Epigenetically repressing human Cytomegalovirus lytic infection and reactivation from latency in THP-1 model by targeting H3K9 and H3K27 histone demethylases

PLoS ONE

Volumn 12, Issue 4, 2017, Pages

  Gan, Xin ^a   Wang, Haifeng ^a   Yu, Yanyan ^a   Yi, Wei ^a   Zhu, Shanshan ^a   Li, En ^a   Liang, Yu ^a  

^a China Novartis Institutes for Biomedical Research Co Ltd   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; ENZYME INHIBITOR; HISTONE DEMETHYLASE; HISTONE H3K27; HISTONE H3K9; ML 324; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS RNA; HISTONE;

ARTICLE; CELL LINE; CHROMATIN STRUCTURE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; CYTOMEGALOVIRUS LYTIC INFECTION; DISEASE MODEL; DRUG TARGETING; EPIGENETIC REPRESSION; GENE EXPRESSION REGULATION; GENE REPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HEK293 CELL LINE; HERPES SIMPLEX VIRUS 1; HISTONE METHYLATION; HISTONE MODIFICATION; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IMMEDIATE EARLY GENE; JMJD3 GENE; NONHUMAN; THP 1 CELL LINE; VERO CELL LINE; VIRUS GENE; VIRUS INHIBITION; VIRUS LATENCY; VIRUS REACTIVATION; VIRUS REPLICATION; BIOSYNTHESIS; CYTOMEGALOVIRUS; GENETIC EPIGENESIS; GENETICS; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE; VIRUS ACTIVATION;

CELL LINE, TUMOR; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, VIRAL; HISTONES; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; VIRUS ACTIVATION; VIRUS LATENCY;

EID: 85017537686     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0175390     Document Type: Article

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