Evaluating the frequency of asymptomatic Ebola virus infection

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 372, Issue 1721, 2017, Pages

  Mbala, Placide ^a,e   Baguelin, Marc ^b,c   Ngay, Ipos ^a,e   Rosello, Alicia ^b,d   Mulembakani, Prime ^e   Demiris, Nikolaos ^f   Edmunds, W John ^c   Muyembe, Jean Jacques ^a  

^a Institut National de Recherche Biomedicale   (Democratic Republic Congo)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e METABIOTA ^*  (Democratic Republic Congo)

^f ATHENS UNIVERSITY OF ECONOMICS AND BUSINESS   (Greece)

Author keywords

Asymptomatic infection; Ebola virus disease; Household survey; Serology

Indexed keywords

AGE STRUCTURE; ANTIBODY; ANTIGEN; DECISION MAKING; DEMOGRAPHY; DISEASE CONTROL; DISEASE INCIDENCE; DISEASE PREVALENCE; EBOLA VIRUS DISEASE; HOUSEHOLD SURVEY; INFECTIOUS DISEASE; NUMERICAL MODEL; PUBLIC HEALTH; SPATIOTEMPORAL ANALYSIS; VIRUS;

CONGO; DEMOCRATIC REPUBLIC CONGO; EQUATEUR;

EBOLA VIRUS;

IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; VIRUS ANTIBODY;

ADOLESCENT; ADULT; ASYMPTOMATIC INFECTION; BLOOD; DEMOCRATIC REPUBLIC CONGO; EBOLA HEMORRHAGIC FEVER; EBOLAVIRUS; FEMALE; HUMAN; MALE; PHYSIOLOGY; PREVALENCE; SEROEPIDEMIOLOGY; THEORETICAL MODEL; VIROLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; ANTIBODIES, VIRAL; ASYMPTOMATIC INFECTIONS; DEMOCRATIC REPUBLIC OF THE CONGO; EBOLAVIRUS; FEMALE; HEMORRHAGIC FEVER, EBOLA; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MALE; MODELS, THEORETICAL; PREVALENCE; SEROEPIDEMIOLOGIC STUDIES; YOUNG ADULT;

EID: 85017292516     PISSN: 09628436     EISSN: 14712970     Source Type: Journal    
DOI: 10.1098/rstb.2016.0303     Document Type: Article

References (24)

1. Whitty CJM, Farrar J, Ferguson N, Edmunds WJ, Piot P, Leach M, Davies SC. 2014 Infectious disease: tough choices to reduce Ebola transmission. Nature 515, 192–194. (doi:10.1038/515192a)
2. Farrar JJ, Piot P. 2014 The Ebola emergency— immediate action, ongoing strategy. N. Engl. J. Med. 371, 1545–1546. (doi:10.1056/NEJMe1411471).
3. Rosello A et al. 2015 Ebola virus disease in the Democratic Republic of the Congo, 1976–2014. Elife 4, e09015. (doi:10.7554/eLife.09015)
4. Maganga GD et al. 2014 Ebola virus disease in the Democratic Republic of Congo. N. Engl. J. Med. 371, 2083–2091. (doi:10.1056/NEJMoa1411099)
5. Bellan SE, Pulliam JRC, Dushoff J, Meyers LA. 2014 Ebola control: effect of asymptomatic infection and acquired immunity. Lancet 384, 1499–1500. (doi:10.1016/S0140-6736(14)61839-0)
6. Bertherat E, Renaut A, Nabias R, Dubreuil G, Georges-Courbot MC. 1999 Leptospirosis and Ebola virus infection in five gold-panning villages in northeastern Gabon. Am. J. Trop. Med. Hyg. 60, 610–615.
7. Leroy E et al. 2000 Human asymptomatic Ebola infection and strong inflammatory response. Lancet 355, 2210–2215. (doi:10.1016/S0140-6736(00) 02405-3)
8. Heffernan RT, Pambo B, Hatchett RJ, Leman PA, Swanepoel R, Ryder RW. 2005 Low seroprevalence of IgG antibodies to Ebola virus in an epidemic zone: Ogooué-Ivindo region, Northeastern Gabon, 1997. J. Infect. Dis. 191, 964–968. (doi:10.1086/427994)
9. Becquart P et al. 2010 High prevalence of both humoral and cellular immunity to Zaire ebolavirus among rural populations in Gabon. PLoS ONE 5, e9126. (doi:10.1371/journal.pone.0009126)
10. Gonzalez JP, Nakoune E, Slenczka W, Vidal P, Morvan JM. 2000 Ebola and Marburg virus antibody prevalence in selected populations of the Central African Republic. Microbes Infect. 2, 39–44. (doi:10. 1016/S1286-4579(00)00287-2)
11. Busico KM, Marshall KL, Ksiazek TG, Roels TH, Fleerackers Y, Feldmann H, Khan AS, Peters CJ. 1999 Prevalence of IgG antibodies to Ebola virus in individuals during an Ebola outbreak, Democratic Republic of the Congo, 1995. J. Infect. Dis. 179, S102–S107. (doi:10.1086/514309)
12. Heymann DL, Weisfeld JS, Webb PA, Johnson KM, Cairns T, Berquist H. 1980 Ebola hemorrhagic fever: Tandala, Zaire, 1977–1978. J. Infect. Dis. 142, 372–376. (doi:10.1093/infdis/142.3.372)
13. Mulangu S, Borchert M, Paweska J, Tshomba A, Afounde A, Kulidri A, Swanepoel R, Muyembe-Tamfum J-J, Van der Stuyft P. 2016 High prevalence of IgG antibodies to Ebola virus in the Efé pygmy population in the Watsa region, Democratic Republic of the Congo. BMC Infect. Dis. 16, 301. (doi:10.1186/s12879-016-1607-y)
14. Dean NE, Halloran ME, Yang Y, Longini IM. 2016 Transmissibility and pathogenicity of Ebola virus: a systematic review and meta-analysis of household secondary attack rate and asymptomatic infection. Clin. Infect. Dis. 62, 1277–1286. (doi:10.1093/cid/ciw114)
15. McElroy AK et al. 2015 Human Ebola virus infection results in substantial immune activation. Proc. Natl Acad. Sci. USA 112, 4719–4724. (doi:10.1073/pnas.1502619112)
16. Wauquier N, Becquart P, Gasquet C, Leroy EM. 2009 Immunoglobulin G in Ebola outbreak survivors, Gabon. Emerg. Infect. Dis. 15, 1136–1137. (doi:10.3201/eid1507.090402)
17. Wu S et al. 2016 An adenovirus vaccine expressing Ebola virus variant Makona glycoprotein is efficacious in guinea pigs and nonhuman primates. J. Infect. Dis. 214, S326–S332. (doi:10.1093/infdis/jiw250)
18. Frey A, Di Canzio J, Zurakowski D. 1998 A statistically defined endpoint titer determination method for immunoassays. J. Immunol. Methods 221, 35–41. (doi:10.1016/S0022-1759(98)00170-7)
19. Jasra A, Holmes CC, Stephens DA. 2005 Markov chain Monte Carlo methods and the label switching problem in Bayesian mixture modeling. Stat. Sci. 20, 50–67. (doi:10.1214/088342305000000016)
20. Lunn DJ, Thomas A, Best N, Spiegelhalter D. 2000 WinBUGS—a Bayesian modelling framework: concepts, structure, and extensibility. Stat. Comput. 10, 325–337. (doi:10.1023/A:1008929526011)
21. Ball F, Britton T, House T, Isham V, Mollison D, Pellis L, Scalia Tomba G. 2015 Seven challenges for metapopulation models of epidemics, including households models. Epidemics 10, 63–67. (doi:10.1016/j.epidem.2014.08.001)
22. Leroy EM et al. 2005 Fruit bats as reservoirs of Ebola virus. Nature 438, 575–576. (doi:10.1038/438575a)
23. Leroy EM, Epelboin A, Mondonge V, Pourrut X, Gonzalez J-P, Muyembe-Tamfum J-J, Formenty P. 2009 Human Ebola outbreak resulting from direct exposure to fruit bats in Luebo, Democratic Republic of Congo, 2007. Vector Borne Zoonotic Dis. 9, 723– 728. (doi:10.1089/vbz.2008.0167)
24. Pigott DM et al. 2014 Mapping the zoonotic niche of Ebola virus disease in Africa. Elife 3, e04395. (doi:10.7554/eLife.04395)