Candida albicans Germ-Tube Antibody: Evaluation of a New Automatic Assay for Diagnosing Invasive Candidiasis in ICU Patients

Mycopathologia

Volumn 182, Issue 7-8, 2017, Pages 645-652

  Parra Sánchez, Manuel ^a   Zakariya Yousef Breval, Ismail ^a   Castro Méndez, Carmen ^a   García Rey, Silvia ^a   Loza Vazquez, Ana ^a   Úbeda Iglesias, Alejandro ^b   Macías Guerrero, Desiree ^a   Romero Mejías, Ana ^a   León Gil, Cristobal ^a   Martín Mazuelos, Estrella ^a   Tomas J I ^c   Gurpegui, M ^c   Gonzalez V ^c   Rezusta, A ^c   Ubeda A ^c   Rodriguez A ^c   Bodi, M ^c   Gomez F ^c   Trefler, S ^c   Llaurado M ^c   Guell R ^c   Gonzalez R ^c   Diaz F J ^c   González, Raúl ^c   Marcos, J M ^c   Carriedo, D ^c   Fernandez I ^c   Valverde, E ^c   Esteban, A ^c   Marrodan, T ^c   Arenzana, A ^c   Gonzalez C ^c   Suarez A I ^c   Ballus J ^c   Esteve, F ^c   Ayats, J ^c   Aguilar, G ^c   Badenes, R ^c   Ferrando, C ^c   Navarro, D ^c   Carbonell, J A ^c   Garcia C ^c   Gomez A ^c   Henao, L ^c   Minana A ^c   Puig, J ^c   Belda, F J ^c   Puppo, A ^c   Garnacho, J ^c   Marquez J A ^c   Gutierrez A ^c   Ruiz, M ^c   Jerez V ^c   Trasmonte, V ^c   Martinez P ^c   Perez D ^c   Fajardo, M ^c   Gaona, C ^c   Munoz C ^c   Tamayo, G ^c   Martinez A ^c   Labayen, F ^c   Iruretagoyena, J R ^c   Lopez L ^c   Hernandez J L ^c   Ruiz Santana, S ^c   Hernandez M A ^c   Bordes, A ^c   Ojeda, N ^c   Jimenez J D ^c   more..

^a HOSPITAL UNIVERSITARIO DE VALME   (Spain)

^b HOSPITAL PUNTA DE EUROPA   (Spain)

^c NONE

Author keywords

Candida albicans germ tube antibody (CAGTA); Critically ill patients; ICU; Invasive candidiasis; Serum diagnostic test

Indexed keywords

FUNGUS ANTIBODY; IMMUNOGLOBULIN G;

BLOOD; CANDIDA ALBICANS; EVALUATION STUDY; HUMAN; IMMUNOASSAY; IMMUNOLOGY; INTENSIVE CARE UNIT; INVASIVE CANDIDIASIS; LABORATORY AUTOMATION; LUMINESCENCE; PREDICTIVE VALUE; PROCEDURES; PROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SEROLOGY;

ANTIBODIES, FUNGAL; AUTOMATION, LABORATORY; CANDIDA ALBICANS; CANDIDIASIS, INVASIVE; HUMANS; IMMUNOASSAY; IMMUNOGLOBULIN G; INTENSIVE CARE UNITS; LUMINESCENT MEASUREMENTS; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; SEROLOGIC TESTS;

EID: 85017182949     PISSN: 0301486X     EISSN: 15730832     Source Type: Journal    
DOI: 10.1007/s11046-017-0125-9     Document Type: Article

References (25)

1. Eggimann P, Bille J, Marchetti O. Diagnosis of invasive candidiasis in the ICU. Ann Intensive Care. 2011;. doi:10.1186/2110-5820-1-37.
2. Lortholary O, Renaudat C, Sitbon K, et al. Worrisome trends in incidence and mortality of candidemia in intensive care units (Paris area, 2002–2010). Intensive Care Med. 2014;40(9):1303–12.
3. Colombo AL, Guimaraes T, Sukienik T, et al. Prognostic factors and historical trends in the epidemiology of candidemia in critically ill patients: an analysis of five multicenter studies sequentially conducted over a 9-year period. Intensive Care Med. 2014;40(10):1489–98.
4. Wisplinghoff H, Bischoff T, Tallent SM, et al. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis. 2004;39(3):309–17.
5. Pappas PG, Kauffman CA, Andes DR, et al. Executive summary: clinical practice guideline for the management of candidiasis: 2016 update by the infectious diseases society of America. Clin Infect Dis. 2016;62(4):409–17.
6. Fernandez J, Erstad BL, Petty W, Nix DE. Time to positive culture and identification for Candida blood stream infections. Diagn Microbiol Infect Dis. 2009;64(4):402–7.
7. Clancy CJ, Nguyen MH. Finding the ‘‘missing 50%’’ of invasive candidiasis: how non-culture diagnostics will improve understanding of disease spectrum and transform patient care. Clin Infect Dis. 2013;56(9):1284–92.
8. Maubon D, Garnaud C, Calandra T, Sanglard D, Cornet M. Resistance of Candida spp. to antifungal drugs in the ICU: where are we now? Intensive Care Med. 2014;40(9):1241–55.
9. Zaragoza R, Peman J, Quindos G, et al. Clinical significance of the detection of Candida albicans germ tube-specific antibodies in critically ill patients. Clin Microbiol Infect. 2009;15(6):592–5.
10. Peman J, Zaragoza R, Quindos R, et al. Clinical factors associated with a Candida albicans germ tube antibody positive test in intensive care unit patients. BMC Infect Dis. 2011;11:60.
11. Martinez-Jimenez MC, Muñoz P, Guinea J, et al. Potential role of Candida albicans germ tube antibody (CAGTA) in the diagnosis of deep-seated candidemia. Med Mycol. 2014;52(3):270–5.
12. Martínez-Jiménez MC, Muñoz P, Valerio M, et al. Candida biomarkers in patients with candidaemia and bacteraemia. J Antimicrob Chemother. 2015;70(8):2354–61.
13. Martín-Mazuelos E, Loza A, Castro C, et al. β-D-Glucan and Candida albicans germ tube antibody in ICU patients with invasive candidiasis. Intensive Care Med. 2015;41(8):1424–32.
14. León C, Ruiz-Santana S, Saavedra P, et al. Contribution of Candida biomarkers and DNA detection for the diagnosis of invasive candidiasis in ICU patients with severe abdominal conditions. Crit Care. 2016;20(1):149. doi:10.1186/s13054-016-1324-3.
15. León C, Ruiz-Santana S, Saavedra P, et al. Usefulness of the Candida score for discriminating between Candida colonization and invasive candidiasis in non-neutropenic critically ill patients: a prospective multicenter study. Crit Care Med. 2009;37(5):1624–33.
16. Alexander BD, Pfaller MA. Contemporary tools for the diagnosis and management of invasive mycoses. Clin Infect Dis. 2006;43(Suppl 1):15–27.
17. Lam SW, Eschenauer GA, Carver PL. Evolving role of early antifungals in the adult intensive care unit. Crit Care Med. 2009;37(5):1580–93.
18. Shorr AF, Gupta V, Sun X, Johannes RS, Spalding J, Tabak YP. Burden of early-onset candidemia: analysis of culture-positive bloodstream infections from a large U.S. database. Crit Care Med. 2009;37(9):2519–26.
19. Azoulay E, Dupont H, Tabah A, et al. Systemic antifungal therapy in critically ill patients without invasive fungal infection. Crit Care Med. 2012;40(3):813–22.
20. Leon C, Ruiz-Santana S, Saavedra P, et al. Value of b-D-glucan and Candida albicans germ tube antibody for discriminating between Candida colonization and invasive candidiasis in patients with severe abdominal conditions. Intensive Care Med. 2012;38(8):1315–25.
21. Moragues MD, Ortiz N, Iruretagoyena JR, et al. Evaluation of a new commercial test (Candida albicans IFA IgG) for the serodiagnosis of invasive candidiasis. Enferm Infecc Microbiol Clin. 2004;22(2):83–8.
22. Linares MJ, Javier MR, Villanueva JL, et al. Detection of antibodies to Candida albicans germ tubes in heroin addicts with systemic candidiasis. Clin Microbiol Infect. 2001;7(4):218–26.
23. García-Ruiz JC, del Carmen Arilla M, Regúlez P, Quindós G, Alvarez A, Pontón J. Detection of antibodies to Candida albicans germ tubes for diagnosis and therapeutic monitoring of invasive candidiasis in patients with hematologic malignancies. J Clin Microbiol. 1997;35(12):3284–7.
24. Puig-Asensio M, Padilla B, Garnacho-Montero J, Zaragoza O, Aguado JM, Zaragoza R, et al. Epidemiology and predictive factors for early and late mortality in Candida bloodstream infections: a population-based surveillance in Spain. Clin Microbiol Infect. 2014;20(4):O245–54.
25. Caggiano G, Coretti C, Bartolomeo N, Lovero G, De Giglio O, Montagna MT. Candida bloodstream infections in Italy: changing epidemiology during 16 years of surveillance. Biomed Res Int. 2015;. doi:10.1155/2015/256580.