메뉴 건너뛰기




Volumn 12, Issue 4, 2017, Pages 414-422

When could new antiretrovirals be recommended for national treatment programmes in low-income and middle-income countries: Results of a WHO Think Tank

Author keywords

antiretroviral treatment; drug drug interactions; HIV TB coinfection; pregnant women

Indexed keywords

ANTIRETROVIRUS AGENT; DOLUTEGRAVIR; EFAVIRENZ; INTEGRASE INHIBITOR; NUCLEOSIDE ANALOG; PROTEINASE INHIBITOR; RITONAVIR; TENOFOVIR ALAFENAMIDE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

EID: 85017456524     PISSN: 1746630X     EISSN: 17466318     Source Type: Journal    
DOI: 10.1097/COH.0000000000000380     Document Type: Review
Times cited : (32)

References (49)
  • 1
    • 84942311939 scopus 로고    scopus 로고
    • World Health Organization. Recommendations for a public health approach. 2nd ed. [Accessed 22 October 2016]
    • World Health Organization. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. Recommendations for a public health approach. 2nd ed. 2015. Available at: http://www. who. int/hiv/ pub/arv/arv-2016/en/. [Accessed 22 October 2016].
    • (2015) Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection
  • 2
    • 84978371920 scopus 로고    scopus 로고
    • Antiretroviral drugs for treatment and prevention of HIV infection in adults [2016] recommendations of the International Antiviral Society-USA Panel
    • Günthard HF, Saag MS, Benson CA, et al. Antiretroviral drugs for treatment and prevention of HIV infection in adults [2016] recommendations of the International Antiviral Society-USA Panel. JAMA 2016; 316: 191-210.
    • (2016) JAMA , vol.316 , pp. 191-210
    • Günthard, H.F.1    Saag, M.S.2    Benson, C.A.3
  • 5
    • 85007387770 scopus 로고    scopus 로고
    • Cutting the cost of South African antiretroviral therapy using newer, safer drugs
    • Venter F, Kaiser B, Pillay Y, et al. Cutting the cost of South African antiretroviral therapy using newer, safer drugs. South Afr Med J 2017; 107:28-30.
    • (2017) South Afr Med J , vol.107 , pp. 28-30
    • Venter, F.1    Kaiser, B.2    Pillay, Y.3
  • 6
    • 84978801654 scopus 로고    scopus 로고
    • Clinton Health Access Initiative. The state of the antiretroviral drug market in low-and middle-income countries. [Accessed 25 August 2016]
    • Clinton Health Access Initiative. ARV market report. The state of the antiretroviral drug market in low-and middle-income countries. 2015. Available at: http://www. clintonhealthaccess. org/content/uploads/2015/ 11/CHAI-ARV-Market-Report-2015-FINAL. pdf. [Accessed 25 August 2016].
    • (2015) ARV Market Report
  • 7
    • 84961529529 scopus 로고    scopus 로고
    • ARVs: The next generation. Going boldly together to new frontiers of HIV treatment
    • Barnhart M, Shelton J. ARVs: The next generation. Going boldly together to new frontiers of HIV treatment. Glob Health Sci Prac 2015; 1:1-11.
    • (2015) Glob Health Sci Prac , vol.1 , pp. 1-11
    • Barnhart, M.1    Shelton, J.2
  • 8
    • 84960192663 scopus 로고    scopus 로고
    • Choice of antiretroviral drugs for continued treatment scale-up in a public health approach: What more do we need to know
    • Vitoria M, Hill AM, Ford N, et al. Choice of antiretroviral drugs for continued treatment scale-up in a public health approach: what more do we need to know J Int AIDS Soc 2016; 19:20504.
    • (2016) J Int AIDS Soc , vol.19 , pp. 20504
    • Vitoria, M.1    Hill, A.M.2    Ford, N.3
  • 9
    • 85020631668 scopus 로고    scopus 로고
    • Adverse birth outcomes differ by art regimen from conception in Botswana
    • 13-16 February 2017, Seattle, Washington [Abstr 25]
    • Zash R, Jacobson D, Diseko M, et al. Adverse birth outcomes differ by art regimen from conception in Botswana. CROI conference, 13-16 February 2017, Seattle, Washington. [Abstr 25].
    • CROI Conference
    • Zash, R.1    Jacobson, D.2    Diseko, M.3
  • 10
    • 85020685296 scopus 로고    scopus 로고
    • Antenatal antiretroviral therapy and adverse birth outcomes: The promise trial
    • February. Seattle, WA, USA. Abstract 776
    • Chi BH, FarhadM, Owor M et al. Antenatal Antiretroviral Therapy and Adverse Birth Outcomes: The PROMISE trial. Conference on Retroviruses and Opportunistic Infections February 2017. Seattle, WA, USA. Abstract 776.
    • (2017) Conference on Retroviruses and Opportunistic Infections
    • Chi, B.H.1    Farhad, M.2    Owor, M.3
  • 11
    • 84947761938 scopus 로고    scopus 로고
    • Brief report: Dolutegravir plus abacavir/lamivudine for the treatment of HIV-1 infection in antiretroviral therapy-näve patients: Week 96 and week 144 results from the SINGLE randomized clinical trial
    • Walmsley S, Baumgarten A, Berenguer J, et al. Brief report: dolutegravir plus abacavir/lamivudine for the treatment of HIV-1 infection in antiretroviral therapy-näve patients: week 96 and week 144 results from the SINGLE randomized clinical trial. J Acquir Immune Defic Syndr 2015; 70:515-519.
    • (2015) J Acquir Immune Defic Syndr , vol.70 , pp. 515-519
    • Walmsley, S.1    Baumgarten, A.2    Berenguer, J.3
  • 12
    • 84903303497 scopus 로고    scopus 로고
    • Once-daily dolutegravir versus darunavir plus ritonavir in antiretroviral-naive adults with HIV-1 infection (FLAMINGO): 48 week results from the randomised open-label phase 3b study
    • Clotet B, Feinberg J, van Lunzen J, et al. Once-daily dolutegravir versus darunavir plus ritonavir in antiretroviral-naive adults with HIV-1 infection (FLAMINGO): 48 week results from the randomised open-label phase 3b study. Lancet 2015; 383:2222-2231.
    • (2015) Lancet , vol.383 , pp. 2222-2231
    • Clotet, B.1    Feinberg, J.2    Van Lunzen, J.3
  • 14
    • 85020681784 scopus 로고    scopus 로고
    • Phase III SWORD 1 & 2: Switch to DTGRPV maintains virologic suppression through 48 weeks
    • 13-16 February. Seattle
    • Llibre JM, et al. Phase III SWORD 1 & 2: Switch to DTGRPV maintains virologic suppression through 48 weeks. Presented at: Conference on Retroviruses and Opportunistic Infections; 13-16 February 2017; Seattle.
    • (2017) Conference on Retroviruses and Opportunistic Infections
    • Llibre, J.M.1
  • 17
    • 84966430634 scopus 로고    scopus 로고
    • Early experience of dolutegravir pharmacokinetics in pregnancy: High maternal levels and significant foetal exposure with twice-daily dosing
    • Lewis JM, Railton E, Riordan A, et al. Early experience of dolutegravir pharmacokinetics in pregnancy: high maternal levels and significant foetal exposure with twice-daily dosing. AIDS 2016; 30:1313-1315.
    • (2016) AIDS , vol.30 , pp. 1313-1315
    • Lewis, J.M.1    Railton, E.2    Riordan, A.3
  • 18
    • 85020628850 scopus 로고    scopus 로고
    • [Accessed 20 March 2017]
    • Dolutegravir prescribing information. Available at: http://www. Accessdata. fda. gov/drugsatfda-docs/label/2013/204790lbl. pdf. [Accessed 20 March 2017].
    • Dolutegravir Prescribing Information
  • 20
    • 85020643323 scopus 로고    scopus 로고
    • [Accessed3 March 2017]. N1/460
    • DOLPHIN 1: dolutegravir in pregnant women. Available at: https://clinicaltrials. gov/ct2/show/NCT02245022?term=dolutegravir&rank=17. [Accessed3 March 2017]. N1/460.
    • DOLPHin 1: Dolutegravir in Pregnant Women
  • 23
    • 84872084395 scopus 로고    scopus 로고
    • Safety, tolerability, and pharmacokinetics of the HIV integrase inhibitor dolutegravir given twice daily with rifampin or once daily with rifabutin: Results of a phase 1 study among healthy subjects
    • Dooley KE, Sayre P, Borland J, et al. Safety, tolerability, and pharmacokinetics of the HIV integrase inhibitor dolutegravir given twice daily with rifampin or once daily with rifabutin: results of a phase 1 study among healthy subjects. J Acquir Immune Defic Syndr 2013; 62:21-27.
    • (2013) J Acquir Immune Defic Syndr , vol.62 , pp. 21-27
    • Dooley, K.E.1    Sayre, P.2    Borland, J.3
  • 24
    • 85020665260 scopus 로고    scopus 로고
    • Early termination of a PK study between dolutegravir and weekly isoniazid/rifapentine
    • 13-16 February, Seattle, Washington [Abstr 409a]
    • Brooks K, Pau A, George J, et al. Early termination of a PK study between dolutegravir and weekly isoniazid/rifapentine. CROI Conference, 13-16 February 2017, Seattle, Washington [Abstr 409a].
    • (2017) CROI Conference
    • Brooks, K.1    Pau, A.2    George, J.3
  • 25
    • 85020641135 scopus 로고    scopus 로고
    • [Accessed 3 March 2017]. N1/4125, Results end 2017
    • INSPIRING Study: dolutegravir versus efavirenz in TB co-infection. Available at: https://clinicaltrials. gov/ct2/show/NCT02178592?term=dolutegravir& rank=89. [Accessed 3 March 2017]. N1/4125, Results end 2017.
    • INSPIRING Study: Dolutegravir Versus Efavirenz in TB Co-infection
  • 26
    • 80052511462 scopus 로고    scopus 로고
    • Efficacy and safety of once-daily nevirapine-or efavirenz-based antiretroviral therapy in HIV-associated tuberculosis: A randomized clinical trial
    • Swaminathan S, Padmapriyadarsini C, Venkatesan P, et al. Efficacy and safety of once-daily nevirapine-or efavirenz-based antiretroviral therapy in HIV-associated tuberculosis: A randomized clinical trial. Clin Infect Dis 2011; 53:716-724.
    • (2011) Clin Infect Dis , vol.53 , pp. 716-724
    • Swaminathan, S.1    Padmapriyadarsini, C.2    Venkatesan, P.3
  • 27
    • 84991474927 scopus 로고    scopus 로고
    • Dolutegravir plus two nucleoside reverse transcriptase inhibitors versus efavirenz plus two nucleoside reverse transcriptase inhibitors as initial antiretroviral therapy for people with HIV: A systematic review
    • Rutherford GW, Horvath H. Dolutegravir plus two nucleoside reverse transcriptase inhibitors versus efavirenz plus two nucleoside reverse transcriptase inhibitors as initial antiretroviral therapy for people with HIV: A systematic review. PLoS One 2016; 11:e0162775.
    • (2016) PLoS One , vol.11 , pp. e0162775
    • Rutherford, G.W.1    Horvath, H.2
  • 28
    • 85020635387 scopus 로고    scopus 로고
    • Integrase inhibitors are an independent risk factor for IRIS; An ATHENA-Cohort study
    • Seattle, abstract 731. Cohort study showing an association between integrase inhibitors and an increased risk of immune reconstitution inflammatory syndrome (IRIS)
    • Wijting I, et al. Integrase inhibitors are an independent risk factor for IRIS; an ATHENA-Cohort study. Conference on Retroviruses and Opportunistic Infections (CROI 2017), Seattle, abstract 731, 2017. Cohort study showing an association between integrase inhibitors and an increased risk of immune reconstitution inflammatory syndrome (IRIS).
    • (2017) Conference on Retroviruses and Opportunistic Infections (CROI 2017)
    • Wijting, I.1
  • 31
    • 85042451838 scopus 로고    scopus 로고
    • NAMSAL Study. [Accessed 3 March 2017]
    • NAMSAL Study. Dolutegravir versus efavirenz in first-line treatment. Available at: https://clinicaltrials. gov/ct2/show/NCT02777229?term=dolutegravir& rank=58. [Accessed 3 March 2017].
    • Dolutegravir Versus Efavirenz in First-line Treatment.
  • 33
    • 85026348107 scopus 로고    scopus 로고
    • Discontinuation of DTG, EVG/c and RAL due to toxicity in a prospective cohort
    • February 13-16, Seattle, Washington. [Abstr 651]
    • LLibre J, Esteve A, Miro J, et al. Discontinuation of DTG, EVG/c and RAL due to toxicity in a prospective cohort. CROI conference, February 13-16, Seattle, Washington. [Abstr 651].
    • CROI Conference
    • Llibre, J.1    Esteve, A.2    Miro, J.3
  • 34
    • 84995883721 scopus 로고    scopus 로고
    • Intolerance of dolutegravir containing cART regimens in real life clinical practice
    • [Epub ahead of print]
    • de Boer M1, van den Berk G, van Holten N, et al. Intolerance of dolutegravir containing cART regimens in real life clinical practice. AIDS 2016. [Epub ahead of print]
    • AIDS 2016
    • De Boer, M.1    Van Den Berk, G.2    Van Holten, N.3
  • 35
    • 85004187482 scopus 로고    scopus 로고
    • Higher rates of neuropsychiatric adverse events leading to dolutegravir discontinuation in women and older patients
    • Hoffmann C, Welz T, Sabranski M, et al. Higher rates of neuropsychiatric adverse events leading to dolutegravir discontinuation in women and older patients. HIV Med 2017; 18:56-63.
    • (2017) HIV Med , vol.18 , pp. 56-63
    • Hoffmann, C.1    Welz, T.2    Sabranski, M.3
  • 36
    • 85020665207 scopus 로고    scopus 로고
    • Effect of dolutegravir plasma concentration on central nervous system side effects
    • February 13-16, Seattle, Washington. [Abstr 426]
    • Yagura H, Watanabe D, Nakauchi T, et al. Effect of dolutegravir plasma concentration on central nervous system side effects. CROI conference, February 13-16, Seattle, Washington. [Abstr 426].
    • CROI Conference
    • Yagura, H.1    Watanabe, D.2    Nakauchi, T.3
  • 37
    • 85020621849 scopus 로고    scopus 로고
    • Psychiatric disorders observed in HIV patients using 6 common third agents in opera
    • February 13-16, Seattle, Washington [Abstr 664]
    • Hsu A, Henegar C, Carpio F, et al. Psychiatric disorders observed in HIV patients using 6 common third agents in opera. CROI conference, February 13-16, Seattle, Washington. [Abstr 664].
    • CROI Conference
    • Hsu, A.1    Henegar, C.2    Carpio, F.3
  • 38
    • 85006007563 scopus 로고    scopus 로고
    • Two case reports of severe myocarditis associated with the initiation of dolutegravir treatment in HIV patients
    • Mahlab-Guri K, Asher I, Rosenberg-Bezalel S, et al. Two case reports of severe myocarditis associated with the initiation of dolutegravir treatment in HIV patients. Medicine 2016; 95:47.
    • (2016) Medicine , vol.95 , pp. 47
    • Mahlab-Guri, K.1    Asher, I.2    Rosenberg-Bezalel, S.3
  • 39
    • 85012005482 scopus 로고    scopus 로고
    • The efficacy and safety of tenofovir alafenamide versus tenofovir disoproxil fumarate in antiretroviral regimens for HIV-1 therapy
    • Wang H, Lu X, Yang X, Xu N. The efficacy and safety of tenofovir alafenamide versus tenofovir disoproxil fumarate in antiretroviral regimens for HIV-1 therapy. Medicine 2016; 95:e5146.
    • (2016) Medicine , vol.95 , pp. e5146
    • Wang, H.1    Lu, X.2    Yang, X.3    Xu, N.4
  • 40
    • 84949515643 scopus 로고    scopus 로고
    • Tenofovir alafenamide: A novel prodrug of tenofovir for the treatment of human immunodeficiency virus
    • Ray A, Fordyce M, Hitchcock M. Tenofovir alafenamide: A novel prodrug of tenofovir for the treatment of human immunodeficiency virus. Antiviral Res 2016; 125:63-70.
    • (2016) Antiviral Res , vol.125 , pp. 63-70
    • Ray, A.1    Fordyce, M.2    Hitchcock, M.3
  • 41
    • 85020664582 scopus 로고    scopus 로고
    • [Date last accessed: 20 March 2017]
    • Tenofovir alafenamide prescribing information. Available at: http://www. Accessdata. fda. gov/drugsatfda-docs/label/2015/207561s000lbl. pdf. [Date last accessed: 20 March 2017].
    • Tenofovir Alafenamide Prescribing Information
  • 42
    • 84937512973 scopus 로고    scopus 로고
    • Efficacy and safety of efavirenz 400mg daily versus 600 mg daily: 96-week data from the randomised, double-blind, placebo-controlled, non-inferiority ENCORE1 study
    • ENCORE-1 Study Group
    • Carey D, Puls R, Amin J, et al., ENCORE-1 Study Group. Efficacy and safety of efavirenz 400mg daily versus 600 mg daily: 96-week data from the randomised, double-blind, placebo-controlled, non-inferiority ENCORE1 study. Lancet Infect Dis 2015; 15:793-802.
    • (2015) Lancet Infect Dis , vol.15 , pp. 793-802
    • Carey, D.1    Puls, R.2    Amin, J.3
  • 43
    • 84952787102 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic comparison of once-daily efavirenz (400mg vs 600 mg) in treatment-näve HIV-infected patients: Results of the ENCORE-1 study
    • Dickinson L, Amin J, Else L, et al. Pharmacokinetic and pharmacodynamic comparison of once-daily efavirenz (400mg vs 600 mg) in treatment-näve HIV-infected patients: results of the ENCORE-1 study. Clin Pharm Therap 2015; 98:406-416.
    • (2015) Clin Pharm Therap , vol.98 , pp. 406-416
    • Dickinson, L.1    Amin, J.2    Else, L.3
  • 44
    • 84960141895 scopus 로고    scopus 로고
    • The drug interaction between rifampicin and efiavirenz is time-dependent: Systematic review of 12 pharmacokinetic studies
    • Melbourne, Australia, July, [Abstr MOPE040]
    • Hill A, Khoo S, Back D, et al. The drug interaction between rifampicin and efiavirenz is time-dependent: systematic review of 12 pharmacokinetic studies. World AIDS Conference, Melbourne, Australia, July 2014 [Abstr MOPE040].
    • (2014) World AIDS Conference
    • Hill, A.1    Khoo, S.2    Back, D.3
  • 45
    • 80054721877 scopus 로고    scopus 로고
    • Timing of antiretroviral therapy for HIV-1 infection and tuberculosis
    • Havlir DV, Kendall MA, Ive P, et al. Timing of antiretroviral therapy for HIV-1 infection and tuberculosis. N Engl J Med 2011; 365:1482-1483.
    • (2011) N Engl J Med , vol.365 , pp. 1482-1483
    • Havlir, D.V.1    Kendall, M.A.2    Ive, P.3
  • 46
    • 84904253549 scopus 로고    scopus 로고
    • Assessment of second-line antiretroviral regimens for HIV therapy in Africa
    • Paton N, Kityo C, Hoppe A, et al. Assessment of second-line antiretroviral regimens for HIV therapy in Africa. N Engl J Med 2014; 371:234-247.
    • (2014) N Engl J Med , vol.371 , pp. 234-247
    • Paton, N.1    Kityo, C.2    Hoppe, A.3
  • 47
    • 84923783265 scopus 로고    scopus 로고
    • Raltegravir non-inferior to nucleoside based regimens in second-line therapy with lopinavir/ritonavir over 96 weeks: A randomised open label study for the treatment of HIV-1 infection
    • Amin J, Boyd MA, Kumarasamy N, et al. Raltegravir non-inferior to nucleoside based regimens in second-line therapy with lopinavir/ritonavir over 96 weeks: A randomised open label study for the treatment of HIV-1 infection. PLoS One 2015; 10:e0118228.
    • (2015) PLoS One , vol.10 , pp. e0118228
    • Amin, J.1    Boyd, M.A.2    Kumarasamy, N.3
  • 48
    • 85020640338 scopus 로고    scopus 로고
    • D2EFT Study. [Accessed 3 March 2017]. N1/4610
    • D2EFT Study. Dolutegravir plus darunavir/ritonavir as a second-line treatment. Available at: https://clinicaltrials. gov/ct2/show/NCT03017872?term= dolutegravir&rank=45. [Accessed 3 March 2017]. N1/4610.
    • Dolutegravir Plus Darunavir/ritonavir As A Second-line Treatment
  • 49
    • 0004018981 scopus 로고    scopus 로고
    • World Health Organisation [Accessed 20 March 2017]
    • World Health Organisation. Hepatitis B factsheet. Available at: http:// www. who. int/mediacentre/factsheets/fs204/en/. [Accessed 20 March 2017].
    • Hepatitis B Factsheet


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.