:333-343. https://doi. org/10. 1128/AAC. 46. 2. 333-343. 2002.
11. Lin CW, Huang YW, Hu RM, Yang TC. 2014. SmeOP-TolCsm efflux pump contributes to multidrug resistance of Stenotrophomonas maltophilia. Antimicrob Agents Chemother 58:2405-2408. https://doi. org/10. 1128/ AAC. 01974-13.
12. Clinical and Laboratory Standards Institute. 2015. Performance standards for antimicrobial susceptibility testing; 25th informational supplement. CLSI M100-S25. Clinical and Laboratory Standards Institute, Wayne, PA.
13. Huang YW, Liou RS, Lin YT, Huang HH, Yang TC. 2014. A linkage between SmeIJK efflux pump, cell envelope integrity, and sigma E-mediated envelope stress response in Stenotrophomonas maltophilia. PLoS One 9:e111784. https://doi. org/10. 1371/journal. pone. 0111784.
14. Lambert T, Ploy MC, Denis F, Courvalin P. 1999. Characterization of the chromosomal aac(6=)-Iz gene of Stenotrophomonas maltophilia. Antimicrob Agents Chemother 43:2366-2371.
15. Okazaki A, Avison MB. 2007. Aph(3=)-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia. Antimicrob Agents Chemother 51:359-360. https://doi. org/10. 1128/AAC. 00795-06.
16. Wu CJ, Huang YW, Lin YT, Yang TC. 2016. Inactivation of lytic transglycosylase increases susceptibility to aminoglycosides and macrolides by altering the outer membrane permeability of Stenotrophomonas maltophilia. Antimicrob Agents Chemother 60:3236-3239. https://doi. org/10. 1128/AAC. 03026-15.
17. Delhaye A, Collet J-F, Laloux G. 2016. Fine-tuning of the Cpx envelope stress response is required for cell wall homeostasis in Escherichia coli. mBio 7:e00047-16.
18. Elofsson A, von Heijne G. 2007. Membrane protein structure: prediction versus reality. Annu Rev Biochem 76:125-140. https://doi. org/10. 1146/ annurev. biochem. 76. 052705. 163539.