Epstein-Barr Virus Lytic Reactivation Activates B Cells Polyclonally and Induces Activation-Induced Cytidine Deaminase Expression: A Mechanism Underlying Autoimmunity and Its Contribution to Graves' Disease

Viral Immunology

Volumn 30, Issue 3, 2017, Pages 240-249

  Nagata, Keiko ^a   Kumata, Keisuke ^a   Nakayama, Yuji ^a   Satoh, Yukio ^a   Sugihara, Hirotsugu ^a   Hara, Sayuri ^a   Matsushita, Michiko ^a   Kuwamoto, Satoshi ^a   Kato, Masako ^a   Murakami, Ichiro ^b   Hayashi, Kazuhiko ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

activation inducedcytidine deaminase; autoreactive B cells; Epstein Barr virus; Graves' disease; polyclonal B cell activation; reactivation

Indexed keywords

CYTIDINE DEAMINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LATENT MEMBRANE PROTEIN 1; EBV-ASSOCIATED MEMBRANE ANTIGEN, EPSTEIN-BARR VIRUS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MATRIX PROTEIN;

ADULT; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CONTROLLED STUDY; EPSTEIN BARR VIRUS; GENE REARRANGEMENT; GRAVES DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN PRODUCTION; PLASMA CELL; POLYCLONAL ACTIVATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; VIRUS REACTIVATION; CELL CULTURE; CHEMISTRY; FEMALE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MALE; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; UPREGULATION; VIROLOGY; VIRUS ACTIVATION;

ADULT; AUTOIMMUNITY; B-LYMPHOCYTES; CELLS, CULTURED; CYTIDINE DEAMINASE; FEMALE; GRAVES DISEASE; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; NF-KAPPA B; UP-REGULATION; VIRAL MATRIX PROTEINS; VIRUS ACTIVATION;

EID: 85017380855     PISSN: 08828245     EISSN: 15578976     Source Type: Journal    
DOI: 10.1089/vim.2016.0179     Document Type: Article

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