Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D: A cross-sectional analysis in population-based data

International Journal of Epidemiology

Volumn 45, Issue 5, 2016, Pages 1469-1481

  Vogt, Susanne ^a,b   Wahl, Simone ^a   Kettunen, Johannes ^d,e,f   Breitner, Susanne ^a   Kastenmüller, Gabi ^a   Gieger, Christian ^a,c   Suhre, Karsten ^a,g   Waldenberger, Melanie ^a   Kratzsch, Jürgen ^h   Perola, Markus ^f,i,j   Salomaa, Veikko ^f   Blankenberg, Stefan ^b,k   Zeller, Tanja ^b,k   Soininen, Pasi ^d,e   Kangas, Antti J ^d   Peters, Annette ^a,b,c   Grallert, Harald ^a,c   Ala Korpela, Mika ^d,e,l   Thorand, Barbara ^a,c  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^c GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^d UNIVERSITY OF OULU   (Finland)

^e UNIVERSITY OF EASTERN FINLAND   (Finland)

^f NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^g WEILL CORNELL MEDICAL COLLEGE   (Qatar)

^h UNIVERSITY OF LEIPZIG   (Germany)

ⁱ UNIVERSITY OF HELSINKI   (Finland)

^j UNIVERSITY OF TARTU   (Estonia)

^k UNIVERSITY HEART CENTER HAMBURG   (Germany)

^l UNIVERSITY OF BRISTOL   (United Kingdom)

more..

Author keywords

25(OH)D; Metabolomics; Molecular epidemiology; Obesity; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; APOLIPOPROTEIN B; CREATININE; FATTY ACID; ISOLEUCINE; LONG CHAIN FATTY ACID; LOW DENSITY LIPOPROTEIN; MONOUNSATURATED FATTY ACID; PALMITOLEIC ACID; PYRIDOXIC ACID; PYRIDOXINE; SATURATED FATTY ACID; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN; 25-HYDROXYVITAMIN D; VITAMIN D;

ABDOMINAL OBESITY; ADULT; ALCOHOL CONSUMPTION; ARTICLE; CROSS-SECTIONAL STUDY; ENZYME BLOOD LEVEL; FEMALE; HEALTH STATUS; HEART MUSCLE METABOLISM; HUMAN; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; METABOLITE; METABOLOMICS; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OBESE PATIENT; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SMOKING; TRIACYLGLYCEROL BLOOD LEVEL; TRIACYLGLYCEROL LEVEL; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; WAIST CIRCUMFERENCE; AGED; ANALOGS AND DERIVATIVES; BLOOD; BODY MASS; GERMANY; METABOLISM; METABOLOME; REGRESSION ANALYSIS; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BODY MASS INDEX; CROSS-SECTIONAL STUDIES; FATTY ACIDS; FEMALE; GERMANY; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; METABOLOME; METABOLOMICS; MIDDLE AGED; OBESITY, ABDOMINAL; REGRESSION ANALYSIS; VITAMIN D; WAIST CIRCUMFERENCE;

EID: 85017292173     PISSN: 03005771     EISSN: 14643685     Source Type: Journal    
DOI: 10.1093/ije/dyw222     Document Type: Article

References (57)

1. Plum LA, DeLuca HF. The functional metabolism and molecular biology of vitamin D action. In: Holick MF (ed). Vitamin D - Physiology, Molecular Biology, and Clinical Applications. 2nd edn. New York, NY: Humana Press, 2010.
2. Theodoratou E, Tzoulaki I, Zgaga L, Ioannidis JP. Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and rando-mised trials. BMJ 2014;348:g2035.
3. Holick MF. Vitamin D and health: evolution, biologic functions, and recommended dietary intakes for vitamin D. In: Holick MF (ed). Vitamin D Physiology, Molecular Biology, and Clinical Applications. 2nd edn. New York, NY: Humana Press, 2010.
4. Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol 2009;19:73–78.
5. Melamed ML, Thadhani RI. Vitamin D therapy in chronic kidney disease and end stage renal disease. Clin J Am Soc Nephrol 2012;7:358–65.
6. Zittermann A, Ernst JB, Birschmann I, Dittrich M. Effect of vitamin D or activated vitamin D on circulating 1,25-dihydroxyvitamin D concentrations: a systematic review and metaanalysis of randomized controlled trials. Clin Chem 2015;61:1484–94.
7. Cashman KD, Dowling KG, Skrabakova Z et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 2016;103:1033–44
8. Rabenberg M, Scheidt-Nave C, Busch MA, Rieckmann N, Hintzpeter B, Mensink GB. Vitamin D status among adults in Germany – results from the German Health Interview and Examination Survey for Adults (DEGS1). BMC Public Health 2015;15:641.
9. Autier P, Boniol M, Pizot C, Mullie P. Vitamin D status and ill health:a systematic review. Lancet Diabetes Endocrinol 2014;2:76–89.
10. Meyer HE, Holvik K, Lips P. Should vitamin D supplements be recommended to prevent chronic diseases? BMJ 2015;350:h321.
11. Earthman CP, Beckman LM, Masodkar K, Sibley SD. The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications. Int J Obes 2012;36:387–96.
12. Forrest KY, Stuhldreher WL. Prevalence and correlates of vitamin D deficiency in US adults. Nutr Res 2011;31:48–54.
13. Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health 2009;9:88.
14. Kunutsor SK, Apekey TA, Steur M. Vitamin D and risk of future hypertension: meta-analysis of 283,537 participants. Eur J Epidemiol 2013;28:205–21.
15. Jorde R, Grimnes G. Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids. Prog Lipid Res 2011;50:303–12.
16. Song Y, Wang L, Pittas AG et al. Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care 2013;36:1422–28.
17. Cornelis MC, Hu FB. Systems epidemiology: a new direction in nutrition and metabolic disease research. Curr Nutr Rep 2013;2:doi: 10.1007/s13668-013-0052-4.
18. Soininen P, Kangas AJ, Wurtz P, Suna T, Ala-Korpela M. Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics. Circ Cardiovasc Genet 2015;8:192–206.
19. Du F, Virtue A, Wang H, Yang XF. Metabolomic analyses for atherosclerosis, diabetes, and obesity. Biomarker Res 2013;1:17.
20. O’Sullivan A, Gibney MJ, Connor AO et al. Biochemical and metabolomic phenotyping in the identification of a vitamin D responsive metabotype for markers of the metabolic syndrome. Mol Nutr Food Res 2011;55:679–90.
21. Finkelstein JL, Pressman EK, Cooper EM, Kent TR, Bar HY, O’Brien KO. Vitamin D status affects serum metabolomic profiles in pregnant adolescents. Reprod Sci 2015;22:685–95.
22. Holle R, Happich M, Lowel H, Wichmann HE; MONICA/ KORA Study Group. KORA - a research platform for population based health research. Gesundheitswesen 2005;6(Suppl 1):S19–25.
23. Ruckert IM, Heier M, Rathmann W, Baumeister SE, Doring A, Meisinger C. Association between markers of fatty liver disease and impaired glucose regulation in men and women from the general population: the KORA-F4-study. PloS One 2011;6:e22932.
24. Vartiainen E, Laatikainen T, Peltonen M et al. Thirty-five-year trends in cardiovascular risk factors in Finland. Int J Epidemiol 2010;39:504–18.
25. Meisinger C, Lowel H, Thorand B, Doring A. Leisure time physical activity and the risk of type 2 diabetes in men and women from the general population. The MONICA/KORA Augsburg Cohort Study. Diabetologia 2005;48:27–34.
26. Jourdan C, Petersen AK, Gieger C et al. Body fat free mass is associated with the serum metabolite profile in a population-based study. PloS One 2012;7:e40009.
27. Richter K, Breitner S, Webb AR et al. Influence of external, intrinsic and individual behaviour variables on serum 25(OH)D in a German survey. J Photochem Photobiol B 2014;140:120–29.
28. Keil U, Chambless LE, Doring A, Filipiak B, Stieber J. The relation of alcohol intake to coronary heart disease and all-cause mortality in a beer-drinking population. Epidemiology 1997;8:150–56.
29. Mühlberger N, Behrend C, Stark R, Holle R. Datenbankgestützte Online-Erfassung von Arzneimitteln im Rahmen gesundheitswis-senschaftlicher Studien - Erfahrungen mit der IDOM-Software. Informatik, Biometrie und Epidemiologie in Medizin und Biologie 2003;34:601–11.
30. Levey AS, Stevens LA, Schmid CH et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009;150:604–12.
31. Tunstall-Pedoe H, Woodward M, Hughes M et al. Prime mover or fellow traveller: 25-hydroxy vitamin D’s seasonal variation, cardiovascular disease and death in the Scottish Heart Health Extended Cohort (SHHEC). Int J Epidemiol 2015;44:1602–12.
32. Wahl S, Vogt S, Stuckler F et al. Multi-omic signature of body weight change: results from a population-based cohort study. BMC Med 2015;13:48.
33. Dehaven CD, Evans AM, Dai H, Lawton KA. Organization of GC/MS and LC/MS metabolomics data into chemical libraries. J Chem Informatics 2010;2:9.
34. Evans AM, DeHaven CD, Barrett T, Mitchell M, Milgram E. Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. Anal Chem 2009;81:6656–67.
35. Soininen P, Kangas AJ, Wurtz P et al. High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism. Analyst 2009;134:1781–85.
36. Inouye M, Kettunen J, Soininen P et al. Metabonomic, transcrip-tomic, and genomic variation of a population cohort. Mol Syst Biol 2010;6:441.
37. van Buuren S, Groothuis-Oudshoorn K. mice: Multivariate Imputation by Chained Equations in R. J Stat Soft 2011;45:1–67.
38. Chuang HY, Lee E, Liu YT, Lee D, Ideker T. Network-based classification of breast cancer metastasis. Mol Syst Biol 2007;3:140.
39. Inouye M, Ripatti S, Kettunen J et al. Novel loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. PLoS Genet 2012;8:e1002907.
40. Walldius G, Jungner I, Aastveit AH, Holme I, Furberg CD, Sniderman AD. The apoB/apoA-I ratio is better than the cholesterol ratios to estimate the balance between plasma proathero-genic and antiatherogenic lipoproteins and to predict coronary risk. Clin Chem Lab Med 2004;42:1355–63.
41. Morita SY. Metabolism and modification of apolipoprotein B-containing lipoproteins involved in dyslipidemia and atherosclerosis. Biol Pharm Bull 2016;39:1–24.
42. Musunuru K. Atherogenic dyslipidemia: cardiovascular risk and dietary intervention. Lipids 2010;45:907–14.
43. Huang Y, Li X, Wang M et al. Lipoprotein lipase links vitamin D, insulin resistance, and type 2 diabetes: a cross-sectional epidemiological study. Cardiovasc Diabetol 2013;12:17.
44. Querfeld U, Hoffmann MM, Klaus G et al. Antagonistic effects of vitamin D and parathyroid hormone on lipoprotein lipase in cultured adipocytes. J Am Soc Nephrol 1999;10:2158–64.
45. Lankinen M, Kolehmainen M, Jaaskelainen T et al. Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities: a randomized trial (Sysdimet). PloS One 2014;9:e90352.
46. >Raiko J. Conventional and Novel Cardiovascular Risk Factors in Young Finns and Their Associations with Structural And Functional Vascular Changes of Subclinical Atherosclerosis - The Cardiovascular Risk in Young Finns Study. Turku, Finland: University of Turku, 2011.
47. Jorde R, Sneve M, Emaus N, Figenschau Y, Grimnes G. Cross-sectional and longitudinal relation between serum 25-hydroxyvi-tamin D and body mass index: the Tromso study. Eur J Nutr 2010;49:401–07.
48. Geldenhuys S, Hart PH, Endersby R et al. Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin D in mice fed a high-fat diet. Diabetes 2014;63:3759–69.
49. Hanhineva K, Lankinen MA, Pedret A et al. Nontargeted metabolite profiling discriminates diet-specific biomarkers for consumption of whole grains, fatty fish, and bilberries in a randomized controlled trial. J Nutr 2015;145:7–17.
50. Autier P. Vitamin D status as a synthetic biomarker of health status. Endocrine 2016;51:201–02.
51. Afzal S, Brondum-Jacobsen P, Bojesen SE, Nordestgaard BG. Vitamin D concentration, obesity, and risk of diabetes:a mendelian randomisation study. Lancet Diabetes Endocrinol 2014;2:298–306.
52. Skaaby T, Husemoen LL, Martinussen T et al. Vitamin D status, filaggrin genotype, and cardiovascular risk factors: a Mendelian randomization approach. PloS One 2013;8:e57647.
53. Vimaleswaran KS, Berry DJ, Lu C et al. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med 2013;10:e1001383.
54. Ye Z, Sharp SJ, Burgess S et al. Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study. Lancet Diabetes Endocrinol 2015;3:35–42.
55. Brondum-Jacobsen P, Benn M, Afzal S, Nordestgaard BG. No evidence that genetically reduced 25-hydroxyvitamin D is associated with increased risk of ischaemic heart disease or myocardial infarction: a Mendelian randomization study. Int J Epidemiol 2015;44:651–61.
56. Afzal S, Brondum-Jacobsen P, Bojesen SE, Nordestgaard BG. Genetically low vitamin D concentrations and increased mortality: Mendelian randomisation analysis in three large cohorts. BMJ 2014;349:g6330.
57. Enko D, Fridrich L, Rezanka E et al. 25-hydroxy-Vitamin D status: limitations in comparison and clinical interpretation of serum-levels across different assay methods. Clin Lab 2014;60:1541–50.