High prevalence of IgG antibodies to Ebola virus in the Efé pygmy population in the Watsa region, Democratic Republic of the Congo

BMC Infectious Diseases

Volumn 16, Issue 1, 2016, Pages

  Mulangu, Sabue ^a,b   Borchert, Matthias ^c,d   Paweska, Janusz ^e   Tshomba, Antoine ^f   Afounde, Afongenda ^g   Kulidri, Amayo ^g   Swanepoel, Robert ^e,h   Muyembe Tamfum, Jean Jacques ^a   Van der Stuyft, Patrick ^c,i  

^a UNIVERSITY OF KINSHASA   (Congo)

^b Southern African Centre for Infectious Diseases and Surveillance   (Tanzania)

^c INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e NATIONAL INSTITUTE FOR COMMUNICABLE DISEASES   (South Africa)

^f UNIVERSITY OF KISANGANI   (Congo)

^g Ministry of Health   (Congo)

^h UNIVERSITY OF PRETORIA   (South Africa)

ⁱ GHENT UNIVERSITY   (Belgium)

Author keywords

Ebola virus; IgG Antibody; Pygmy

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G; VIRUS ANTIBODY;

ARTICLE; CHILD; CONGO; CONTROLLED STUDY; DISEASE TRANSMISSION; EBOLA HEMORRHAGIC FEVER; EBOLAVIRUS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; LIFESTYLE MODIFICATION; MALE; NONHUMAN; PYGMY; RAT; RISK FACTOR; SEROPREVALENCE; VIRUS ENTRY; ADOLESCENT; ADULT; AGE; AGED; ANIMAL; BAT; CAVE; CROSS-SECTIONAL STUDY; DEMOCRATIC REPUBLIC CONGO; ENVIRONMENTAL EXPOSURE; HAPLORHINI; HEMORRHAGIC FEVER, EBOLA; IMMUNOLOGY; MIDDLE AGED; PREVALENCE; SEROEPIDEMIOLOGY; STATISTICS AND NUMERICAL DATA; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; AGED; ANIMALS; ANTIBODIES, VIRAL; CAVES; CHILD; CHIROPTERA; CROSS-SECTIONAL STUDIES; DEMOCRATIC REPUBLIC OF THE CONGO; EBOLAVIRUS; ENVIRONMENTAL EXPOSURE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HAPLORHINI; HEMORRHAGIC FEVER, EBOLA; HUMANS; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; PREVALENCE; RATS; RISK FACTORS; SEROEPIDEMIOLOGIC STUDIES; YOUNG ADULT;

EID: 84975474206     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/s12879-016-1607-y     Document Type: Article

References (32)

1. Kuhn JH, Bao Y, Bavari S, Becker S, Bradfute S, et al. Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae. Arch Virol. 2013;158:301-11.
2. Feldmann H, Geisbert TW. Ebola haemorrhagic fever. Lancet. 2011;377:849-62.
3. Baize S, Pannetier D, Oestereich L, Rieger T, Koivogui L, et al. Emergence of Zaire Ebola virus disease in Guinea. N Engl J Med. 2014;371:1418-25.
4. Leroy EM, Rouquet P, Formenty P, Souquiere S, Kilbourne A, et al. Multiple Ebola virus transmission events and rapid decline of central African wildlife. Science. 2004;303:387-90.
5. Baron RC, McCormick JB, Zubeir OA. Ebola virus disease in southern Sudan: hospital dissemination and intrafamilial spread. Bull World Health Organ. 1983;61:997-1003.
6. Leroy EM, Epelboin A, Mondonge V, Pourrut X, Gonzalez JP, et al. Human Ebola outbreak resulting from direct exposure to fruit bats in Luebo, Democratic Republic of Congo, 2007. Vector Borne Zoonotic Dis. 2009;9:723-8.
7. Leroy EM, Kumulungui B, Pourrut X, Rouquet P, Hassanin A, et al. Fruit bats as reservoirs of Ebola virus. Nature. 2005;438:575-6.
8. Mari Saez A, Weiss S, Nowak K, Lapeyre V, Zimmermann F, et al. Investigating the zoonotic origin of the West African Ebola epidemic. EMBO Mol Med. 2014;7:17-23.
9. Busico KM, Marshall KL, Ksiazek TG, Roels TH, Fleerackers Y, et al. Prevalence of IgG antibodies to Ebola virus in individuals during an Ebola outbreak, Democratic Republic of the Congo, 1995. J Infect Dis. 1999;179 Suppl 1:S102-107.
10. Heffernan RT, Pambo B, Hatchett RJ, Leman PA, Swanepoel R, et al. Low seroprevalence of IgG antibodies to Ebola virus in an epidemic zone: Ogooue-Ivindo region, Northeastern Gabon, 1997. J Infect Dis. 2005;191:964-8.
11. Nkoghe D, Padilla C, Becquart P, Wauquier N, Moussavou G, et al. Risk Factors for Zaire ebolavirus--specific IgG in rural Gabonese populations. J Infect Dis. 2011;204 Suppl 3:S768-775.
12. Ivanoff B, Duquesnoy P, Languillat G, Saluzzo JF, Georges A, et al. Haemorrhagic fever in Gabon. I. Incidence of Lassa, Ebola and Marburg viruses in Haut-Ogooue. Trans R Soc Trop Med Hyg. 1982;76:719-20.
13. Van der Groen G, Pattyn SR. Measurement of antibodies to Ebola virus in human sera from N. W.-Zaire. Ann Soc Belg Med Trop. 1979;59:87-92.
14. Gonzalez JP, Nakoune E, Slenczka W, Vidal P, Morvan JM. Ebola and Marburg virus antibody prevalence in selected populations of the Central African Republic. Microbes Infect. 2000;2:39-44.
15. Bouree P, Bergmann JF. Ebola virus infection in man: a serological and epidemiological survey in the Cameroons. Am J Trop Med Hyg. 1983;32:1465-6.
16. Gonzalez JP, Josse R, Johnson ED, Merlin M, Georges AJ, et al. Antibody prevalence against haemorrhagic fever viruses in randomized representative Central African populations. Res Virol. 1989;140:319-31.
17. Meunier DM, Johnson ED, Gonzalez JP, Georges-Courbot MC, Madelon MC, et al. Current serologic data on viral hemorrhagic fevers in the Central African Republic. Bull Soc Pathol Exot Filiales. 1987;80:51-61.
18. Saluzzo JF, Gonzalez JP, Herve JP, Georges AJ, Johnson KM. Preliminary note on the presence of antibodies to Ebola virus in the human population in the eastern part of the Central African Republic. Bull Soc Pathol Exot Filiales. 1980;73:238-41.
19. Knobloch J, Albiez EJ, Schmitz H. A Serological Survey on Viral Hemorrhagic Fevers in Liberia. Annales De Virologie. 1982;133:125-8.
20. Johnson ED, Gonzalez JP, Georges A. Filovirus activity among selected ethnic groups inhabiting the tropical forest of equatorial Africa. Trans R Soc Trop Med Hyg. 1993;87:536-8.
21. Borchert M, Mulangu S, Swanepoel R, Tshomba A, Afounde A, et al. Pygmy populations seronegative for Marburg virus. Emerg Infect Dis. 2005;11:174-7.
22. Bausch DG, Borchert M, Grein T, Roth C, Swanepoel R, et al. Risk factors for Marburg hemorrhagic fever, Democratic Republic of the Congo. Emerg Infect Dis. 2003;9:1531-7.
23. Bausch DG, Nichol ST, Muyembe-Tamfum JJ, Borchert M, Rollin PE, et al. Marburg hemorrhagic fever associated with multiple genetic lineages of virus. N Engl J Med. 2006;355:909-19.
24. Towner JS, Amman BR, Sealy TK, Carroll SA, Comer JA, et al. Isolation of genetically diverse Marburg viruses from Egyptian fruit bats. PLoS Pathog. 2009;5:e1000536.
25. Morvan JM, Deubel V, Gounon P, Nakoune E, Barriere P, et al. Identification of Ebola virus sequences present as RNA or DNA in organs of terrestrial small mammals of the Central African Republic. Microbes Infect. 1999;1:1193-201.
26. Ksiazek TG, West CP, Rollin PE, Jahrling PB, Peters CJ. ELISA for the detection of antibodies to Ebola viruses. Journal of Infectious Diseases. 1999;179:S192-8.
27. Cuzick J. A Wilcoxon-type test for trend. Stat Med. 1985;4:87-90.
28. Ksiazek TG, West CP, Rollin PE, Jahrling PB, Peters CJ. ELISA for the detection of antibodies to Ebola viruses. J Infect Dis. 1999;179 Suppl 1:S192-198.
29. Van der Waals FW, Pomeroy KL, Goudsmit J, Asher DM, Gajdusek DC. Hemorrhagic fever virus infections in an isolated rainforest area of central Liberia. Limitations of the indirect immunofluorescence slide test for antibody screening in Africa. Trop Geogr Med. 1986;38:209-14.
30. Macneil A, Reed Z, Rollin PE. Serologic cross-reactivity of human IgM and IgG antibodies to five species of Ebola virus. PLoS Negl Trop Dis. 2011;5:e1175.
31. Monath TP. Ecology of Marburg and Ebola viruses: speculations and directions for future research. J Infect Dis. 1999;179 Suppl 1:S127-138.
32. Hewlett B, Vandekoppel JMH, Cavallisforza LL. Exploration Ranges of Aka Pygmies of the Central-African-Republic. Man. 1982;17:418-30.