TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemia is similar to de novo diseases

Journal of Hematology and Oncology

Volumn 8, Issue 1, 2015, Pages

  Ok, Chi Young ^a   Patel, Keyur P ^a   Garcia Manero, Guillermo ^a   Routbort, Mark J ^a   Peng, Jie ^a,b   Tang, Guilin ^a   Goswami, Maitrayee ^a   Young, Ken H ^a   Singh, Rajesh ^a   Medeiros, L Jeffrey ^a   Kantarjian, Hagop M ^a   Luthra, Rajyalakshmi ^a   Wang, Sa A ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

AML; Karyotype; MDS; Therapy related; TP53

Indexed keywords

PROTEIN P53; ANTINEOPLASTIC AGENT; TP53 PROTEIN, HUMAN; DNA;

ACUTE MYELOBLASTIC LEUKEMIA; ADULT; AGED; ARTICLE; BONE MARROW; CHROMOSOME ABERRATION; CLINICAL ARTICLE; CYTOGENETICS; DNA BINDING; ELECTRONIC MEDICAL RECORD; FEMALE; GENE FREQUENCY; HUMAN; INDEL MUTATION; KARYOTYPE; MALE; MISSENSE MUTATION; MYELODYSPLASTIC SYNDROME; NEXT GENERATION SEQUENCING; NONSENSE MUTATION; OVERALL SURVIVAL; ACUTE MYELOID LEUKEMIA; ADOLESCENT; ADVERSE EFFECTS; GENETICS; KAPLAN MEIER METHOD; MIDDLE AGED; MORTALITY; MUTATION; RADIOTHERAPY; VERY ELDERLY; YOUNG ADULT; ALLELE; BONE MARROW CELL; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER STAGING; COHORT ANALYSIS; CONTROLLED STUDY; DNA STRUCTURE; FRAMESHIFT MUTATION; GENE; GENE CLUSTER; GENE MUTATION; GENETIC ASSOCIATION; HUMAN CELL; MAJOR CLINICAL STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; THERAPY RELATED ACUTE MYELOBLASTIC LEUKEMIA; THERAPY RELATED MYELODYSPLASTIC SYNDROME; TP53 GENE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; MUTATION; MYELODYSPLASTIC SYNDROMES; RADIOTHERAPY; TUMOR SUPPRESSOR PROTEIN P53; YOUNG ADULT;

EID: 85018115555     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/s13045-015-0139-z     Document Type: Article

References (29)

1. Vardiman JW, Arber DA, Brunning RD, Larson RA, Matutes E, Baumann I, et al. Therapy-related myeloid neoplasms. In: Swerdlow SH et al., editors. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon: International Agency for Research on Cancer (IARC); 2008. p. 127-9.
2. Singh ZN, Huo D, Anastasi J, Smith SM, Karrison T, Le Beau MM, et al. Therapy-related myelodysplastic syndrome: morphologic subclassification may not be clinically relevant. Am J Clin Pathol. 2007;127:197-205.
3. Ok CY, Hasserjian RP, Fox PS, Stingo F, Zuo Z, Young KH, et al. Application of the international prognostic scoring system-revised in therapy-related myelodysplastic syndromes and oligoblastic acute myeloid leukemia. Leukemia. 2014;28:185-9.
4. Bhatia S. Therapy-related myelodysplasia and acute myeloid leukemia. Semin Oncol. 2013;40:666-75.
5. Greco M, D'Alò F, Scardocci A, Criscuolo M, Fabiani E, Guidi F, et al. Promoter methylation of DAPK1, E-cadherin and thrombospondin-1 in de novo and therapy-related myeloid neoplasms. Blood Cells Mol Dis. 2010;45:181-5.
6. Voso MT, D'Alò F, Greco M, Fabiani E, Criscuolo M, Migliara G, et al. Epigenetic changes in therapy-related MDS/AML. Chem Biol Interact. 2010;184:46-9.
7. Smith SM, Le Beau MM, Huo D, Karrison T, Sobecks RM, Anastasi J, et al. Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series. Blood. 2003;102:43-52.
8. Zhou Y, Tang G, Medeiros LJ, McDonnell TJ, Keating MJ, Wierda WG, et al. Therapy-related myeloid neoplasms following fludarabine, cyclophosphamide, and rituximab (FCR) treatment in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma. Mod Pathol. 2012;25:237-45.
9. Ok CY, Patel KP, Garcia-Manero G, Routbort MJ, Fu B, Tang G, et al. Mutational profiling of therapy-related myelodysplastic syndromes and acute myeloid leukemia by next generation sequencing, a comparison with de novo diseases. Leuk Res. 2014;39:348-54.
10. Xu-Monette ZY, Medeiros LJ, Li Y, Orlowski RZ, Andreeff M, Bueso-Ramos CE, et al. Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies. Blood. 2012;119:3668-83.
11. Olivier M, Hollstein M, Hainaut P. TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb Perspect Biol. 2010;2:a001008.
12. Kulasekararaj AG, Smith AE, Mian SA, Mohamedali AM, Krishnamurthy P, Lea NC, et al. TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis. Br J Haematol. 2013;160:660-72.
13. Bejar R, Stevenson K, Abdel-Wahab O, Galili N, Nilsson B, Garcia-Manero G, et al. Clinical effect of point mutations in myelodysplastic syndromes. N Engl J Med. 2011;364:2496-506.
14. Bejar R, Levine R, Ebert BL. Unraveling the molecular pathophysiology of myelodysplastic syndromes. J Clin Oncol. 2011;29:504-15.
15. Ben-Yehuda D, Krichevsky S, Caspi O, Rund D, Polliack A, Abeliovich D, et al. Microsatellite instability and p53 mutations in therapy-related leukemia suggest mutator phenotype. Blood. 1996;88:4296-303.
16. Christiansen DH, Andersen MK, Pedersen-Bjergaard J. Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor prognosis. J Clin Oncol. 2001;19:1405-13.
17. Shih AH, Chung SS, Dolezal EK, Zhang SJ, Abdel-Wahab OI, Park CY, et al. Mutational analysis of therapy-related myelodysplastic syndromes and acute myelogenous leukemia. Haematologica. 2013;98:908-12.
18. Wong TN, Ramsingh G, Young AL, Miller CA, Touma W, Welch JS, et al. Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia. Nature. 2014;518:552-5.
19. Pedersen-Bjergaard J, Andersen MK, Andersen MT, Christiansen DH. Genetics of therapy-related myelodysplasia and acute myeloid leukemia. Leukemia. 2008;22:240-8.
20. Petitjean A, Mathe E, Kato S, Ishioka C, Tavtigian SV, Hainaut P, et al. Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Hum Mutat. 2007;28:622-9.
21. Pfeifer GP, Denissenko MF, Olivier M, Tretyakova N, Hecht SS, Hainaut P. Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers. Oncogene. 2002;21:7435-51.
22. Nagai MA, Schaer Barbosa H, Zago MA, Araújo Silva Jr W, Nishimoto IN, Salaorni S, et al. TP53 mutations in primary breast carcinomas from white and African-Brazilian patients. Int J Oncol. 2003;23:189-96.
23. Bowen D, Groves MJ, Burnett AK, Patel Y, Allen C, Green C. TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis. Leukemia. 2009;23:203-6.
24. Junemann S, Sedlazeck FJ, Prior K, Albersmeier A, John U, Kalinowski J, et al. Updating benchtop sequencing performance comparison. Nat Biotechnol. 2013;31:294-6.
25. Robinson JT, Thorvaldsdóttir H, Winckler W, Guttman M, Lander ES, Getz G, et al. Integrative genomics viewer. Nat Biotechnol. 2011;29:24-6.
26. Khoury JD, Sen F, Abruzzo LV, Hayes K, Glassman A, Medeiros LJ. Cytogenetic findings in blastoid mantle cell lymphoma. Hum Pathol. 2003;34:1022-9.
27. Shaffer LG, McGowan-Jordan J, Schmid M. An international system for human cytogenetic nomenclature. In: Shaffer LG, McGowan-Jordan J, Schmid M, editors. Basel: Karger; 2013.
28. Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G, et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood. 1997;89:2079-88.
29. Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, et al. Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the united kingdom medical research council trials. Blood. 2010;116:354-65.